DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hip14 and zdhhc13

DIOPT Version :9

Sequence 1:	NP_001261910.1	Gene:	Hip14 / 39747	FlyBaseID:	FBgn0259824	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001008650.2	Gene:	zdhhc13 / 494107	ZFINID:	ZDB-GENE-041212-79	Length:	645	Species:	Danio rerio

Alignment Length:	611	Identity:	216/611 - (35%)
Similarity:	334/611 - (54%)	Gaps:	53/611 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 GSCVPGTGQQPDNERQSALIAQQPPTAPVEPDYSGFDIVKATQYGAIARVRELVESGWDVNQPDS 76
            |..|||. ..|         .|||..:....|.|.:||:||||:||:.|.:||||:|:||.|||.
Zfish    49 GQLVPGP-MDP---------TQQPRKSSHPEDSSSWDIIKATQFGALERCKELVEAGYDVRQPDK 103

  Fly    77 ETVTLLHWAAINNRRDIIRYFLEKGATVDAVGGELNATPLHWATRQGHLGAVVLLMAAGADPRIR 141
            |.||||||||||||.||::|::.|||.:|.:||:||:||||||.|||||..|:.||..||||.:.
Zfish   104 ENVTLLHWAAINNRADIVKYYISKGAVIDQLGGDLNSTPLHWAIRQGHLSMVIQLMRYGADPSLA 168

  Fly   142 DAEGCSCIHIAAQFAHTALVAYFIAKGVDPDLQDRGGMTALMWAAWKVCALDPVRLLLTLGANPA 206
            |.||...:|:|..|.:..:.||.:|||.:.||.|..|.|.||.||.|:...:|...|:...|:..
Zfish   169 DGEGYRGLHLAVLFQNMPIAAYLMAKGQEVDLPDLNGQTPLMLAAQKIIGPEPTNFLIKCNASVN 233

  Fly   207 MVDYTHGNTALHWAILARNATAISTLVLKSKASLDVPNLRGETPLSMLESQTGAIWI---GAKVM 268
            .||..:.|:.||.|:||.|..::. ::|::.||:|:.|..|.|.:.:.:.....:.|   .....
Zfish   234 AVDKVNRNSPLHCAVLAGNVDSVH-ILLEAGASVDMQNDNGHTAIDLAQQVHSPLLIHMLSVVKT 297

  Fly   269 DRVK--EAALTSQQRRSLLSKLRHDKRLRWWSMVACPFTAFYLA-----GIVFTVNT-LYIIKFF 325
            :|:|  .|.|      .||::.:           .|..:.|.:.     |.:..:.| .:::|..
Zfish   298 ERIKANSACL------KLLNRYK-----------VCLQSVFSVVVVGAFGAILDMRTESWLLKGI 345

  Fly   326 LLGCLYSIFHTIGKALFDEHLMALLPLSVYLATKAWFYVTW-LMYIDDAVSFTATVCFLISSLLL 389
            ||.|:.::.:...:.|....:.:|:|.:..:|:..|..||| |.::.|..|....:.|.::...:
Zfish   346 LLACIMAVINLASRQLATVAVRSLIPSTGLIASVFWMVVTWVLWFLPDEPSAAVQMLFTVNITAV 410

  Fly   390 WVCFLKSWKGDPGIIRPTREQRFKTIIELSERGGIGFEPASFCSGCLVRRPIRSKHCSVCDRCVA 454
            ...:::|.:.|||.::.|.|::.|.|:.|:|.|.:  :|..||:.|::|:|:|:.||..|:.|||
Zfish   411 LYYYIRSCRTDPGHVKATEEEKKKNIVVLAEAGCL--DPRIFCTSCMMRKPMRANHCFSCNACVA 473

  Fly   455 RFDHHCPWVGNCIGLKNHSYFMGFLWMLLIMCAWMLYGGSKYYVNQCNVRFDD--FLGAMRAIGN 517
            :.|||..|:..|||.:||.:|:.||..|..:|.||.||...|:...|.:.:.:  ..||:.|:..
Zfish   474 KQDHHSIWINGCIGARNHPFFVLFLVALNFLCIWMFYGSITYWSRHCPLHYSEEGIWGALTALMG 538

  Fly   518 CDAWVGWVMGNALLHMSWVILLTICQTYQVICLGMTTNERMNRGRYRHFQAK------GGHSPFT 576
            |..|:.:|......|.:|..:|.:.|.||:..||:||:||.|   ..|.|.|      ...:||.
Zfish   539 CSPWLLYVFCFVFFHTTWASILLVLQLYQIAFLGLTTSERAN---LMHRQRKLPQAVSLRQNPFN 600

  Fly   577 RGPIQNLVDFLECSCFGLVQPKRVDW 602
            .|.::|||:|.:....||.:|..:||
Zfish   601 HGVVKNLVNFFQWRFCGLCKPMVLDW 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hip14	NP_001261910.1	ANK	52..165	CDD:238125	66/112 (59%)
		Ank_2	52..142	CDD:289560	58/89 (65%)
		ANK repeat	77..108	CDD:293786	20/30 (67%)
		ANK repeat	110..142	CDD:293786	20/31 (65%)
		ANK	114..233	CDD:238125	51/118 (43%)
		Ank_2	116..209	CDD:289560	40/92 (43%)
		ANK repeat	144..175	CDD:293786	12/30 (40%)
		ANK repeat	177..209	CDD:293786	10/31 (32%)
		Ank_5	198..251	CDD:290568	18/52 (35%)
		ANK repeat	212..244	CDD:293786	11/31 (35%)
		zf-DHHC	426..559	CDD:279823	51/134 (38%)
zdhhc13	NP_001008650.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..73		9/33 (27%)
		ANKYR	<62..204	CDD:223738	78/141 (55%)
		ANK repeat	76..102	CDD:293786	16/25 (64%)
		ANK repeat	104..135	CDD:293786	20/30 (67%)
		ANK 1. /evidence=ECO:0000255	104..133		19/28 (68%)
		PHA03095	115..>312	CDD:222980	79/203 (39%)
		ANK repeat	137..169	CDD:293786	20/31 (65%)
		ANK 2. /evidence=ECO:0000255	138..167		20/28 (71%)
		ANK 3. /evidence=ECO:0000255	171..200		10/28 (36%)
		ANK repeat	176..202	CDD:293786	10/25 (40%)
		ANK repeat	204..236	CDD:293786	10/31 (32%)
		ANK 4. /evidence=ECO:0000255	204..234		10/29 (34%)
		ANK repeat	239..270	CDD:293786	11/31 (35%)
		ANK 5. /evidence=ECO:0000255	239..268		10/29 (34%)
		DHHC	450..580	CDD:396215	50/129 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586677
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54696
OrthoDB	1	1.010	-	-		D213306at33208
OrthoFinder	1	1.000	-	-		FOG0001761
OrthoInspector	1	1.000	-	-		otm25861
orthoMCL	1	0.900	-	-		OOG6_101007
Panther	1	1.100	-	-	O	PTHR24161
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X628
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.860