DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Hip14 and app

DIOPT Version :9

Sequence 1:NP_001261910.1 Gene:Hip14 / 39747 FlyBaseID:FBgn0259824 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_648561.2 Gene:app / 39399 FlyBaseID:FBgn0260941 Length:755 Species:Drosophila melanogaster


Alignment Length:329 Identity:85/329 - (25%)
Similarity:131/329 - (39%) Gaps:100/329 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   323 KFFLLGCLYSIFHTIGKALFDEHLMALLPLSVYLATKAWFYVTWLMYIDDAVS-----FTATVCF 382
            ||:..|.|.|..||   .:|  :|..:|    ...|.|.|:.....::.|:::     ..|.:.|
  Fly    30 KFYCDGLLMSAPHT---GVF--YLTCIL----ITGTSALFFAFDCPFLADSINPAIPIVGAVLYF 85

  Fly   383 LISSLLLWVCFLKSWKGDPGII-RPTREQ-----------------------RFKTIIELSERGG 423
            ...|.||...|.     |||:| |.:.::                       |.|.::...:...
  Fly    86 FTMSSLLRTTFT-----DPGVIPRASNDEAAYIEKQIEVPNSLNSPTYRPPPRTKEVLVKGQTVK 145

  Fly   424 IGFEPASFCSGCLVRRPIRSKHCSVCDRCVARFDHHCPWVGNCIGLKNHSYFMGFLWMLLIMCAW 488
            :     .:|..|.:.||.|:.|||:||.||.||||||||||||:|.:|:.:|..||..|..:.. 
  Fly   146 L-----KYCFTCKIFRPPRASHCSLCDNCVDRFDHHCPWVGNCVGKRNYRFFYLFLVSLAFLAV- 204

  Fly   489 MLYGGSKYYVNQCNV--------RFDDFLGAMRA-------IGNCDAWVGWVMGNALLHMSWVIL 538
                    ::..|:|        :..:....::|       :..|...:..|:|.|..|      
  Fly   205 --------FIFSCSVTHLVLLMKKEHEVFNVIKAAPFTVIVVFICFFSIWSVIGLAGFH------ 255

  Fly   539 LTICQTYQVICLGMTTNERMNRGRYRHFQAKGG---HSPFTRGPIQNLVDFLECS---CFGLVQP 597
                 || :.....||||.:...    |.:|||   .:|::||.|     .|.|.   | |.:.|
  Fly   256 -----TY-LTTSDQTTNEDLKGS----FSSKGGPRTQNPYSRGNI-----CLNCCHILC-GPMTP 304

  Fly   598 KRVD 601
            ..:|
  Fly   305 SLID 308

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hip14NP_001261910.1 ANK 52..165 CDD:238125
Ank_2 52..142 CDD:289560
ANK repeat 77..108 CDD:293786
ANK repeat 110..142 CDD:293786
ANK 114..233 CDD:238125
Ank_2 116..209 CDD:289560
ANK repeat 144..175 CDD:293786
ANK repeat 177..209 CDD:293786
Ank_5 198..251 CDD:290568
ANK repeat 212..244 CDD:293786
zf-DHHC 426..559 CDD:279823 44/147 (30%)
appNP_648561.2 zf-DHHC 146..270 CDD:279823 44/149 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5273
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
21.810

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