DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hip14 and zdhhc16b

DIOPT Version :9

Sequence 1:	NP_001261910.1	Gene:	Hip14 / 39747	FlyBaseID:	FBgn0259824	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_009304660.1	Gene:	zdhhc16b / 393316	ZFINID:	ZDB-GENE-040426-1301	Length:	382	Species:	Danio rerio

Alignment Length:	386	Identity:	92/386 - (23%)
Similarity:	144/386 - (37%)	Gaps:	132/386 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   291 DKRLRWWSMVACPFTAFYLAGIVFTVNTLYIIKFFLLGCLYSIFHTIGKALFDEHLMALLPLSVY 355
            |...||:.:|   |....:|   .|.:.:.|:...:|..::|.:                  .||
Zfish    71 DNMTRWFGVV---FVCLVMA---LTSSVVVIVYLCVLPIIFSSY------------------PVY 111

  Fly   356 LATKAWFYVTWLMYIDDAVSFTATVCFLISSLLLWVC-FLKSWKGDPGIIRPTREQRFKTIIELS 419
                      |:::         .:|:...:||:.|. :.|:....||.  |.:|   ||.|
Zfish   112 ----------WILW---------HLCYGHWNLLMVVFHYYKATTTQPGF--PPQE---KTDI--- 149

  Fly   420 ERGGIGFEPASFCSGCLVRRPIRSKHCSVCDRCVARFDHHCPWVGNCIGLKNHSYFMGFLWMLLI 484
                   ...:.|..|:|.:|.|:.|||:|:||:.:.||||||:.||:|..||.||..|...:.:
Zfish   150 -------PTVTICKKCIVPKPARTHHCSICNRCILKMDHHCPWLNNCVGHFNHRYFFSFCLFMTM 207

  Fly   485 MCAWMLYGGSKYYVNQCNVRFDD-FLGAMRAIGNCDAWVGWVMGNA------------------- 529
            .|.:            |::...| ||.|..||.:.....|...|.|
Zfish   208 GCVY------------CSISAKDMFLDAYNAIESGRYKGGASQGEAVPGAGLIYISFQHQSSYQT 260

  Fly   530 ----------LLHMS----WVILLTICQTYQVICL--------GMTTNER-MNRGRYRHFQAKGG 571
                      ::|.|    ||:..::......:.|        |.|:.|| :||...|..:.:|.
Zfish   261 PPPAFTHQERMVHKSLVYLWVLTSSVAVALGALTLWHAILITRGETSVERHINRKERRRLKLRGK 325

  Fly   572 --HSPFTRGPIQNLVDFLECSCFGLVQPKRVDWMNYYDYDAQTHQTIEKEPL---LSVDCP 627
              .:|:..|.|.|...|     ||:  .|..||: :......||     .||   |:.|||
Zfish   326 LFRNPYHHGRINNWRIF-----FGV--EKGSDWL-WRVLLPSTH-----PPLGDGLTWDCP 373

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hip14	NP_001261910.1	ANK	52..165	CDD:238125
		Ank_2	52..142	CDD:289560
		ANK repeat	77..108	CDD:293786
		ANK repeat	110..142	CDD:293786
		ANK	114..233	CDD:238125
		Ank_2	116..209	CDD:289560
		ANK repeat	144..175	CDD:293786
		ANK repeat	177..209	CDD:293786
		Ank_5	198..251	CDD:290568
		ANK repeat	212..244	CDD:293786
		zf-DHHC	426..559	CDD:279823	45/175 (26%)
zdhhc16b	XP_009304660.1	zf-DHHC	83..>206	CDD:327686	45/177 (25%)
zdhhc16b	XP_009304660.1	zf-DHHC	154..310	CDD:307600	43/167 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810