DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hip14 and Patsas

DIOPT Version :9

Sequence 1:	NP_001261910.1	Gene:	Hip14 / 39747	FlyBaseID:	FBgn0259824	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001356957.1	Gene:	Patsas / 34634	FlyBaseID:	FBgn0029137	Length:	613	Species:	Drosophila melanogaster

Alignment Length:	570	Identity:	160/570 - (28%)
Similarity:	259/570 - (45%)	Gaps:	118/570 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 FDIVKATQYGAIARVRELVES-GWD-VNQPDSETVTLLHWAAINNRRDIIRYFLEKGATVD-AVG 108
            |||:|   .|.::.|..||:. |.: ::..|....|..||.|:|....::||.:|:.|.:| ...
  Fly   119 FDIIK---NGEVSEVENLVDKFGMECLSARDRHGYTPAHWIALNGNVQLMRYLIERTAPIDLPCL 180

  Fly   109 GELNATPLHWATRQGHLGAVVLLMAAGADPRIRDAEGCSCIHIAAQFAHTALVAYFIAKGVDPDL 173
            |.....|:|||.|:||...|.:|:.||......|.:|.:.:|:|..:..||..||.:..|...:|
  Fly   181 GTQGPRPIHWACRKGHASVVQVLLQAGVAVNAADFKGLTPLHLACMYGRTATAAYLLGMGALNNL 245

  Fly   174 QDRGGMTALMWAAWKVCALDPVRLLLTLGANPAMVDYTHGNTALHWAILARNATAISTLVLKSKA 238
            .|..|.|||.|||:|..| |.:|||:..|......| ..|:|.||.|.|:.|.|.:..|..||:.
  Fly   246 TDINGDTALHWAAYKGHA-DLMRLLMYSGVELQKTD-NFGSTPLHLACLSGNMTCVRLLCEKSQL 308

  Fly   239 SLDVPNLRGETPLSMLESQTGAIWIGAKVMDRVKEAALTSQQRRSLLSKLRHDKRLRWWSMVACP 303
            .|:..:..|:||:.:.::.        :..|.|          |.|..:::  |:.||...|:..
  Fly   309 DLEPRDKNGKTPIMLAQAH--------QHQDVV----------RLLYGEVK--KKSRWIPSVSES 353

  Fly   304 FTAFYLAGIVFTVNTLYIIKFFLLGCLYSIFHTIGKALFDEHLMALLPLSVYLATKAWFYVTWLM 368
            : .:...|...:...|::..|.:|                                .|.|.   |
  Fly   354 W-GWLFGGAGDSKGPLFLFLFSVL--------------------------------LWGYP---M 382

  Fly   369 YIDDAVSFTATV------CFLISSLLLWVCFLKSWKGDPGIIRPTREQRFKTIIE------LSER 421
            |:..|:..|..:      ||:..:.::|:.:..:.:.|||.|..:.:..::.|.:      |.:|
  Fly   383 YMIRAIPITWNILRRSHYCFIYWNAVMWISWAIANRRDPGYIPLSSDAYYRAIKQIPYFDKLKKR 447

  Fly   422 GGIGFEPASFCSGCLVRRPIRSKHCSVCDRCVARFDHHCPWVGNCIGLKNHSYFMGFLWMLLIMC 486
            ..:   ....|..|...||:|:|||.||:|||:.||||||::.||:||:|..:|..|:..:.:.|
  Fly   448 NVM---LTRLCHSCRCLRPLRAKHCRVCNRCVSYFDHHCPFIYNCVGLRNRMWFFLFVLSVAVNC 509

  Fly   487 AWMLY---------GGSKYYVNQCNVRFDDFLGAMRAIGNCDAWVGWVMG-NALLHMSWVILLTI 541
            ::.:|         |.:..||          ||.:.|:..|.  :||::. .::||
  Fly   510 SFTIYFACYCVMIEGFTMLYV----------LGLIEAVVFCG--LGWILTCTSILH--------- 553

  Fly   542 CQTYQVICLGMTTNERMNRGRYRHFQAKGG--HSPFTRGPIQNLVDFLEC 589
                  .|:.:||||..|..||.:.:.|.|  .:||:||||.||::|..|
  Fly   554 ------ACMNLTTNEMFNYKRYPYLRDKRGRYQNPFSRGPILNLLEFFVC 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hip14	NP_001261910.1	ANK	52..165	CDD:238125	36/115 (31%)
		Ank_2	52..142	CDD:289560	28/92 (30%)
		ANK repeat	77..108	CDD:293786	10/31 (32%)
		ANK repeat	110..142	CDD:293786	11/31 (35%)
		ANK	114..233	CDD:238125	45/118 (38%)
		Ank_2	116..209	CDD:289560	35/92 (38%)
		ANK repeat	144..175	CDD:293786	9/30 (30%)
		ANK repeat	177..209	CDD:293786	14/31 (45%)
		Ank_5	198..251	CDD:290568	17/52 (33%)
		ANK repeat	212..244	CDD:293786	12/31 (39%)
		zf-DHHC	426..559	CDD:279823	44/142 (31%)
Patsas	NP_001356957.1	ANKYR	113..306	CDD:223738	67/191 (35%)
		ANK repeat	148..181	CDD:293786	10/32 (31%)
		ANK repeat	187..214	CDD:293786	11/26 (42%)
		ANK repeat	216..247	CDD:293786	9/30 (30%)
		ANK repeat	249..280	CDD:293786	14/31 (45%)
		ANK repeat	282..314	CDD:293786	12/31 (39%)
		Ank_4	283..336	CDD:316185	18/70 (26%)
		DHHC	455..567	CDD:334580	45/138 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	69	1.000	Domainoid score	I2290
eggNOG	1	0.900	-	-		E1_COG5273
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2373
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D213306at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101007
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R35
SonicParanoid	1	1.000	-	-		X628
	8	7.700