DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hip14 and ZDHHC22

DIOPT Version :9

Sequence 1:	NP_001261910.1	Gene:	Hip14 / 39747	FlyBaseID:	FBgn0259824	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_001351101.1	Gene:	ZDHHC22 / 283576	HGNCID:	20106	Length:	263	Species:	Homo sapiens

Alignment Length:	225	Identity:	55/225 - (24%)
Similarity:	87/225 - (38%)	Gaps:	37/225 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   374 VSFTATVCFLISSLLLWV----CFLKSWKGDPGIIR----------------PTREQRFKTIIEL 418
            ::..|...||..||:.:|    .||.|.:.||...|                ......:..:|:.
Human     7 LNVVAPAYFLCISLVTFVLQLFLFLPSMREDPAAARLFSPALLHGALFLFLSANALGNYVLVIQN 71

  Fly   419 SERGGIGFEPASFCSGCLVRR---PIRSKH-CSVCDRCVARFDHHCPWVGNCIGLKNHSYFMGFL 479
            |.      :....|.|...|:   |..|.| |.||.|...|.||||.:.|||||.:|...|:.|.
Human    72 SP------DDLGACQGASARKTPCPSPSTHFCRVCARVTLRHDHHCFFTGNCIGSRNMRNFVLFC 130

  Fly   480 WMLLIMCAWMLYGGSKYYVNQCNVRFDDFLGAMRAIGN--CDAWVGWVMGNALLHMSWVILLTIC 542
            ....:.|.:.:..|..|.....::.|...|..:..:..  ...:.|.|:|:   .|..:::|.:.
Human   131 LYTSLACLYSMVAGVAYISAVLSISFAHPLAFLTLLPTSISQFFSGAVLGS---EMFVILMLYLW 192

  Fly   543 QTYQVICLGMTTNERM--NRGRYRHFQAKG 570
            ....:.|.|...::.:  .||:.||...||
Human   193 FAIGLACAGFCCHQLLLILRGQTRHQVRKG 222

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hip14	NP_001261910.1	ANK	52..165	CDD:238125
		Ank_2	52..142	CDD:289560
		ANK repeat	77..108	CDD:293786
		ANK repeat	110..142	CDD:293786
		ANK	114..233	CDD:238125
		Ank_2	116..209	CDD:289560
		ANK repeat	144..175	CDD:293786
		ANK repeat	177..209	CDD:293786
		Ank_5	198..251	CDD:290568
		ANK repeat	212..244	CDD:293786
		zf-DHHC	426..559	CDD:279823	35/140 (25%)
ZDHHC22	NP_001351101.1	DHHC	92..218	CDD:366691	34/128 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810