DRSC/TRiP Functional Genomics Resources

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Protein Alignment Hip14 and Zdhhc2

DIOPT Version :9

Sequence 1:NP_001261910.1 Gene:Hip14 / 39747 FlyBaseID:FBgn0259824 Length:655 Species:Drosophila melanogaster
Sequence 2:NP_659564.3 Gene:Zdhhc2 / 246326 RGDID:628681 Length:366 Species:Rattus norvegicus


Alignment Length:256 Identity:57/256 - (22%)
Similarity:97/256 - (37%) Gaps:54/256 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   352 LSVYLATKAWFYVTWLMYIDDAVSFTATVCFLISSLLLWVCFLKSWKGDPGI-IRPTREQRF--- 412
            :|:.|....:.|...|..:.........||.:...||..:.....||....: :.|::|...   
  Rat    25 ISLLLGWSYYAYAIQLCIVSMENIGEQVVCLMAYHLLFAMFVWSYWKTIFTLPMNPSKEFHLSYA 89

  Fly   413 -KTIIELSERGGIGFE------------------PASFCSGCLVRRPIRSKHCSVCDRCVARFDH 458
             |.::|...||....|                  ...:|..|.:.:|.|..||||||:|:.:.||
  Rat    90 EKELLEREPRGEAHQEVLRRAAKDLPIYTRTMSGAIRYCDRCRLIKPDRCHHCSVCDKCILKMDH 154

  Fly   459 HCPWVGNCIGLKNHSYFMGFLWMLLIMCAWMLYGGSKYYVN-----------QCNVRFDDFLGAM 512
            |||||.||:|..|:.:|:.||...|:.|.::.....:|::.           :.::.|..|..||
  Rat   155 HCPWVNNCVGFSNYKFFLLFLAYSLLYCLFIAATDLQYFIRFWTNGLPDTQAKFHIMFLFFAAAM 219

  Fly   513 RAIGNCDAWVGWVMGNALLHMSWVILLTICQTYQVICLGMTTNERMNRGRYRHFQAKGGHS 573
            .::.         :.:...:..|           ::....:|.|......:||...|.|.|
  Rat   220 FSVS---------LSSLFGYHCW-----------LVSKNKSTLEAFRNPVFRHGTDKNGFS 260

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Hip14NP_001261910.1 ANK 52..165 CDD:238125
Ank_2 52..142 CDD:289560
ANK repeat 77..108 CDD:293786
ANK repeat 110..142 CDD:293786
ANK 114..233 CDD:238125
Ank_2 116..209 CDD:289560
ANK repeat 144..175 CDD:293786
ANK repeat 177..209 CDD:293786
Ank_5 198..251 CDD:290568
ANK repeat 212..244 CDD:293786
zf-DHHC 426..559 CDD:279823 36/161 (22%)
Zdhhc2NP_659564.3 DHHC 19..301 CDD:418707 57/256 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 297..366
Mediates localization to plasma membrane and recycling endosomes. /evidence=ECO:0000250|UniProtKB:P59267 298..366
Non-canonical dileucine endocytic signal. /evidence=ECO:0000250|UniProtKB:P59267 334..335
NPxY-like endocytic signal. /evidence=ECO:0000250|UniProtKB:P59267 357..360
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5273
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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