DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hip14 and Zdhhc5

DIOPT Version :9

Sequence 1:	NP_001261910.1	Gene:	Hip14 / 39747	FlyBaseID:	FBgn0259824	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	NP_659136.1	Gene:	Zdhhc5 / 228136	MGIID:	1923573	Length:	715	Species:	Mus musculus

Alignment Length:	318	Identity:	92/318 - (28%)
Similarity:	133/318 - (41%)	Gaps:	73/318 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   338 GKALFDEHLMALLPLSVYL--ATKAWFYVT---WLMYIDDAVSFTATVCFL-ISSLLLWVCFLKS 396
            ||.......:.:...:::|  ||..:|..|   ..:.:..||.....:.|| :.:......|:
Mouse     6 GKRFKPSKYVPVSAAAIFLVGATTLFFAFTCPGLSLNVSPAVPIYNAIMFLFVLANFSMATFM-- 68

  Fly   397 WKGDPGIIRPTREQR----------FKTIIELSERGGIGFEPASFCSGCLVRRPIRSKHCSVCDR 451
               ||||.....|..          :||:    |..||... ..:|:.|...||.|..||||||.
Mouse    69 ---DPGIFPRAEEDEDKEDDFRAPLYKTV----EIKGIQVR-MKWCATCRFYRPPRCSHCSVCDN 125

  Fly   452 CVARFDHHCPWVGNCIGLKNHSYFMGFLWMLLIMCAWM-LYGGSKYYVNQCNVRFDDFLGAMRAI 515
            ||..||||||||.||||.:|:.||  ||::|.:....| ::|....||   ....::..|...|:
Mouse   126 CVEEFDHHCPWVNNCIGRRNYRYF--FLFLLSLTAHIMGVFGFGLLYV---LYHIEELSGVRTAV 185

  Fly   516 G---NCDAWVGW--VMGNALLHMSWVILLTICQTYQVICLGMTTNERMNRGRYRHFQAKGGHSPF 575
            .   .|.|.:.:  |.|....|   |:|         :..|.||||::. |::|     ||.:||
Mouse   186 TMAVMCVAGLFFIPVAGLTGFH---VVL---------VARGRTTNEQVT-GKFR-----GGVNPF 232

  Fly   576 TRGPIQNLVDFLECSCFG---LVQPKRVDWMNYYDYDAQTHQTIE-KEPLLSVDCPDG 629
            |.|...|:...| ||...   |.:||:             .:||. :.|.|..:..||
Mouse   233 TNGCCNNVSRVL-CSSPAPRYLGRPKK-------------EKTIVIRPPFLRPEVSDG 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hip14	NP_001261910.1	ANK	52..165	CDD:238125
		Ank_2	52..142	CDD:289560
		ANK repeat	77..108	CDD:293786
		ANK repeat	110..142	CDD:293786
		ANK	114..233	CDD:238125
		Ank_2	116..209	CDD:289560
		ANK repeat	144..175	CDD:293786
		ANK repeat	177..209	CDD:293786
		Ank_5	198..251	CDD:290568
		ANK repeat	212..244	CDD:293786
		zf-DHHC	426..559	CDD:279823	49/138 (36%)
Zdhhc5	NP_659136.1	zf-DHHC	99..224	CDD:279823	50/143 (35%)
Zdhhc5	NP_659136.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..715
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810