DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hip14 and si:ch211-223a10.1

DIOPT Version :9

Sequence 1:	NP_001261910.1	Gene:	Hip14 / 39747	FlyBaseID:	FBgn0259824	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_009305694.1	Gene:	si:ch211-223a10.1 / 101884554	ZFINID:	ZDB-GENE-090313-86	Length:	544	Species:	Danio rerio

Alignment Length:	596	Identity:	162/596 - (27%)
Similarity:	248/596 - (41%)	Gaps:	124/596 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 SGFDIVKATQYGAIARVRELV--------ESGWDVNQPDSETVTLLHWAAINNRRDIIRYFLEKG 101
            ||..|.::.|.|.|.||..|:        :.||.       ..|.||:||:|..|.:....|..|
Zfish     5 SGSCIFESVQRGEIDRVSHLLQQDRGVLKQKGWG-------GFTALHFAALNGNRAVAELLLNSG 62

  Fly   102 ATVDAVGGELNATPLHWATRQGHLGAVVLLMAAGADPRIRDAEGCSCIH--------IAAQFAHT 158
            |..: :..:...||.|:|.|.|::..:..:|..|||.||.|.:|.:.:|        ||.|:...
Zfish    63 ADPN-IPCDAGQTPFHFACRNGNIYIMYKMMQQGADLRIADEQGKTALHYAVSGGSVIATQYLWE 126

  Fly   159 ALVAYFIAKGVDPDLQDRGGMTALMWAAWKVCALDPVRLLLTLG-ANPAMVDYTHGNTALHWAIL 222
            ..:.:|    .|||...   :|.|..|| .....|.||.||... .:|..||: .|.||||.| .
Zfish   127 TRMFHF----SDPDNYQ---VTPLHLAA-STGNTDVVRYLLRANRCSPEAVDH-QGATALHVA-A 181

  Fly   223 ARNATAISTLVLKSKA--SLDVPNLRGETPLSMLESQTGAIWIGAKVMDRVKEAALT--SQQRRS 283
            .:....:..|:|||..  .|.:.|..|.|||.:...       |.....:.....||  |||.::
Zfish   182 EKGMIEVCWLLLKSAGLHILHMTNHTGLTPLDLCNQ-------GNTFRHQQLSKILTDFSQQPKN 239

  Fly   284 LLSKLRHDKRLRWWSMVACPFTAFYLAGIVFTVNTLYIIKFFLLGCLYS--IFHTIGKALFDE-H 345
            |:.|   |..:.::.|:..|    .|:|:...|....:.::   |.::|  :|..:.|.:..: |
Zfish   240 LIPK---DSYVMYFWMLLLP----SLSGVAVLVIAAALGEY---GGIFSAVLFPFMAKTILSQYH 294

  Fly   346 LMA---LLPLSVYLATKAWFYVTWLMYIDDAVSFTATVCFLISSL-------------LLWVC-- 392
            .::   .||..|||.|..            |....:|||||...:             |:..|
Zfish   295 RLSSFQRLPNPVYLGTLT------------AGLIHSTVCFLYKIIPSFWPAHTLLHLSLVHFCVL 347

  Fly   393 ---FLKSWKGDPGIIRPT-REQRFKTIIELSERGGIGFEPASFCSGCLVRRPIRSKHCSVCDRCV 453
               |.|..|..||.::.. .:.||.:|.:|.|.|.   .|..||..|.:.:....|||.:||.|:
Zfish   348 AGLFWKVLKQSPGQLKDADTDSRFSSIGDLMEAGQ---SPDRFCIYCELIQVENCKHCRLCDMCI 409

  Fly   454 ARFDHHCPWVGNCIGLKNHSYFMGFLW-MLLIMCAWMLYGGSKYYVNQCNVRFDDFLGAMRAIGN 517
            ..:||||.::..|:|.:||..|:.||. |::....::|......|:....::..|
Zfish   410 KDYDHHCLFINQCVGRENHRTFILFLMSMVMAHLIFILSAIFYLYLKVSGLQLSD---------- 464

  Fly   518 CDAWVGWVMGNALLHMSWVILLTICQTYQVICLGMTTNERM---NRGR---YRHFQAKGGHSPFT 576
               | |.|.|..    :||:|||:.....:..:|....|::   :||.   ||.:..||   |..
Zfish   465 ---W-GSVAGRE----AWVLLLTLLNLLSLFWVGWLLGEQLDAISRGTTTYYRRYDLKG---PSK 518

  Fly   577 RGPIQNLVDFL 587
            |..:..:|.||
Zfish   519 RQRLGTVVSFL 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hip14	NP_001261910.1	ANK	52..165	CDD:238125	36/128 (28%)
		Ank_2	52..142	CDD:289560	30/97 (31%)
		ANK repeat	77..108	CDD:293786	10/30 (33%)
		ANK repeat	110..142	CDD:293786	12/31 (39%)
		ANK	114..233	CDD:238125	40/127 (31%)
		Ank_2	116..209	CDD:289560	30/101 (30%)
		ANK repeat	144..175	CDD:293786	9/38 (24%)
		ANK repeat	177..209	CDD:293786	10/32 (31%)
		Ank_5	198..251	CDD:290568	19/55 (35%)
		ANK repeat	212..244	CDD:293786	11/33 (33%)
		zf-DHHC	426..559	CDD:279823	36/136 (26%)
si:ch211-223a10.1	XP_009305694.1	ANK repeat	7..36	CDD:293786	7/28 (25%)
		Ank_2	9..102	CDD:289560	31/100 (31%)
		ANK	39..159	CDD:238125	39/128 (30%)
		ANK repeat	39..69	CDD:293786	10/30 (33%)
		ANK repeat	71..102	CDD:293786	12/30 (40%)
		Ank_2	76..162	CDD:289560	29/93 (31%)
		ANK repeat	138..170	CDD:293786	10/35 (29%)
		Ank_4	139..192	CDD:290365	18/58 (31%)
		zf-DHHC	384..509	CDD:279823	38/142 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54696
OrthoDB	1	1.010	-	-		D213306at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.830