DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hip14 and zdhhc17

DIOPT Version :9

Sequence 1:	NP_001261910.1	Gene:	Hip14 / 39747	FlyBaseID:	FBgn0259824	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_002935687.3	Gene:	zdhhc17 / 100486328	XenbaseID:	XB-GENE-966618	Length:	623	Species:	Xenopus tropicalis

Alignment Length:	576	Identity:	282/576 - (48%)
Similarity:	382/576 - (66%)	Gaps:	17/576 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 DYSGFDIVKATQYGAIARVRELVESGWDVNQPDSETVTLLHWAAINNRRDIIRYFLEKGATVDAV 107
            |||.:|||||||||...|.||||::|:||.|||.|.||||||||||||.|::::::.|||.||.:
Frog    46 DYSTWDIVKATQYGIYERCRELVDAGYDVRQPDKENVTLLHWAAINNRMDLVKFYISKGAIVDQL 110

  Fly   108 GGELNATPLHWATRQGHLGAVVLLMAAGADPRIRDAEGCSCIHIAAQFAHTALVAYFIAKGVDPD 172
            ||:||:||||||||||||..||.||..||||.:.|.|||||||:||||.||::|||.||||.|.|
Frog   111 GGDLNSTPLHWATRQGHLSMVVQLMKYGADPSLIDGEGCSCIHLAAQFGHTSIVAYLIAKGQDVD 175

  Fly   173 LQDRGGMTALMWAAWKVCALDPVRLLLTLGANPAMVDYTHGNTALHWAILARNATAISTLVLKSK 237
            :.|:.|||.|||||::..::||.|||||...:..:.|..|.|||||||:||.|.|.|| |:|.:.
Frog   176 MMDQNGMTPLMWAAYRTHSVDPTRLLLTFNVSVNLGDKYHKNTALHWAVLAGNTTVIS-LLLDAG 239

  Fly   238 ASLDVPNLRGETPLSMLESQTGAIWIGAKVMDRVKEA-ALTSQQRRSLLSKLRHDKRLRWWSMVA 301
            |::|..|::||:||. |..|...:|    :::.::|| ........|...||:.||..|...|:.
Frog   240 ANVDAQNIKGESPLD-LAKQRKNVW----MINHLQEARQAKGYDNPSFFKKLKADKEFRQKVMLG 299

  Fly   302 CPFTAFYLAGIVFTVN-TLYIIKFFLLGCLYSIFHTIGKALFDEHLMALLPLSVYLATKAWFYVT 365
            .||...:|.|.:..:: ..::||..:.|.::::...:.|:.||..:.:.|||.:|||||.|.|||
Frog   300 TPFLVIWLVGFIADLDIDSWLIKGLMYGGVWAMVQFLSKSFFDHSMHSALPLGIYLATKFWMYVT 364

  Fly   366 WLMYIDDAVSFT-ATVCFLISSLLLWVCFLKSWKGDPGIIRPTREQRFKTIIELSERGGIGFEPA 429
            |..:..:.:||. ..:.||.:|..|:..|.||||.|||||:.|.||:.|||:||:|.|.:  :.:
Frog   365 WFFWFWNDLSFLFIHLPFLANSFALFYNFGKSWKSDPGIIKATEEQKKKTIVELAETGSL--DLS 427

  Fly   430 SFCSGCLVRRPIRSKHCSVCDRCVARFDHHCPWVGNCIGLKNHSYFMGFLWMLLIMCAWMLYGGS 494
            .|||.||:|:|:|||||.:|:||:|:|||||||||||:|..||.||||:|:.||.|..||:||..
Frog   428 IFCSTCLIRKPVRSKHCGICNRCIAKFDHHCPWVGNCVGSGNHRYFMGYLFFLLCMICWMIYGCI 492

  Fly   495 KYYVNQCNVRF--DDFLGAMRAIGNCDAWVGWVMGNALLHMSWVILLTICQTYQVICLGMTTNER 557
            .|:...|:..:  |.|...:..|..|..|:.|:..|::.|:.||.:|.:||.||:.|||:|||||
Frog   493 SYWGIHCDTTYTKDGFWTYITQIATCSPWMFWMFLNSVFHLMWVAVLLMCQMYQISCLGITTNER 557

  Fly   558 MNRGRYRHFQ--AKGGHSPFTRGPIQNLVDFLECSCFGLVQPKRVDWMNYY--DYD 609
            ||..||:||:  .....|||..|.|:|::||.|..|.||..|..|||...|  :||
Frog   558 MNARRYKHFKVTTTSIESPFNHGCIRNIIDFFEFRCCGLFHPVTVDWTRQYTIEYD 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hip14	NP_001261910.1	ANK	52..165	CDD:238125	76/112 (68%)
		Ank_2	52..142	CDD:289560	59/89 (66%)
		ANK repeat	77..108	CDD:293786	19/30 (63%)
		ANK repeat	110..142	CDD:293786	22/31 (71%)
		ANK	114..233	CDD:238125	74/118 (63%)
		Ank_2	116..209	CDD:289560	57/92 (62%)
		ANK repeat	144..175	CDD:293786	22/30 (73%)
		ANK repeat	177..209	CDD:293786	15/31 (48%)
		Ank_5	198..251	CDD:290568	25/52 (48%)
		ANK repeat	212..244	CDD:293786	18/31 (58%)
		zf-DHHC	426..559	CDD:279823	67/134 (50%)
zdhhc17	XP_002935687.3	PHA02874	<62..>256	CDD:165205	117/195 (60%)
		ANK repeat	80..111	CDD:293786	19/30 (63%)
		ANK repeat	113..145	CDD:293786	22/31 (71%)
		ANK repeat	147..178	CDD:293786	22/30 (73%)
		Ank_2	152..246	CDD:403870	52/94 (55%)
		ANK repeat	180..212	CDD:293786	15/31 (48%)
		ANK repeat	215..246	CDD:293786	18/31 (58%)
		DHHC	429..559	CDD:396215	67/129 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	173	1.000	Domainoid score	I3662
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H56324
Inparanoid	1	1.050	566	1.000	Inparanoid score	I1061
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D213306at33208
OrthoFinder	1	1.000	-	-		FOG0001761
OrthoInspector	1	1.000	-	-		otm47523
Panther	1	1.100	-	-	LDO	PTHR24161
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R35
SonicParanoid	1	1.000	-	-		X628
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190