DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hip14 and zdhhc23a

DIOPT Version :9

Sequence 1:	NP_001261910.1	Gene:	Hip14 / 39747	FlyBaseID:	FBgn0259824	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_021327278.1	Gene:	zdhhc23a / 100150190	ZFINID:	ZDB-GENE-060526-38	Length:	434	Species:	Danio rerio

Alignment Length:	379	Identity:	83/379 - (21%)
Similarity:	129/379 - (34%)	Gaps:	118/379 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   309 LAGIVFTVNTLYIIKFFLLGCLYSIFHTIGKALFDEHLMALLPLSVY-LATKAWFYVTWLMYIDD 372
            |..|:.|...|.::.::     |.......:.||      .|.|::: ||...:.::|.::...|
Zfish   100 LGVIILTALPLLVLWYY-----YMTHRRKRRTLF------FLSLALFSLAYMYYLFLTEIVPRGD 153

  Fly   373 AVSF---TATVCFLISSLLLWVCFLKSWKGDPGIIRP-----------TREQRFKTIIELSERGG 423
            ....   |||     :.::|.:..|...|..||.::.           ...:.....::...|.|
Zfish   154 VTHLQVVTAT-----TGMMLTLISLVRTKQGPGFVKSQSLALGINSSLATNRSTNLTLDTDLRNG 213

  Fly   424 IGF-----EPASFCSGCLVRRPIRSKHCSVCDRCVARFDHHCPWVGNCIGLKNHSYFMGFLWMLL 483
            :..     :....|..|.:.||.|:.||.:|..||.|.||||.|:.:|:|..||..|:..|.:.|
Zfish   214 VSHLKGEKDVKKKCPVCQLVRPPRAGHCRICGACVLRMDHHCVWINSCVGQANHRQFILTLLLFL 278

  Fly   484 IMCAW------------------MLYGGSKYYVNQCNVRFDDFLGAMRAIGNCDAWVGWVMGNAL 530
            :...:                  |||....|  ||.:.          |:.....|...::...|
Zfish   279 LTSFYGISLVLRSICPKQSLFTAMLYCPGVY--NQYST----------ALCFTCVWYSVIITGGL 331

  Fly   531 LHMSWVILLTICQTYQVICLGMTTNE-----RMNRGRYRH---FQAKGGHSPFTRGPIQNLVDFL 587
            ||      |.|.|...|.| .:|..|     |...||.|.   ....|.||   ||.:||.:.||
Zfish   332 LH------LFILQIINVSC-NVTEREAQIALRNKTGRRRFCGLVVETGDHS---RGFLQNWIQFL 386

  Fly   588 ECS----------------------------CFGLVQPKRVDWMNYYDYDAQTH 613
            ..:                            ||.|:      ||:...:....|
Zfish   387 TMNMDEIGSSLNLTDMPQQTIARSLKETGGLCFSLL------WMSSGPFAEAVH 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hip14	NP_001261910.1	ANK	52..165	CDD:238125
		Ank_2	52..142	CDD:289560
		ANK repeat	77..108	CDD:293786
		ANK repeat	110..142	CDD:293786
		ANK	114..233	CDD:238125
		Ank_2	116..209	CDD:289560
		ANK repeat	144..175	CDD:293786
		ANK repeat	177..209	CDD:293786
		Ank_5	198..251	CDD:290568
		ANK repeat	212..244	CDD:293786
		zf-DHHC	426..559	CDD:279823	42/160 (26%)
zdhhc23a	XP_021327278.1	zf-DHHC	224..352	CDD:307600	41/146 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5273
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810