DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Hip14 and zdhhc20b

DIOPT Version :9

Sequence 1:	NP_001261910.1	Gene:	Hip14 / 39747	FlyBaseID:	FBgn0259824	Length:	655	Species:	Drosophila melanogaster
Sequence 2:	XP_005162815.2	Gene:	zdhhc20b / 100001188	ZFINID:	ZDB-GENE-091117-30	Length:	409	Species:	Danio rerio

Alignment Length:	336	Identity:	84/336 - (25%)
Similarity:	133/336 - (39%)	Gaps:	95/336 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   278 SQQRRSLLSK--LRHDKR-LRWWSMVACPFTAFYLAGIVFTVNTLYIIKFFLLGCLYSIFHTIGK 339
            ||.||.:...  ||..:| |.|..::       ::|.:|......|:::.    ||.:|..| |:
Zfish    27 SQGRRKMAPTHVLRCCQRGLAWIPVI-------FIALVVCWSYYAYVVEL----CLLTISST-GE 79

  Fly   340 ALFDEHLMALLPLSVYLATKAWFYVTWLMYIDDAVSFTATVCFLISSLLLWVCFLKSWKGD-PGI 403
            .:            |||..   |:::::|::   .|:..|:....::.....|..||.|.. ...
Zfish    80 KI------------VYLVV---FHLSFVMFV---WSYWKTIFTKPANPSKEFCLPKSEKEQYEKE 126

  Fly   404 IRPTREQ----RFKTIIELSERGGIGFEPASFCSGCLVRRPIRSKHCSVCDRCVARFDHHCPWVG 464
            .||..:|    :..|.:.|..|.|.|  ...:|..|.|.:|.|..|||.||.||.:.|||||||.
Zfish   127 QRPETQQEILKKVATSLPLYTRTGAG--AIRYCDRCQVIKPDRCHHCSACDMCVLKMDHHCPWVN 189

  Fly   465 NCIGLKNHSYFMGFLWMLLIMCAWMLYGGSKYYV-----------NQC------------NVRFD 506
            ||:|..|:.:|:.||...|:.|.::.....:|::           ..|            :|.|.
Zfish   190 NCVGFSNYKFFILFLTYSLVYCLFIAASVLQYFIKFWTLCRRKSAENCPKSDLPESHAKFHVLFL 254

  Fly   507 DFLGAMRAIGNCDAWVGWVMGNALLHMSWVILLTICQTYQVICLGMTTNERMNRGRYRHFQAKGG 571
            .|:.||..|.                     :|::. ||.:..:|      .||.....|:|
Zfish   255 FFVAAMFCIS---------------------ILSLF-TYHLWLVG------KNRSTIEAFRA--- 288

  Fly   572 HSPFTRGPIQN 582
             ..|..||.:|
Zfish   289 -PVFRNGPDKN 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hip14	NP_001261910.1	ANK	52..165	CDD:238125
		Ank_2	52..142	CDD:289560
		ANK repeat	77..108	CDD:293786
		ANK repeat	110..142	CDD:293786
		ANK	114..233	CDD:238125
		Ank_2	116..209	CDD:289560
		ANK repeat	144..175	CDD:293786
		ANK repeat	177..209	CDD:293786
		Ank_5	198..251	CDD:290568
		ANK repeat	212..244	CDD:293786
		zf-DHHC	426..559	CDD:279823	40/155 (26%)
zdhhc20b	XP_005162815.2	zf-DHHC	44..342	CDD:327686	78/319 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910