DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-delta and POL2

DIOPT Version :9

Sequence 1:	NP_524099.2	Gene:	DNApol-delta / 39746	FlyBaseID:	FBgn0263600	Length:	1092	Species:	Drosophila melanogaster
Sequence 2:	NP_014137.1	Gene:	POL2 / 855459	SGDID:	S000005206	Length:	2222	Species:	Saccharomyces cerevisiae

Alignment Length:	1292	Identity:	245/1292 - (18%)
Similarity:	423/1292 - (32%)	Gaps:	475/1292 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KFNGTSNGHAKKPRN-------PDDDEEMGFEAELAAFEN----SEDMDQ--------------- 44
            |:|..||.:|...:.       .|.|..||||..:....|    ::|:||
Yeast    22 KYNTLSNNYALSAQQLLNASKIDDIDSMMGFERYVPPQYNGRFDAKDIDQIPGRVGWLTNMHATL 86

  Fly    45 ----TLLMG-DGPENQTTSERWSRPPPPELDPSKHNLEFQQLDVENYLGQPLPGMPGAQIGPVPV 104
                ||..| :|..|....||.:      .:.....::|..||.|
Yeast    87 VSQETLSSGSNGGGNSNDGERVT------TNQGISGVDFYFLDEE-------------------- 125

  Fly   105 VRMFGVTMEGNSVCCHVHGFCPYFYIEAPSQFEEHHCEKLQKALDQKVIADIRNNKDNVQEAVLM 169
                |.:.:...|      :.|||:|....:...:..|:|.|..              ::..:..
Yeast   126 ----GGSFKSTVV------YDPYFFIACNDESRVNDVEELVKKY--------------LESCLKS 166

  Fly   170 VELVEK--LNIHGYNGDKKQRYIKISVTLPRFVAAASRLLK----------------------KE 210
            ::::.|  |.:..:....::..||:|......:..|.:||:                      .|
Yeast   167 LQIIRKEDLTMDNHLLGLQKTLIKLSFVNSNQLFEARKLLRPILQDNANNNVQRNIYNVAANGSE 231

  Fly   211 VIMSEIDFQDCRAFENNIDFDIRFMVDTDVVGCNWIELPMGHWRIRNSHSKPLPESRCQIEVDVA 275
            .:.::...:|.|  |.::.:.:|..:|.|:        .:|.|                  ..|.
Yeast   232 KVDAKHLIEDIR--EYDVPYHVRVSIDKDI--------RVGKW------------------YKVT 268

  Fly   276 FDRFISHEPEGEWSKVA---PFRILSFDIECAGRKGIFPEAKIDPVIQIANMVIRQG----ERE- 332
            ...||.     :..|:|   |. :::||||.......||::.:|.::.|:.|:..:|    .||
Yeast   269 QQGFIE-----DTRKIAFADPV-VMAFDIETTKPPLKFPDSAVDQIMMISYMIDGEGFLITNREI 327

  Fly   333 -------------PFIRNVFTL-NECAPIIGSQVLCHDKETQMLDKWSAFVREVDPDILTGYNIN 383
                         |.....||: ||            :.|..:|.::...:|:|.|.:::.:|.:
Yeast   328 ISEDIEDFEYTPKPEYPGFFTIFNE------------NDEVALLQRFFEHIRDVRPTVISTFNGD 380

  Fly   384 NFDFPYLLNRAAHLKVRNFE------------------YLGRIKNIRSVIKEQMLQSKQMGRREN 430
            .||:|::.||:   |:...:                  |...:...|.|.::..|.....|.:..
Yeast   381 FFDWPFIHNRS---KIHGLDMFDEIGFAPDAEGEYKSSYCSHMDCFRWVKRDSYLPQGSQGLKAV 442

  Fly   431 QYVNFEGRVPFDLLFVLLRDY------KLRSYTL-NAVSYHFLQEQKEDVH---HSIITDLQ-NG 484
            ..... |..|.:|...|:..|      .|..|:: :||:.::|  ..:.||   .|:.|.:. |.
Yeast   443 TQSKL-GYNPIELDPELMTPYAFEKPQHLSEYSVSDAVATYYL--YMKYVHPFIFSLCTIIPLNP 504

  Fly   485 DEQTRRRLAMYC----LKDAY-----LPLR------------LLEKLMAIVNYMEMARVTGVPLE 528
            ||..|:.....|    :..||     ||.:            |||....:..::|       .||
Yeast   505 DETLRKGTGTLCEMLLMVQAYQHNILLPNKHTDPIERFYDGHLLESETYVGGHVE-------SLE 562

  Fly   529 SLLTRG---QQIKV-------LSQLLRKAKTKGFIMPSYTSQGSDEQYE------GATVIEPKRG 577
            :.:.|.   .:.|:       |.|.|.:|......:.:.:|......:|      ...::|.|..
Yeast   563 AGVFRSDLKNEFKIDPSAIDELLQELPEALKFSVEVENKSSVDKVTNFEEIKNQITQKLLELKEN 627

  Fly   578 YYADPISTL---DFASLYPSIMMAHNL----------------------CYTTLVLGGTRE---- 613
            ...:.:..:   |.||:||:||..:.|                      |...|......|
Yeast   628 NIRNELPLIYHVDVASMYPNIMTTNRLQPDSIKAERDCASCDFNRPGKTCARKLKWAWRGEFFPS 692

  Fly   614 KLRQQENLQDD-QVERTPANNYFVKSEV---------------------------RRGLLPEILE 650
            |:.:...::.. |.|..|..|.|.|.:|                           .|..:.||:|
Yeast   693 KMDEYNMIKRALQNETFPNKNKFSKKKVLTFDELSYADQVIHIKKRLTEYSRKVYHRVKVSEIVE 757

  Fly   651 SLLAARKRAKNDLKVET---------------------------------DPFKRKVL--DGRQL 680
            ......:| :|...|:|                                 |..|:.::  |..||
Yeast   758 REAIVCQR-ENPFYVDTVKSFRDRRYEFKGLAKTWKGNLSKIDPSDKHARDEAKKMIVLYDSLQL 821

  Fly   681 ALKISANSVYGFTGAQVGKLPCLEISGSVTAYGRTMIEMTKNEVES------------------- 726
            |.|:..||.||:...:..:...:|::|.....|.|:|:|.:..||.
Yeast   822 AHKVILNSFYGYVMRKGSRWYSMEMAGITCLTGATIIQMARALVERVGRPLELDTDGIWCILPKS 886

  Fly   727 -----HYTQANGYENNAVVIYGDTDSVMVNFGVK---TLERSMELGREAAELVSSKFVHPIKLEF 783
                 .:|..||.:     :|......|:|:.|.   |..:..||......:..:...:.|..|.
Yeast   887 FPETYFFTLENGKK-----LYLSYPCSMLNYRVHQKFTNHQYQELKDPLNYIYETHSENTIFFEV 946

  Fly   784 EKVYYPYLLIN--------KKRYAGLYFTRPDTYDKMDCKGIETVRRDNSPLVANLMNSCLQKLL 840
            :..|...:|.:        |||||  .|....:..::  ||.|..||....|:.| ..|.:.|:.
Yeast   947 DGPYKAMILPSSKEEGKGIKKRYA--VFNEDGSLAEL--KGFELKRRGELQLIKN-FQSDIFKVF 1006

  Fly   841 IERDP-DGAVAYVKQVIADLLCNR-IDI--SH-LVITKE-----------LAKT--DYAAKQAHV 887
            :|.|. :|..:.|..|     ||| :|:  || |::..|           ::||  :|..:
Yeast  1007 LEGDTLEGCYSAVASV-----CNRWLDVLDSHGLMLEDEDLVSLICENRSMSKTLKEYEGQ---- 1062

  Fly   888 ELAAKMKKRDPGTAPKLGD------------RVPYVICAAAKNTPAYQKAEDPLYVLENSVP--- 937
                  |.....||.:|||            :..|:|.:...|.|..::| .|:.:....:|
Yeast  1063 ------KSTSITTARRLGDFLGEDMVKDKGLQCKYIISSKPFNAPVTERA-IPVAIFSADIPIKR 1120

  Fly   938 --------------------IDATYYLE----------------QQLSKPLLRIFEP 958
                                ||..||.|                |.:|.|:.|:..|
Yeast  1121 SFLRRWTLDPSLEDLDIRTIIDWGYYRERLGSAIQKIITIPAALQGVSNPVPRVEHP 1177

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-delta	NP_524099.2	PTZ00166	48..1092	CDD:240301	228/1220 (19%)
		DNA_polB_delta_exo	288..517	CDD:99820	63/300 (21%)
		POLBc_delta	564..960	CDD:99916	117/597 (20%)
		zf-C4pol	997..1070	CDD:290959
POL2	NP_014137.1	DNA_pol_B_exo1	121..442	CDD:397292	69/413 (17%)
		DNA_polB_epsilon_exo	283..486	CDD:99822	45/221 (20%)
		POLBc_epsilon	545..1166	CDD:99918	125/654 (19%)
		DUF1744	1528..1920	CDD:400678
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810