DRSC/TRiP Functional Genomics Resources

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Protein Alignment DNApol-delta and Pola1

DIOPT Version :9

Sequence 1:NP_524099.2 Gene:DNApol-delta / 39746 FlyBaseID:FBgn0263600 Length:1092 Species:Drosophila melanogaster
Sequence 2:NP_445931.1 Gene:Pola1 / 85241 RGDID:621816 Length:1468 Species:Rattus norvegicus


Alignment Length:1244 Identity:293/1244 - (23%)
Similarity:480/1244 - (38%) Gaps:317/1244 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 GHAKKPRNPDDDEEMG-FEAELAAFE---NSEDMDQTLLMGDGPENQTTSERWSRPPPP------ 67
            |...:|..|:|::|.| .|.|...|:   ::|::|:        |...|::.|.:...|      
  Rat   236 GDLAQPECPEDEQESGVIEFEDGDFDEPMDTEEVDE--------EEPVTAKIWDQESEPVEGVKH 292

  Fly    68 ELDPSKHNLEF-------------QQLDVENYLGQP-------LPGMPGAQIGPV---------- 102
            |.||......|             .|.|..::|.|.       ||.:.||....|          
  Rat   293 EADPETGTTSFLDSFLPDVSCWDIDQKDENSFLLQEVQVDSNHLPLVKGADDEQVFQFYWLDAYE 357

  Fly   103 ------PVVRMFG-VTMEGNSV---CCHVHGFCPYFYIEAPSQFEEHHCEKLQKALDQKVIADIR 157
                  .||.:|| |.:|....   ||.:                ..:.|:....|.:::..|:.
  Rat   358 DPYNQPGVVFLFGKVWVESAKTHVSCCVM----------------VKNIERTLYFLPREMKIDLN 406

  Fly   158 NNKDNVQEAVLMVELVE--------KLNIHGYNG--------------DKKQRYIKISVTLPRFV 200
            ..|:.. ..:.|.::.|        |..|..:..              .:|..|:::     |:.
  Rat   407 TGKETA-TPITMKDVYEEFDSKISAKYKIMKFKSKIVEKNYAFEIPDVPEKSEYLEV-----RYS 465

  Fly   201 AAASRL---LKKEVIMSEIDFQDCRAFENNIDFDIRFMVDTDVVGCNWIELPMGHWRIRNSHSKP 262
            |...:|   ||.|..        ...|..|......|:::..:.|..|:|       ::|.....
  Rat   466 AEVPQLPQNLKGETF--------SHVFGTNTSSLELFLMNRKIKGPCWLE-------VKNPQLLN 515

  Fly   263 LPESRCQIEV------------DV--------------------------AFDRFISHE-PEGEW 288
            .|.|.|:.|.            ||                          |....:.|. |..:.
  Rat   516 QPISWCKFEAMALKPDLVNVIKDVSPPPLVVMSFSMKTMQNVQNHQHEIIAMAALVHHNFPLDKA 580

  Fly   289 SKVAPFR----ILSFDIECAGRKGIFPEAKIDPVIQIANMVIRQGEREPFIRNVFTLNECAPIIG 349
            ....||:    ::|...:|     |||.| ...||:..||.:.....|..:...|.         
  Rat   581 PPKPPFQTHFCVVSKPKDC-----IFPCA-FKEVIKKKNMEVEVAATERTLLGFFL--------- 630

  Fly   350 SQVLCHDKETQMLDKWSAFVREVDPDILTGYNINNFDFPYLLNRAAHLKVRNFEYLGRIKNIRSV 414
                             |.|.::|||||.|:||..|:...||.|....||..:..:||::  ||.
  Rat   631 -----------------AKVHKLDPDILVGHNICGFELEVLLQRINECKVPFWSKIGRLR--RSN 676

  Fly   415 IKEQMLQSKQ-MGRRENQYVNFEGRVPFDLLFVLLRDYKLRSYTLNAVSYHFLQEQKEDVHHSII 478
            :.:  |.|:. .|.|....    ||:..|:...:......:||.|:.:....|:.::..:....|
  Rat   677 MPK--LGSRSGFGERNATC----GRMICDVEISVKELIHCKSYHLSELVQQILKTERIVIPTENI 735

  Fly   479 TDLQNGDEQTRRRLAMYCLKDAYLPLRLLEKLMAIVNYMEMA----RVTGVPLESLLTRGQQIKV 539
            .::.:....     .:|.|:..:...|.:.::|..:|.:.:|    .:.|..:...|..|:..:.
  Rat   736 RNMYSEPSH-----LLYLLEHIWKDARFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERN 795

  Fly   540 LSQLLRKAKTKGFIMPS-------YTSQGSDEQ-----------------YEGATVIEPKRGYYA 580
            ...||.......:|:|.       ....|.:::                 |.|..|::||.|:|.
  Rat   796 EFLLLHAFYENNYIVPDKQIFRKPQQKPGDEDEEIDGDTNKYKKGRKKAAYAGGLVLDPKVGFYD 860

  Fly   581 DPISTLDFASLYPSIMMAHNLCYTTLVLGGTREKLRQQENLQDDQVERTPANNYFVKSEVRRGLL 645
            ..|..|||.||||||:...|:|:|| |.....|.|:..|:.:.:|:...|..|      :..|:|
  Rat   861 KFILLLDFNSLYPSIIQEFNICFTT-VQRVASETLKATEDEEQEQIPELPDPN------LDMGIL 918

  Fly   646 PEILESLLAARKRAKNDLK-VETDPFKRKVLDGRQLALKISANSVYGFTGAQVGKLPCLEISGSV 709
            |..:..|:..||:.|..:| .:.:|......|.||.|||::|||:||..|....:.....::..|
  Rat   919 PREIRKLVERRKQVKQLMKQQDLNPDLVLQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALV 983

  Fly   710 TAYGRTMIEMTKNEVESHYTQANGYENNAVVIYGDTDSVMVNFGVKTLERSMELGREAAELVSSK 774
            |..||.::..||..|:         :.|..||||||||:|:|.....||...:||.:....| :|
  Rat   984 TYKGREILMHTKEMVQ---------KMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKNEV-NK 1038

  Fly   775 FVHPIKLEFEKVYYPYLLINKKRYAGLYF--TRPDTY-DKMDCKGIETVRRDNSPLVANLMNSCL 836
            ....::::.:.|:...||:.||:||.|..  |....| .|.:.||::.||||...|..:..|..:
  Rat  1039 LYKLLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYITKQELKGLDIVRRDWCDLAKDTGNFVI 1103

  Fly   837 QKLLIERDPDGAVAYVKQVIADL----LCNRIDISHLVITKELAK--TDYAAKQA--HVELAAKM 893
            .::|.::..|..|..:::.:.::    |...:.:|...|.|.|.|  .||..|::  ||.:|..:
  Rat  1104 GQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALTKDPQDYPDKKSLPHVHVALWI 1168

  Fly   894 KKRDPGTAPKLGDRVPYVICAAAKNTPAYQKAEDPLYV-LENSVPIDATYYLEQQLSKPLLRIFE 957
            ..:. |...|.||.|.||||....|.||.|:|..|..: .::::.||..|||.||:...:.||.|
  Rat  1169 NSQG-GRKVKAGDTVSYVICQDGSNLPATQRAYAPEQLQKQDNLAIDTQYYLAQQIHPVVARICE 1232

  Fly   958 PILGDNAESIL----LKGEHTRTRTVVTSK-------VGGLAGFMTKKTSCLGCKSLMPKGYEQA 1011
            ||  |..:::|    |..:.|:.|.....|       :||.|. :|.:.....|:..       .
  Rat  1233 PI--DGIDAVLIALWLGLDSTQFRVHQYHKDEENDALLGGPAQ-LTDEEKYKDCEKF-------K 1287

  Fly  1012 CLCPHC--EPRMSELYQKEVGAKRELEETFSRLWTECQRCQESLHEEVICSNRDC---PIFYMRQ 1071
            ||||.|  |.....:::   |:..::|.:.:|                 |||.||   |..:|.|
  Rat  1288 CLCPSCGTENIYDNVFE---GSGMDMEPSLNR-----------------CSNIDCKASPATFMVQ 1332

  Fly  1072 ---KVRMDL 1077
               |:.||:
  Rat  1333 LSNKLIMDI 1341

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNApol-deltaNP_524099.2 PTZ00166 48..1092 CDD:240301 282/1205 (23%)
DNA_polB_delta_exo 288..517 CDD:99820 51/233 (22%)
POLBc_delta 564..960 CDD:99916 133/425 (31%)
zf-C4pol 997..1070 CDD:290959 16/77 (21%)
Pola1NP_445931.1 DNA_pol_alpha_N 41..101 CDD:289058
pol2 56..1232 CDD:273159 259/1103 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 105..135
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 174..226
DNA_polB_alpha_exo 542..774 CDD:99819 55/276 (20%)
DNA-binding. /evidence=ECO:0000255 657..722 17/72 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 816..836 1/19 (5%)
POLBc_alpha 839..1249 CDD:99915 137/429 (32%)
DNA-binding. /evidence=ECO:0000255 1252..1383 27/118 (23%)
zf-DNA_Pol 1272..1461 CDD:286132 23/98 (23%)
CysB motif 1355..1381
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0417
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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