Protein Alignment PolD1 and Pola1

DIOPT Version :10

• Sequence 1: NP_524099.2
• Gene: PolD1 / 39746
• FlyBaseID: FBgn0263600
• Length: 1092
• Species: Drosophila melanogaster
• Sequence 2: NP_445931.1
• Gene: Pola1 / 85241
• RGDID: 621816
• Length: 1468
• Species: Rattus norvegicus
• Alignment Length: 1244
• Identity: 297/1244 - (23%)
• Similarity: 477/1244 - (38%)
• Gaps: 317/1244 - (25%)

  Fly    13 GHAKKPRNPDDDEEMG-FEAELAAFE---NSEDMDQTLLMGDGPENQTTSERWSRPPPP------ 67
            |...:|..|:|::|.| .|.|...|:   ::|::|:        |...|::.|.:...|
  Rat   236 GDLAQPECPEDEQESGVIEFEDGDFDEPMDTEEVDE--------EEPVTAKIWDQESEPVEGVKH 292

  Fly    68 ELDPSKHNLEF-------------QQLDVENYLGQP-------LPGMPGAQIGPV---------- 102
            |.||......|             .|.|..::|.|.       ||.:.||....|
  Rat   293 EADPETGTTSFLDSFLPDVSCWDIDQKDENSFLLQEVQVDSNHLPLVKGADDEQVFQFYWLDAYE 357

  Fly   103 ------PVVRMFG-VTMEGN----SVCCHVHGFCPYFY-------------------IEAPSQFE 137
                  .||.:|| |.:|..    |.|..|.......|                   |.....:|
  Rat   358 DPYNQPGVVFLFGKVWVESAKTHVSCCVMVKNIERTLYFLPREMKIDLNTGKETATPITMKDVYE 422

  Fly   138 EHHCEKLQKALDQKVIA--DIRNNKDNVQEAVLMVELVEKLNIHGYNGDKKQRYIKISVTLPRFV 200
            |         .|.|:.|  .|...|..:.|.....|:.:.        .:|..|:::     |:.
  Rat   423 E---------FDSKISAKYKIMKFKSKIVEKNYAFEIPDV--------PEKSEYLEV-----RYS 465

  Fly   201 AAASRL---LKKEVIMSEIDFQDCRAFENNIDFDIRFMVDTDVVGCNWIELPMGHWRIRNSHSKP 262
            |...:|   ||.|..        ...|..|......|:::..:.|..|:|       ::|.....
  Rat   466 AEVPQLPQNLKGETF--------SHVFGTNTSSLELFLMNRKIKGPCWLE-------VKNPQLLN 515

  Fly   263 LPESRCQIEV------------DV--------------------------AFDRFISHE-PEGEW 288
            .|.|.|:.|.            ||                          |....:.|. |..:.
  Rat   516 QPISWCKFEAMALKPDLVNVIKDVSPPPLVVMSFSMKTMQNVQNHQHEIIAMAALVHHNFPLDKA 580

  Fly   289 SKVAPFR----ILSFDIECAGRKGIFPEAKIDPVIQIANMVIRQGEREPFIRNVFTLNECAPIIG 349
            ....||:    ::|...:|     |||.| ...||:..||.:.....|..:...|.
  Rat   581 PPKPPFQTHFCVVSKPKDC-----IFPCA-FKEVIKKKNMEVEVAATERTLLGFFL--------- 630

  Fly   350 SQVLCHDKETQMLDKWSAFVREVDPDILTGYNINNFDFPYLLNRAAHLKVRNFEYLGRIKNIRSV 414
                             |.|.::|||||.|:||..|:...||.|....||..:..:||::  ||.
  Rat   631 -----------------AKVHKLDPDILVGHNICGFELEVLLQRINECKVPFWSKIGRLR--RSN 676

  Fly   415 IKEQMLQSKQ-MGRRENQYVNFEGRVPFDLLFVLLRDYKLRSYTLNAVSYHFLQEQKEDVHHSII 478
            :.:  |.|:. .|.|....    ||:..|:...:......:||.|:.:....|:.::..:....|
  Rat   677 MPK--LGSRSGFGERNATC----GRMICDVEISVKELIHCKSYHLSELVQQILKTERIVIPTENI 735

  Fly   479 TDLQNGDEQTRRRLAMYCLKDAYLPLRLLEKLMAIVNYMEMA----RVTGVPLESLLTRGQQIKV 539
            .::.:....     .:|.|:..:...|.:.::|..:|.:.:|    .:.|..:...|..|:..:.
  Rat   736 RNMYSEPSH-----LLYLLEHIWKDARFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERN 795

  Fly   540 LSQLLRKAKTKGFIMPS-------YTSQGSDEQ-----------------YEGATVIEPKRGYYA 580
            ...||.......:|:|.       ....|.:::                 |.|..|::||.|:|.
  Rat   796 EFLLLHAFYENNYIVPDKQIFRKPQQKPGDEDEEIDGDTNKYKKGRKKAAYAGGLVLDPKVGFYD 860

  Fly   581 DPISTLDFASLYPSIMMAHNLCYTTLVLGGTREKLRQQENLQDDQVERTPANNYFVKSEVRRGLL 645
            ..|..|||.||||||:...|:|:|| |.....|.|:..|:.:.:|:...|..|      :..|:|
  Rat   861 KFILLLDFNSLYPSIIQEFNICFTT-VQRVASETLKATEDEEQEQIPELPDPN------LDMGIL 918

  Fly   646 PEILESLLAARKRAKNDLK-VETDPFKRKVLDGRQLALKISANSVYGFTGAQVGKLPCLEISGSV 709
            |..:..|:..||:.|..:| .:.:|......|.||.|||::|||:||..|....:.....::..|
  Rat   919 PREIRKLVERRKQVKQLMKQQDLNPDLVLQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALV 983

  Fly   710 TAYGRTMIEMTKNEVESHYTQANGYENNAVVIYGDTDSVMVNFGVKTLERSMELGREAAELVSSK 774
            |..||.::..||..|:         :.|..||||||||:|:|.....||...:||.:....| :|
  Rat   984 TYKGREILMHTKEMVQ---------KMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKNEV-NK 1038

  Fly   775 FVHPIKLEFEKVYYPYLLINKKRYAGLYF--TRPDTY-DKMDCKGIETVRRDNSPLVANLMNSCL 836
            ....::::.:.|:...||:.||:||.|..  |....| .|.:.||::.||||...|..:..|..:
  Rat  1039 LYKLLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYITKQELKGLDIVRRDWCDLAKDTGNFVI 1103

  Fly   837 QKLLIERDPDGAVAYVKQVIADL----LCNRIDISHLVITKELAK--TDYAAKQA--HVELAAKM 893
            .::|.::..|..|..:::.:.::    |...:.:|...|.|.|.|  .||..|::  ||.:|..:
  Rat  1104 GQILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALTKDPQDYPDKKSLPHVHVALWI 1168

  Fly   894 KKRDPGTAPKLGDRVPYVICAAAKNTPAYQKAEDPLYV-LENSVPIDATYYLEQQLSKPLLRIFE 957
            ..:. |...|.||.|.||||....|.||.|:|..|..: .::::.||..|||.||:...:.||.|
  Rat  1169 NSQG-GRKVKAGDTVSYVICQDGSNLPATQRAYAPEQLQKQDNLAIDTQYYLAQQIHPVVARICE 1232

  Fly   958 PILGDNAESIL----LKGEHTRTRTVVTSK-------VGGLAGFMTKKTSCLGCKSLMPKGYEQA 1011
            ||  |..:::|    |..:.|:.|.....|       :||.|. :|.:.....|:..       .
  Rat  1233 PI--DGIDAVLIALWLGLDSTQFRVHQYHKDEENDALLGGPAQ-LTDEEKYKDCEKF-------K 1287

  Fly  1012 CLCPHC--EPRMSELYQKEVGAKRELEETFSRLWTECQRCQESLHEEVICSNRDC---PIFYMRQ 1071
            ||||.|  |.....:::   |:..::|.:.:|                 |||.||   |..:|.|
  Rat  1288 CLCPSCGTENIYDNVFE---GSGMDMEPSLNR-----------------CSNIDCKASPATFMVQ 1332

  Fly  1072 ---KVRMDL 1077
               |:.||:
  Rat  1333 LSNKLIMDI 1341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolD1	NP_524099.2	PTZ00166	48..1092	CDD:240301	286/1205 (24%)
Pola1	NP_445931.1	pol2	56..1232	CDD:273159	263/1103 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	109..135
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	174..226
		DNA-binding. /evidence=ECO:0000255	657..722		17/72 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	816..836		1/19 (5%)
		DNA-binding. /evidence=ECO:0000255	1252..1383		27/118 (23%)
		zf-DNA_Pol	1272..1461	CDD:462651	23/98 (23%)
		CysB motif	1355..1381