Protein Alignment DNApol-delta and pold1

DIOPT Version :9

• Sequence 1: NP_524099.2
• Gene: DNApol-delta / 39746
• FlyBaseID: FBgn0263600
• Length: 1092
• Species: Drosophila melanogaster
• Sequence 2: NP_001039204.1
• Gene: pold1 / 734063
• XenbaseID: XB-GENE-1002131
• Length: 1109
• Species: Xenopus tropicalis
• Alignment Length: 1119
• Identity: 695/1119 - (62%)
• Similarity: 854/1119 - (76%)
• Gaps: 37/1119 - (3%)

  Fly     1 MDGKRKFNGTSNG----HAKKPRNP-DDDEEMGFEAELAAFENSEDMDQTLLMGDG-------PE 53
            ||.||| .|.::|    ..||.|.. |||....||.|| ||.:..:.:..:.:.:|       |.
 Frog     1 MDFKRK-KGQASGLPASQTKKLRGDWDDDAPSQFEEEL-AFMDEVEAEMAMELSEGQLSADILPV 63

  Fly    54 NQTTSE----RWSRPPPPELDPSKHNLEFQQLDVENYLGQPLPGMPGAQIGPVPVVRMFGVTMEG 114
            .:..|:    :|.|||....||.:..|.|||:::::|:|..:.||.||..||||::||||:|.||
 Frog    64 GKLISDNIPPKWLRPPVSLTDPKEQTLCFQQVELDHYVGSHVSGMLGATQGPVPIIRMFGITEEG 128

  Fly   115 NSVCCHVHGFCPYFYIEAPSQFEEHHCEKLQKALDQKVIADIRNNKDNVQEAVLMVELVEKLNIH 179
            ||||||:|||.||||:...:.|::......:|.|:..||.|:|:|||::.:|||.|::..|.|::
 Frog   129 NSVCCHIHGFAPYFYVPCHTGFKQEDLSDFKKELNSAVIKDMRSNKDSISQAVLAVDVCHKENMY 193

  Fly   180 GYNGDKKQRYIKISVTLPRFVAAASRLLKKEVIMSEIDFQDCRAFENNIDFDIRFMVDTDVVGCN 244
            ||:|.|...::||::.|||.:|.|.|||::.:..........:|:|.||||:||||||.|:||||
 Frog   194 GYHGKKIIPFMKITMALPRLIAPAKRLLEQGLRFGRHPTHCYQAYEANIDFEIRFMVDNDIVGCN 258

  Fly   245 WIELPMGHWRIRN-------SHSKPLPESRCQIEVDVAFDRFISHEPEGEWSKVAPFRILSFDIE 302
            |||||.|.:|:|.       |...|...|..|||||:::...|||..||:|.|:||.|:||||||
 Frog   259 WIELPAGKYRLRKESQDEGPSKENPSKVSLAQIEVDISWADLISHPAEGDWQKIAPLRVLSFDIE 323

  Fly   303 CAGRKGIFPEAKIDPVIQIANMVIRQGEREPFIRNVFTLNECAPIIGSQVLCHDKETQMLDKWSA 367
            ||||||:|||...||||||||||:||||::.||||||||..|:.|:||||||.|:|..:|..|:.
 Frog   324 CAGRKGVFPEPDKDPVIQIANMVLRQGEKDAFIRNVFTLGTCSSIVGSQVLCFDREDALLKAWAD 388

  Fly   368 FVREVDPDILTGYNINNFDFPYLLNRAAHLKVRNFEYLGRIKNIRSVIKEQMLQSKQMGRRENQY 432
            |||.:||||:|||||.|||.|||:|||..|||.||.:||||::::|||::...||||||||||:.
 Frog   389 FVRTIDPDIITGYNIQNFDMPYLINRAQTLKVPNFPFLGRIRSMKSVIRDSSFQSKQMGRRENKV 453

  Fly   433 VNFEGRVPFDLLFVLLRDYKLRSYTLNAVSYHFLQEQKEDVHHSIITDLQNGDEQTRRRLAMYCL 497
            :|.||||.||||.|||||||||||||||||:||||||||||.||||||||||:||||||||:|||
 Frog   454 INTEGRVQFDLLQVLLRDYKLRSYTLNAVSFHFLQEQKEDVQHSIITDLQNGNEQTRRRLAVYCL 518

  Fly   498 KDAYLPLRLLEKLMAIVNYMEMARVTGVPLESLLTRGQQIKVLSQLLRKAKTKGFIMPSYTSQGS 562
            |||||||||:||||.::|||||||||||||..||:|||||||:|||||:|..:..:||...|:|.
 Frog   519 KDAYLPLRLMEKLMCVINYMEMARVTGVPLSYLLSRGQQIKVVSQLLRQAMKQDLVMPVVKSEGG 583

  Fly   563 DEQYEGATVIEPKRGYYADPISTLDFASLYPSIMMAHNLCYTTLVLGGTREKLRQQENLQDDQVE 627
             |.|.|||||||.:|||..||:||||:|||||||||||||||||:..|:.:|.    .|..:...
 Frog   584 -EDYTGATVIEPLKGYYDVPIATLDFSSLYPSIMMAHNLCYTTLLQSGSIDKY----GLSPEDFI 643

  Fly   628 RTPANNYFVKSEVRRGLLPEILESLLAARKRAKNDLKVETDPFKRKVLDGRQLALKISANSVYGF 692
            :||..:.|||:.:|:||||||||:||.||||||.:||.||||||:|||||||||||:||||||||
 Frog   644 KTPTGDCFVKASIRKGLLPEILENLLCARKRAKAELKKETDPFKQKVLDGRQLALKVSANSVYGF 708

  Fly   693 TGAQVGKLPCLEISGSVTAYGRTMIEMTKNEVESHYTQANGYENNAVVIYGDTDSVMVNFGVKTL 757
            ||||||||||||||.|||.:||.|||.||..|||.||..|||:.:|.||||||||||...||:|:
 Frog   709 TGAQVGKLPCLEISQSVTGFGRQMIEKTKQLVESKYTLDNGYKADAKVIYGDTDSVMCKLGVQTV 773

  Fly   758 ERSMELGREAAELVSSKFVHPIKLEFEKVYYPYLLINKKRYAGLYF-TRPDTYDKMDCKGIETVR 821
            ..:||:||||||.|||.|..||||||||||:||||||||||||||| :..:|:||||||||||||
 Frog   774 VEAMEIGREAAEWVSSHFTPPIKLEFEKVYFPYLLINKKRYAGLYFSSSANTHDKMDCKGIETVR 838

  Fly   822 RDNSPLVANLMNSCLQKLLIERDPDGAVAYVKQVIADLLCNRIDISHLVITKELAKT--DYAAKQ 884
            |||.||||||:|:||||:||:|||.|||.:.|.||:||||||||||.|||||||.:|  :||.||
 Frog   839 RDNCPLVANLINTCLQKILIDRDPMGAVEHAKDVISDLLCNRIDISQLVITKELTRTADEYAGKQ 903

  Fly   885 AHVELAAKMKKRDPGTAPKLGDRVPYVICAAAKNTPAYQKAEDPLYVLENSVPIDATYYLEQQLS 949
            ||||||.:|:|||||:||.|||||||||..|||...||.|:|||:|||||::|||..|||||||:
 Frog   904 AHVELAERMRKRDPGSAPNLGDRVPYVIIGAAKGVAAYMKSEDPIYVLENNIPIDTQYYLEQQLA 968

  Fly   950 KPLLRIFEPILGDN-AESILLKGEHTRTRTVVTSKVGGLAGFMTKKTSCLGCKSLMPKGYEQACL 1013
            ||||||||||||:: ||||||||||||.:||:|:|||||..|..|:::|:|||:.:   .....:
 Frog   969 KPLLRIFEPILGESKAESILLKGEHTRCKTVLTAKVGGLMAFAKKRSTCIGCKATL---NHDGAV 1030

  Fly  1014 CPHCEPRMSELYQKEVGAKRELEETFSRLWTECQRCQESLHEEVICSNRDCPIFYMRQKVRMDLD 1078
            |.:|:.|.|||.|||:.....|||.||||||:|||||.||||:|:|::|||||||||:||:.|||
 Frog  1031 CNYCKQRESELIQKEISQLSGLEEKFSRLWTQCQRCQGSLHEDVLCTSRDCPIFYMRKKVQKDLD 1095

  Fly  1079 NQEKRVLRFGLAEW 1092
            :|||.:||||...|
 Frog  1096 DQEKLILRFGPPAW 1109

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-delta	NP_524099.2	PTZ00166	48..1092	CDD:240301	675/1065 (63%)
		DNA_polB_delta_exo	288..517	CDD:99820	168/228 (74%)
		POLBc_delta	564..960	CDD:99916	286/398 (72%)
		zf-C4pol	997..1070	CDD:290959	40/72 (56%)
pold1	NP_001039204.1	PTZ00166	76..1105	CDD:240301	669/1036 (65%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	596	1.000	Domainoid score	I203
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H2014
Inparanoid	1	1.050	1265	1.000	Inparanoid score	I171
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D20210at2759
OrthoFinder	1	1.000	-	-		FOG0001033
OrthoInspector	1	1.000	-	-		oto104012
Panther	1	1.100	-	-	LDO	PTHR10322
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3678
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.160