Protein Alignment PolD1 and REV3L

DIOPT Version :10

• Sequence 1: NP_524099.2
• Gene: PolD1 / 39746
• FlyBaseID: FBgn0263600
• Length: 1092
• Species: Drosophila melanogaster
• Sequence 2: XP_011534330.1
• Gene: REV3L / 5980
• HGNCID: 9968
• Length: 3157
• Species: Homo sapiens
• Alignment Length: 1205
• Identity: 303/1205 - (25%)
• Similarity: 495/1205 - (41%)
• Gaps: 250/1205 - (20%)

  Fly    20 NPDDDEEMGFEAELA------AFENSEDMDQTLLMGDGPE---NQTTSERWSRPP-----PPELD 70
            ||||...:..:.:::      .....||:|.:.:....|.   :||.||....||     .||.|
Human  2043 NPDDKPVVPPKMDVSPCILPTTAHTKEDVDNSQIALQAPTTGCSQTASESQMLPPVASASDPEKD 2107

  Fly    71 --------------------------------------PSKHNLEFQQLDVENYLGQPLPGMPGA 97
                                                  ||....|...|..||:|   .|...|.
Human  2108 EDDDDNYYISYSSPDSPVIPPWQQPISPDSKALNGDDRPSSPVEELPSLAFENFL---KPIKDGI 2169

  Fly    98 QIGP---------VPVVRMFGVTMEGNSVCCHVHGFCPYFYI----EAPSQFEEHHCEKLQKALD 149
            |..|         :..:.....|.:..|:|.|.........:    |||.........|.||..:
Human  2170 QKSPCSEPQEPLVISPINTRARTGKCESLCFHSTPIIQRKLLERLPEAPGLSPLSTEPKTQKLSN 2234

  Fly   150 QKVIADIRNNKDNVQEAVL--------MVELVEK----------LNIHGYNGDKKQRYIKISVTL 196
            :|     .:|.|.::..:|        .|...:|          .|.:|:         |:|:..
Human  2235 KK-----GSNTDTLRRVLLTQAKNQFAAVNTPQKETSQIDGPSLNNTYGF---------KVSIQN 2285

  Fly   197 PRFVAAASRLLKKEVIMSEIDFQDCRAFENNIDFD----IRFMVDTDVVGCNWIELPMGHWRIRN 257
            .:...|...:....:|..|:..:..|..|.:.:||    :.:.:.:|.
Human  2286 LQEAKALHEIQNLTLISVELHARTRRDLEPDPEFDPICALFYCISSDT----------------- 2333

  Fly   258 SHSKPLPES-RCQIEVDVAFDR---FISHEPEGEWSKVAPFRILSFDIE-CAGRKGIFPEAKIDP 317
                |||:: :.::...:..|:   ..|.:...:...:....|...::. .|..|.:|.|
Human  2334 ----PLPDTEKTELTGVIVIDKDKTVFSQDIRYQTPLLIRSGITGLEVTYAADEKALFHE----- 2389

  Fly   318 VIQIANMVIRQGEREPFIRNVFTLNECAPIIGSQVLCHD-----------------KETQMLDKW 365
               ||| :|::|                        ||.                 :|..|
Human  2390 ---IAN-IIKRG------------------------CHQHVRCFQYPHFFYFCKQLRERNM---- 2422

  Fly   366 SAFVREVDPDILTGYNINNFDFPYLLNRAAHLKVRNFEYLGRIKNIRSVIKEQMLQSK-QMGRRE 429
                  .|||||.||.|....:.|||.|||.|.:.....:.|:.:.:  |:.:....: :.|...
Human  2423 ------YDPDILLGYEIQMHSWGYLLQRAAALSIDLCRMISRVPDDK--IENRFAAERDEYGSYT 2479

  Fly   430 NQYVNFEGRVPFDLLFVLLRDYKLRSYTLNAVSYHFLQEQKEDVHHSIITD-LQNGDEQTRRRLA 493
            ...:|..||:..:|..::..:..|.:||...||:|.|.::.......:::| ..|..:..|.::.
Human  2480 MSEINIVGRITLNLWRIMRNEVALTNYTFENVSFHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMV 2544

  Fly   494 MYCLKDAYLPLRLLEKLMAIVNYMEMARVTGVPLESLLTRGQQIKVLSQLLRKAKTKGFIMPSYT 558
            .:.:......|::||:|..|....||||:.|:....:||||.|.:|.|.:||.||...:| |...
Human  2545 DHYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVLTRGSQYRVESMMLRIAKPMNYI-PVTP 2608

  Fly   559 SQGSDEQYEG----ATVIEPKRGYYADPISTLDFASLYPSIMMAHNLCYTTLVLGGTREKLRQQE 619
            |.....|...    ..::||:..:|::.:..|||.||||||::|:|.|::|.:  |..|.|.:.:
Human  2609 SVQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTCL--GHVENLGKYD 2671

  Fly   620 NLQ----------------DDQVERTPANNYFVKSEVRRGLLPEILESLLAARKRAKNDLKV-ET 667
            ..:                ...:..:|....|||..||:|:||.:||.:|..|...|..:|. :.
Human  2672 EFKFGCTSLRVPPDLLYQVRHDITVSPNGVAFVKPSVRKGVLPRMLEEILKTRFMVKQSMKAYKQ 2736

  Fly   668 DPFKRKVLDGRQLALKISANSVYGFTGAQV-GKLPCLEISGSVTAYGRTMIEMTKNEVESHYTQA 731
            |....::||.|||.||:.||..:|:|.|.. |::||:|:..|:....|..:|.....|..  |:.
Human  2737 DRALSRMLDARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKARETLERAIKLVND--TKK 2799

  Fly   732 NGYENNAVVIYGDTDSVMVNFGVKTLERSMELGREAAELVSSKFVHPIKLEFEKVYYPYLLINKK 796
            .|    |.|:||||||:.|.....|.|:|.::|:|.||.|::....|:||:|||||.|.:|..||
Human  2800 WG----ARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPVKLKFEKVYLPCVLQTKK 2860

  Fly   797 RYAGLYFTRPDTYDKM-DCKGIETVRRDNSPLVANLMNSCLQKLLIERDPDGAVAYVKQVIADLL 860
            ||.|..:...|..|.: |.|||||||||:.|.|:.::...|:.|...||......||::....||
Human  2861 RYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKLLFETRDISLIKQYVQRQCMKLL 2925

  Fly   861 CNRIDISHLVITKELAKTDYAAKQA----HVELAAKMKKRDPGTAPKLGDRVPYVICAAAKNTPA 921
            ..:..|...:..||. :..::.|..    .:||..||...|..:.|::|:||||||.......|.
Human  2926 EGKASIQDFIFAKEY-RGSFSYKPGACVPALELTRKMLTYDRRSEPQVGERVPYVIIYGTPGVPL 2989

  Fly   922 YQKAEDPLYVLEN-SVPIDATYYLEQQLSKPLLRIFEPILGDNAESIL--LKGEHTRT---RTVV 980
            .|....|:.||:: ::.::||||:.:|:..||.|||. ::|.:..|..  |...|..|   |:..
Human  2990 IQLVRRPVEVLQDPTLRLNATYYITKQILPPLARIFS-LIGIDVFSWYHELPRIHKATSSSRSEP 3053

  Fly   981 TSKVGGLAGFMTKKTSCLGCKSLMPKGYEQACLCPHC--EPR-MSELYQKEVGAKRELEETFSRL 1042
            ..:.|.::.:.| ...|..|..|...|     :|..|  :|: ::.:..:|:   ||||....:|
Human  3054 EGRKGTISQYFT-TLHCPVCDDLTQHG-----ICSKCRSQPQHVAVILNQEI---RELERQQEQL 3109

  Fly  1043 WTECQRCQESLHEEVICSNRDCPIFYMRQKVRMDL 1077
            ...|:.|.......:.|.:.:||:.:...:|..:|
Human  3110 VKICKNCTGCFDRHIPCVSLNCPVLFKLSRVNREL 3144

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolD1	NP_524099.2	PTZ00166	48..1092	CDD:240301	296/1171 (25%)
REV3L	XP_011534330.1	PTZ00166	41..>195	CDD:240301
		DUF4683	754..1134	CDD:464832
		REV3L_RBD	1874..1896	CDD:412083
		DNA_polB_zeta_exo	2295..2559	CDD:99821	59/329 (18%)
		POLBc_zeta	2585..3033	CDD:99917	156/458 (34%)
		zf-C4pol	3069..3136	CDD:464119	18/74 (24%)