DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-delta and rev3l

DIOPT Version :9

Sequence 1:	NP_524099.2	Gene:	DNApol-delta / 39746	FlyBaseID:	FBgn0263600	Length:	1092	Species:	Drosophila melanogaster
Sequence 2:	XP_002665692.3	Gene:	rev3l / 569100	ZFINID:	ZDB-GENE-050302-55	Length:	2953	Species:	Danio rerio

Alignment Length:	1195	Identity:	313/1195 - (26%)
Similarity:	492/1195 - (41%)	Gaps:	270/1195 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SNGHAKKPRNPDDDEE---------MGFEAELAAFENS--------EDMDQTLLMGD----GPEN 54
            |..|.|:|....:.:.         :.|....||..:|        :|:|:|   .|    .|.|
Zfish  1887 SENHDKRPEKNSESQHNSRNDFCSPIHFSPVKAASSDSSPSSVKCVQDIDKT---KDCRITSPPN 1948

  Fly    55 QTTSERW-SRPPPPELDPSKHNLE--FQQLDVENYLGQPL-----------PGMPGAQ------- 98
            ......| ..|...|.|..|.||.  .|.|.::..|.:.|           |...|.:
Zfish  1949 SPEISTWQDSPDEVEQDEDKENLTGGLQPLSMDQNLNETLLENAESKDHLSPSFFGIKGLVSDVR 2013

  Fly    99 ----IGPVPVVRMFGVTMEGNSVCCHVHGFCPYFYIEAPSQFEEHHCEKLQKALDQKVIADIRNN 159
                :...||.|......|.:|        |      :|.:.|:..|.      .|::......|
Zfish  2014 CSHLLHSTPVQRRNSTDDEASS--------C------SPVRHEDTECR------SQRLHQRSNKN 2058

  Fly   160 KDNVQEAVLMVELVEKLNIHGYNGDKKQRYIKISVTLPRFVAAASRLLKKEVIMSEIDFQDCRAF 224
            |:.::..:|..::..:|               |::.:|          |||  .|:|:..   :|
Zfish  2059 KNALRRVLLSTQVKNQL---------------INMNVP----------KKE--NSQIEGP---SF 2093

  Fly   225 ENNIDFDIRFMVDTDVVGCNWIELPMGHWRIRNSHSKPLPESRCQIEVDVAFDRFISHEPEGEWS 289
            .|:..|.:..                          :.|.|::.            .||
Zfish  2094 CNSYGFKVSM--------------------------QNLQEAKA------------LHE------ 2114

  Fly   290 KVAPFRILSFDIECAGRKGIFPEAKIDP--------------------------VIQIANMVIRQ 328
             |....::|.::....|:.:.|:.:.||                          ||...:....|
Zfish  2115 -VQHLTLMSMELHARTRRNLEPDPEFDPICALFYCLSSDVLLHDSGTTRIEGAIVIDKESCTSAQ 2178

  Fly   329 GERE--PFIRNVFTLNECAPIIGSQV--LCHDKETQMLDKWSAFVREVDPDILTGYNINNFDFPY 389
            ..|.  ||      |..|. :.|..|  .|.:||  :.::.|..:|:.|||||.||.:....:.|
Zfish  2179 ASRSSTPF------LFRCG-VTGLPVTYTCDEKE--LFEEVSNIIRKYDPDILVGYEVQMHSWGY 2234

  Fly   390 LLNRAAHLKVRNFEYLGRIKNIRSVIKEQMLQSKQMGRRENQYVNFEGRVPFDLLFVLLRDYKLR 454
            ||.||:.|.|...:.|.|:.. .|.....:.:..:.|......::..||:..::..::..:..|.
Zfish  2235 LLQRASTLGVNLCQQLSRVPG-DSQQNHFIPEKDEYGAETMTEIHITGRIILNIWRIMKTEAALN 2298

  Fly   455 SYTLNAVSYHFLQEQKEDVHHSIITDLQNGDEQTRRRLAMYCLKDAYL-----PLRLLEKLMAIV 514
            :||...|::|.|.::.....|..::|..:      ..|..:.:.|.|:     .::||::...|.
Zfish  2299 NYTFENVAFHLLHQRYPLYSHRTLSDWFD------THLHRWKVMDHYVSRVCGTVQLLQQQDIIG 2357

  Fly   515 NYMEMARVTGVPLESLLTRGQQIKVLSQLLRKAKTKGFIMPSYTSQGSDEQYEG---ATVIEPKR 576
            ...|:|||.|:....:||||.|.:|.|.:||.||...:|..:.::|...:|...   ..|:||:.
Zfish  2358 RTSELARVFGIQFYHVLTRGSQYRVESMMLRVAKPMNYIPVTPSTQQRAQQRAAQCIPLVMEPES 2422

  Fly   577 GYYADPISTLDFASLYPSIMMAHNLCYTTLVLG-----GTREK-------LRQQEN----LQDDQ 625
            .:|::.:..|||.||||||::|:|.||:| .||     ||.::       ||...:    |::|
Zfish  2423 RFYSNSVIVLDFQSLYPSIVIAYNYCYST-CLGHIENLGTYDEFKFGCASLRVPPDLLYQLRND- 2485

  Fly   626 VERTPANNYFVKSEVRRGLLPEILESLLAARKRAKNDLKV-ETDPFKRKVLDGRQLALKISANSV 689
            :..:|....||||.||||:||.:||.:|..|...|..:|. ..|....::||.|||.||:.||..
Zfish  2486 ITVSPNGVAFVKSSVRRGVLPRMLEEILKTRIMVKQSMKAYRNDKALSRLLDARQLGLKLIANVT 2550

  Fly   690 YGFTGAQV-GKLPCLEISGSVTAYGRTMIEMTKNEVESHYTQANGYENNAVVIYGDTDSVMVNFG 753
            :|:|.|.. |::||:|:..|:....|..:|.....|..  |:..|    |.|:||||||:.|...
Zfish  2551 FGYTSANFSGRMPCVEVGDSIVHKARETLERAIKMVND--TKKWG----ARVVYGDTDSMFVLLK 2609

  Fly   754 VKTLERSMELGREAAELVSSKFVHPIKLEFEKVYYPYLLINKKRYAGLYFTRPDTYDKM-DCKGI 817
            ..|.|::.::|.|.||.|::....||||:|||||.|.:|..||||.|..:...|..:.: |.|||
Zfish  2610 GATKEQAFKIGNEIAEAVTATNPKPIKLKFEKVYLPCILQTKKRYVGYMYESVDQENPVFDAKGI 2674

  Fly   818 ETVRRDNSPLVANLMNSCLQKLLIERDPDGAVAYVKQVIADLLCNRIDISHLVITKELAKTDYAA 882
            ||||||..|.|:.::...|:.|...||......||::....::..:..:..|...||     |..
Zfish  2675 ETVRRDGCPGVSKILERSLKLLFESRDISQVKQYVQRQCVKVVEGKASMQDLTFAKE-----YRG 2734

  Fly   883 KQAH--------VELAAKMKKRDPGTAPKLGDRVPYVICAAAKNTPAYQKAEDPLYVLEN-SVPI 938
            ..::        :||..:|...|....|::|:||||||...:...|..|....||.||:: |:.:
Zfish  2735 SGSYRPGACVPALELTRRMMAFDRRLEPRVGERVPYVIVYGSPGVPLIQLVRRPLEVLQDPSLRL 2799

  Fly   939 DATYYLEQQLSKPLLRIFEPILGDNAESILLKGEHTRTRTVVTSKVGGLAGFMTKKTSCLGCKSL 1003
            :||||:.:|:..||.|||. ::|.:..|...:....:.....||...|..|  |||.:.
Zfish  2800 NATYYITKQILPPLARIFN-LIGVDVFSWYHELPRVQRAWSFTSSGRGEEG--TKKGTI------ 2855

  Fly  1004 MPKGYEQACLCPHCEPRMSELYQKEVGAKRELE--------ETFSRLWTE--------CQRCQES 1052
              ..|.....||.|:    ||.|..|.|:...|        ....|||..        |:.|..|
Zfish  2856 --SQYFTTLHCPVCD----ELTQLGVCARCRAEPQCVAVHLHQDLRLWESQQDQLLKICRSCSGS 2914

  Fly  1053 LHEEVICSNRDCPIFYMRQKVRMDL 1077
            ...:|.|.:.||||.|...:|..:|
Zfish  2915 AERQVPCVSLDCPILYKLSRVNRNL 2939

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-delta	NP_524099.2	PTZ00166	48..1092	CDD:240301	302/1141 (26%)
		DNA_polB_delta_exo	288..517	CDD:99820	55/263 (21%)
		POLBc_delta	564..960	CDD:99916	151/426 (35%)
		zf-C4pol	997..1070	CDD:290959	23/88 (26%)
rev3l	XP_002665692.3	DUF4683	710..1099	CDD:292363
		DNA_polB_zeta_exo	2116..2350	CDD:99821	51/249 (20%)
		POLBc_zeta	2377..2825	CDD:99917	162/461 (35%)
		DNA_pol_B	2377..2820	CDD:278562	161/456 (35%)
		zf-C4pol	2864..2931	CDD:290959	21/70 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D20210at2759
OrthoFinder	1	1.000	-	-		FOG0001033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820