DRSC/TRiP Functional Genomics Resources

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Protein Alignment DNApol-delta and POLD1

DIOPT Version :9

Sequence 1:NP_524099.2 Gene:DNApol-delta / 39746 FlyBaseID:FBgn0263600 Length:1092 Species:Drosophila melanogaster
Sequence 2:NP_001295561.1 Gene:POLD1 / 5424 HGNCID:9175 Length:1133 Species:Homo sapiens


Alignment Length:1142 Identity:660/1142 - (57%)
Similarity:825/1142 - (72%) Gaps:70/1142 - (6%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MDGKRKFNGTSNGHAKKPRN---PDDD--------------EEMGFEAELAAFENSEDMDQTLLM 48
            |||||:.........|:.|.   .|||              |||  |||....|..|:..|::|.
Human     1 MDGKRRPGPGPGVPPKRARGGLWDDDDAPRPSQFEEDLALMEEM--EAEHRLQEQEEEELQSVLE 63

  Fly    49 G--DGPENQTTSE-RWSRPPPPELDPSKHNLEFQQLDVENYLG--QPLPGMPGAQIGPVPVVRMF 108
            |  ||....:..: ||.||.||.|||....|.||||::::|:|  ||:||.|....|.|||:|.|
Human    64 GVADGQVPPSAIDPRWLRPTPPALDPQTEPLIFQQLEIDHYVGPAQPVPGGPPPSRGSVPVLRAF 128

  Fly   109 GVTMEGNSVCCHVHGFCPYFYIEAPSQFEEHHCEKLQKALDQKVIADIRNNKDNVQEAVLMVELV 173
            |||.||.|||||:|||.||||..||..|...|...||:.|:..:..|.|..::....|||.|||.
Human   129 GVTDEGFSVCCHIHGFAPYFYTPAPPGFGPEHMGDLQRELNLAISRDSRGGRELTGPAVLAVELC 193

  Fly   174 EKLNIHGYNGDKKQRYIKISVTLPRFVAAASRLLKKEVIMSEIDFQDCRAFENNIDFDIRFMVDT 238
            .:.::.||:|.....:::|:|.|||.||.|.|||::.:.::.:.......:|.|:||:|||||||
Human   194 SRESMFGYHGHGPSPFLRITVALPRLVAPARRLLEQGIRVAGLGTPSFAPYEANVDFEIRFMVDT 258

  Fly   239 DVVGCNWIELPMGHWRIRNSHSKPLPE--SRCQIEVDVAFDRFISHEPEGEWSKVAPFRILSFDI 301
            |:|||||:|||.|.:.:|      |.|  ::||:|.||.:...:||.|||.|.::||.|:|||||
Human   259 DIVGCNWLELPAGKYALR------LKEKATQCQLEADVLWSDVVSHPPEGPWQRIAPLRVLSFDI 317

  Fly   302 ECAGRKGIFPEAKIDPVIQIANMVIRQGEREPFIRNVFTLNECAPIIGSQVLCHDKETQMLDKWS 366
            |||||||||||.:.||||||.::.:|.||.|||:|...||..||||:|::|..::||..:|..||
Human   318 ECAGRKGIFPEPERDPVIQICSLGLRWGEPEPFLRLALTLRPCAPILGAKVQSYEKEEDLLQAWS 382

  Fly   367 AFVREVDPDILTGYNINNFDFPYLLNRAAHLKVRNFEYLGRIKNIRSVIKEQMLQSKQMGRRENQ 431
            .|:|.:|||::|||||.|||.|||::||..|||:.|.:|||:..:.|.|::...||||.|||:.:
Human   383 TFIRIMDPDVITGYNIQNFDLPYLISRAQTLKVQTFPFLGRVAGLCSNIRDSSFQSKQTGRRDTK 447

  Fly   432 YVNFEGRVPFDLLFVLLRDYKLRSYTLNAVSYHFLQEQKEDVHHSIITDLQNGDEQTRRRLAMYC 496
            .|:..|||..|:|.||||:||||||||||||:|||.||||||.||||||||||::|||||||:||
Human   448 VVSMVGRVQMDMLQVLLREYKLRSYTLNAVSFHFLGEQKEDVQHSIITDLQNGNDQTRRRLAVYC 512

  Fly   497 LKDAYLPLRLLEKLMAIVNYMEMARVTGVPLESLLTRGQQIKVLSQLLRKAKTKGFIMPSYTSQG 561
            ||||||||||||:||.:||.:||||||||||..||:||||:||:|||||:|..:|.:||...|:|
Human   513 LKDAYLPLRLLERLMVLVNAVEMARVTGVPLSYLLSRGQQVKVVSQLLRQAMHEGLLMPVVKSEG 577

  Fly   562 SDEQYEGATVIEPKRG--------------------------YYADPISTLDFASLYPSIMMAHN 600
            . |.|.|||||||.:|                          ||..||:||||:|||||||||||
Human   578 G-EDYTGATVIEPLKGVRPQDRAGAAWELLALTPGRGCSPPRYYDVPIATLDFSSLYPSIMMAHN 641

  Fly   601 LCYTTLVLGGTREKLRQQENLQDDQVERTPANNYFVKSEVRRGLLPEILESLLAARKRAKNDLKV 665
            ||||||:..||.:||    .|.:||..|||..:.|||:.||:||||:|||:||:||||||.:|..
Human   642 LCYTTLLRPGTAQKL----GLTEDQFIRTPTGDEFVKTSVRKGLLPQILENLLSARKRAKAELAK 702

  Fly   666 ETDPFKRKVLDGRQLALKISANSVYGFTGAQVGKLPCLEISGSVTAYGRTMIEMTKNEVESHYTQ 730
            ||||.:|:||||||||||:||||||||||||||||||||||.|||.:||.|||.||..|||.||.
Human   703 ETDPLRRQVLDGRQLALKVSANSVYGFTGAQVGKLPCLEISQSVTGFGRQMIEKTKQLVESKYTV 767

  Fly   731 ANGYENNAVVIYGDTDSVMVNFGVKTLERSMELGREAAELVSSKFVHPIKLEFEKVYYPYLLINK 795
            .|||..:|.|:||||||||..|||.::..:|.||||||:.||..|..||:|||||||:|||||:|
Human   768 ENGYSTSAKVVYGDTDSVMCRFGVSSVAEAMALGREAADWVSGHFPSPIRLEFEKVYFPYLLISK 832

  Fly   796 KRYAGLYF-TRPDTYDKMDCKGIETVRRDNSPLVANLMNSCLQKLLIERDPDGAVAYVKQVIADL 859
            ||||||.| :|||.:|:|||||:|.|||||.||||||:.:.|::|||:|||:||||:.:.||:||
Human   833 KRYAGLLFSSRPDAHDRMDCKGLEAVRRDNCPLVANLVTASLRRLLIDRDPEGAVAHAQDVISDL 897

  Fly   860 LCNRIDISHLVITKEL--AKTDYAAKQAHVELAAKMKKRDPGTAPKLGDRVPYVICAAAKNTPAY 922
            ||||||||.|||||||  |.:|||.||||||||.:|:|||||:||.|||||||||.:|||...||
Human   898 LCNRIDISQLVITKELTRAASDYAGKQAHVELAERMRKRDPGSAPSLGDRVPYVIISAAKGVAAY 962

  Fly   923 QKAEDPLYVLENSVPIDATYYLEQQLSKPLLRIFEPILGD-NAESILLKGEHTRTRTVVTSKVGG 986
            .|:||||:|||:|:|||..|||||||:||||||||||||: .||::||:|:|||.:||:|.||||
Human   963 MKSEDPLFVLEHSLPIDTQYYLEQQLAKPLLRIFEPILGEGRAEAVLLRGDHTRCKTVLTGKVGG 1027

  Fly   987 LAGFMTKKTSCLGCKSLMPKGYEQACLCPHCEPRMSELYQKEVGAKRELEETFSRLWTECQRCQE 1051
            |..|..::..|:||::::.   .|..:|..|:||.||||||||.....|||.||||||:|||||.
Human  1028 LLAFAKRRNCCIGCRTVLS---HQGAVCEFCQPRESELYQKEVSHLNALEERFSRLWTQCQRCQG 1089

  Fly  1052 SLHEEVICSNRDCPIFYMRQKVRMDLDNQEKRVLRFG 1088
            ||||:|||::|||||||||:|||.||::||:.:.|||
Human  1090 SLHEDVICTSRDCPIFYMRKKVRKDLEDQEQLLRRFG 1126

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNApol-deltaNP_524099.2 PTZ00166 48..1092 CDD:240301 640/1078 (59%)
DNA_polB_delta_exo 288..517 CDD:99820 146/228 (64%)
POLBc_delta 564..960 CDD:99916 279/424 (66%)
zf-C4pol 997..1070 CDD:290959 44/72 (61%)
POLD1NP_001295561.1 PTZ00166 81..1126 CDD:240301 633/1058 (60%)
DNA_polB_delta_exo 304..533 CDD:99820 146/228 (64%)
POLBc_delta 579..1000 CDD:99916 279/424 (66%)
zf-C4pol 1038..1108 CDD:290959 44/72 (61%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142548
Domainoid 1 1.000 586 1.000 Domainoid score I204
eggNOG 1 0.900 - - E1_COG0417
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H2014
Inparanoid 1 1.050 1275 1.000 Inparanoid score I168
Isobase 1 0.950 - 0 Normalized mean entropy S540
OMA 1 1.010 - - QHG53777
OrthoDB 1 1.010 - - D20210at2759
OrthoFinder 1 1.000 - - FOG0001033
OrthoInspector 1 1.000 - - oto90208
orthoMCL 1 0.900 - - OOG6_101046
Panther 1 1.100 - - LDO PTHR10322
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R345
SonicParanoid 1 1.000 - - X3678
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1716.750

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