DRSC/TRiP Functional Genomics Resources

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Protein Alignment DNApol-delta and POLA1

DIOPT Version :9

Sequence 1:NP_524099.2 Gene:DNApol-delta / 39746 FlyBaseID:FBgn0263600 Length:1092 Species:Drosophila melanogaster
Sequence 2:NP_001317289.1 Gene:POLA1 / 5422 HGNCID:9173 Length:1468 Species:Homo sapiens


Alignment Length:1241 Identity:275/1241 - (22%)
Similarity:463/1241 - (37%) Gaps:309/1241 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 KKPRNPDDD---EEMGFEAELAAFENSE-DMDQTLLMGDGPENQTTSERWSRPPPP------ELD 70
            |:.....||   |....|.|..|.|..: |.|:.:.:.:.......::.|.:...|      |.|
Human   230 KRAEFAGDDVQVESTEEEQESGAMEFEDGDFDEPMEVEEVDLEPMAAKAWDKESEPAEEVKQEAD 294

  Fly    71 PSKHNLEF-----------------------QQLDVENYLGQPLPGMPGA--------------- 97
            ..|..:.:                       |::.|::   ..||.:.||               
Human   295 SGKGTVSYLGSFLPDVSCWDIDQEGDSSFSVQEVQVDS---SHLPLVKGADEEQVFHFYWLDAYE 356

  Fly    98 -QIGPVPVVRMFG----VTMEGNSVCCHVHGFCPYFYIEAPSQFEEHHCEKLQKALDQKVIADIR 157
             |.....||.:||    .:.|.:..||.:                ..:.|:....|.:::..|:.
Human   357 DQYNQPGVVFLFGKVWIESAETHVSCCVM----------------VKNIERTLYFLPREMKIDLN 405

  Fly   158 NNKDNVQEAVLMVELVE--------KLNIHGYNG--------------DKKQRY--IKISVTLPR 198
            ..|: ....:.|.::.|        |..|..:..              .:|..|  :|.|..:|:
Human   406 TGKE-TGTPISMKDVYEEFDEKIATKYKIMKFKSKPVEKNYAFEIPDVPEKSEYLEVKYSAEMPQ 469

  Fly   199 FVAAASRLLKKEVIMSEIDFQDCRAFENNIDFDIRFMVDTDVVGCNWIELPMGHWRIRNSHSKPL 263
            .    .:.||.|..        ...|..|......|:::..:.|..|:|       :::......
Human   470 L----PQDLKGETF--------SHVFGTNTSSLELFLMNRKIKGPCWLE-------VKSPQLLNQ 515

  Fly   264 PESRCQIE--------------------VDVAFDRFISHEPEGEWSKVAPFRIL---SFDIECAG 305
            |.|.|::|                    |.:||........:...:::.....|   ||.::.|.
Human   516 PVSWCKVEAMALKPDLVNVIKDVSPPPLVVMAFSMKTMQNAKNHQNEIIAMAALVHHSFALDKAA 580

  Fly   306 RKG---------------IFPEAKIDPVIQIANMVIRQGEREPFIRNVFTLNECAPIIGSQVLCH 355
            .|.               |||.| ...||:..|:.:.....|..:...|.               
Human   581 PKPPFQSHFCVVSKPKDCIFPYA-FKEVIEKKNVKVEVAATERTLLGFFL--------------- 629

  Fly   356 DKETQMLDKWSAFVREVDPDILTGYNINNFDFPYLLNRAAHLKVRNFEYLGRIKNIRSVIKEQML 420
                       |.|.::||||:.|:||..|:...||.|....|..::..:||:|  ||       
Human   630 -----------AKVHKIDPDIIVGHNIYGFELEVLLQRINVCKAPHWSKIGRLK--RS------- 674

  Fly   421 QSKQMGRRENQYVNFE------GRVPFDLLFVLLRDYKLRSYTLNAVSYHFLQEQKEDVHHSIIT 479
            ...::|.|.    .|.      ||:..|:........:.:||.|:.:....|:.::..:....|.
Human   675 NMPKLGGRS----GFGERNATCGRMICDVEISAKELIRCKSYHLSELVQQILKTERVVIPMENIQ 735

  Fly   480 DLQNGDEQTRRRLAMYCL----KDAYLPLRLLEKLMAIVNYMEMARVTGVPLESLLTRGQQIKVL 540
            ::.:...|     .:|.|    |||...|:::.:|..:...:::..:.|..:...|..|:..:..
Human   736 NMYSESSQ-----LLYLLEHTWKDAKFILQIMCELNVLPLALQITNIAGNIMSRTLMGGRSERNE 795

  Fly   541 SQLLRKAKTKGFIMP------------------------SYTSQGSDEQYEGATVIEPKRGYYAD 581
            ..||.......:|:|                        .|........|.|..|::||.|:|..
Human   796 FLLLHAFYENNYIVPDKQIFRKPQQKLGDEDEEIDGDTNKYKKGRKKAAYAGGLVLDPKVGFYDK 860

  Fly   582 PISTLDFASLYPSIMMAHNLCYTTLVLGGTREKLRQQENLQDDQVERTPANNYFVKSEVRRGLLP 646
            .|..|||.||||||:...|:|:||:    .|.....|:..:|.:.|:.|.   .....:..|:||
Human   861 FILLLDFNSLYPSIIQEFNICFTTV----QRVASEAQKVTEDGEQEQIPE---LPDPSLEMGILP 918

  Fly   647 EILESLLAARKRAKNDLK-VETDPFKRKVLDGRQLALKISANSVYGFTGAQVGKLPCLEISGSVT 710
            ..:..|:..||:.|..:| .:.:|......|.||.|||::|||:||..|....:.....::..||
Human   919 REIRKLVERRKQVKQLMKQQDLNPDLILQYDIRQKALKLTANSMYGCLGFSYSRFYAKPLAALVT 983

  Fly   711 AYGRTMIEMTKNEVESHYTQANGYENNAVVIYGDTDSVMVNFGVKTLERSMELGREAAELVSSKF 775
            ..||.::..||..|:         :.|..||||||||:|:|.....||...:||.:....| :|.
Human   984 YKGREILMHTKEMVQ---------KMNLEVIYGDTDSIMINTNSTNLEEVFKLGNKVKSEV-NKL 1038

  Fly   776 VHPIKLEFEKVYYPYLLINKKRYAGLYF--TRPDTY-DKMDCKGIETVRRDNSPLVANLMNSCLQ 837
            ...::::.:.|:...||:.||:||.|..  |....| .|.:.||::.||||...|..:..|..:.
Human  1039 YKLLEIDIDGVFKSLLLLKKKKYAALVVEPTSDGNYVTKQELKGLDIVRRDWCDLAKDTGNFVIG 1103

  Fly   838 KLLIERDPDGAVAYVKQVIADL----LCNRIDISHLVITKELAK--TDYAAKQA--HVELAAKMK 894
            ::|.::..|..|..:::.:.::    |...:.:|...|.|.|.|  .||..|::  ||.:|..:.
Human  1104 QILSDQSRDTIVENIQKRLIEIGENVLNGSVPVSQFEINKALTKDPQDYPDKKSLPHVHVALWIN 1168

  Fly   895 KRDPGTAPKLGDRVPYVICAAAKNTPAYQKAEDPLYV-LENSVPIDATYYLEQQLSKPLLRIFEP 958
            .:. |...|.||.|.||||....|..|.|:|..|..: .::::.||..|||.||:...:.||.||
Human  1169 SQG-GRKVKAGDTVSYVICQDGSNLTASQRAYAPEQLQKQDNLTIDTQYYLAQQIHPVVARICEP 1232

  Fly   959 ILGDNAESILL-----------KGEHTRTRTVVTSKVGGLAGFMTKKTSCLGCKSLMPKGYEQAC 1012
            |  |..:::|:           :..|........:.:||.|. :|.:.....|:..       .|
Human  1233 I--DGIDAVLIATWLGLDPTQFRVHHYHKDEENDALLGGPAQ-LTDEEKYRDCERF-------KC 1287

  Fly  1013 LCPHCEPRMSELYQKEVGAKRELEETFSRLWTECQRCQESLHEEVICSNRDC---PIFY---MRQ 1071
            .||.|            |.:...:..|....|:   .:.||:.   |||.||   |:.:   :..
Human  1288 PCPTC------------GTENIYDNVFDGSGTD---MEPSLYR---CSNIDCKASPLTFTVQLSN 1334

  Fly  1072 KVRMDL 1077
            |:.||:
Human  1335 KLIMDI 1340

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
DNApol-deltaNP_524099.2 PTZ00166 48..1092 CDD:240301 265/1205 (22%)
DNA_polB_delta_exo 288..517 CDD:99820 52/256 (20%)
POLBc_delta 564..960 CDD:99916 130/408 (32%)
zf-C4pol 997..1070 CDD:290959 16/78 (21%)
POLA1NP_001317289.1 DNA_pol_alpha_N 41..101 CDD:289058
pol2 56..1231 CDD:273159 246/1102 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 104..129
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 238..257 6/18 (33%)
DNA_polB_alpha_exo 541..773 CDD:99819 55/276 (20%)
DNA-binding. /evidence=ECO:0000255 656..721 16/77 (21%)
POLBc_alpha 838..1248 CDD:99915 133/429 (31%)
DNA-binding. /evidence=ECO:0000255 1251..1382 24/116 (21%)
zf-DNA_Pol 1271..1461 CDD:286132 21/96 (22%)
CysB motif. /evidence=ECO:0000250|UniProtKB:P15436 1354..1380
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0417
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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