DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-delta and DNApol-zeta

DIOPT Version :9

Sequence 1:	NP_524099.2	Gene:	DNApol-delta / 39746	FlyBaseID:	FBgn0263600	Length:	1092	Species:	Drosophila melanogaster
Sequence 2:	NP_524881.2	Gene:	DNApol-zeta / 47186	FlyBaseID:	FBgn0002891	Length:	2130	Species:	Drosophila melanogaster

Alignment Length:	996	Identity:	271/996 - (27%)
Similarity:	408/996 - (40%)	Gaps:	177/996 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 RNNKDNVQEAVLMVELVEKLNIHGYNGDKKQRYIKISVTLPRFVAAASRLLKKEVIMSEIDFQDC 221
            ::::.:|..:....||.....:....|..:.|...:|..|                 |.....:.
  Fly  1231 QSSEQSVSSSAAQAELDRSSFLRQLEGSSQDRQHDLSFGL-----------------SHATLDNT 1278

  Fly   222 RAFENNIDFDIRFMVDTDVVGCNWIEL----------------PMGHWRIR-----NSHSKP--- 262
            ..|:.|::...:...|.|   ||.:.:                || |..||     ..||.|
  Fly  1279 FGFKVNLENLQQAKADID---CNHLTIITLEVFVSTRGDLQPDPM-HDEIRCLFYAIEHSLPDEK 1339

  Fly   263 LPESRC-QIEVDVAFDRFISHEPEGEWSKVAPFRILSFDIECAGRKGIFPEAKIDPVIQIANMVI 326
            ||...| .|.|:...|..    .||      ||..:..|||                :|:..
  Fly  1340 LPSKACGYIMVNTVQDLL----SEG------PFHGIDRDIE----------------VQVVT--- 1375

  Fly   327 RQGEREPFIRNVFTLNECAPIIGSQVLCHDKETQMLDKWSAFVREVDPDILTGYNINNFDFPYLL 391
              .|.|.|...:             .||        ::|       |.||..||.|....:.|::
  Fly  1376 --SEAEAFEALL-------------ALC--------ERW-------DADIYAGYEIEMSSWGYVI 1410

  Fly   392 NRAAHLKVRNFEYLGRI--KNIRSVIKEQMLQSKQMGRRENQYVNFE------GRVPFDLLFVLL 448
            :||.||.......|.|:  :.:|..:.|.         || |:.:.:      ||:..|:..::.
  Fly  1411 DRAKHLCFNIAPLLSRVPTQKVRDFVDED---------RE-QFTDLDVEMKLCGRILLDVWRLMR 1465

  Fly   449 RDYKLRSYTLNAVSYHFLQEQKEDVHHSIITDLQNGDEQTRRRLAMYCLKDAYLPLRLLEKLMAI 513
            .:..|.|||...|.||.|.::........:|: ..|...||..:..|.|:.....|.||::|..:
  Fly  1466 SEIALTSYTFENVMYHILHKRCPWHTAKSLTE-WFGSPCTRWIVMEYYLERVRGTLTLLDQLDLL 1529

  Fly   514 VNYMEMARVTGVPLESLLTRGQQIKVLSQLLRKAKTKGFI--MPSYTSQGSDEQYEG-ATVIEPK 575
            ....|||::.|:....:|:||.|.:|.|.:||.||.|..:  .||..::......|. |.::||:
  Fly  1530 GRTSEMAKLIGIQFYEVLSRGSQFRVESMMLRIAKPKNLVPLSPSVQARAHMRAPEYLALIMEPQ 1594

  Fly   576 RGYYADPISTLDFASLYPSIMMAHNLCYTTLV-----LGG-------------TREKLRQQENLQ 622
            ..:||||:..|||.|||||:::|:|.|::|.:     |||             :|:.|  |:.|:
  Fly  1595 SRFYADPLIVLDFQSLYPSMIIAYNYCFSTCLGRVEHLGGSSPFEFGASQLRVSRQML--QKLLE 1657

  Fly   623 DDQVERTPANNYFVKSEVRRGLLPEILESLLAARKRAKNDLKVETDPFK-RKVLDGRQLALKISA 686
            .|.|..:|....|||.|||.|:||.:|..:|..|:..|..:|:..|... :::|..|||.||:.|
  Fly  1658 HDLVTVSPCGVVFVKREVREGILPRMLTEILDTRQMVKQSMKLHKDSSALQRILHSRQLGLKLMA 1722

  Fly   687 NSVYGFTGAQV-GKLPCLEISGSVTAYGRTMIEMTKNEVESHYTQANGYENNAVVIYGDTDSVMV 750
            |..||:|.|.. |::|.:|:..||.:.||..:|.....||      |..|....|:||||||:.|
  Fly  1723 NVTYGYTAANFSGRMPSVEVGDSVVSKGRETLERAIKLVE------NNEEWKVRVVYGDTDSMFV 1781

  Fly   751 NFGVKTLERSMELGREAAELVSSKFVHPIKLEFEKVYYPYLLINKKRYAG-LYFTRPDTYDKMDC 814
            ....:....:..:|.|.|:.|:.....|:||:.||||.|.:|..||||.| :|.|........:.
  Fly  1782 LVPGRNRAEAFRIGEEIAKAVTEMNPQPVKLKLEKVYQPCMLQTKKRYVGYMYETADQEQPVYEA 1846

  Fly   815 KGIETVRRDNSPLVANLMNSCLQKLLIERDPDGAVAYVKQVIADLLCNRIDISHLVITKELAKTD 879
            |||||||||..|.||.::...|:.|...:|.....|||.:....||..|.::..|:..||....:
  Fly  1847 KGIETVRRDGCPAVAKMLEKVLRILFETQDVSKIKAYVCRQFTKLLSGRANLQDLIFAKEFRGLN 1911

  Fly   880 YAAKQAHV---ELAAKMKKRDPGTAPKLGDRVPYVICAAAKNTPAYQKAEDPLYVLEN-SVPIDA 940
            .....|.|   ||..|..::||...|:.|:|||::|..........:....|..:|.| ...|:|
  Fly  1912 GYKPTACVPALELTRKWMQKDPRHVPRRGERVPFIIVNGPPGMQLIRLVRSPHDILANEGHKINA 1976

  Fly   941 TYYLEQQLSKPLLRIFEPILGDNAESILLKGEHTRTRTVVTSKVGGLAGFMTKK---------TS 996
            .||:.:.:..||.|.. .::|.|..............|........|||....|         ||
  Fly  1977 IYYITKAIIPPLNRCL-LLIGANVHDWFASLPRKLLMTPAVGTANELAGARGAKSTISQYFSTTS 2040

  Fly   997 C-LGCKSLMPKGYEQACLCPHCEPRMSELYQKEVGAKRELEETFSRLWTECQRCQESLHEEVICS 1060
            | :.|......|     :||.|....:............||..:......||.|...| ..:.|.
  Fly  2041 CVIDCGRQTKAG-----ICPDCLKNATTCVVVLSDKTARLERGYQLTRQICQACCGRL-GSLQCD 2099

  Fly  1061 NRDCPIFYMRQKVRMDLDNQE 1081
            :.|||:.|:.:..|.:|...|
  Fly  2100 SLDCPVLYVLEGKRRELQQIE 2120

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-delta	NP_524099.2	PTZ00166	48..1092	CDD:240301	271/996 (27%)
		DNA_polB_delta_exo	288..517	CDD:99820	51/236 (22%)
		POLBc_delta	564..960	CDD:99916	144/421 (34%)
		zf-C4pol	997..1070	CDD:290959	17/73 (23%)
DNApol-zeta	NP_524881.2	PTZ00166	20..>196	CDD:240301
		DNA_polB_zeta_exo	1297..1518	CDD:99821	65/291 (22%)
		POLBc_zeta	1550..2000	CDD:99917	157/458 (34%)
		zf-C4pol	2041..2107	CDD:405022	16/71 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45462122
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0417
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D20210at2759
OrthoFinder	1	1.000	-	-		FOG0001033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.750