DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-delta and Rev3l

DIOPT Version :9

Sequence 1:	NP_524099.2	Gene:	DNApol-delta / 39746	FlyBaseID:	FBgn0263600	Length:	1092	Species:	Drosophila melanogaster
Sequence 2:	XP_006256586.1	Gene:	Rev3l / 309812	RGDID:	1307087	Length:	3133	Species:	Rattus norvegicus

Alignment Length:	1157	Identity:	293/1157 - (25%)
Similarity:	493/1157 - (42%)	Gaps:	235/1157 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 PDDDEEMGFEAELAAFENSEDMDQTLLMGDGPENQTTSERWSRPPPPELDPSKH--NLEFQQLD- 82
            |:::||...|.|    |..||           ||...|  :|.|..|.:.|.:.  :.:|:.|:
  Rat  2099 PEEEEEEEEEEE----EEEED-----------ENGYVS--YSSPDSPGIPPWQQAASPDFRALNG 2146

  Fly    83 ---------------VENYLGQPLPGMPGAQ------IGPVPVVRMFGVTMEGNSVCCHVHGFCP 126
                           |||:|.....|:..|.      |.|:.....   |.:...:|.|.....|
  Rat  2147 EHRCSSPVEELCSRAVENFLKPIKDGIQKASCCESQVISPIHARTR---TEKCEPLCLHSTPVMP 2208

  Fly   127 YFYIE--------APSQFEEHHCEKLQKALDQKVIADIRNNKDNVQEAVLMVELVEKLNIHGYNG 183
            ..::|        :|...|    .|.||..::|     .::.|:::. ||:...||. .....|.
  Rat  2209 RKFLEKLPEATGLSPLSVE----PKTQKLYNKK-----GSDTDHLRR-VLLTTQVEN-QFAAVNT 2262

  Fly   184 DKKQRY------------IKISVTLPRFVAAASRLLKKEVIMSEIDFQDCRAFENNIDFD----I 232
            .||:..            .|:|:...:...|...:....:|..|:..:..|..:.:.:||    :
  Rat  2263 PKKETSQIDGPSLNNTYGFKVSIQNLQEAKALHEIQNLTLISVELHARTRRDLQPDPEFDPICAL 2327

  Fly   233 RFMVDTDVVGCNWIELPMGHWRIRNSHSKPLPESRCQ-----IEVDVAFDRFISHEPEGEWSKVA 292
            .:.:.:|.                     |||::...     |.:|.  |:.::|:
  Rat  2328 FYCISSDT---------------------PLPDTEKTELTGVIVIDK--DKTVTHQ--------- 2360

  Fly   293 PFRILSFDIECAGRKGIFPEAKIDPVIQIANMVIRQGEREPFIRNVFTLNECAPIIGSQVLCHDK 357
                   ||.|.                 ..::||.|                 :.|.:|.....
  Rat  2361 -------DIRCQ-----------------TPLLIRSG-----------------VTGLEVTYAAD 2384

  Fly   358 ETQMLDKWSAFVREVDPDILTGYNINNFDFPYLLNRAAHLKVRNFEYLGRIKNIRSVIKEQMLQS 422
            |..:..:.:..::..|||||.||.|....:.|||.|||.|.|...:.:.|       :.:..:::
  Rat  2385 EKALFQEVTNIMKRYDPDILLGYEIQMHSWGYLLQRAAALSVDLCQMISR-------VPDDKIEN 2442

  Fly   423 KQMGRREN------QYVNFEGRVPFDLLFVLLRDYKLRSYTLNAVSYHFLQEQKEDVHHSIITD- 480
            :....|::      ..:|..||:..:|..::..:..|.:||...||:|.|.::.......:::|
  Rat  2443 RFAAERDDYGSDTMSEINIVGRITLNLWRIMRNEVALTNYTFENVSFHVLHQRFPLFTFRVLSDW 2507

  Fly   481 LQNGDEQTRRRLAMYCLKDAYLPLRLLEKLMAIVNYMEMARVTGVPLESLLTRGQQIKVLSQLLR 545
            ..|..:..|.::..:.:......|::||:|..|....||||:.|:....:||||.|.:|.|.:||
  Rat  2508 FDNKTDLYRWKMVDHYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVLTRGSQYRVESMMLR 2572

  Fly   546 KAKTKGFIMPSYTSQGSDEQYEG----ATVIEPKRGYYADPISTLDFASLYPSIMMAHNLCYTTL 606
            .||...:| |...|.....|...    ..::||:..:|::.:..|||.||||||::|:|.|::|.
  Rat  2573 IAKPMNYI-PVTPSVQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTC 2636

  Fly   607 VLGGTREKLRQQENLQ----------------DDQVERTPANNYFVKSEVRRGLLPEILESLLAA 655
            :  |..|.|.:.:..:                ...:..:|....|||..||:|:||.:||.:|..
  Rat  2637 L--GHIENLGKYDEFKFGCTSLRVPPDLLYQIRHDITVSPNGVAFVKPSVRKGVLPRMLEEILKT 2699

  Fly   656 RKRAKNDLKV-ETDPFKRKVLDGRQLALKISANSVYGFTGAQV-GKLPCLEISGSVTAYGRTMIE 718
            |...|..:|. ..|....::|:.|||.||:.||..:|:|.|.. |::||:|:..|:....|..:|
  Rat  2700 RFMVKQSMKAYRQDRALSRMLNARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKARETLE 2764

  Fly   719 MTKNEVESHYTQANGYENNAVVIYGDTDSVMVNFGVKTLERSMELGREAAELVSSKFVHPIKLEF 783
            .....|..  |:..|    |.|:||||||:.|.....|.|:|.::|:|.||.|::....|:||:|
  Rat  2765 RAIKLVND--TKKWG----ARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPVKLKF 2823

  Fly   784 EKVYYPYLLINKKRYAGLYFTRPDTYDKM-DCKGIETVRRDNSPLVANLMNSCLQKLLIERDPDG 847
            ||||.|.:|..||||.|..:...|..|.: |.|||||||||:.|.|:.::...|:.|...||...
  Rat  2824 EKVYLPCVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKLLFETRDISL 2888

  Fly   848 AVAYVKQVIADLLCNRIDISHLVITKELAKTDYAAKQAH--------VELAAKMKKRDPGTAPKL 904
            ...||::....|:..:..|...:..||     |....::        :||..||...|..:.|::
  Rat  2889 IKQYVQRQCMKLVEGKASIQDFIFAKE-----YRGSFSYRPGACVPALELTRKMLAYDRRSEPRV 2948

  Fly   905 GDRVPYVICAAAKNTPAYQKAEDPLYVLEN-SVPIDATYYLEQQLSKPLLRIFEPILGDNA---- 964
            |:||||||.......|..|....|..||:: ::.::||||:.:|:..||.|||. ::|.:.
  Rat  2949 GERVPYVIVYGTPGLPLIQLIRRPAEVLQDPTLRLNATYYITKQILPPLARIFS-LIGIDVFSWY 3012

  Fly   965 -ESILLKGEHTRTRTVVTSKVGGLAGFMTKKTSCLGCKSLMPKGYEQACLCPHC--EPR-MSELY 1025
             |...::...:.:|:.:..:.|.::.:.| ...|..|..|...|     :|..|  :|: ::.:.
  Rat  3013 QELPRIQKATSSSRSDLEGRKGTISQYFT-TLHCPVCDGLTQHG-----ICSQCRSQPQHVAIIL 3071

  Fly  1026 QKEVGAKRELEETFSRLWTECQRCQESLHEEVICSNRDCPIFYMRQKVRMDL 1077
            .:|:   ||||....:|...|:.|..|....:.|.:.:||:.:...:|..:|
  Rat  3072 NQEI---RELERQQEQLVKICRNCTGSFDRHIPCVSLNCPVLFKLSRVNREL 3120

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-delta	NP_524099.2	PTZ00166	48..1092	CDD:240301	285/1130 (25%)
		DNA_polB_delta_exo	288..517	CDD:99820	46/235 (20%)
		POLBc_delta	564..960	CDD:99916	142/427 (33%)
		zf-C4pol	997..1070	CDD:290959	19/75 (25%)
Rev3l	XP_006256586.1	DUF4683	747..1133	CDD:292363
		DNA_polB_zeta_exo	2297..2535	CDD:99821	55/317 (17%)
		POLBc_zeta	2561..3009	CDD:99917	154/462 (33%)
		DNA_pol_B	2561..3008	CDD:278562	154/461 (33%)
		zf-C4pol	3045..3112	CDD:290959	19/74 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D20210at2759
OrthoFinder	1	1.000	-	-		FOG0001033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820