Protein Alignment PolD1 and Rev3l

DIOPT Version :10

• Sequence 1: NP_524099.2
• Gene: PolD1 / 39746
• FlyBaseID: FBgn0263600
• Length: 1092
• Species: Drosophila melanogaster
• Sequence 2: XP_006256586.1
• Gene: Rev3l / 309812
• RGDID: 1307087
• Length: 3133
• Species: Rattus norvegicus
• Alignment Length: 1157
• Identity: 293/1157 - (25%)
• Similarity: 493/1157 - (42%)
• Gaps: 235/1157 - (20%)

  Fly    21 PDDDEEMGFEAELAAFENSEDMDQTLLMGDGPENQTTSERWSRPPPPELDPSKH--NLEFQQLD- 82
            |:::||...|.|    |..||           ||...|  :|.|..|.:.|.:.  :.:|:.|:
  Rat  2099 PEEEEEEEEEEE----EEEED-----------ENGYVS--YSSPDSPGIPPWQQAASPDFRALNG 2146

  Fly    83 ---------------VENYLGQPLPGMPGAQ------IGPVPVVRMFGVTMEGNSVCCHVHGFCP 126
                           |||:|.....|:..|.      |.|:.....   |.:...:|.|.....|
  Rat  2147 EHRCSSPVEELCSRAVENFLKPIKDGIQKASCCESQVISPIHARTR---TEKCEPLCLHSTPVMP 2208

  Fly   127 YFYIE--------APSQFEEHHCEKLQKALDQKVIADIRNNKDNVQEAVLMVELVEKLNIHGYNG 183
            ..::|        :|...|    .|.||..::|     .::.|:::. ||:...||. .....|.
  Rat  2209 RKFLEKLPEATGLSPLSVE----PKTQKLYNKK-----GSDTDHLRR-VLLTTQVEN-QFAAVNT 2262

  Fly   184 DKKQRY------------IKISVTLPRFVAAASRLLKKEVIMSEIDFQDCRAFENNIDFD----I 232
            .||:..            .|:|:...:...|...:....:|..|:..:..|..:.:.:||    :
  Rat  2263 PKKETSQIDGPSLNNTYGFKVSIQNLQEAKALHEIQNLTLISVELHARTRRDLQPDPEFDPICAL 2327

  Fly   233 RFMVDTDVVGCNWIELPMGHWRIRNSHSKPLPESRCQ-----IEVDVAFDRFISHEPEGEWSKVA 292
            .:.:.:|.                     |||::...     |.:|.  |:.::|:
  Rat  2328 FYCISSDT---------------------PLPDTEKTELTGVIVIDK--DKTVTHQ--------- 2360

  Fly   293 PFRILSFDIECAGRKGIFPEAKIDPVIQIANMVIRQGEREPFIRNVFTLNECAPIIGSQVLCHDK 357
                   ||.|.                 ..::||.|                 :.|.:|.....
  Rat  2361 -------DIRCQ-----------------TPLLIRSG-----------------VTGLEVTYAAD 2384

  Fly   358 ETQMLDKWSAFVREVDPDILTGYNINNFDFPYLLNRAAHLKVRNFEYLGRIKNIRSVIKEQMLQS 422
            |..:..:.:..::..|||||.||.|....:.|||.|||.|.|...:.:.|       :.:..:::
  Rat  2385 EKALFQEVTNIMKRYDPDILLGYEIQMHSWGYLLQRAAALSVDLCQMISR-------VPDDKIEN 2442

  Fly   423 KQMGRREN------QYVNFEGRVPFDLLFVLLRDYKLRSYTLNAVSYHFLQEQKEDVHHSIITD- 480
            :....|::      ..:|..||:..:|..::..:..|.:||...||:|.|.::.......:::|
  Rat  2443 RFAAERDDYGSDTMSEINIVGRITLNLWRIMRNEVALTNYTFENVSFHVLHQRFPLFTFRVLSDW 2507

  Fly   481 LQNGDEQTRRRLAMYCLKDAYLPLRLLEKLMAIVNYMEMARVTGVPLESLLTRGQQIKVLSQLLR 545
            ..|..:..|.::..:.:......|::||:|..|....||||:.|:....:||||.|.:|.|.:||
  Rat  2508 FDNKTDLYRWKMVDHYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQFLHVLTRGSQYRVESMMLR 2572

  Fly   546 KAKTKGFIMPSYTSQGSDEQYEG----ATVIEPKRGYYADPISTLDFASLYPSIMMAHNLCYTTL 606
            .||...:| |...|.....|...    ..::||:..:|::.:..|||.||||||::|:|.|::|.
  Rat  2573 IAKPMNYI-PVTPSVQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDFQSLYPSIVIAYNYCFSTC 2636

  Fly   607 VLGGTREKLRQQENLQ----------------DDQVERTPANNYFVKSEVRRGLLPEILESLLAA 655
            :  |..|.|.:.:..:                ...:..:|....|||..||:|:||.:||.:|..
  Rat  2637 L--GHIENLGKYDEFKFGCTSLRVPPDLLYQIRHDITVSPNGVAFVKPSVRKGVLPRMLEEILKT 2699

  Fly   656 RKRAKNDLKV-ETDPFKRKVLDGRQLALKISANSVYGFTGAQV-GKLPCLEISGSVTAYGRTMIE 718
            |...|..:|. ..|....::|:.|||.||:.||..:|:|.|.. |::||:|:..|:....|..:|
  Rat  2700 RFMVKQSMKAYRQDRALSRMLNARQLGLKLIANVTFGYTSANFSGRMPCIEVGDSIVHKARETLE 2764

  Fly   719 MTKNEVESHYTQANGYENNAVVIYGDTDSVMVNFGVKTLERSMELGREAAELVSSKFVHPIKLEF 783
            .....|..  |:..|    |.|:||||||:.|.....|.|:|.::|:|.||.|::....|:||:|
  Rat  2765 RAIKLVND--TKKWG----ARVVYGDTDSMFVLLKGATKEQSFKIGQEIAEAVTATNPKPVKLKF 2823

  Fly   784 EKVYYPYLLINKKRYAGLYFTRPDTYDKM-DCKGIETVRRDNSPLVANLMNSCLQKLLIERDPDG 847
            ||||.|.:|..||||.|..:...|..|.: |.|||||||||:.|.|:.::...|:.|...||...
  Rat  2824 EKVYLPCVLQTKKRYVGYMYETLDQKDPVFDAKGIETVRRDSCPAVSKILERSLKLLFETRDISL 2888

  Fly   848 AVAYVKQVIADLLCNRIDISHLVITKELAKTDYAAKQAH--------VELAAKMKKRDPGTAPKL 904
            ...||::....|:..:..|...:..||     |....::        :||..||...|..:.|::
  Rat  2889 IKQYVQRQCMKLVEGKASIQDFIFAKE-----YRGSFSYRPGACVPALELTRKMLAYDRRSEPRV 2948

  Fly   905 GDRVPYVICAAAKNTPAYQKAEDPLYVLEN-SVPIDATYYLEQQLSKPLLRIFEPILGDNA---- 964
            |:||||||.......|..|....|..||:: ::.::||||:.:|:..||.|||. ::|.:.
  Rat  2949 GERVPYVIVYGTPGLPLIQLIRRPAEVLQDPTLRLNATYYITKQILPPLARIFS-LIGIDVFSWY 3012

  Fly   965 -ESILLKGEHTRTRTVVTSKVGGLAGFMTKKTSCLGCKSLMPKGYEQACLCPHC--EPR-MSELY 1025
             |...::...:.:|:.:..:.|.::.:.| ...|..|..|...|     :|..|  :|: ::.:.
  Rat  3013 QELPRIQKATSSSRSDLEGRKGTISQYFT-TLHCPVCDGLTQHG-----ICSQCRSQPQHVAIIL 3071

  Fly  1026 QKEVGAKRELEETFSRLWTECQRCQESLHEEVICSNRDCPIFYMRQKVRMDL 1077
            .:|:   ||||....:|...|:.|..|....:.|.:.:||:.:...:|..:|
  Rat  3072 NQEI---RELERQQEQLVKICRNCTGSFDRHIPCVSLNCPVLFKLSRVNREL 3120

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolD1	NP_524099.2	PTZ00166	48..1092	CDD:240301	285/1130 (25%)
Rev3l	XP_006256586.1	PTZ00166	41..>195	CDD:240301
		DUF4683	753..1133	CDD:464832
		REV3L_RBD	1869..1891	CDD:412083
		DNA_polB_zeta_exo	2297..2535	CDD:99821	55/317 (17%)
		POLBc_zeta	2561..3009	CDD:99917	154/462 (33%)
		zf-C4pol	3045..3112	CDD:464119	19/74 (26%)