DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-delta and cdc6

DIOPT Version :9

Sequence 1:	NP_524099.2	Gene:	DNApol-delta / 39746	FlyBaseID:	FBgn0263600	Length:	1092	Species:	Drosophila melanogaster
Sequence 2:	NP_596124.1	Gene:	cdc6 / 2540255	PomBaseID:	SPBC336.04	Length:	1086	Species:	Schizosaccharomyces pombe

Alignment Length:	1098	Identity:	587/1098 - (53%)
Similarity:	752/1098 - (68%)	Gaps:	50/1098 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DGKRKFNGTSNGHAKKPRNPDDDEEMGFEAELAAFENSEDMDQTLLMGDGPENQTTSERWSRPPP 66
            |.||:.....||:..|..:...::...||.|||.:.:..|.|:.        ..:..::|.||..
pombe    32 DVKRRRLSERNGYGDKKGSSSKEKTSSFEDELAEYASQLDQDEI--------KSSKDQQWQRPAL 88

  Fly    67 PELDPSKHNLEFQQLDVENYLGQPLPGMPGAQIGPVPVVRMFGVTMEGNSVCCHVHGFCPYFYIE 131
            |.::|.|.::.|||:|.|.:..           |.||.:|:||||..|||:..||.||.||||::
pombe    89 PAINPEKDDIYFQQIDSEEFTE-----------GSVPSIRLFGVTDNGNSILVHVVGFLPYFYVK 142

  Fly   132 APSQFEEHHCEKLQKALDQKVIADIRNNKDNVQEAVLMVELVEKLNIHGYNGDKKQRYIKISVTL 196
            ||..|.....|:..:.||......:.::        .::|:.|  |::|:.|::|..:|||..|.
pombe   143 APVGFRPEMLERFTQDLDATCNGGVIDH--------CIIEMKE--NLYGFQGNEKSPFIKIFTTN 197

  Fly   197 PRFVAAASRLLKKEVIMSEIDFQD-------CRAFENNIDFDIRFMVDTDVVGCNWIELPMGHWR 254
            ||.::.|..:.::    .|.:|::       ...||:|..:.:|||:|.||||.|||.||...::
pombe   198 PRILSRARNVFER----GEFNFEELFPVGVGVTTFESNTQYLLRFMIDCDVVGMNWIHLPASKYQ 258

  Fly   255 IRNSHSKPLPESRCQIEVDVAFDRFISHEPEGEWSKVAPFRILSFDIECAGRKGIFPEAKIDPVI 319
            .|..:.    .|.||||..:.:...||...||:|||:||.||:|||||||||||:||:..|||||
pombe   259 FRYQNR----VSNCQIEAWINYKDLISLPAEGQWSKMAPLRIMSFDIECAGRKGVFPDPSIDPVI 319

  Fly   320 QIANMVIRQGEREPFIRNVFTLNECAPIIGSQVLCHDKETQMLDKWSAFVREVDPDILTGYNINN 384
            |||::|.:.|:..||:||||.::.|:.|:|:||.....:.:||..||.|||:||||:|.||||.|
pombe   320 QIASIVTQYGDSTPFVRNVFCVDTCSQIVGTQVYEFQNQAEMLSSWSKFVRDVDPDVLIGYNICN 384

  Fly   385 FDFPYLLNRAAHLKVRNFEYLGRIKNIRSVIKEQMLQSKQMGRRENQYVNFEGRVPFDLLFVLLR 449
            ||.||||:||..|::.||..||||.|..||.||....||..|.||::..:..||:..|:|.|:.|
pombe   385 FDIPYLLDRAKSLRIHNFPLLGRIHNFFSVAKETTFSSKAYGTRESKTTSIPGRLQLDMLQVMQR 449

  Fly   450 DYKLRSYTLNAVSYHFLQEQKEDVHHSIITDLQNGDEQTRRRLAMYCLKDAYLPLRLLEKLMAIV 514
            |:|||||:||||...||.|||||||:|||||||||...:|||||:|||||||||.||::|||..|
pombe   450 DFKLRSYSLNAVCSQFLGEQKEDVHYSIITDLQNGTADSRRRLAIYCLKDAYLPQRLMDKLMCFV 514

  Fly   515 NYMEMARVTGVPLESLLTRGQQIKVLSQLLRKAKTKGFIMPSYTSQGSDEQYEGATVIEPKRGYY 579
            ||.|||||||||...||.|||||||:|||.|||.....::|:....|:||||||||||||.:|||
pombe   515 NYTEMARVTGVPFNFLLARGQQIKVISQLFRKALQHDLVVPNIRVNGTDEQYEGATVIEPIKGYY 579

  Fly   580 ADPISTLDFASLYPSIMMAHNLCYTTLVLGGTREKLRQQENLQDDQVERTPANNYFVKSEVRRGL 644
            ..||:||||:|||||||.|||||||||:...|.|.|:.:   ||.....||..:||||..||:||
pombe   580 DTPIATLDFSSLYPSIMQAHNLCYTTLLDSNTAELLKLK---QDVDYSVTPNGDYFVKPHVRKGL 641

  Fly   645 LPEILESLLAARKRAKNDLKVETDPFKRKVLDGRQLALKISANSVYGFTGAQVGKLPCLEISGSV 709
            ||.||..||.|||:||.|||.||||||:.||||||||||:|||||||||||..|:||||.||.||
pombe   642 LPIILADLLNARKKAKADLKKETDPFKKAVLDGRQLALKVSANSVYGFTGATNGRLPCLAISSSV 706

  Fly   710 TAYGRTMIEMTKNEVESHYTQANGYENNAVVIYGDTDSVMVNFGVKTLERSMELGREAAELVSSK 774
            |:|||.|||.||:.||..|...|||.::|||||||||||||.||||||..:|:||.|||..||.:
pombe   707 TSYGRQMIEKTKDVVEKRYRIENGYSHDAVVIYGDTDSVMVKFGVKTLPEAMKLGEEAANYVSDQ 771

  Fly   775 FVHPIKLEFEKVYYPYLLINKKRYAGLYFTRPDTYDKMDCKGIETVRRDNSPLVANLMNSCLQKL 839
            |.:||||||||||:|||||:|||||||::||.|||||||.||||||||||.|||:.::::.|:|:
pombe   772 FPNPIKLEFEKVYFPYLLISKKRYAGLFWTRTDTYDKMDSKGIETVRRDNCPLVSYVIDTALRKM 836

  Fly   840 LIERDPDGAVAYVKQVIADLLCNRIDISHLVITKELAKTDYAAKQAHVELAAKMKKRDPGTAPKL 904
            ||::|.:||..:.|:||:|||.|:||:|.|||||.|:|||||||.||||||.:|:|||.|:||.:
pombe   837 LIDQDVEGAQLFTKKVISDLLQNKIDMSQLVITKALSKTDYAAKMAHVELAERMRKRDAGSAPAI 901

  Fly   905 GDRVPYVICAAAKNTPAYQKAEDPLYVLENSVPIDATYYLEQQLSKPLLRIFEPILGDNAESILL 969
            ||||.|||...|:....|.::|||:|||||::||||.||||.|||||||||||||||:.|.| ||
pombe   902 GDRVAYVIIKGAQGDQFYMRSEDPIYVLENNIPIDAKYYLENQLSKPLLRIFEPILGEKASS-LL 965

  Fly   970 KGEHTRTRTVVTSKVGGLAGFMTKKTSCLGCKSLMPKGYEQACLCPHCEPRMSELYQKEVGAKRE 1034
            .|:||||.::....|||:..|..|..:|||||:.:.||  :..||.:|..|.:||||::|....:
pombe   966 HGDHTRTISMAAPSVGGIMKFAVKVETCLGCKAPIKKG--KTALCENCLNRSAELYQRQVAQVND 1028

  Fly  1035 LEETFSRLWTECQRCQESLHEEVICSNRDCPIFYMRQKVRMDLDNQEKRVLRFGLAEW 1092
            ||..|:||||:|||||.|:|::|||::|||||||||......|......:.||....|
pombe  1029 LEVRFARLWTQCQRCQGSMHQDVICTSRDCPIFYMRIAEHKKLQQSVDLLKRFDEMSW 1086

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-delta	NP_524099.2	PTZ00166	48..1092	CDD:240301	573/1050 (55%)
		DNA_polB_delta_exo	288..517	CDD:99820	138/228 (61%)
		POLBc_delta	564..960	CDD:99916	268/395 (68%)
		zf-C4pol	997..1070	CDD:290959	40/72 (56%)
cdc6	NP_596124.1	PTZ00166	85..1083	CDD:240301	572/1032 (55%)
		DNA_polB_delta_exo	288..517	CDD:99820	138/228 (61%)
		POLBc_delta	564..957	CDD:99916	268/395 (68%)
		zf-C4pol	993..1064	CDD:290959	40/72 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	557	1.000	Domainoid score	I37
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2014
Inparanoid	1	1.050	1117	1.000	Inparanoid score	I23
OMA	1	1.010	-	-		QHG53777
OrthoFinder	1	1.000	-	-		FOG0001033
OrthoInspector	1	1.000	-	-		oto101375
orthoMCL	1	0.900	-	-		OOG6_101046
Panther	1	1.100	-	-	LDO	PTHR10322
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R345
SonicParanoid	1	1.000	-	-		X3678
TreeFam	1	0.960	-	-
	14	13.860