Protein Alignment PolD1 and cdc6

DIOPT Version :10

• Sequence 1: NP_524099.2
• Gene: PolD1 / 39746
• FlyBaseID: FBgn0263600
• Length: 1092
• Species: Drosophila melanogaster
• Sequence 2: NP_596124.1
• Gene: cdc6 / 2540255
• PomBaseID: SPBC336.04
• Length: 1086
• Species: Schizosaccharomyces pombe
• Alignment Length: 1098
• Identity: 587/1098 - (53%)
• Similarity: 752/1098 - (68%)
• Gaps: 50/1098 - (4%)

  Fly     2 DGKRKFNGTSNGHAKKPRNPDDDEEMGFEAELAAFENSEDMDQTLLMGDGPENQTTSERWSRPPP 66
            |.||:.....||:..|..:...::...||.|||.:.:..|.|:.        ..:..::|.||..
pombe    32 DVKRRRLSERNGYGDKKGSSSKEKTSSFEDELAEYASQLDQDEI--------KSSKDQQWQRPAL 88

  Fly    67 PELDPSKHNLEFQQLDVENYLGQPLPGMPGAQIGPVPVVRMFGVTMEGNSVCCHVHGFCPYFYIE 131
            |.::|.|.::.|||:|.|.:..           |.||.:|:||||..|||:..||.||.||||::
pombe    89 PAINPEKDDIYFQQIDSEEFTE-----------GSVPSIRLFGVTDNGNSILVHVVGFLPYFYVK 142

  Fly   132 APSQFEEHHCEKLQKALDQKVIADIRNNKDNVQEAVLMVELVEKLNIHGYNGDKKQRYIKISVTL 196
            ||..|.....|:..:.||......:.::        .::|:.|  |::|:.|::|..:|||..|.
pombe   143 APVGFRPEMLERFTQDLDATCNGGVIDH--------CIIEMKE--NLYGFQGNEKSPFIKIFTTN 197

  Fly   197 PRFVAAASRLLKKEVIMSEIDFQD-------CRAFENNIDFDIRFMVDTDVVGCNWIELPMGHWR 254
            ||.::.|..:.::    .|.:|::       ...||:|..:.:|||:|.||||.|||.||...::
pombe   198 PRILSRARNVFER----GEFNFEELFPVGVGVTTFESNTQYLLRFMIDCDVVGMNWIHLPASKYQ 258

  Fly   255 IRNSHSKPLPESRCQIEVDVAFDRFISHEPEGEWSKVAPFRILSFDIECAGRKGIFPEAKIDPVI 319
            .|..:.    .|.||||..:.:...||...||:|||:||.||:|||||||||||:||:..|||||
pombe   259 FRYQNR----VSNCQIEAWINYKDLISLPAEGQWSKMAPLRIMSFDIECAGRKGVFPDPSIDPVI 319

  Fly   320 QIANMVIRQGEREPFIRNVFTLNECAPIIGSQVLCHDKETQMLDKWSAFVREVDPDILTGYNINN 384
            |||::|.:.|:..||:||||.::.|:.|:|:||.....:.:||..||.|||:||||:|.||||.|
pombe   320 QIASIVTQYGDSTPFVRNVFCVDTCSQIVGTQVYEFQNQAEMLSSWSKFVRDVDPDVLIGYNICN 384

  Fly   385 FDFPYLLNRAAHLKVRNFEYLGRIKNIRSVIKEQMLQSKQMGRRENQYVNFEGRVPFDLLFVLLR 449
            ||.||||:||..|::.||..||||.|..||.||....||..|.||::..:..||:..|:|.|:.|
pombe   385 FDIPYLLDRAKSLRIHNFPLLGRIHNFFSVAKETTFSSKAYGTRESKTTSIPGRLQLDMLQVMQR 449

  Fly   450 DYKLRSYTLNAVSYHFLQEQKEDVHHSIITDLQNGDEQTRRRLAMYCLKDAYLPLRLLEKLMAIV 514
            |:|||||:||||...||.|||||||:|||||||||...:|||||:|||||||||.||::|||..|
pombe   450 DFKLRSYSLNAVCSQFLGEQKEDVHYSIITDLQNGTADSRRRLAIYCLKDAYLPQRLMDKLMCFV 514

  Fly   515 NYMEMARVTGVPLESLLTRGQQIKVLSQLLRKAKTKGFIMPSYTSQGSDEQYEGATVIEPKRGYY 579
            ||.|||||||||...||.|||||||:|||.|||.....::|:....|:||||||||||||.:|||
pombe   515 NYTEMARVTGVPFNFLLARGQQIKVISQLFRKALQHDLVVPNIRVNGTDEQYEGATVIEPIKGYY 579

  Fly   580 ADPISTLDFASLYPSIMMAHNLCYTTLVLGGTREKLRQQENLQDDQVERTPANNYFVKSEVRRGL 644
            ..||:||||:|||||||.|||||||||:...|.|.|:.:   ||.....||..:||||..||:||
pombe   580 DTPIATLDFSSLYPSIMQAHNLCYTTLLDSNTAELLKLK---QDVDYSVTPNGDYFVKPHVRKGL 641

  Fly   645 LPEILESLLAARKRAKNDLKVETDPFKRKVLDGRQLALKISANSVYGFTGAQVGKLPCLEISGSV 709
            ||.||..||.|||:||.|||.||||||:.||||||||||:|||||||||||..|:||||.||.||
pombe   642 LPIILADLLNARKKAKADLKKETDPFKKAVLDGRQLALKVSANSVYGFTGATNGRLPCLAISSSV 706

  Fly   710 TAYGRTMIEMTKNEVESHYTQANGYENNAVVIYGDTDSVMVNFGVKTLERSMELGREAAELVSSK 774
            |:|||.|||.||:.||..|...|||.::|||||||||||||.||||||..:|:||.|||..||.:
pombe   707 TSYGRQMIEKTKDVVEKRYRIENGYSHDAVVIYGDTDSVMVKFGVKTLPEAMKLGEEAANYVSDQ 771

  Fly   775 FVHPIKLEFEKVYYPYLLINKKRYAGLYFTRPDTYDKMDCKGIETVRRDNSPLVANLMNSCLQKL 839
            |.:||||||||||:|||||:|||||||::||.|||||||.||||||||||.|||:.::::.|:|:
pombe   772 FPNPIKLEFEKVYFPYLLISKKRYAGLFWTRTDTYDKMDSKGIETVRRDNCPLVSYVIDTALRKM 836

  Fly   840 LIERDPDGAVAYVKQVIADLLCNRIDISHLVITKELAKTDYAAKQAHVELAAKMKKRDPGTAPKL 904
            ||::|.:||..:.|:||:|||.|:||:|.|||||.|:|||||||.||||||.:|:|||.|:||.:
pombe   837 LIDQDVEGAQLFTKKVISDLLQNKIDMSQLVITKALSKTDYAAKMAHVELAERMRKRDAGSAPAI 901

  Fly   905 GDRVPYVICAAAKNTPAYQKAEDPLYVLENSVPIDATYYLEQQLSKPLLRIFEPILGDNAESILL 969
            ||||.|||...|:....|.::|||:|||||::||||.||||.|||||||||||||||:.|.| ||
pombe   902 GDRVAYVIIKGAQGDQFYMRSEDPIYVLENNIPIDAKYYLENQLSKPLLRIFEPILGEKASS-LL 965

  Fly   970 KGEHTRTRTVVTSKVGGLAGFMTKKTSCLGCKSLMPKGYEQACLCPHCEPRMSELYQKEVGAKRE 1034
            .|:||||.::....|||:..|..|..:|||||:.:.||  :..||.:|..|.:||||::|....:
pombe   966 HGDHTRTISMAAPSVGGIMKFAVKVETCLGCKAPIKKG--KTALCENCLNRSAELYQRQVAQVND 1028

  Fly  1035 LEETFSRLWTECQRCQESLHEEVICSNRDCPIFYMRQKVRMDLDNQEKRVLRFGLAEW 1092
            ||..|:||||:|||||.|:|::|||::|||||||||......|......:.||....|
pombe  1029 LEVRFARLWTQCQRCQGSMHQDVICTSRDCPIFYMRIAEHKKLQQSVDLLKRFDEMSW 1086

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PolD1	NP_524099.2	PTZ00166	48..1092	CDD:240301	573/1050 (55%)
cdc6	NP_596124.1	PTZ00166	85..1083	CDD:240301	572/1032 (55%)