DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-delta and Rev3l

DIOPT Version :9

Sequence 1:	NP_524099.2	Gene:	DNApol-delta / 39746	FlyBaseID:	FBgn0263600	Length:	1092	Species:	Drosophila melanogaster
Sequence 2:	XP_006512685.1	Gene:	Rev3l / 19714	MGIID:	1337131	Length:	3123	Species:	Mus musculus

Alignment Length:	1175	Identity:	298/1175 - (25%)
Similarity:	499/1175 - (42%)	Gaps:	230/1175 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 TSNGHAKKPRNPDDDEEMGFEAELAAFENSEDMDQTLLMG--------DGPENQTTSERWSRPPP 66
            :|:.|.|        ||:. ::::|...::....||||..        |..:|......:|.|..
Mouse  2059 SSSAHTK--------EEVS-KSQIALQTSTTGCSQTLLAAASAAVPEEDEDDNDNCYVSYSSPDS 2114

  Fly    67 PELDP------------------SKHNLEFQQLDVENYLGQPLPGMPGAQ------------IGP 101
            |.:.|                  |....|...|.|||:|   .|...|.|            |.|
Mouse  2115 PGIPPWQQAASPDFRSLNGDDRHSSPGKELCSLAVENFL---KPIKDGIQKSSCSESWEPQVISP 2176

  Fly   102 VPVVRMFGVTMEGNSVCCHVHGFCPYFYIEAPSQFEEHHCEKLQKALDQKVIADIRNNKDNVQEA 166
            :......|   :.:.:|.|           :....:....|||.:|...               :
Mouse  2177 IHARARTG---KWDPLCLH-----------STPVMQRKFLEKLPEATGL---------------S 2212

  Fly   167 VLMVE-LVEKL-NIHGYNGDKKQRYIKISVTLPRFVAAASRLLKKEVIMSEIDFQDCRAFENNID 229
            .|.|| ..:|| |..|.:.|..:|.:..:....:|  ||....|||.  |:||..   :..|...
Mouse  2213 PLSVEPKTQKLYNKKGSDADGLRRVLLTTQVENQF--AAVNTPKKET--SQIDGP---SLNNTYG 2270

  Fly   230 FDIRFMVDTDVVGCNWIELPMGHWRIRNSHSKPLPESRCQIEVDVAFDRFISHEPEGEWSKVAPF 294
            |.:                     .|:|     |.|::.            .||       :...
Mouse  2271 FKV---------------------SIQN-----LQEAKA------------LHE-------IQNL 2290

  Fly   295 RILSFDIECAGRKGIFPEAKIDPV------------------IQIANMVIRQGER---EPFIRNV 338
            .::|.::....|:.:.|:.:.||:                  .::..:::...::   ...||:.
Mouse  2291 TLISVELHARTRRDLQPDPEFDPICALFYCISSDTPLPDTEKTELTGVIVIDKDKTVTHQDIRSQ 2355

  Fly   339 FTLNECAPIIGSQVLCHDKETQMLDKWSAFVREVDPDILTGYNINNFDFPYLLNRAAHLKVRNFE 403
            ..|...:.|.|.:|.....|..:..:.:..::..|||||.||.|....:.|||.|||.|.|...:
Mouse  2356 TPLLIRSGITGLEVTYAADEKALFQEITNIIKRYDPDILLGYEIQMHSWGYLLQRAAALSVDLCQ 2420

  Fly   404 YLGRIKNIRSVIKEQMLQSKQMGRREN------QYVNFEGRVPFDLLFVLLRDYKLRSYTLNAVS 462
            .:.|       :.:..::::....|::      ..:|..||:..:|..::..:..|.:||...||
Mouse  2421 MISR-------VPDDKIENRFAAERDDYGSDTMSEINIVGRITLNLWRIMRNEVALTNYTFENVS 2478

  Fly   463 YHFLQEQKEDVHHSIITD-LQNGDEQTRRRLAMYCLKDAYLPLRLLEKLMAIVNYMEMARVTGVP 526
            :|.|.::.......:::| ..|..:..|.::..:.:......|::||:|..|....||||:.|:.
Mouse  2479 FHVLHQRFPLFTFRVLSDWFDNKTDLYRWKMVDHYVSRVRGNLQMLEQLDLIGKTSEMARLFGIQ 2543

  Fly   527 LESLLTRGQQIKVLSQLLRKAKTKGFI--MPSYTSQGSDEQYEGATVI-EPKRGYYADPISTLDF 588
            ...:||||.|.:|.|.:||.||...:|  .||...:......:...:| ||:..:|::.:..|||
Mouse  2544 FLHVLTRGSQYRVESMMLRIAKPMNYIPVTPSIQQRSQMRAPQCVPLIMEPESRFYSNSVLVLDF 2608

  Fly   589 ASLYPSIMMAHNLCYTTLVLGGTREKLRQQENLQ----------------DDQVERTPANNYFVK 637
            .||||||::|:|.|::|.:  |..|.|.:.:..:                ...|..:|....|||
Mouse  2609 QSLYPSIVIAYNYCFSTCL--GHVENLGKYDEFKFGCTSLRVPPDLLYQIRHDVTVSPNGVAFVK 2671

  Fly   638 SEVRRGLLPEILESLLAARKRAKNDLK-VETDPFKRKVLDGRQLALKISANSVYGFTGAQV-GKL 700
            ..||:|:||.:||.:|..|...|..:| .:.|....::|:.|||.||:.||..:|:|.|.. |::
Mouse  2672 PSVRKGVLPRMLEEILKTRLMVKQSMKSYKQDRALSRMLNARQLGLKLIANVTFGYTAANFSGRM 2736

  Fly   701 PCLEISGSVTAYGRTMIEMTKNEVESHYTQANGYENNAVVIYGDTDSVMVNFGVKTLERSMELGR 765
            ||:|:..|:....|..:|.....|..  |:..|    |.|:||||||:.|.....|.|:|.::|:
Mouse  2737 PCIEVGDSIVHKARETLERAIKLVND--TKKWG----ARVVYGDTDSMFVLLKGATKEQSFKIGQ 2795

  Fly   766 EAAELVSSKFVHPIKLEFEKVYYPYLLINKKRYAG-LYFTRPDTYDKMDCKGIETVRRDNSPLVA 829
            |.||.|::....|:||:|||||.|.:|..||||.| :|.|........|.|||||||||:.|.|:
Mouse  2796 EIAEAVTATNPRPVKLKFEKVYLPCVLQTKKRYVGYMYETLDQKEPVFDAKGIETVRRDSCPAVS 2860

  Fly   830 NLMNSCLQKLLIERDPDGAVAYVKQVIADLLCNRIDISHLVITKELAKTDYAAKQAH-------- 886
            .::...|:.|...||......||::....|:..:..|...:..||     |....::
Mouse  2861 KILERSLKLLFETRDISLIKQYVQRQCMKLVEGKASIQDFIFAKE-----YRGSFSYRPGACVPA 2920

  Fly   887 VELAAKMKKRDPGTAPKLGDRVPYVICAAAKNTPAYQKAEDPLYVLEN-SVPIDATYYLEQQLSK 950
            :||..||...|..:.|::|:||||||.......|..|....|..||:: ::.::||||:.:|:..
Mouse  2921 LELTRKMLAYDRRSEPRVGERVPYVIIYGTPGLPLIQLIRRPAEVLQDPTLRLNATYYITKQILP 2985

  Fly   951 PLLRIFEPILGDNA-----ESILLKGEHTRTRTVVTSKVGGLAGFMTKKTSCLGCKSLMPKGYEQ 1010
            ||.|||. ::|.:.     |...::...:.:|:.:..:.|.::.:.| ...|..|..|...|
Mouse  2986 PLARIFS-LIGIDVFSWYQELPRIQKATSSSRSELEGRKGTISQYFT-TLHCPVCDDLTQHG--- 3045

  Fly  1011 ACLCPHC--EPR-MSELYQKEVGAKRELEETFSRLWTECQRCQESLHEEVICSNRDCPIFYMRQK 1072
              :|..|  :|: ::.:..:|:   ||||....:|...|:.|..|....:.|.:.:||:.:...:
Mouse  3046 --ICSKCRSQPQHVAIILNQEI---RELERKQEQLIKICRNCTGSFDRHIPCVSLNCPVLFKLSR 3105

  Fly  1073 VRMDL 1077
            |..:|
Mouse  3106 VNREL 3110

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-delta	NP_524099.2	PTZ00166	48..1092	CDD:240301	288/1137 (25%)
		DNA_polB_delta_exo	288..517	CDD:99820	49/256 (19%)
		POLBc_delta	564..960	CDD:99916	143/424 (34%)
		zf-C4pol	997..1070	CDD:290959	19/75 (25%)
Rev3l	XP_006512685.1	PTZ00166	6..>195	CDD:240301
		DUF4683	747..1133	CDD:374062
		DNA_polB_zeta_exo	2287..2525	CDD:99821	45/244 (18%)
		POLBc_zeta	2551..2999	CDD:99917	155/461 (34%)
		zf-C4pol	3035..3102	CDD:372984	19/74 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D20210at2759
OrthoFinder	1	1.000	-	-		FOG0001033
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820