DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment DNApol-delta and Pole

DIOPT Version :9

Sequence 1:	NP_524099.2	Gene:	DNApol-delta / 39746	FlyBaseID:	FBgn0263600	Length:	1092	Species:	Drosophila melanogaster
Sequence 2:	NP_035262.2	Gene:	Pole / 18973	MGIID:	1196391	Length:	2283	Species:	Mus musculus

Alignment Length:	1332	Identity:	242/1332 - (18%)
Similarity:	419/1332 - (31%)	Gaps:	511/1332 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 FCPYFYIEAPSQFEEHHCEKLQKALDQKVIADIRNNKDNVQEAVLMVELVEKLNIHGYNGDKKQR 188
            :.|||||.|....:......|.|....|:.     ..:||.:        |.|::..:....|:.
Mouse   100 YMPYFYIAARKGCDREVSSFLSKKFQGKIA-----KLENVPK--------EDLDLPNHLVGLKRS 151

  Fly   189 YIKIS-------VTLPRFVAAA------------------SRLLKKEVIMSEID----------- 217
            |||:|       |.:.:.::.|                  |.:|:...::::.|
Mouse   152 YIKLSFHTVEDLVKVRKEISPAVKKNREQDHASDEYTTMLSSILQGGSVITDEDETSKKIADQLD 216

  Fly   218 -FQDCRAFENNIDFDIRFMVDTDVVGCNWIELPMGHWRIRNSHSKPLPESRCQIEVDVAFDRFIS 281
             ..|.|  |.::.:.||..:|        :.:.:.||..........|     :|:....|....
Mouse   217 NIVDMR--EYDVPYHIRLSID--------LRIHVAHWYNVRFRGNAFP-----VEITRRDDLVER 266

  Fly   282 HEPEGEWSKVAPFRILSFDIECAGRKGIFPEAKIDPVIQIANMVIRQG----EREPFIRNV---- 338
            .:|.          :|:||||.......||:|:.|.::.|:.|:..||    .||....::
Mouse   267 PDPV----------VLAFDIETTKLPLKFPDAETDQIMMISYMIDGQGYLITNREIVSEDIEDFE 321

  Fly   339 FTLNE------CAPIIGSQVLCHDKETQMLDKWSAFVREVDPDILTGYNINNFDFPYLLNRAAHL 397
            ||...      |       |.....|..::.:|...::|..|.|:..||.:.||:|::..|||..
Mouse   322 FTPKPEYEGPFC-------VFNEPDEVHLIQRWFEHIQETKPTIMVTYNGDFFDWPFVEARAAIH 379

  Fly   398 KVRNFEYLGRIKNIRSVIKEQMLQSKQMGRRENQYVNFEGRVPFDLLFVLLRDYKL--RSYTLNA 460
            .:..::.:|..|:.:...|....                  :..|.|..:.||..|  .|:.|.|
Mouse   380 GLSMYQEIGFQKDSQGEYKAPQC------------------IHMDCLRWVKRDSYLPVGSHNLKA 426

  Fly   461 -----VSYHFLQEQKEDVHHSIITDLQNGDEQTRRRLAMYCLKDAYLPLRLLEKLMAIVNYMEMA 520
                 :.|..::...||:       .:...||. :.||.|.:.||.....|   .|..|:....|
Mouse   427 AAKAKLGYDPVELDPEDM-------CRMATEQP-QTLATYSVSDAVATYYL---YMKYVHPFIFA 480

  Fly   521 RVTGVPLE--SLLTRGQQIKVLSQLLRKAKTKGFIMPSYTSQGSD-----------EQYEGATVI 572
            ..|.:|:|  .:|.:|......:.|:.:|.....|.|:...|..:           |.|.|..|.
Mouse   481 LCTIIPMEPDEVLRKGSGTLCEALLMVQAFHANIIFPNKQEQEFNKLTDDGHMLDAETYVGGHVE 545

  Fly   573 EPKRGYY-----------------------------------------------ADPIST----- 585
            ..:.|.:                                               .:.|.|
Mouse   546 ALESGVFRSDIPCRFRMNPAAFDFLLQRVEKTMRHAIEEEEKVPVEQATNFQEVCEQIKTKLTSL 610

  Fly   586 --------------LDFASLYPSIMMAHNLCYTTLVLGGT------------------------- 611
                          ||..::||:|::.:.|..:.:|...|
Mouse   611 KDVPNRIECPLIYHLDVGAMYPNIILTNRLQPSAIVDEATCAACDFNKPGASCQRKMAWQWRGEF 675

  Fly   612 -----REKLRQQENLQDDQ----VERTPANNYF-------VKSEVRRGLLPEI------------ 648
                 .|..|.|..|:.::    ....||..:.       .|.|.||  |.:.
Mouse   676 MPASRSEYHRIQHQLESEKFPPLFPEGPARAFHELSREEQAKYEKRR--LADYCRKAYKKIHVTK 738

  Fly   649 LESLLAARKRAKNDLKVET---------------DPFKRK---------------------VLDG 677
            :|..|....:.:|...|:|               ..:|:|                     :.|.
Mouse   739 VEERLTTICQRENSFYVDTVRAFRDRRYEFKGLHKVWKKKLSAAVEVGDASEVKRCKNMEILYDS 803

  Fly   678 RQLALKISANSVYGFTGAQVGKLPCLEISGSVTAYGRTMIEMTKNEVESHYTQANGYENNAVVIY 742
            .|||.|...||.||:...:..:...:|::|.|...|..:|...:..:|.               .
Mouse   804 LQLAHKCILNSFYGYVMRKGARWYSMEMAGIVCFTGANIITQARELIEQ---------------I 853

  Fly   743 G-----DTDSVMV--------NFGVKT----------------LERSMELG------REAAELVS 772
            |     |||.:..        ||.:||                |...::.|      :|..|..|
Mouse   854 GRPLELDTDGIWCVLPNSFPENFVIKTTNAKKPKLTISYPGAMLNIMVKEGFTNHQYQELTEPSS 918

  Fly   773 SKFV-HPIKLEFEKVYYPYLLI-----------NKKRYAGLYFTRPDTYDKMDCKGIETVRRDNS 825
            ..:| |.....|.:|..|||.:           .|||||  .|....:..::  ||.|..||...
Mouse   919 LTYVTHSENSIFFEVDGPYLAMILPASKEEGKKLKKRYA--VFNEDGSLAEL--KGFEVKRRGEL 979

  Fly   826 PLVANLMNSCLQKLL----IERDPDGAVAYVKQVIADLLCNRI------DISHLV-----ITKEL 875
            .|:....:|..:..|    :| :..|:||.|.....|:|.::.      ::..|:     ::::|
Mouse   980 QLIKIFQSSVFEAFLKGSTLE-EVYGSVAKVADYWLDVLYSKAANMPDSELFELISENRSMSRKL 1043

  Fly   876 AKTDYA-AKQAHVELAAKMKKRDPGTAPKLGDRV--------PYVICAAAKNTPAYQKAEDPLYV 931
              .||. .|...:..|.::       |..|||::        .|:|....:.:|..::| .||.:
Mouse  1044 --EDYGEQKSTSISTAKRL-------AEFLGDQMVKDAGLSCRYIISRKPEGSPVTERA-IPLAI 1098

  Fly   932 LENSVPI-----------------------DATYYLE----------------QQLSKPLLRIFE 957
            .:....:                       |..||:|                ||:..|:.|:..
Mouse  1099 FQAEPTVRKHFLRKWLKSSSLQDFDIRTILDWDYYIERLGSAIQKIITIPAALQQVKNPVPRVKH 1163

  Fly   958 P------ILGDN--------AESILLKGEHTRTRTVVTSKVGGLAGFMTKKTSCLGCKSLMPKGY 1008
            |      :|..|        :|..:|:|:    |.:|                       |.:..
Mouse  1164 PDWLHKKLLEKNDIYKQKKISELFVLEGK----RQIV-----------------------MAQAS 1201

  Fly  1009 EQACLCPHCEPRMSELYQKE-------VGAKRELEETFSRLWTECQRCQESL-----HEEVI--- 1058
            |.:...  |.|.|.::...:       |..||:      |:| |.|:..:.:     .:||:
Mouse  1202 ENSLSL--CTPDMEDIGLTKPHHSTVPVATKRK------RVW-ETQKESQDIALTVPWQEVLGQP 1257

  Fly  1059 ----CSNRDCPIFYMRQKVRMDLDNQEKRVLR 1086
                .:..:..::....|.:..|..|::..||
Mouse  1258 PSLGTTQEEWLVWLQFHKKKWQLQAQQRLALR 1289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
DNApol-delta	NP_524099.2	PTZ00166	48..1092	CDD:240301	242/1332 (18%)
		DNA_polB_delta_exo	288..517	CDD:99820	56/249 (22%)
		POLBc_delta	564..960	CDD:99916	114/666 (17%)
		zf-C4pol	997..1070	CDD:290959	14/91 (15%)
Pole	NP_035262.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		PolB	99..1165	CDD:223494	215/1170 (18%)
		Lyase_I_like	<125..>231	CDD:294018	18/120 (15%)
		DNA_polB_epsilon_exo	268..471	CDD:99822	55/248 (22%)
		POLBc_epsilon	531..1153	CDD:99918	109/653 (17%)
		DUF1744	1528..1924	CDD:285663
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1935..1968
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2014..2041
		CysB motif. /evidence=ECO:0000250\|UniProtKB:P15436	2218..2235
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900