DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brm and Smarca5

DIOPT Version :9

Sequence 1:	NP_001261906.1	Gene:	brm / 39744	FlyBaseID:	FBgn0000212	Length:	1658	Species:	Drosophila melanogaster
Sequence 2:	NP_444354.2	Gene:	Smarca5 / 93762	MGIID:	1935129	Length:	1051	Species:	Mus musculus

Alignment Length:	928	Identity:	305/928 - (32%)
Similarity:	464/928 - (50%)	Gaps:	160/928 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   680 LNMHPGWDWI-DDEEDSCGSNDDHKPKVEEQPTATEDATDKAQATGNDEDAKDLITKAKVEDDEY 743
            |.|.||...: .||:.:..|..|::.:..||.                            ||:|.
Mouse   117 LKMKPGRPRVKKDEKQNLLSVGDYRHRRTEQE----------------------------EDEEL 153

  Fly   744 RTEEQTYYSIAHTIHEKVVEQASIMVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQT 808
            .||.    |.|..:..:..:..|.:..|.|::||::||.||:|||.|.:|||||||||||||:||
Mouse   154 LTES----SKATNVCTRFEDSPSYVKWGKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQT 214

  Fly   809 ISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGR-RLLQNQMRATKF 872
            |||:.|:...:.:.||::::||.|||.||:.||:||.|.:..|...|..:.| ..:::.:...::
Mouse   215 ISLLGYMKHYRNIPGPHMVLVPKSTLHNWMSEFKKWVPTLRSVCLIGDKEQRAAFVRDVLLPGEW 279

  Fly   873 NVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKL 937
            :|.:|:||.:||:|:|..|..|:|::|||.||:||...||::::. .:....|||||||||||.|
Mouse   280 DVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVR-EFKTTNRLLLTGTPLQNNL 343

  Fly   938 PELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKE 1002
            .|||:|||||||.:|.|...|:.||:.......:|          ::.|||.|||||||||:|.:
Mouse   344 HELWSLLNFLLPDVFNSADDFDSWFDTNNCLGDQK----------LVERLHMVLRPFLLRRIKAD 398

  Fly  1003 VEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEKGKHGKGGAKALMNTIVQLRKLCNH 1067
            ||..||.|.|..|...:|.:||..|..:..|.:.:.:.:     ||.....|:|.::||||.|||
Mouse   399 VEKSLPPKKEVKIYVGLSKMQREWYTRILMKDIDILNSA-----GKMDKMRLLNILMQLRKCCNH 458

  Fly  1068 PFMFQHIEEKYCDHTGGHGVVSGP----DLYRV--SGKFELLDRILPKLKATNHRVLLFCQMTQC 1126
            |::|.             |...||    |::.|  |||..:||::|||||....|||:|.|||:.
Mouse   459 PYLFD-------------GAEPGPPYTTDMHLVTNSGKMVVLDKLLPKLKEQGSRVLIFSQMTRV 510

  Fly  1127 MTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVI 1191
            :.|:|||..||.:.|.||||.|..::|.:.:..:|...|..|||:|||||||||:||.|||.|::
Mouse   511 LDILEDYCMWRNYEYCRLDGQTPHDERQDSINAYNEPNSTKFVFMLSTRAGGLGINLATADVVIL 575

  Fly  1192 FDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAG-MFDQK 1255
            :||||||..||||.||||||||...|||.|.:|.|:|||||:..|..||.:|..|||.| :.||.
Mouse   576 YDSDWNPQVDLQAMDRAHRIGQTKTVRVFRFITDNTVEERIVERAEMKLRLDSIVIQQGRLVDQN 640

  Fly  1256 STGSERQQFLQTILHQDDNE-EEEENEVPDDEMINMMIARSEEEIEIFKRMDAERKKEDEEIHPG 1319
            .....:.:.||.|.|...:. ..:|:|:.|:::..::...:::..|:.:::..
Mouse   641 LNKIGKDEMLQMIRHGATHVFASKESEITDEDIDGILERGAKKTAEMNEKLSK------------ 693

  Fly  1320 RERLIDESELPDWLTKDDDEVERFHYQYDEDTILGRGSRQRKEVDYTDSLTEKEWLK-------- 1376
                :.||.|.::....:..|..|.         |...|:::::.:|      ||::
Mouse   694 ----MGESSLRNFTMDTESSVYNFE---------GEDYREKQKIAFT------EWIEPPKRERKA 739

  Fly  1377 --AIDDGAEFDEEEEEDDSKRKRRKRKNRKEESDD------------DSLILKRRRR-------- 1419
              |:|  |.|.|.....:.|..:..|..::....|            :..||..|:.
Mouse   740 NYAVD--AYFREALRVSEPKAPKAPRPPKQPNVQDFQFFPPRLFELLEKEILYYRKTIGYKVPRS 802

  Fly  1420 ---QNLDKRSKKQMHKIMSAVIKHNQD----GRTLSEPFMKLPSRQRLPDYYEIIKRPV-----D 1472
               .|..:..|::..||..|...::::    .:.|::.|.....|    |:.:.||...     |
Mouse   803 PDLPNAAQAQKEEQLKIDEAEPLNDEELEEKEKLLTQGFTNWNKR----DFNQFIKANEKWGRDD 863

  Fly  1473 IKKILQRIEDCKYADLNELEKDFMQLCQN--------AQIYNEEASLIYLDSIALQKVFVGARQR 1529
            |:.|.:.:|.....::.|....|.:.|..        |||...||.:  ...|:::|.......|
Mouse   864 IENIAREVEGKTPEEVIEYSAVFWERCNELQDIEKIMAQIERGEARI--QRRISIKKALDTKIGR 926

  Fly  1530 ITAAADAAAVAAGDNTGE 1547
            ..|......::.|.|.|:
Mouse   927 YKAPFHQLRISYGTNKGK 944

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	172..202	CDD:214931
		Drf_FH1	251..390	CDD:283903
		HSA	501..573	CDD:214727
		BRK	649..693	CDD:197800	5/13 (38%)
		PHA02934	687..>824	CDD:165245	45/137 (33%)
		SNF2_N	776..1071	CDD:278600	131/295 (44%)
		DEXDc	793..932	CDD:238005	62/139 (45%)
		Helicase_C	1097..1212	CDD:278689	65/114 (57%)
		SnAC	1304..1375	CDD:291293	9/70 (13%)
		Bromo_SNF2L2	1425..1530	CDD:99947	24/121 (20%)
Smarca5	NP_444354.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..81
		SNF2_N	182..462	CDD:278600	131/295 (44%)
		DEXDc	199..338	CDD:238005	62/139 (45%)
		DEAH box	307..310		2/2 (100%)
		Helicase_C	481..596	CDD:278689	65/114 (57%)
		HAND	742..827	CDD:286232	16/86 (19%)
		SANT	841..882	CDD:197842	9/44 (20%)
		SANT	843..882	CDD:238096	8/42 (19%)
		SLIDE	897..1009	CDD:286233	12/50 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1014..1051
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910