Protein Alignment brm and CHD1

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: NP_011091.1
• Gene: CHD1 / 856911
• SGDID: S000000966
• Length: 1468
• Species: Saccharomyces cerevisiae
• Alignment Length: 1282
• Identity: 367/1282 - (28%)
• Similarity: 572/1282 - (44%)
• Gaps: 344/1282 - (26%)

  Fly   497 LEKQQKLEAERKRRQKHLEFLAAVLQ----HGKDLREFHRNNKAQLARMNKAVMNHHANAEREQK 557
            ||.:....:|....::::...:|..|    ||.|:                 |:||......|:.
Yeast   147 LESEDDYGSEEALSEENVHEASANPQPEDFHGIDI-----------------VINHRLKTSLEEG 194

  Fly   558 KEQERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAFLLSQTDEYISNLTQMVKQHKDDQMKKKEE 622
            |..|:...:     :...:|.|.            ||:..|||          .|..:..:..|.
Yeast   195 KVLEKTVPD-----LNNCKENYE------------FLIKWTDE----------SHLHNTWETYES 232

  Fly   623 EG-----KRLIQFKKELLMSGEYIGIDEGSIVADMRVHVVEQCTGKKLTGDDAPMLKHLHRWLNM 682
            .|     |||..:.|:.::..:.:.:|......|:.:..:|:                 .|.|
Yeast   233 IGQVRGLKRLDNYCKQFIIEDQQVRLDPYVTAEDIEIMDMER-----------------ERRL-- 278

  Fly   683 HPGWDWIDDEEDSCGSNDDHKPK--VEEQPTATEDATDKAQ------------ATGNDEDAKDLI 733
                   |:.|:.      |.|:  ::.|..:.||.|.:.|            ||.  |:|.|::
Yeast   279 -------DEFEEF------HVPERIIDSQRASLEDGTSQLQYLVKWRRLNYDEATW--ENATDIV 328

  Fly   734 TKAKVEDDEYRTEEQT----YYSIAHTIH----EKVVEQASIMVNGTLKEYQIKGLEWLVSLYNN 790
            ..|..:...::..|.:    .||..:|..    ||:..|...:..|.|:::|:.|:.|:..|::.
Yeast   329 KLAPEQVKHFQNRENSKILPQYSSNYTSQRPRFEKLSVQPPFIKGGELRDFQLTGINWMAFLWSK 393

  Fly   791 NLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKG 855
            ..|||||||||||||:||::.:::|:..::..||::|:|||||:|.|:..||||||.:..:.|.|
Yeast   394 GDNGILADEMGLGKTVQTVAFISWLIFARRQNGPHIIVVPLSTMPAWLDTFEKWAPDLNCICYMG 458

  Fly   856 SPQGRRLLQNQ----------MRATKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHC 910
            :.:.|..::..          .:..|||||||||||::||:|.|..|:|::|.:||.||:||...
Yeast   459 NQKSRDTIREYEFYTNPRAKGKKTMKFNVLLTTYEYILKDRAELGSIKWQFMAVDEAHRLKNAES 523

  Fly   911 KLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVEL 975
            .|.:.||:..:| .|:|:|||||||.:.||.||:|||:|..|    |.:|..:         .|.
Yeast   524 SLYESLNSFKVA-NRMLITGTPLQNNIKELAALVNFLMPGRF----TIDQEID---------FEN 574

  Fly   976 NEEETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGV-LLTD 1039
            .:||....|..||:.::||:||||||:||..||.|.|.|::.::|.:|...||::.:|.. .||.
Yeast   575 QDEEQEEYIHDLHRRIQPFILRRLKKDVEKSLPSKTERILRVELSDVQTEYYKNILTKNYSALTA 639

  Fly  1040 GSEKGKHGKGGAKALMNTIVQLRKLCNHPFMFQHIEEKYCDHTGG-----HGVVSGPDLYRVSGK 1099
            |:      |||..:|:|.:.:|:|..|||::|.:.||:.....|.     ..|:.|  |...|||
Yeast   640 GA------KGGHFSLLNIMNELKKASNHPYLFDNAEERVLQKFGDGKMTRENVLRG--LIMSSGK 696

  Fly  1100 FELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKG 1164
            ..|||::|.:||...||||:|.||.:.:.|:.|||..:...:.|||||..:..|...:..||:..
Yeast   697 MVLLDQLLTRLKKDGHRVLIFSQMVRMLDILGDYLSIKGINFQRLDGTVPSAQRRISIDHFNSPD 761

  Fly  1165 SDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVE 1229
            |:.|||||||||||||:||.||||||||||||||..||||..|||||||:|.|.|.||::.::||
Yeast   762 SNDFVFLLSTRAGGLGINLMTADTVVIFDSDWNPQADLQAMARAHRIGQKNHVMVYRLVSKDTVE 826

  Fly  1230 ERILAAARYKLNMDEKVIQAGMFDQKS------------------------TGSERQQFLQTILH 1270
            |.:|..||.|:.::..:|..|:.|...                        |.::.|:.|:. |:
Yeast   827 EEVLERARKKMILEYAIISLGVTDGNKYTKKNEPNAGELSAILKFGAGNMFTATDNQKKLED-LN 890

  Fly  1271 QDD--NEEEEENEVPD--------------------------DEMINMMIARSEEEIEIFKRMDA 1307
            .||  |..|:....||                          |::|      .|||::  |..|.
Yeast   891 LDDVLNHAEDHVTTPDLGESHLGGEEFLKQFEVTDYKADIDWDDII------PEEELK--KLQDE 947

  Fly  1308 ERKKEDEEIHPGRERLIDESELPDWLTKDDDEVERFHYQYD----------EDTILGRGSRQRKE 1362
            |:|::|||.  .:|:|       :.:.:.|:.:::.....:          :|....|.||:|..
Yeast   948 EQKRKDEEY--VKEQL-------EMMNRRDNALKKIKNSVNGDGTAANSDSDDDSTSRSSRRRAR 1003

  Fly  1363 VDYTDSLTE----------------KEWL-KAIDDGA----EFDEEEEEDDSKRKRRK------R 1400
            .:..||:.|                ||.| :.|.||.    .|::..|..|...:..|      .
Yeast  1004 ANDMDSIGESEVRALYKAILKFGNLKEILDELIADGTLPVKSFEKYGETYDEMMEAAKDCVHEEE 1068

  Fly  1401 KNRKEESDDDSLILKRRRRQNLDKRSKKQMHKIMSAVIKHNQDGRTLSEPFMKLPSRQR-----L 1460
            |||||       ||::     |:|.:.....|:.|..||  .:.:....|..:|..::|     |
Yeast  1069 KNRKE-------ILEK-----LEKHATAYRAKLKSGEIK--AENQPKDNPLTRLSLKKREKKAVL 1119

  Fly  1461 PDYYEIIKRPVDIKKILQRIEDCKYAD--LNELEKDFMQLCQNAQIYNEEASLIYLDSIALQKVF 1523
            .::..:  :.::.:.:|.|:||.||..  :|...||
Yeast  1120 FNFKGV--KSLNAESLLSRVEDLKYLKNLINSNYKD----------------------------- 1153

  Fly  1524 VGARQRITAAADAAAVAAGDNTGEAHGNGGSDNSDNDDD-----------DGGDDGSDDEEIATT 1577
                       |....:.|:||.:...|..|:.:..:|:           .......||..:..|
Yeast  1154 -----------DPLKFSLGNNTPKPVQNWSSNWTKEEDEKLLIGVFKYGYGSWTQIRDDPFLGIT 1207

  Fly  1578 SAAAVKMKLKLN--------KSLASAPATPTQSSSNVSSGAATTSKK 1616
            .      |:.||        ||.:|:..|||.|..  ..|...:|||
Yeast  1208 D------KIFLNEVHNPVAKKSASSSDTTPTPSKK--GKGITGSSKK 1246

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580
		PTZ00121	<477..651	CDD:173412	29/162 (18%)
		HSA	501..573	CDD:214727	12/75 (16%)
		BRK	650..691	CDD:462196	4/40 (10%)
		PLN03142	739..>1368	CDD:215601	256/714 (36%)
		Bromo_SNF2L2	1425..1530	CDD:99947	17/111 (15%)
CHD1	NP_011091.1	CD1_tandem_CHD1_yeast_like	175..247	CDD:349312	22/115 (19%)
		CD2_tandem_ScCHD1_like	283..341	CDD:349311	13/65 (20%)
		PLN03142	363..>961	CDD:215601	244/630 (39%)
		Cdh1_DBD_1	1010..1129	CDD:408024	28/134 (21%)
		SANT_TRF	1175..>1204	CDD:212558	3/28 (11%)
		DUF4208	1368..1460	CDD:464035