Protein Alignment brm and MOT1

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: NP_015243.1
• Gene: MOT1 / 856023
• SGDID: S000006003
• Length: 1867
• Species: Saccharomyces cerevisiae
• Alignment Length: 1022
• Identity: 267/1022 - (26%)
• Similarity: 448/1022 - (43%)
• Gaps: 250/1022 - (24%)

  Fly   488 LREARATEKLEKQQKLEAERKRRQKHLEFLAAVLQHGKDLREFHRNNKAQLARMNKAVMN----- 547
            :|....:.|.|:.:||:........||            :::...|||..::  .|.|.|
Yeast   936 IRSLMDSVKEERNEKLQTMAGESVVHL------------IQQLLENNKVNVS--GKIVKNLCGFL 986

  Fly   548 ---------HHANAEREQK-----KEQERIEKERMRRLMAEDEEGYRKLIDQKKDKR-------- 590
                     ...|||.::|     ||...|        .|:|:....|:.::.:.||
Yeast   987 CVDTSEVPDFSVNAEYKEKILTLIKESNSI--------AAQDDINLAKMSEEAQLKRKGGLITLK 1043

  Fly   591 LAF------LLSQTDEYISNLTQMVKQHKDDQMKKKE-EEGKRLIQ----------FKKELLMSG 638
            :.|      :|.:..:..|.|...:..|::::..|.: |:|::::.          |..:.|.|.
Yeast  1044 ILFEVLGPSILQKLPQLRSILFDSLSDHENEEASKVDNEQGQKIVDSFGVLRALFPFMSDSLRSS 1108

  Fly   639 E-----------------YIGIDEGSIVADM-RVHVVEQCTGKKLTGDDAPMLKHLHRWLNMHPG 685
            |                 ..........||: ::..||..         |..::.:...:|
Yeast  1109 EVFTRFPVLLTFLRSNLSVFRYSAARTFADLAKISSVEVM---------AYTIREILPLMN---- 1160

  Fly   686 WDWIDDEEDSCGSNDDHKPKVE---EQPTATEDATD------------KAQATGNDEDAKDLIT- 734
                     |.||..|.:...|   ....:.|  ||            ..:.:.::||.::|.|
Yeast  1161 ---------SAGSLSDRQGSTELIYHLSLSME--TDVLPYVIFLIVPLLGRMSDSNEDVRNLATT 1214

  Fly   735 -----------KAKVEDDEYRTEEQTYYSIAHTIHEK-VVEQ-----------ASIMVNGTLKEY 776
                       :|.:.|.:...||    .:|....|: .::|           ..|.:..||::|
Yeast  1215 TFASIIKLVPLEAGIADPKGLPEE----LVASRERERDFIQQMMDPSKAKPFKLPIAIKATLRKY 1275

  Fly   777 QIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVT---YLM--DRKKVMG------PYLIIVP 830
            |..|:.||..|...:|:|||.|:||||||:|||.::.   ||.  |.:|...      |.|||.|
Yeast  1276 QQDGVNWLAFLNKYHLHGILCDDMGLGKTLQTICIIASDQYLRKEDYEKTRSVESRALPSLIICP 1340

  Fly   831 LSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQNQMRATKFNVLLTTYEYVIKDKAVLAKIQWK 895
            .|...:|..||:::||.:.||.|.|.|..|..|:.|:  :..::::|:|:....|.|||.|.::.
Yeast  1341 PSLTGHWENEFDQYAPFLKVVVYAGGPTVRLTLRPQL--SDADIIVTSYDVARNDLAVLNKTEYN 1403

  Fly   896 YMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQ 960
            |.::||||.:||...||.:.:. ...|.:||:|||||:||.:.|||:|.:||:|....:...|::
Yeast  1404 YCVLDEGHIIKNSQSKLAKAVK-EITANHRLILTGTPIQNNVLELWSLFDFLMPGFLGTEKMFQE 1467

  Fly   961 WFNAPFATT-GEKVELNEEET-ILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQ 1023
            .|..|.|.: ..|....|:|. :|.:..|||.:.||:|||||::|...||.|:.....|::..||
Yeast  1468 RFAKPIAASRNSKTSSKEQEAGVLALEALHKQVLPFMLRRLKEDVLSDLPPKIIQDYYCELGDLQ 1532

  Fly  1024 RVLYKHMQSKGVLLTDGSEKGKHGKGGAKALMNTIVQLRKLCNHPFMF---QHIE----EKYCDH 1081
            :.||.....|...:.:...:......|.:.:...:..:|||||||.:.   .|.:    :.|...
Yeast  1533 KQLYMDFTKKQKNVVEKDIENSEIADGKQHIFQALQYMRKLCNHPALVLSPNHPQLAQVQDYLKQ 1597

  Fly  1082 TG--GHGVVSGPDLYRVS--------GKFEL-----LDRILP-KLKATNHRVLLFCQMTQCMTII 1130
            ||  .|.:::.|.|..:.        |:.::     .|:..| :...:.||.|:|||:...:.::
Yeast  1598 TGLDLHDIINAPKLSALRTLLFECGIGEEDIDKKASQDQNFPIQNVISQHRALIFCQLKDMLDMV 1662

  Fly  1131 EDYLGWRQF----GYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVI 1191
            |:.| ::::    .|:||||:....||.:::||||...| :...||:|:.|||||||..||||:.
Yeast  1663 ENDL-FKKYMPSVTYMRLDGSIDPRDRQKVVRKFNEDPS-IDCLLLTTKVGGLGLNLTGADTVIF 1725

  Fly  1192 FDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQKS 1256
            .:.||||..||||.||||||||:..|.|.|::|..::||:|:...::|:|:...|:     :|::
Yeast  1726 VEHDWNPMNDLQAMDRAHRIGQKKVVNVYRIITKGTLEEKIMGLQKFKMNIASTVV-----NQQN 1785

  Fly  1257 TG---SERQQFLQTILHQDDNEEEEENEVPDDEMINMMIARSEEEIEIFKRMDAERKKEDEEIHP 1318
            :|   .:..|.|.  |...||...::||                          |:...|.:...
Yeast  1786 SGLASMDTHQLLD--LFDPDNVTSQDNE--------------------------EKNNGDSQAAK 1822

  Fly  1319 GRERLIDES-----------ELPD-WLTKDDDEVERFHYQYDEDTIL 1353
            |.|.:.:|:           ||.: |      :..::..:|:.||.:
Yeast  1823 GMEDIANETGLTGKAKEALGELKELW------DPSQYEEEYNLDTFI 1863

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580
		PTZ00121	<477..651	CDD:173412	37/223 (17%)
		HSA	501..573	CDD:214727	17/90 (19%)
		BRK	650..691	CDD:462196	6/41 (15%)
		PLN03142	739..>1368	CDD:215601	211/682 (31%)
		Bromo_SNF2L2	1425..1530	CDD:99947
MOT1	NP_015243.1	HEAT repeat	360..385	CDD:293787
		HEAT repeat	406..438	CDD:293787
		HEAT repeat	449..481	CDD:293787
		HEAT repeat	490..519	CDD:293787
		HEAT repeat	543..572	CDD:293787
		DUF3535	611..1063	CDD:463447	27/148 (18%)
		HepA	<1258..1781	CDD:440319	184/527 (35%)