Protein Alignment brm and STH1

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: NP_012140.1
• Gene: STH1 / 854680
• SGDID: S000001388
• Length: 1359
• Species: Saccharomyces cerevisiae
• Alignment Length: 1336
• Identity: 512/1336 - (38%)
• Similarity: 706/1336 - (52%)
• Gaps: 347/1336 - (25%)

  Fly   389 KPNRIT----TVAKPVGL-------------DPITLLQERENRIAARISLRMQELQRLPATM--- 433
            ||.:|:    ..||.:||             ||.|     |.||:||||.|:.||:||||.:
Yeast   157 KPIKISADFNAKAKSLGLESKFSNATKTALGDPDT-----EIRISARISNRINELERLPANLGTY 216

  Fly   434 ----------SEDL-------RLQAAIELRALRVLNFQRQLRMEFVQCTR----------RDTTL 471
                      .:||       :::|.:||::|::|..|:.:|.:.:....          ||:..
Yeast   217 SLDDCLEFITKDDLSSRMDTFKIKALVELKSLKLLTKQKSIRQKLINNVASQAHHNIPYLRDSPF 281

  Fly   472 ETALNIKLYKRTKRQGLREARATEKLEKQQKLEAERKRRQKHLEFLAAVLQHGKDLR--EFHRNN 534
            ..|....:..|:|....:..|..|:||:||.||..:|.|..||:.:.:::...|:.:  ::.|..
Yeast   282 TAAAQRSVQIRSKVIVPQTVRLAEELERQQLLEKRKKERNLHLQKINSIIDFIKERQSEQWSRQE 346

  Fly   535 KA-QLARMNKAVMNHHANAEREQKKEQERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAFLLSQT 598
            :. |..|:..::   |...|::::|..||..|:|:..|.:.|||.|.||:||.||.|:..||.||
Yeast   347 RCFQFGRLGASL---HNQMEKDEQKRIERTAKQRLAALKSNDEEAYLKLLDQTKDTRITQLLRQT 408

  Fly   599 DEYISNLTQMVKQHKDDQMKKKEEEGKRLIQFKKELLMSGEYIGIDEGSIVADMRVHVVEQCTGK 663
            :.::.:|::.|        :.::.|.|         ::.||
Yeast   409 NSFLDSLSEAV--------RAQQNEAK---------ILHGE------------------------ 432

  Fly   664 KLTGDDAPMLKHLHRWLNMHPGWDWIDDEEDSCGSNDDHKPKVEEQPTATEDATDKAQATGNDED 728
                                                       |.||
Yeast   433 -------------------------------------------EVQP------------------ 436

  Fly   729 AKDLITKAKVEDDEYRTEEQTYYSIAHTIHEKVVEQASIMVNGTLKEYQIKGLEWLVSLYNNNLN 793
                     :.|:|  .|:..||.:||.|.||:.:|.||:|.|||||||::||||:||||||:||
Yeast   437 ---------ITDEE--REKTDYYEVAHRIKEKIDKQPSILVGGTLKEYQLRGLEWMVSLYNNHLN 490

  Fly   794 GILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQ 858
            ||||||||||||||:|||:|||.:.||.:||:|:||||||:.||.||||||||::..:.|||:|.
Yeast   491 GILADEMGLGKTIQSISLITYLYEVKKDIGPFLVIVPLSTITNWTLEFEKWAPSLNTIIYKGTPN 555

  Fly   859 GRRLLQNQMRATKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAP 923
            .|..||:|:|...|:||||||||:||||::|:|..|.:|||||||||||...||:..::.:|...
Yeast   556 QRHSLQHQIRVGNFDVLLTTYEYIIKDKSLLSKHDWAHMIIDEGHRMKNAQSKLSFTISHYYRTR 620

  Fly   924 YRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTG--EKVELNEEETILIIRR 986
            .||:||||||||.||||||||||:||.||.|..|||.|||.|||.||  ||:||.||||:|||||
Yeast   621 NRLILTGTPLQNNLPELWALLNFVLPKIFNSAKTFEDWFNTPFANTGTQEKLELTEEETLLIIRR 685

  Fly   987 LHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEKGKHGKGGA 1051
            ||||||||||||||||||..||||||.:|||.:|.||:.||:.|.....|......:|. .|||.
Yeast   686 LHKVLRPFLLRRLKKEVEKDLPDKVEKVIKCKLSGLQQQLYQQMLKHNALFVGAGTEGA-TKGGI 749

  Fly  1052 KALMNTIVQLRKLCNHPFMFQHIEEKYCDHTGGHGVVSGPD------LYRVSGKFELLDRILPKL 1110
            |.|.|.|:||||:|||||:|..:|          |||: |.      |:||:||||||||:|||.
Yeast   750 KGLNNKIMQLRKICNHPFVFDEVE----------GVVN-PSRGNSDLLFRVAGKFELLDRVLPKF 803

  Fly  1111 KATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTR 1175
            ||:.||||:|.||||.|.|:||:|..:...|:||||:||.|:|.|:|..|||..||.|.||||||
Yeast   804 KASGHRVLMFFQMTQVMDIMEDFLRMKDLKYMRLDGSTKTEERTEMLNAFNAPDSDYFCFLLSTR 868

  Fly  1176 AGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKL 1240
            ||||||||||||||:|||:|||||||||||||||||||:||||:|||:|.:||||.||..|..||
Yeast   869 AGGLGLNLQTADTVIIFDTDWNPHQDLQAQDRAHRIGQKNEVRILRLITTDSVEEVILERAMQKL 933

  Fly  1241 NMDEKVIQAGMFDQKSTGSERQQFLQTILHQDDNEEEEENEVPDDEMINMMIARSEEEIEIFKRM 1305
            ::|.||||||.||.|||..|::.||:.::..:.|.::::....||:.:|..:|||.:|..:|.::
Yeast   934 DIDGKVIQAGKFDNKSTAEEQEAFLRRLIESETNRDDDDKAELDDDELNDTLARSADEKILFDKI 998

  Fly  1306 DAERKKEDE--------EIHPGRERLIDESELPDWLTKDDDEVERFHYQYDEDTILGRGSRQRKE 1362
            |.||..::.        .:.|  .|||...|||....:|.:|    |::.::...||| .||:|.
Yeast   999 DKERMNQERADAKAQGLRVPP--PRLIQLDELPKVFREDIEE----HFKKEDSEPLGR-IRQKKR 1056

  Fly  1363 VDYTDSLTEKEWLKAIDDGAEFDEEEEEDDSKRKRRKRKNRK-----------------EESDDD 1410
            |.|.|.|||:::|:|::|    |....||..|::|..|:.|:                 .|:.:.
Yeast  1057 VYYDDGLTEEQFLEAVED----DNMSLEDAIKKRREARERRRLRQNGTKENEIETLENTPEASET 1117

  Fly  1411 SLI---------------------LKRRRRQNLDKR----------------------------- 1425
            |||                     .:.:||.:..||
Yeast  1118 SLIENNSFTAAVDEETNADKETTASRSKRRSSRKKRTISIVTAEDKENTQEESTSQENGGAKVEE 1182

  Fly  1426 --------------SKKQMHKIM------SAVIKHNQDGRTLSEP-------------------- 1450
                          |||:..|:.      ...:..|.||:...|.
Yeast  1183 EVKSSSVEIINGSESKKKKPKLTVKIKLNKTTVLENNDGKRAEEKPESKSPAKKTAAKKTKTKSK 1247

  Fly  1451 ------------------------------FMKLPSRQRLPDYYEIIKRPVDIKKILQRIEDCKY 1485
                                          |.||||::..|||:::|::|:.|..||:..::..|
Yeast  1248 SLGIFPTVEKLVEEMREQLDEVDSHPRTSIFEKLPSKRDYPDYFKVIEKPMAIDIILKNCKNGTY 1312

  Fly  1486 ADLNELEKDFMQLCQNAQIYNEEASLIYLDSIALQK 1521
            ..|.|:.:....:.:||:.||||.|.:|:|:..|.:
Yeast  1313 KTLEEVRQALQTMFENARFYNEEGSWVYVDADKLNE 1348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580	5/15 (33%)
		PTZ00121	<477..651	CDD:173412	47/176 (27%)
		HSA	501..573	CDD:214727	19/74 (26%)
		BRK	650..691	CDD:462196	0/40 (0%)
		PLN03142	739..>1368	CDD:215601	370/644 (57%)
		Bromo_SNF2L2	1425..1530	CDD:99947	35/196 (18%)
STH1	NP_012140.1	HSA	312..378	CDD:462194	16/68 (24%)
		PLN03142	370..>955	CDD:215601	367/709 (52%)
		SnAC	1006..1069	CDD:464219	22/69 (32%)
		COG5076	<1211..>1359	CDD:227408	30/138 (22%)