DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brm and SNF2

DIOPT Version :9

Sequence 1:	NP_001261906.1	Gene:	brm / 39744	FlyBaseID:	FBgn0000212	Length:	1658	Species:	Drosophila melanogaster
Sequence 2:	NP_014933.3	Gene:	SNF2 / 854465	SGDID:	S000005816	Length:	1703	Species:	Saccharomyces cerevisiae

Alignment Length:	1788	Identity:	601/1788 - (33%)
Similarity:	836/1788 - (46%)	Gaps:	490/1788 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PSPANSPMPPPQAPSPMAPPSQSPAPSPHSPYPHQQPGPLQGPPPPGHPGAYGHPMQHGPPGQGP 68
            |:.|:|.:....:|. :||..|.......|...||.|                 .||...|....
Yeast    81 PNNASSHISASASPH-LAPNMQLNGNETFSTSAHQSP-----------------IMQTQMPLNSN 127

  Fly    69 PGHHMPPHHQGMI-------FSKGP-----------------HMGMQMPPTGPNMSPYQTHGMPP 109
            .|::|.|..|..:       ||..|                 ::.:......|.....|.|.:
Yeast   128 GGNNMLPQRQSSVGSLNATNFSPTPANNGENAAEKPDNSNHNNLNLNNSELQPQNRSLQEHNI-- 190

  Fly   110 NAPTQPCIVSPGGPPGGPPPPERSSQENLHALQRAIDSME-EKGLQEDPRYSQLLAMRATSKHQH 173
                |...|.||.....|.|.:...|:.....|:|..:.: ::..|...|..|...:..|.
Yeast   191 ----QDSNVMPGSQINSPMPQQAQMQQAQFQAQQAQQAQQAQQAQQAQARLQQGRRLPMTM---- 247

  Fly   174 LNGNQVNLLRTQITAYRLLARNKPISMQMQQALQAAQQQPP-----------------PGPPIGP 221
            ....|..||:.|||:.:.|...|||..:.|..:|.:...||                 |......
Yeast   248 FTAEQSELLKAQITSLKCLVNRKPIPFEFQAVIQKSINHPPDFKRMLLSLSEFARRRQPTDQNNQ 312

  Fly   222 PGAPGGPPPGSQHAGQPPVPPQQQQQPPPSAGTPPQCSTPPASNPYG----PPVPGQK---MQVA 279
            ....||               ...|||    ||....:.....|..|    .|:..:.   ..|:
Yeast   313 SNLNGG---------------NNTQQP----GTNSHYNNTNTDNVSGLTRNAPLDSKDENFASVS 358

  Fly   280 PPPP---HMQQGQPLPPQPPQVGGPPPIQQQQPPQQQQ-----------------QQSQPPPPEP 324
            |..|   |..:...|......|.|.|..|.:...::.:                 :|:.||.|:
Yeast   359 PAGPSSVHNAKNGTLDKNSQTVSGTPITQTESKKEENETISNVAKTAPNSNKTHTEQNNPPKPQ- 422

  Fly   325 HQHQLPNGGKPLSMGPSGGQPLIPSSPMQPQVRGTLPGMPPGSQVPQPGGGPQRQVPPAGMPMPK 389
                     ||           :|.:.:|.|.:       .|.:|... ..|...|....||...
Yeast   423 ---------KP-----------VPLNVLQDQYK-------EGIKVVDI-DDPDMMVDSFTMPNIS 459

  Fly   390 PNRI---TTVAK-------------PVGLDPITLLQERENRIAARISLRMQEL--QRLPATMSED 436
            .:.|   |.:|.             |||:|..|.....:..||..:...:.:.  :.|....:|.
Yeast   460 HSNIDYQTLLANSDHAKFTIEPGVLPVGIDTHTATDIYQTLIALNLDTTVNDCLDKLLNDECTES 524

  Fly   437 LRLQAAIELRALRVLNFQRQLRMEFVQCTRRDTTLETALNIKLYKRTKRQGLREARATEKLEKQQ 501
            .|..|..:..||::|..|:.:|...:|......:|.|..:.....:.:...:::|..|.:|.|..
Yeast   525 TRENALYDYYALQLLPLQKAVRGHVLQFEWHQNSLLTNTHPNFLSKIRNINVQDALLTNQLYKNH 589

  Fly   502 K-LEAERKRRQKHLEFLAAVLQHGKDLREFHRNNKAQLARMNKAVMNH----------------- 548
            : |:.|||:.:       ||               |:|..|||:.:|.
Yeast   590 ELLKLERKKTE-------AV---------------ARLKSMNKSAINQYNRRQDKKNKRLKFGHR 632

  Fly   549 ----HANAEREQKKEQERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAFLLSQTDEYISNLTQMV 609
                |.|.||:::|..|:..|||::.|.|.|||.|.||:||.||.|:..||.||:.::.:||:.|
Yeast   633 LIATHTNLERDEQKRAEKKAKERLQALKANDEEAYIKLLDQTKDTRITHLLRQTNAFLDSLTRAV 697

  Fly   610 KQHKDDQMKKKEEEGKRLIQFKKELLMSGEYIGIDEGSIVADMRVHVVEQCTGKKLTGDDAPMLK 674
            |    ||.|           :.||::.|                 |:.|.
Yeast   698 K----DQQK-----------YTKEMIDS-----------------HIKEA--------------- 715

  Fly   675 HLHRWLNMHPGWDWIDDEEDSCGSNDDHKPKVEEQPTATEDATDKAQATGNDEDAKDLITKAKVE 739
                                                               .|:..||....|::
Yeast   716 ---------------------------------------------------SEEVDDLSMVPKMK 729

  Fly   740 DDEYRTEEQT----YYSIAHTIHEKVVEQASIMVNGTLKEYQIKGLEWLVSLYNNNLNGILADEM 800
            |:||..::..    ||::||.|.|.:.:|.||:|.||||:||||||:|:|||:||:|||||||||
Yeast   730 DEEYDDDDDNSNVDYYNVAHRIKEDIKKQPSILVGGTLKDYQIKGLQWMVSLFNNHLNGILADEM 794

  Fly   801 GLGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQN 865
            |||||||||||:|||.:.|.:.||||:|||||||.||..||.||||.:..:|:||||..|:..|.
Yeast   795 GLGKTIQTISLLTYLYEMKNIRGPYLVIVPLSTLSNWSSEFAKWAPTLRTISFKGSPNERKAKQA 859

  Fly   866 QMRATKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTG 930
            ::||.:|:|:|||:||:||::|:|:|::|.:|||||||||||...||:..|||||.|.|||:|||
Yeast   860 KIRAGEFDVVLTTFEYIIKERALLSKVKWVHMIIDEGHRMKNAQSKLSLTLNTHYHADYRLILTG 924

  Fly   931 TPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTG--EKVELNEEETILIIRRLHKVLRP 993
            |||||.||||||||||:||.||.|..:|::|||.|||.||  :|:||:||||:|:||||||||||
Yeast   925 TPLQNNLPELWALLNFVLPKIFNSVKSFDEWFNTPFANTGGQDKIELSEEETLLVIRRLHKVLRP 989

  Fly   994 FLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHM-QSKGVLLTDGSEKGKHGKGGAKALMNT 1057
            ||||||||:||.:||||||.::||.|||||:::|:.| :.:.:.:.|.:.|...|..|   ..|.
Yeast   990 FLLRRLKKDVEKELPDKVEKVVKCKMSALQQIMYQQMLKYRRLFIGDQNNKKMVGLRG---FNNQ 1051

  Fly  1058 IVQLRKLCNHPFMFQHIEEKYCDHTGGHGVVSGP------DLYRVSGKFELLDRILPKLKATNHR 1116
            |:||:|:|||||:|:.:|::.           .|      |::||:||||||||||||||||.||
Yeast  1052 IMQLKKICNHPFVFEEVEDQI-----------NPTRETNDDIWRVAGKFELLDRILPKLKATGHR 1105

  Fly  1117 VLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGL 1181
            ||:|.||||.|.|:||:|.:....||||||.||:::|.||||.|||..|:...|:||||||||||
Yeast  1106 VLIFFQMTQIMDIMEDFLRYINIKYLRLDGHTKSDERSELLRLFNAPDSEYLCFILSTRAGGLGL 1170

  Fly  1182 NLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKV 1246
            ||||||||:|||:|||||||||||||||||||:||||:|||:|.|||||.||..|..||::|.||
Yeast  1171 NLQTADTVIIFDTDWNPHQDLQAQDRAHRIGQKNEVRILRLITTNSVEEVILERAYKKLDIDGKV 1235

  Fly  1247 IQAGMFDQKSTGSERQQFLQTILHQDDNEE---------EEENEVPDDEMINMMIARSEEEIEIF 1302
            ||||.||.|||..|::..|:::|  |..||         |||.|:.|.| ||.::||::||:.:.
Yeast  1236 IQAGKFDNKSTSEEQEALLRSLL--DAEEERRKKRESGVEEEEELKDSE-INEILARNDEEMAVL 1297

  Fly  1303 KRMDAERKKEDEEIHPGRERLIDESELPDWLTKD-DDEVERFHYQYDEDTIL--GRGSRQRKEVD 1364
            .|||.:|.|::||:.. :.||:::|||||..::| ..|::|   :..|...:  |||:|:||...
Yeast  1298 TRMDEDRSKKEEELGV-KSRLLEKSELPDIYSRDIGAELKR---EESESAAVYNGRGARERKTAT 1358

  Fly  1365 YTDSLTEKEWLKAIDDGAEFDEEEEEDDSKRKRRKRKNRKEE----------------------- 1406
            |.|:::|::||:..    |..::|:.|...||:|.:|..|.|
Yeast  1359 YNDNMSEEQWLRQF----EVSDDEKNDKQARKQRTKKEDKSEAIDGNGEIKGENIDADNDGPRIN 1419

  Fly  1407 --------------SDDDSLILKR----------------------------------------- 1416
                          :|||.|..||
Yeast  1420 NISAEDRADTDLAMNDDDFLSKKRKAGRPRGRPKKVKLEGSENSEPPALESSPVTGDNSPSEDFM 1484

  Fly  1417 -----------------------------------------RRRQNLD----------------K 1424
                                                     :.|..||                |
Yeast  1485 DIPKPRTAGKTSVKSARTSTRGRGRGRGRGRGRGRGRGRPPKARNGLDYVRTPAAATSPIDIREK 1549

  Fly  1425 RSKKQMHKIMSAVIKHNQDGRTLSEPFMKLPSRQRLPDYYEIIKRPVDIKKILQRIEDCKYADLN 1489
            .:|:.:.....|:...|:.||.||:.|:..||:...||||.|||.||....|...||...|..|.
Yeast  1550 VAKQALDLYHFALNYENEAGRKLSDIFLSKPSKALYPDYYMIIKYPVAFDNINTHIETLAYNSLK 1614

  Fly  1490 ELEKDFMQLCQNAQIYNEEASLIYLDSIALQKV 1522
            |..:||..:..||:|||.|.|::|.||:.|:||
Yeast  1615 ETLQDFHLIFSNARIYNTEGSVVYEDSLELEKV 1647

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	172..202	CDD:214931	10/29 (34%)
		Drf_FH1	251..390	CDD:283903	29/165 (18%)
		HSA	501..573	CDD:214727	22/93 (24%)
		BRK	649..693	CDD:197800	2/43 (5%)
		PHA02934	687..>824	CDD:165245	57/140 (41%)
		SNF2_N	776..1071	CDD:278600	188/297 (63%)
		DEXDc	793..932	CDD:238005	89/138 (64%)
		Helicase_C	1097..1212	CDD:278689	85/114 (75%)
		SnAC	1304..1375	CDD:291293	27/73 (37%)
		Bromo_SNF2L2	1425..1530	CDD:99947	40/98 (41%)
SNF2	NP_014933.3	QLQ	248..281	CDD:400990	11/32 (34%)
		HSA	<617..660	CDD:400077	9/42 (21%)
		PLN03142	650..>1297	CDD:215601	383/761 (50%)
		SnAC	1299..1369	CDD:405324	27/73 (37%)
		Bromo_SNF2	1550..1652	CDD:99950	40/98 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	380	1.000	Domainoid score	I106
eggNOG	1	0.900	-	-		E2759_KOG0386
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	834	1.000	Inparanoid score	I52
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001147
OrthoInspector	1	1.000	-	-		otm46887
orthoMCL	1	0.900	-	-		OOG6_101122
Panther	1	1.100	-	-	LDO	PTHR10799
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X702
TreeFam	1	0.960	-	-
	11	10.820