Protein Alignment brm and RDH54

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: NP_009629.6
• Gene: RDH54 / 852365
• SGDID: S000000277
• Length: 958
• Species: Saccharomyces cerevisiae
• Alignment Length: 855
• Identity: 196/855 - (22%)
• Similarity: 357/855 - (41%)
• Gaps: 230/855 - (26%)

  Fly   685 GWDWIDDEEDS-------CGSND---DHKPKVEEQPTATEDA---------------TDKAQATG 724
            |...:..:.||       .|||:   |::.|...:..:.::|               |:...:|.
Yeast   149 GSSMLPSDSDSLFETLFKAGSNEVQLDYELKENAEIRSAKEALSQNMGNPSPPTTSTTETVPSTK 213

  Fly   725 NDEDAKDL----------------ITKAKVEDDEYRT---------EEQTYYSIAH--------T 756
            ||.....:                :||   :.:|:.|         :.:.||.:..        .
Yeast   214 NDGGKYQMPLSQLFSLNTVKRFKSVTK---QTNEHMTTVPKTSQNSKAKKYYPVFDVNKIDNPIV 275

  Fly   757 IHEKVVEQASIMVNGT----LKEYQIKGLEW------------------------LVSLYNNNLN 793
            :::....:..::|:..    |:.:|.:|:::                        ||...:::::
Yeast   276 MNKNAAAEVDVIVDPLLGKFLRPHQREGVKFMYDCLMGLARPTIENPDIDCTTKSLVLENDSDIS 340

  Fly   794 G-ILADEMGLGKTIQTISLVTYLMDR--------------------KKVMGPYLIIVPLSTLPNW 837
            | :|||:||||||:.:|:|:..|:.:                    ||:    |::.|::.:.||
Yeast   341 GCLLADDMGLGKTLMSITLIWTLIRQTPFASKVSCSQSGIPLTGLCKKI----LVVCPVTLIGNW 401

  Fly   838 VLEFEKW--APAVGV--VSYKGSP-QGRRLLQNQMRATK-FNVLLTTYEYVIKDKAVLAKIQW-- 894
            ..||.||  ...:||  :|.:.|| ..:..::|.::..: :.||:..||.::.....|.|.:.
Yeast   402 KREFGKWLNLSRIGVLTLSSRNSPDMDKMAVRNFLKVQRTYQVLIIGYEKLLSVSEELEKNKHLI 466

  Fly   895 KYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFE 959
            ..::.|||||:||...|:...|.:..|. .:|||||||:||.|.|.:.:::|:.|.|..|.::|:
Yeast   467 DMLVCDEGHRLKNGASKILNTLKSLDIR-RKLLLTGTPIQNDLNEFFTIIDFINPGILGSFASFK 530

  Fly   960 QWFNAPFAT--------TGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIK 1016
            :.|..|...        ..|.:|..||.:    :.:.::.:.|:|||....:|..||.|.:.|:.
Yeast   531 RRFIIPITRARDTANRYNEELLEKGEERS----KEMIEITKRFILRRTNAILEKYLPPKTDIILF 591

  Fly  1017 CDMSALQRVLYKHMQSKGVL----LTDGSEKGKHGKGGAKALMNTIVQLRKLCN-------HPFM 1070
            |...:.|.:.:|.:.....|    ||..|..|            .|..|:|:||       .|:.
Yeast   592 CKPYSQQILAFKDILQGARLDFGQLTFSSSLG------------LITLLKKVCNSPGLVGSDPYY 644

  Fly  1071 FQHIEEKYCDHTGGHGVVSGPDLYR---VSGKFELLDRILPKL-KATNHRVLLFCQMTQCMTIIE 1131
            ..||::           ....|.|.   .|||.::|..:|..: |.|..:|::....||.:.|||
Yeast   645 KSHIKD-----------TQSQDSYSRSLNSGKLKVLMTLLEGIRKGTKEKVVVVSNYTQTLDIIE 698

  Fly  1132 DYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDW 1196
            :.:......:.||||:..|:.|..::..|| :...:|.||||.::||:||||..|..:::||:||
Yeast   699 NLMNMAGMSHCRLDGSIPAKQRDSIVTSFN-RNPAIFGFLLSAKSGGVGLNLVGASRLILFDNDW 762

  Fly  1197 NPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQKSTGSER 1261
            ||..||||..|.||.||:....:.||:|...::|:||.....|.::.:|.:
Yeast   763 NPSVDLQAMSRIHRDGQKKPCFIYRLVTTGCIDEKILQRQLMKNSLSQKFL-------------- 813

  Fly  1262 QQFLQTILHQDDNEEEEENEVPDDEMINMMIARSEEEIEIFKRMDAERKKEDEEIHPGRERLIDE 1326
                       .:.|....|..:|::.|      :|:::....:..:.|....::....:.|.:|
Yeast   814 -----------GDSEMRNKESSNDDLFN------KEDLKDLFSVHTDTKSNTHDLICSCDGLGEE 861

  Fly  1327 SELPDWLTKDDDEVERFHYQYDEDTILGRGSRQRKEVDYTDSLTEKEWLKAIDDGAEFDEEEEED 1391
            .|.|:                        .::|:..|:.....| ..|..|:|...:.:|....|
Yeast   862 IEYPE------------------------TNQQQNTVELRKRST-TTWTSALDLQKKMNEAATND 901

  Fly  1392 DSKRKRRKRK 1401
            |:|:.:..|:
Yeast   902 DAKKSQYIRQ 911

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580
		PTZ00121	<477..651	CDD:173412
		HSA	501..573	CDD:214727
		BRK	650..691	CDD:462196	1/5 (20%)
		PLN03142	739..>1368	CDD:215601	172/725 (24%)
		Bromo_SNF2L2	1425..1530	CDD:99947
RDH54	NP_009629.6	DUF2439	108..>158	CDD:463065	1/8 (13%)
		DEXHc_RAD54	296..573	CDD:350762	74/285 (26%)
		SF2_C_SNF	663..789	CDD:350180	49/126 (39%)