Protein Alignment brm and FUN30

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: NP_009383.1
• Gene: FUN30 / 851214
• SGDID: S000000017
• Length: 1131
• Species: Saccharomyces cerevisiae
• Alignment Length: 1214
• Identity: 315/1214 - (25%)
• Similarity: 502/1214 - (41%)
• Gaps: 356/1214 - (29%)

  Fly   328 QLPNGGKPLSMGPSGGQPLIPSSPMQPQV-------RGTLPGMPPG----SQVPQPGGGPQRQVP 381
            |:|....|..:..|  .||.|:||..|..       |.|.....|.    :..|.|.|.|  :|.
Yeast    14 QVPETSSPTKVASS--SPLKPTSPTVPDASVASLRSRFTFKPSDPSEGAHTSKPLPSGSP--EVA 74

  Fly   382 PAGMPMPKPNRITTVAKPVGLDPITLLQERENRIAARISLRMQ------------ELQRLPATMS 434
            ...:....|:...|:.:.|.......||....|:.   .||.|            :....|..:.
Yeast    75 LVNLAREFPDFSQTLVQAVFKSNSFNLQSARERLT---RLRQQRQNWTWNKNASPKKSETPPPVK 136

  Fly   435 EDLRL-------------------------QAAIELRALRVLNFQRQLRMEFVQCTRRDTTLETA 474
            :.|.|                         :.:|..|...|:| |:|...|          |.|.
Yeast   137 KSLPLANTGRLSSIHGNINNKSSKITVAKQKTSIFDRYSNVIN-QKQYTFE----------LPTN 190

  Fly   475 LNIKLYKRTKRQGLREARATEKLEKQQKLEAERKRRQKHLEFLAAVLQH--GKDLREFHRNNKAQ 537
            |||            ::.|..||    .:...:|||      |....||  ||.    :.::..|
Yeast   191 LNI------------DSEALSKL----PVNYNKKRR------LVRADQHPIGKS----YESSATQ 229

  Fly   538 LARMNKAVM-----NHHANAEREQKKEQERIEKERMRRLMAEDEEG----YRKLIDQ--KKDKRL 591
            |....:.::     ..|||...|:::|.          :|.:|::.    |.:...|  ..::.|
Yeast   230 LGSAREKLLANRKYGRHANDNDEEEEES----------MMTDDDDASGDDYTESTPQINLDEQVL 284

  Fly   592 AFL-------LSQTDEYISNLTQMVKQHK-------------DDQMKKKEEEGKRLIQFKKELLM 636
            .|:       ||...:...:..|::..|:             :|:..::....||    |:....
Yeast   285 QFINDSDIVDLSDLSDTTMHKAQLIASHRPYSSLNAFVNTNFNDKDTEENASNKR----KRRAAA 345

  Fly   637 SGEYIGIDEGSIVADMRVH-----VVEQCT-------------GKKLTGDDAPM-LKHLHRWLNM 682
            |..........|...:|.:     |:::|:             |.::.||::.: |.:|
Yeast   346 SANESERLLDKITQSIRGYNAIESVIKKCSSYGDLVTSQMKKWGVQVEGDNSELDLMNL------ 404

  Fly   683 HPGWDWIDDEEDSCGSNDDHKPKVEEQPTATEDATDKAQATGNDEDAKDLI-------------- 733
              |.|  ||:::..|:||::..  ....||..|||.|.:     ||.|.::
Yeast   405 --GED--DDDDNDDGNNDNNNS--NNNNTAGADATSKEK-----EDTKAVVEGFDETSAEPTPAP 458

  Fly   734 ---------------TKAKV----------------------EDDEYRTEEQTYYS--------- 752
                           ||.||                      |||:|..|::.|..
Yeast   459 APAPVERETKRIRNTTKPKVVEDEDDDVDLEAIDDELPQSEHEDDDYEEEDEDYNDEEEDVEYDD 523

  Fly   753 -----------IAHTIHEKVVEQASIMVNG-------------------TLKEYQIKGLEWLVSL 787
                       :|...:..|:...|  .||                   :||:||..|:.||..|
Yeast   524 GDDDDDDDDEFVATRKNTHVISTTS--RNGRKPIVKFFKGKPRLLSPEISLKDYQQTGINWLNLL 586

  Fly   788 YNNNLNGILADEMGLGKTIQTISLVTYLMDRKKV--MGPYLIIVPLSTLPNWVLEFEKWAPAVGV 850
            |.|.::.||||:||||||.|.||...||   |::  .||:|::||.|||.||:.||:|:|||:.:
Yeast   587 YQNKMSCILADDMGLGKTCQVISFFAYL---KQINEPGPHLVVVPSSTLENWLREFQKFAPALKI 648

  Fly   851 VSYKGSPQGRRLLQN--QMRATKFNVLLTTYEYVIKDK---AVLAKIQWKYMIIDEGHRMKN--- 907
            ..|.||.|.|..|::  :..|.|::|::|||.....:|   :.|....:..::.||||.:||
Yeast   649 EPYYGSLQEREELRDILERNAGKYDVIVTTYNLAAGNKYDVSFLKNRNFNVVVYDEGHMLKNSTS 713

  Fly   908 -HHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGE 971
             ...||.::.     |.:|||||||||||.|.||.:||.|::|::|.|   .::.|:|.|....:
Yeast   714 ERFAKLMKIR-----ANFRLLLTGTPLQNNLKELMSLLEFIMPNLFIS---KKESFDAIFKQRAK 770

  Fly   972 KVELNEEETILI----IRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLY----- 1027
            ..:.|:....|:    |.|...:::||:|||.|.:|...||.|..:|..|:::|:|:.:|
Yeast   771 TTDDNKNHNPLLAQEAITRAKTMMKPFILRRRKDQVLKHLPPKHTHIQYCELNAIQKKIYDKEIQ 835

  Fly  1028 -----KHMQSKGVLLTDGSEKGKHGKGGAKALMNTIVQLRKLCNHPFMFQHI------------- 1074
                 |.|...|.|..|..||.|.....:|   |.|:.|||...||.:|::|
Yeast   836 IVLEHKRMIKDGELPKDAKEKSKLQSSSSK---NLIMALRKASLHPLLFRNIYNDKIITKMSDAI 897

  Fly  1075 --EEKYCDHTGGHGV------VSGPDLYRV--------------------SGKFELLDRILPKLK 1111
              |..|.::.....:      ::..:|:::                    |||.:.|.::|..:.
Yeast   898 LDEPAYAENGNKEYIKEDMSYMTDFELHKLCCNFPNTLSKYQLHNDEWMQSGKIDALKKLLKTII 962

  Fly  1112 A-TNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTR 1175
            . ...:||:|...||.:.|:|..|....:.:|||||:|:..||..|:.|| .:..|:.:|:|||:
Yeast   963 VDKQEKVLIFSLFTQVLDILEMVLSTLDYKFLRLDGSTQVNDRQLLIDKF-YEDKDIPIFILSTK 1026

  Fly  1176 AGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKL 1240
            |||.|:||..|:.|:|||..:|||.|.||.|||||:||..||.:..|:|.:|:||:|...|:.||
Yeast  1027 AGGFGINLVCANNVIIFDQSFNPHDDRQAADRAHRVGQTKEVNITTLITKDSIEEKIHQLAKNKL 1091

  Fly  1241 NMDEKVIQAGMFDQKSTG---SERQQFLQTILHQDDNEEEEENE 1281
            .:|..:.:    |:||..   |:....|:.|::.::::.:...|
Yeast  1092 ALDSYISE----DKKSQDVLESKVSDMLEDIIYDENSKPKGTKE 1131

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580	20/83 (24%)
		PTZ00121	<477..651	CDD:173412	35/206 (17%)
		HSA	501..573	CDD:214727	15/78 (19%)
		BRK	650..691	CDD:462196	10/59 (17%)
		PLN03142	739..>1368	CDD:215601	211/652 (32%)
		Bromo_SNF2L2	1425..1530	CDD:99947
FUN30	NP_009383.1	HepA	<571..1093	CDD:440319	192/536 (36%)