Protein Alignment brm and IRC5

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: NP_116696.2
• Gene: IRC5 / 850599
• SGDID: S000001934
• Length: 853
• Species: Saccharomyces cerevisiae
• Alignment Length: 967
• Identity: 280/967 - (28%)
• Similarity: 436/967 - (45%)
• Gaps: 247/967 - (25%)

  Fly   469 TTLETALNIKLYKRTKRQ----GLREARATEKL----EKQQKLEAERKRRQKHLEFLAAVLQHGK 525
            |.:|.|:..::..||:..    ..||....:..    :....|::|..:             |||
Yeast    11 TVVEDAVGARVAARTRNMSNGVNYREKEVNDLTADISDSDSDLDSEDNK-------------HGK 62

  Fly   526 DLREFHRNNKAQLARMNKAVMNHHANAEREQKKEQERIEKERMRRLMAEDEEGYRKLIDQKKDKR 590
            .     .|:.|.:...:....:.....:.|...:.|.::.:.:.:| |:|.:..:|.:|.:
Yeast    63 G-----DNDTAPIWLQDDVHSDEDIQLDSEDDSDTEAVQAQVVDKL-AKDTKSEQKSLDDE---- 117

  Fly   591 LAFLLSQTDEYISNLTQMVKQHKDDQMKKKEEEGKRLIQFKKELLMSGEYIGIDEGSIVADMRVH 655
                ||:.|....:|                 :.|:|.:|.::   |..|     .||:||..:|
Yeast   118 ----LSEMDTKTVSL-----------------KLKKLNEFVRQ---SQVY-----SSIIADTLLH 153

  Fly   656 VVEQCTGKKLTGDDAPMLKHLHRWLNMHPGWDWIDDEEDSCGSNDDHKPKVEEQPTATEDATDKA 720
            ...:..... |.|::..                 ||||.|.          :::.|..:..||..
Yeast   154 RSNEVANAN-TKDNSNS-----------------DDEEHSS----------KKRKTKKKSITDFF 190

  Fly   721 QATGNDEDAKDLITKAKVEDDEYRTEEQTYYSIAHTIHEKVVEQASIMVNGTLKEYQIKGLEWLV 785
            :....:||.   .|:....||                  ..::|..::.|..||.||::||.||:
Yeast   191 KKQKKNEDT---TTQNGAPDD------------------AAIKQPRLLKNCILKPYQLEGLNWLI 234

  Fly   786 SLYNNNLNGILADEMGLGKTIQTISLVTYL--MDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAV 848
            :||.|.||||||||||||||:|:|:|:.::  ||.|   ||:|:..|||||.||:.||.|:||.:
Yeast   235 TLYENGLNGILADEMGLGKTVQSIALLAFIYEMDTK---GPFLVTAPLSTLDNWMNEFAKFAPDL 296

  Fly   849 GVVSYKGSPQGRRLLQNQMRATKF-------NVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMK 906
            .|:.|.|: .|.:  :...:...|       .:::|:||.:::|..::....||::|:|||||:|
Yeast   297 PVLKYYGT-NGYK--ERSAKLKNFFKQHGGTGIVITSYEIILRDTDLIMSQNWKFLIVDEGHRLK 358

  Fly   907 NHHCKLTQVL---NTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWF-----N 963
            |.:|:|.:.|   ||    ..|||||||||||.|.|||:||||::|.||.....|.:||     |
Yeast   359 NINCRLIKELKKINT----SNRLLLTGTPLQNNLAELWSLLNFIMPDIFADFEIFNKWFDFDSLN 419

  Fly   964 APFATTGEKVE--LNEEETILIIRRLHKVLRPFLLRRLKKEV-EHQLPDKVEYIIKCDMSALQRV 1025
            ....:..|.:.  :|:|....:|..||.:|:|||||||||.| .:.||.|.||||.|.|::.|..
Yeast   420 LGSGSNSEALNKLINDELQKNLISNLHTILKPFLLRRLKKVVLANILPPKREYIINCPMTSAQEK 484

  Fly  1026 LYK----------------------------HMQSKGV-----LLTDGSE--------------- 1042
            .||                            |:.::.:     ....|:|
Yeast   485 FYKAGLNGKLKKTMFKELIKDFFTLNDEYIGHVSNRSIRDFINYKLSGNETSNTDNKINPTLLQM 549

  Fly  1043 -----KGKHGKGGAKALMNTIVQLRKLCNHPFMFQ----HIEEKYCDHTGGHGVVSGPDLYRVSG 1098
                 |....:...|.|.|.::|||::.:..|:|.    |.|:           ::...|.:.||
Yeast   550 DKLYKKNLQMEISNKKLQNMMMQLRQIIDSTFLFYFPYLHPED-----------LTLETLLKTSG 603

  Fly  1099 KFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAK 1163
            |.::|.:::|.|.:..|:||::.|....:.:|||:.....|...|:||:...|.|.:.|.|||:.
Yeast   604 KLQILQKLIPPLISEGHKVLIYSQFVNMLDLIEDWCDLNSFATFRIDGSVNNETRKDQLEKFNSS 668

  Fly  1164 GSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSV 1228
            .....:|||||||.|||:||..|||||:|||||||..||||.||.|||||.:.|.|.||...|::
Yeast   669 KDKHNIFLLSTRAAGLGINLVGADTVVLFDSDWNPQVDLQAMDRCHRIGQESPVIVYRLCCDNTI 733

  Fly  1229 EERILAAARYKLNMDEKVIQAGMFDQ-------------------KSTGSERQQFLQTILHQD-- 1272
            |..||..|..|.|::..|||.|.|:.                   ..|..:..|.|..:|..|
Yeast   734 EHVILTRAANKRNLERMVIQMGKFNNLKKLALNEGSFLKANKAGVNVTNKDLVQELSMLLMSDES 798

  Fly  1273 ----DNEEEEENEVPDDEMINMMIARSEEEIEIFKRMDAERKKEDEEIHPGRERLID 1325
                :|..::||:..:.::       :::|:|.......|..|.:        |::|
Yeast   799 NIGFENGGQKENKATEGQL-------TDKEVEELTNRSLEAYKAN--------RVVD 840

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580
		PTZ00121	<477..651	CDD:173412	29/181 (16%)
		HSA	501..573	CDD:214727	10/71 (14%)
		BRK	650..691	CDD:462196	5/40 (13%)
		PLN03142	739..>1368	CDD:215601	232/689 (34%)
		Bromo_SNF2L2	1425..1530	CDD:99947
IRC5	NP_116696.2	PLN03142	74..>767	CDD:215601	252/796 (32%)