DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brm and SMARCA5

DIOPT Version :9

Sequence 1:	NP_001261906.1	Gene:	brm / 39744	FlyBaseID:	FBgn0000212	Length:	1658	Species:	Drosophila melanogaster
Sequence 2:	NP_003592.3	Gene:	SMARCA5 / 8467	HGNCID:	11101	Length:	1052	Species:	Homo sapiens

Alignment Length:	1058	Identity:	320/1058 - (30%)
Similarity:	494/1058 - (46%)	Gaps:	226/1058 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   550 ANAEREQKKEQERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAFLLSQTDEYISNLTQMVKQHKD 614
            |:||.|:..:.....|::.   :.|.:..|.:.:...:..|..:||.||:.:
Human    54 ADAEMEEIFDDASPGKQKE---IQEPDPTYEEKMQTDRANRFEYLLKQTELF------------- 102

  Fly   615 DQMKKKEEEGKRLIQFKKELLMSGEYIGIDEGSIVADMRVHVVEQCTGKKLTGDDAPMLKHLHRW 679
                                                   .|.::....|..|..
Human   103 ---------------------------------------AHFIQPAAQKTPTSP----------- 117

  Fly   680 LNMHPGWDWI-DDEEDSCGSNDDHKPKVEEQPTATEDATDKAQATGNDEDAKDLITKAKVEDDEY 743
            |.|.||...| .||:.:..|..|::.:..||.                            ||:|.
Human   118 LKMKPGRPRIKKDEKQNLLSVGDYRHRRTEQE----------------------------EDEEL 154

  Fly   744 RTEEQTYYSIAHTIHEKVVEQASIMVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQT 808
            .||.    |.|..:..:..:..|.:..|.|::||::||.||:|||.|.:|||||||||||||:||
Human   155 LTES----SKATNVCTRFEDSPSYVKWGKLRDYQVRGLNWLISLYENGINGILADEMGLGKTLQT 215

  Fly   809 ISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGR-RLLQNQMRATKF 872
            |||:.|:...:.:.||::::||.|||.||:.||::|.|.:..|...|..:.| ..:::.:...::
Human   216 ISLLGYMKHYRNIPGPHMVLVPKSTLHNWMSEFKRWVPTLRSVCLIGDKEQRAAFVRDVLLPGEW 280

  Fly   873 NVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKL 937
            :|.:|:||.:||:|:|..|..|:|::|||.||:||...||::::. .:....|||||||||||.|
Human   281 DVCVTSYEMLIKEKSVFKKFNWRYLVIDEAHRIKNEKSKLSEIVR-EFKTTNRLLLTGTPLQNNL 344

  Fly   938 PELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKE 1002
            .|||:|||||||.:|.|...|:.||:.......:|          ::.|||.|||||||||:|.:
Human   345 HELWSLLNFLLPDVFNSADDFDSWFDTNNCLGDQK----------LVERLHMVLRPFLLRRIKAD 399

  Fly  1003 VEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEKGKHGKGGAKALMNTIVQLRKLCNH 1067
            ||..||.|.|..|...:|.:||..|..:..|.:.:.:.:     ||.....|:|.::||||.|||
Human   400 VEKSLPPKKEVKIYVGLSKMQREWYTRILMKDIDILNSA-----GKMDKMRLLNILMQLRKCCNH 459

  Fly  1068 PFMFQHIEEKYCDHTGGHGVVSGP----DLYRV--SGKFELLDRILPKLKATNHRVLLFCQMTQC 1126
            |::|.             |...||    |::.|  |||..:||::|||||....|||:|.|||:.
Human   460 PYLFD-------------GAEPGPPYTTDMHLVTNSGKMVVLDKLLPKLKEQGSRVLIFSQMTRV 511

  Fly  1127 MTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVI 1191
            :.|:|||..||.:.|.||||.|..::|.:.:..:|...|..|||:|||||||||:||.|||.|::
Human   512 LDILEDYCMWRNYEYCRLDGQTPHDERQDSINAYNEPNSTKFVFMLSTRAGGLGINLATADVVIL 576

  Fly  1192 FDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAG-MFDQK 1255
            :||||||..||||.||||||||...|||.|.:|.|:|||||:..|..||.:|..|||.| :.||.
Human   577 YDSDWNPQVDLQAMDRAHRIGQTKTVRVFRFITDNTVEERIVERAEMKLRLDSIVIQQGRLVDQN 641

  Fly  1256 STGSERQQFLQTILHQDDNE-EEEENEVPDDEMINMMIARSEEEIEIFKRMDAERKKEDEEIHPG 1319
            .....:.:.||.|.|...:. ..:|:|:.|:::..::...:::..|:.:::..
Human   642 LNKIGKDEMLQMIRHGATHVFASKESEITDEDIDGILERGAKKTAEMNEKLSK------------ 694

  Fly  1320 RERLIDESELPDWLTKDDDEVERFHYQYDEDTILGRGSRQRKEVDYTDSLTEKEWLK-------- 1376
                :.||.|.::....:..|..|.         |...|:::::.:|      ||::
Human   695 ----MGESSLRNFTMDTESSVYNFE---------GEDYREKQKIAFT------EWIEPPKRERKA 740

  Fly  1377 --AIDDGAEFDEEEEEDDSKRKRRKRKNRKEESDD------------DSLILKRRRR-------- 1419
              |:|  |.|.|.....:.|..:..|..::....|            :..||..|:.
Human   741 NYAVD--AYFREALRVSEPKAPKAPRPPKQPNVQDFQFFPPRLFELLEKEILFYRKTIGYKVPRN 803

  Fly  1420 ---QNLDKRSKKQMHKIMSAVIKHNQD----GRTLSEPFMKLPSRQRLPDYYEIIKRPV-----D 1472
               .|..:..|::..||..|...::::    .:.|::.|.....|    |:.:.||...     |
Human   804 PELPNAAQAQKEEQLKIDEAESLNDEELEEKEKLLTQGFTNWNKR----DFNQFIKANEKWGRDD 864

  Fly  1473 IKKILQRIEDCKYADLNELEKDFMQLCQN--------AQIYNEEASLIYLDSIALQKVFVGARQR 1529
            |:.|.:.:|.....::.|....|.:.|..        |||...||.:  ...|:::|.......|
Human   865 IENIAREVEGKTPEEVIEYSAVFWERCNELQDIEKIMAQIERGEARI--QRRISIKKALDTKIGR 927

  Fly  1530 ITAAADAAAVAAGDNTGE 1547
            ..|......::.|.|.|:
Human   928 YKAPFHQLRISYGTNKGK 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	172..202	CDD:214931
		Drf_FH1	251..390	CDD:283903
		HSA	501..573	CDD:214727	5/22 (23%)
		BRK	649..693	CDD:197800	9/44 (20%)
		PHA02934	687..>824	CDD:165245	46/137 (34%)
		SNF2_N	776..1071	CDD:278600	130/295 (44%)
		DEXDc	793..932	CDD:238005	61/139 (44%)
		Helicase_C	1097..1212	CDD:278689	65/114 (57%)
		SnAC	1304..1375	CDD:291293	9/70 (13%)
		Bromo_SNF2L2	1425..1530	CDD:99947	24/121 (20%)
SMARCA5	NP_003592.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..83		7/31 (23%)
		PLN03142	69..1012	CDD:215601	316/1043 (30%)
		DEAH box	308..311		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1015..1052
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910