Protein Alignment brm and CHD6

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: XP_016883588.1
• Gene: CHD6 / 84181
• HGNCID: 19057
• Length: 2716
• Species: Homo sapiens
• Alignment Length: 1520
• Identity: 385/1520 - (25%)
• Similarity: 613/1520 - (40%)
• Gaps: 389/1520 - (25%)

  Fly   365 PGSQVPQPGGGPQRQVPPAGMPMPKPNRITTVAKPVGLDPITLLQERE--NRIAARISLRMQELQ 427
            ||.|.....|...|:..|.....||..:....||    :|....:.:|  .:..|:.:.:.:|..
Human   102 PGDQEGAAKGSKDREPKPKRKREPKEPKEPRKAK----EPKKAKEHKEPKQKDGAKKARKPREAS 162

  Fly   428 RLPATMSEDLRLQAAIELRALRVLNFQRQLRMEFVQCTRR--DTTLETALNIKLYKRTKRQGLRE 490
            .......:.....:|...::.:....|....:|..:..:|  :||:|   :::|.:......||.
Human   163 GTKEAKEKRSCTDSAARTKSRKASKEQGPTPVEKKKKGKRKSETTVE---SLELDQGLTNPSLRS 224

  Fly   491 -ARATEKLEKQQKLEAERKRRQKHLEFL--AAVLQHGKDLREFHRNNKAQLARMNKAVMNHHANA 552
             ..:||..:.|::....:.:|:|:.|.|  ..|...|:.:........:.|:....|     ..|
Human   225 PEESTESTDSQKRRSGRQVKRRKYNEDLDFKVVDDDGETIAVLGAGRTSALSASTLA-----WQA 284

  Fly   553 EREQKKEQERIEKERMRRLMAEDEEG------------YRK----------LIDQKKDKRLAFLL 595
            |...:.:...|||....:.:.|...|            ||.          :.:.:||.|:|
Human   285 EEPPEDDANIIEKILASKTVQEVHPGEPPFDLELFYVKYRNFSYLHCKWATMEELEKDPRIA--- 346

  Fly   596 SQTDEYISNLTQMVKQHKDDQMKKKEEEGKRLIQFKKELLMSGEYIGIDEGSIVADMRVHVVEQC 660
                       |.:|     :.:.|:.:.|.:.....|.|.:.:|:.:|....||    |..:..
Human   347 -----------QKIK-----RFRNKQAQMKHIFTEPDEDLFNPDYVEVDRILEVA----HTKDAE 391

  Fly   661 TGKKLTGDDAPMLKHLHRWLNM---HPGWDWIDDEEDSCGSNDDHK----PKVEEQPTATEDATD 718
            ||:::|       .:|.:|.::   ...|: ::::.|.....:...    |:::.......|:..
Human   392 TGEEVT-------HYLVKWCSLPYEESTWE-LEEDVDPAKVKEFESLQVLPEIKHVERPASDSWQ 448

  Fly   719 KAQATGNDEDAKDLITKAKVEDDEYRTEEQTYYSIAHTIHEKVVEQASIMVNGTLKEYQIKGLEW 783
            |.:                 :..||:...|                        |:|||::|:.|
Human   449 KLE-----------------KSREYKNSNQ------------------------LREYQLEGMNW 472

  Fly   784 LVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAV 848
            |:..:.|..|.|||||||||||||:|:.::.:..| .:.||:|||.||||:.||..||..|....
Human   473 LLFNWYNRKNCILADEMGLGKTIQSITFLSEIFLR-GIHGPFLIIAPLSTITNWEREFRTWTEMN 536

  Fly   849 GVVSYKGSPQGRRLLQ-----------NQMRAT-KFNVLLTTYEYVIKDKAVLAKIQWKYMIIDE 901
            .:| |.||...|:::|           |.:... ||:|::||:|.::.|...|.||.|..:||||
Human   537 AIV-YHGSQISRQMIQQYEMVYRDAQGNPLSGVFKFHVVITTFEMILADCPELKKIHWSCVIIDE 600

  Fly   902 GHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPF 966
            .||:||.:|||.:.|....: .:::|||||||||.:.||::|||||.||.|.|.:.|.:.|.
Human   601 AHRLKNRNCKLLEGLKLMAL-EHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETAFLEEFG--- 661

  Fly   967 ATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQ 1031
                   :|..||.   :::|..:|:|.:|||||.:||..|..|.|.||:.:::.:|:..|:.:.
Human   662 -------DLKTEEQ---VKKLQSILKPMMLRRLKDDVEKNLAPKQETIIEVELTNIQKKYYRAIL 716

  Fly  1032 SKGV-LLTDGSEKGKHGKGGAKALMNTIVQLRKLCNHPFMFQHIEEKYCDHTGGHGVVSGPD--- 1092
            .|.. .||.|:  .:|....   |:||:::|||.||||::....|||..:..........||
Human   717 EKNFSFLTKGA--NQHNMPN---LINTMMELRKCCNHPYLINGAEEKILEDFRKTHSPDAPDFQL 776

  Fly  1093 --LYRVSGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGE 1155
              :.:.:||..|:|::||||.|..|:||:|.||.:|:.|:||||..|::.|.|:||..:...|..
Human   777 QAMIQAAGKLVLIDKLLPKLIAGGHKVLIFSQMVRCLDILEDYLIQRRYTYERIDGRVRGNLRQA 841

  Fly  1156 LLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVL 1220
            .:.:|....||.|||||.|||||||:||..|||.:||||||||..|||||.|.|||||...|:|.
Human   842 AIDRFCKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKVY 906

  Fly  1221 RLMTVNSVEERILAAARYKLNMDEKVIQ--------AGMFDQKSTGSERQQFLQTILHQDDNEEE 1277
            ||:|.||.|..:...|..||.:|:.|:|        .|:  |:.:..|.:..|:...:....:||
Human   907 RLITRNSYEREMFDKASLKLGLDKAVLQDINRKGGTNGV--QQLSKMEVEDLLRKGAYGALMDEE 969

  Fly  1278 EENEVPDDEMINMMIARSEEEIEI------------------------------------FKRMD 1306
            :|.....:|.|:.::.|....|.|                                    ...:|
Human   970 DEGSKFCEEDIDQILQRRTHTITIQSEGKGSTFAKASFVASGNRTDISLDDPNFWQKWAKIAELD 1034

  Fly  1307 AERKKEDEEIHPGRERL---------IDESELPDWLTKDDDEVERFHYQYDEDTILGRGSRQRKE 1362
            .|.|.|.|.:...|.|:         .:|.||.::...|.|..|             |.:|.|:.
Human  1035 TEAKNEKESLVIDRPRVRKQTKHYNSFEEDELMEFSELDSDSDE-------------RPTRSRRL 1086

  Fly  1363 VDYTDSLTEKE---------------WLKAIDDGA---EFDEEEEE---------------DDSK 1394
            .|........|               |...:..|.   ..:|::.|               .|.|
Human  1087 NDKARRYLRAECFRVEKNLLIFGWGRWKDILTHGRFKWHLNEKDMEMICRALLVYCVKHYKGDEK 1151

  Fly  1395 ---------------------------------RKRRKRKNR---KEESDDD-------SLILKR 1416
                                             ||.:|.||:   .|..|.|       .::|
Human  1152 IKSFIWELITPTKDGQAQTLQNHSGLSAPVPRGRKGKKTKNQLLIPELKDADWLATCNPEVVL-- 1214

  Fly  1417 RRRQNLDKRSKKQMHKIMSAV-----IKHNQDGRTLSEPFMKLPSRQ---RLP--DYYEIIKRPV 1471
             ......|..|:..:|::..|     :|....|....:.|...|:|:   .||  ||.||   ||
Human  1215 -HDDGYKKHLKQHCNKVLLRVRMLYYLKAEILGEAAEKAFEGSPARELDVPLPDIDYMEI---PV 1275

  Fly  1472 D------IKKILQRIEDCKYADLNELEKDFMQLCQNAQIYNEEASLIYLDSIAL-QKVFVGARQR 1529
            |      .|.:|..:....|...|.:..|              .:|.:|:.:.: .:..:.|.|.
Human  1276 DWWDAEADKSLLIGVFKHGYERYNAMRAD--------------PALCFLEKVGMPDEKSLSAEQG 1326

  Fly  1530 ITAAADAAAVAAGDNTGEAHGNGGSDNSDNDDD-------------DGGD--------------D 1567
            :|           |.|.:....|.:|..||.:|             ||||              |
Human  1327 VT-----------DGTSDIPERGNTDKEDNAEDKVDGLQKQTESSSDGGDGVFSEKKDDSRAAQD 1380

  Fly  1568 GSDDEEIATTSAAAVKMKL--------KLNKSLASAPAT--PTQSSSNVSSGA-ATTSKKQTRRK 1621
            |||.::.....::|:..:|        :.|:.....|..  |......|.... ..||:.....|
Human  1381 GSDPDKSPWPVSSALTARLRRLVTVYQRCNRKELCRPEILGPGNQGYWVQEEMFRRTSEMDLINK 1445

  Fly  1622 RSQKKYTISDDDDDDMDXLPLGVIF 1646
            .:||::|..:..|.... ...||::
Human  1446 EAQKRWTRREQADFYRTVSSFGVVY 1470

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580	10/35 (29%)
		PTZ00121	<477..651	CDD:173412	36/198 (18%)
		HSA	501..573	CDD:214727	13/73 (18%)
		BRK	650..691	CDD:462196	8/43 (19%)
		PLN03142	739..>1368	CDD:215601	242/699 (35%)
		Bromo_SNF2L2	1425..1530	CDD:99947	26/121 (21%)
CHD6	XP_016883588.1	PTZ00449	<105..374	CDD:185628	52/299 (17%)
		CD1_tandem_CHD5-9_like	289..354	CDD:349315	13/83 (16%)
		CD2_tandem_CHD5-9_like	373..431	CDD:349310	12/69 (17%)
		PLN03142	461..>986	CDD:215601	220/571 (39%)
		DEXHc_CHD6	462..683	CDD:350816	97/236 (41%)
		PHA03247	<2320..2694	CDD:223021
		BRK	2403..2438	CDD:470653