DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brm and CHR23

DIOPT Version :9

Sequence 1:	NP_001261906.1	Gene:	brm / 39744	FlyBaseID:	FBgn0000212	Length:	1658	Species:	Drosophila melanogaster
Sequence 2:	NP_197432.2	Gene:	CHR23 / 832051	AraportID:	AT5G19310	Length:	1064	Species:	Arabidopsis thaliana

Alignment Length:	1068	Identity:	414/1068 - (38%)
Similarity:	596/1068 - (55%)	Gaps:	172/1068 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   407 LLQERENRIAARISLRMQELQRLPATMSEDLRLQAAIELRALRVLNFQRQLRMEF-------VQC 464
            |.:.:|.|...||..|:.:|:.||:...|||:.:..:||..|::...|.::|.|.       :.|
plant    91 LAELKETRYKNRIHNRLSQLEGLPSNRGEDLQEKCLLELYGLKLQELQCRVRGEVSAEYWLRLNC 155

  Fly   465 TRRDTTLETALNIKLYKRTKRQG-------------LREARATEKLEKQQKLEAERKRRQKHLEF 516
            ...:..|.....::|.:|....|             .|:|....:||:::|...|..:|:...|.
plant   156 ADPERQLYDWGMMRLPRRMYGVGDSFVMEADDQFRNKRDAERLLRLEEEEKNLIETTQRKFFAEV 220

  Fly   517 LAAVLQHGKDLREFHRNNKAQLARMNKAVMNHHANAEREQKKEQERIEKERMRRLMAEDEEGYRK 581
            |.||.:....::..||..|    :.|..|...|.    :|::...|.||.|:..|.::|:|.|.|
plant   221 LNAVREFQLQIQASHRRCK----QRNDGVQAWHG----KQRQRATRAEKLRIMALKSDDQEEYMK 277

  Fly   582 LIDQKKDKRLAFLLSQTDEYISNLTQMVKQHKDDQMKKKEEEGKRLIQFKKELLMSGEYIGIDEG 646
            |..:.|:::|...|.:|::...:|...|::.||.::.:           ..:||...|
plant   278 LAKESKNEKLTLFLEETNKIFVSLGAAVQRQKDAKLSE-----------NTKLLKGSE------- 324

  Fly   647 SIVADMRVHVVEQCTGKKLTGDDAPMLKHLHRWLNMHPGWDWIDDEEDSCGSNDDHKPKVEEQPT 711
            |.::|:                |||                     ||..             |.
plant   325 SDLSDV----------------DAP---------------------EDVL-------------PA 339

  Fly   712 ATEDATDKAQATGNDEDAKDLITKAKVEDDEYRTEEQTYYSIA-HTIHEKVVEQASIMVNGTLKE 775
            ...:..|    :.|::|:.||:            |.:..:::| |:|.|||.:|.|::..|.|:.
plant   340 QDIEIID----SDNNDDSNDLL------------EGERQFNLAIHSIQEKVTKQPSLLQGGELRS 388

  Fly   776 YQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLE 840
            ||::||:|:||||||:.|||||||||||||||||:|:.||::.|.:.||:||:.|.:.||||..|
plant   389 YQLEGLQWMVSLYNNDYNGILADEMGLGKTIQTIALIAYLLESKDLHGPHLILAPKAVLPNWENE 453

  Fly   841 FEKWAPAVGVVSYKGSPQGRRLLQNQMRATKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRM 905
            |..|||::....|.||.:.|..::.::...|||||:|.|:.:::|||.|.||.|.|||:|||||:
plant   454 FALWAPSISAFLYDGSKEKRTEIRARIAGGKFNVLITHYDLIMRDKAFLKKIDWNYMIVDEGHRL 518

  Fly   906 KNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTG 970
            |||.|.|.:.|.|.|....||||||||:||.|.|||:|||||||.||.|...||:|||.|||..|
plant   519 KNHECALAKTLGTGYRIKRRLLLTGTPIQNSLQELWSLLNFLLPHIFNSIHNFEEWFNTPFAECG 583

  Fly   971 EKVELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGV 1035
             ...|.:||.:|||.|||.|:|||||||.|.|||..||.|.:.|:||||||.|::.||.
plant   584 -SASLTDEEELLIINRLHHVIRPFLLRRKKSEVEKFLPGKTQVILKCDMSAWQKLYYKQ------ 641

  Fly  1036 LLTDGSEKGKH-GKGGAKALMNTIVQLRKLCNHPFMFQHIEEKYCDHTGGHGVVSGPDLYRVSGK 1099
             :||....|.| |.|.:|:|.|..:||||.||||::|...:...|         ..|::.|.|||
plant   642 -VTDVGRVGLHSGNGKSKSLQNLTMQLRKCCNHPYLFVGADYNMC---------KKPEIVRASGK 696

  Fly  1100 FELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKG 1164
            ||||||:|||||...||:|||.|||:.:.::|.||....:.||||||:||.:.||.||::||...
plant   697 FELLDRLLPKLKKAGHRILLFSQMTRLIDLLEIYLSLNDYMYLRLDGSTKTDQRGILLKQFNEPD 761

  Fly  1165 SDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVE 1229
            |..|:|||||||||||||||||||::||||||||..|.||:||||||||:.||||..|:::.|:|
plant   762 SPYFMFLLSTRAGGLGLNLQTADTIIIFDSDWNPQMDQQAEDRAHRIGQKKEVRVFVLVSIGSIE 826

  Fly  1230 ERILAAARYKLNMDEKVIQAGMFDQKSTGSERQQFLQTILHQDDNEEEEENEVPDDEMINMMIAR 1294
            |.||..|:.|:.:|.||||||:|:..||..:|::.|:.|:.:..:...|  :||.:..||.:.||
plant   827 EVILERAKQKMGIDAKVIQAGLFNTTSTAQDRREMLEEIMSKGTSSLGE--DVPSEREINRLAAR 889

  Fly  1295 SEEEIEIFKRMDAERKKEDEEIHPGRERLIDESELPDWL----TKDDDEVERFHYQYDEDTILG- 1354
            :|||..:|::||.||:|::..    :.||::|.|:|:|.    |::|....:.|:        |
plant   890 TEEEFWMFEQMDEERRKKENY----KTRLMEEKEVPEWAYTSETQEDKTNAKNHF--------GS 942

  Fly  1355 -RGSRQRKEVDYTDSLTEKEWLKAIDDGAEFDEEEEEDDS----KRKRRKRKNRK---------- 1404
             .|.|:|||..|:|||::.:|:||:       |.|:||.|    ||||...|.|.
plant   943 LTGKRKRKEAVYSDSLSDLQWMKAM-------ESEDEDASKVSQKRKRTDTKTRMSNGSKAEAVL 1000

  Fly  1405 EESDDDSLILKRRRRQNLDKRSKKQMHK 1432
            .|||::....:..|::...|.|:::..|
plant  1001 SESDEEKEEEEEERKEESGKESEEENEK 1028

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	172..202	CDD:214931
		Drf_FH1	251..390	CDD:283903
		HSA	501..573	CDD:214727	19/71 (27%)
		BRK	649..693	CDD:197800	4/43 (9%)
		PHA02934	687..>824	CDD:165245	51/137 (37%)
		SNF2_N	776..1071	CDD:278600	164/295 (56%)
		DEXDc	793..932	CDD:238005	75/138 (54%)
		Helicase_C	1097..1212	CDD:278689	76/114 (67%)
		SnAC	1304..1375	CDD:291293	24/76 (32%)
		Bromo_SNF2L2	1425..1530	CDD:99947	2/8 (25%)
CHR23	NP_197432.2	PLN03142	373..>893	CDD:215601	286/538 (53%)
CHR23	NP_197432.2	SnAC	898..964	CDD:373166	24/77 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	321	1.000	Domainoid score	I277
eggNOG	1	0.900	-	-		E2759_KOG0386
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2308
Inparanoid	1	1.050	664	1.000	Inparanoid score	I154
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D685477at2759
OrthoFinder	1	1.000	-	-		FOG0001147
OrthoInspector	1	1.000	-	-		otm2826
orthoMCL	1	0.900	-	-		OOG6_101122
Panther	1	1.100	-	-	O	PTHR10799
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X702
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.830