Protein Alignment brm and RGD3

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: NP_001190085.1
• Gene: RGD3 / 824595
• AraportID: AT3G54280
• Length: 2129
• Species: Arabidopsis thaliana
• Alignment Length: 1173
• Identity: 278/1173 - (23%)
• Similarity: 441/1173 - (37%)
• Gaps: 358/1173 - (30%)

  Fly   462 VQCTRRDTTLETALNIKLYKRTKRQGLREARATEKLEKQQKLEAERKRRQ--------------K 512
            |:....|.|::.|..:.|:.       :|:...|.||||...:.|..|:|              .
plant  1055 VESVTADETIDFASTLDLWN-------KESAGNESLEKQVFEDVESSRQQLLSTAGYLKCVQSNL 1112

  Fly   513 HLEFLAAVLQHGKDLREFHRNNKAQLARMNKAVMNHHANAEREQKKEQERIEKERMRRLMAEDEE 577
            |:...:.|......:.||.       ||:|..::...|:.:|||::..::|..|.:..|:|
plant  1113 HITVTSLVAAAVVWMSEFP-------ARLNPIILPLMASIKREQEQILQQIAAEALAELIA---- 1166

  Fly   578 GYRKLIDQKKDKRLAFLLSQTDEYISNLTQMVKQHKD-----------------DQMKKKEEEGK 625
               ..:|:|.        |..|:.|.|:..:......                 |.:..:...||
plant  1167 ---YCVDRKP--------SPNDKLIKNICSLTCMDPSETPQASIISSMDIVDDMDFLSSRSNTGK 1220

  Fly   626 RLIQFKKELLMSGEYIGIDEGSI------------------------------------------ 648
               |..|.:|.|||.....||.|
plant  1221 ---QKAKVVLASGEDRSKVEGFITRRGSELALKHLSLKFGGSLFDKLPKLWECLTEVLVPEIPSD 1282

  Fly   649 ----------VADMRV-------------------------------------HV-----VEQCT 661
                      ::|.:|                                     ||     ..:|.
plant  1283 QQKIDLKIESISDPQVLINNIQVVRSIAPVMEETLKPRLLSLLPCIFKCVRHSHVAVRLAASRCV 1347

  Fly   662 ---GKKLTGD--------DAPMLKHL--------------------------HRWLNMHPGWDWI 689
               .|.:|.|        ..|||..|                          :..|.:.|....:
plant  1348 MTMAKSMTTDVMAAVVESAIPMLGDLTCISGRQGAGMLIGLLVQGLGVELVPYSPLLVVPLLRCM 1412

  Fly   690 DDEEDSCGSNDDHK--------PKVEEQPTATEDATDKAQATGNDEDAK---DLITKAKVEDDEY 743
            .|.:.|...:....        |.....|.....:.|   .:.|.||||   .|:..:.::|.:.
plant  1413 SDVDSSVRQSVTRSFAALVPMLPLARGVPPPVGLSKD---LSSNAEDAKFLEQLLDNSHIDDYKL 1474

  Fly   744 RTEEQTYYSIAHTIHEKVVEQASIMVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQT 808
            .||                      :...|:.||.:|:.||..|....|:|||.|:||||||:|.
plant  1475 CTE----------------------LKVQLRRYQQEGINWLGFLKRFKLHGILCDDMGLGKTLQA 1517

  Fly   809 ISLVTYLMDRKKVMG--------PYLIIVPLSTLPNWVLEFEKW--APAVGVVSYKGSPQGRRLL 863
            .::|.  .|..:..|        |.:|:.|.:.:.:|..|.||:  ...:.|:.|.||.|.|..|
plant  1518 SAIVA--SDAAERRGSTDELDVFPSIIVCPSTLVGHWAFEIEKYIDLSLLSVLQYVGSAQDRVSL 1580

  Fly   864 QNQMRATKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLL 928
            :.|.  ...||::|:|:.|.||...|.:..|.|.|:||||.:||...|:|..:. ...|.:||:|
plant  1581 REQF--NNHNVIITSYDVVRKDVDYLTQFSWNYCILDEGHIIKNAKSKITAAVK-QLKAQHRLIL 1642

  Fly   929 TGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAP-FATTGEKVELNEEET-ILIIRRLHKVL 991
            :|||:||.:.|||:|.:||:|....:...|:..:..| .|....|....:.|. :|.:..|||.:
plant  1643 SGTPIQNNIMELWSLFDFLMPGFLGTERQFQASYGKPLLAARDPKCSAKDAEAGVLAMEALHKQV 1707

  Fly   992 RPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKH-------MQSKGVLLTDGS-EKGKHGK 1048
            .||||||.|:||...||:|:.....||:|.:|..||:.       .:...::..||| :.|....
plant  1708 MPFLLRRTKEEVLSDLPEKIIQDRYCDLSPVQLKLYEQFSGSSAKQEISSIIKVDGSADSGNADV 1772

  Fly  1049 GGAKA---LMNTIVQLRKLCNHPFMFQHIEEKYCDHTGGH--GVVSG-----PDLYRV--SGKFE 1101
            ...||   :...:..|.|||:||.:.  :.:|..:.....  .:::|     .:|::|  |.|..
plant  1773 APTKASTHVFQALQYLLKLCSHPLLV--LGDKVTEPVASDLAAMINGCSDIITELHKVQHSPKLV 1835

  Fly  1102 LLDRILPK-------------LKATNHRVLLFCQMTQCMTIIEDYL---GWRQFGYLRLDGTTKA 1150
            .|..||.:             |....||||:|.|....:.|||..|   ..:...|:||||:...
plant  1836 ALQEILEECGIGSDASSSDGTLSVGQHRVLIFAQHKALLDIIEKDLFQAHMKSVTYMRLDGSVVP 1900

  Fly  1151 EDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRN 1215
            |.|.|:::.||:..: :.|.||:|..|||||||.:|||:|..:.||||.:|.||.|||||:||:.
plant  1901 EKRFEIVKAFNSDPT-IDVLLLTTHVGGLGLNLTSADTLVFMEHDWNPMRDHQAMDRAHRLGQKR 1964

  Fly  1216 EVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQKSTGSERQQFLQTILHQDDNEEEEEN 1280
            .|.|.||:...::||::::..::|:::...||.|.....|:..:
plant  1965 VVNVHRLIMRGTLEEKVMSLQKFKVSVANTVINAENASMKTMNT--------------------- 2008

  Fly  1281 EVPDDEMINMMIARSEEEIEIFKRMDAERKKEDEEIHPGRERLIDESELPDWLTKDDDEVERFHY 1345
                |:::::..:     .|..|:.....||..|
plant  2009 ----DQLLDLFAS-----AETSKKGGGSSKKGSE------------------------------- 2033

  Fly  1346 QYDEDTILGRGSRQRKEVDYTDSLTEKEWLKAIDDGAEFDEEEEEDDSKRKRRKRKNRKEESDDD 1410
              |.|.|.|.|...:..:...:.|    |     |.:::.||........|....:|.|.|.||.
plant  2034 --DNDQIAGTGKGMKAILGNLEEL----W-----DQSQYTEEYNLSQFLTKLNGGENEKREVDDI 2087

  Fly  1411 SLI 1413
            .::
plant  2088 GVV 2090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580
		PTZ00121	<477..651	CDD:173412	43/256 (17%)
		HSA	501..573	CDD:214727	17/85 (20%)
		BRK	650..691	CDD:462196	14/119 (12%)
		PLN03142	739..>1368	CDD:215601	195/676 (29%)
		Bromo_SNF2L2	1425..1530	CDD:99947
RGD3	NP_001190085.1	HEAT repeat	9..34	CDD:293787
		HEAT repeat	46..73	CDD:293787
		HEAT repeat	541..566	CDD:293787
		HEAT repeat	579..607	CDD:293787
		HEAT repeat	619..668	CDD:293787
		HEAT repeat	677..724	CDD:293787
		HEAT repeat	735..764	CDD:293787
		DUF3535	813..1270	CDD:463447	47/246 (19%)
		HepA	1378..1996	CDD:440319	193/650 (30%)