DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brm and ATCHR12

DIOPT Version :9

Sequence 1:	NP_001261906.1	Gene:	brm / 39744	FlyBaseID:	FBgn0000212	Length:	1658	Species:	Drosophila melanogaster
Sequence 2:	NP_187252.2	Gene:	ATCHR12 / 819772	AraportID:	AT3G06010	Length:	1102	Species:	Arabidopsis thaliana

Alignment Length:	1200	Identity:	446/1200 - (37%)
Similarity:	631/1200 - (52%)	Gaps:	240/1200 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   317 SQPPPPEPH----QHQLPNGGKPLSMGPSGGQPLIPSSPMQPQVRGTLPGMPPGSQVPQPGGGPQ 377
            |:..|..||    ...:.:|....|:..|...|.:|:||                        |.
plant    33 SRDLPLPPHLFTAVSSIYHGASSSSLSDSDVSPPLPTSP------------------------PA 73

  Fly   378 RQVPPAGMPMPKPNRITTVAKPVGLDPITLLQERENRIAARISLRMQELQRLPATMSEDLRLQAA 442
            .:.|.....|.:........:|.......|:|..:||..:.|..|:.||:.||:|..|||:.:..
plant    74 NKAPYGADLMGEFEDALLKQRPDCESGSRLIQLLDNRNKSHIQRRLSELEELPSTRGEDLQAKCL 138

  Fly   443 IELRALRVLNFQRQLR----MEF---VQCTRRDTTLET-------------------ALNIKLYK 481
            :||..|::...|.::|    .||   :.|.  |.:.:.                   |:......
plant   139 LELYGLKLRELQGKVRTAVSSEFWLRLNCA--DVSSQVFDWGMMRLPRPFYGVGDPFAMEADDQF 201

  Fly   482 RTKRQGLREARATEKLEKQQKLEAERKRRQKHLEFLAAVLQHGKDLREFHRNNKAQLAR---MNK 543
            |.|    |:|....:||:::|...|..:|:...|.|.||       |||....:|...|   .|.
plant   202 RKK----RDAERLSRLEEEEKNLIETAKRKFFAEVLNAV-------REFQLQIQATQKRRRQRND 255

  Fly   544 AVMNHHANAEREQKKEQERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAFLLSQTDEYISNLTQM 608
            .|...|.    .|::...|.||.|:..|.::|:|.|.||:.:.|::||..||.:|::.::||...
plant   256 GVQAWHG----RQRQRATRAEKLRLMALKSDDQEAYMKLVKESKNERLTTLLEETNKLLANLGAA 316

  Fly   609 VKQHKDDQMKKKEEEGKRLIQFKKELLMSGEYIGIDEGSIVADMRVHVVEQCTGKKLTGDDAPML 673
            |::.||    .|..||..|::              |..|.::::                |||
plant   317 VQRQKD----AKLPEGIDLLK--------------DSESDLSEL----------------DAP-- 345

  Fly   674 KHLHRWLNMHPGWDWIDDEEDSCGSNDDHKPKVEEQPTATEDATDKAQATGNDEDAKDLITKAKV 738
                   ...|..|.:.|::.....:|                        |::|:.||:
plant   346 -------RSEPLQDLLPDQDIDITESD------------------------NNDDSNDLL----- 374

  Fly   739 EDDEYRTEEQTYYSIAHTIHEKVVEQASIMVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLG 803
                  ..::.|.|..|:|.|||.||.|::..|.|:.||::||:|:|||:|||||||||||||||
plant   375 ------EGQRQYNSAIHSIQEKVTEQPSLLEGGELRSYQLEGLQWMVSLFNNNLNGILADEMGLG 433

  Fly   804 KTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQNQMR 868
            ||||||||:.||::.|.|.|||||:.|.:.|||||.||..|.|::....|.|..:.|:.::.::.
plant   434 KTIQTISLIAYLLENKGVPGPYLIVAPKAVLPNWVNEFATWVPSIAAFLYDGRLEERKAIREKIA 498

  Fly   869 AT-KFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTP 932
            .. |||||:|.|:.:::|||.|.||:|.|||:|||||:|||...|.:.|.|.|....||||||||
plant   499 GEGKFNVLITHYDLIMRDKAFLKKIEWYYMIVDEGHRLKNHESALAKTLLTGYRIKRRLLLTGTP 563

  Fly   933 LQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLR 997
            :||.|.|||:|||||||.||.|...||:|||||||..| .|.|.:||.:|||.|||.|:|||:||
plant   564 IQNSLQELWSLLNFLLPHIFNSVQNFEEWFNAPFADRG-NVSLTDEEELLIIHRLHHVIRPFILR 627

  Fly   998 RLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEKG-KHGKGGAKALMNTIVQL 1061
            |.|.|||..||.|.:.|:||||||.|:|.||.       :||....| :.|.|.:|:|.|..:||
plant   628 RKKDEVEKFLPGKTQVILKCDMSAWQKVYYKQ-------VTDMGRVGLQTGSGKSKSLQNLTMQL 685

  Fly  1062 RKLCNHPFMFQHIEEKYCDHTGG-HGVVSGPDLYRVSGKFELLDRILPKLKATNHRVLLFCQMTQ 1125
            ||.||||::|          .|| :.:...|::.|.|||||||||:||||:...||:|||.|||:
plant   686 RKCCNHPYLF----------VGGDYNMWKKPEIVRASGKFELLDRLLPKLRKAGHRILLFSQMTR 740

  Fly  1126 CMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVV 1190
            .:.::|.||....:.|||||||||.:.||.||::||...|..|:||||||||||||||||||||:
plant   741 LIDVLEIYLTLNDYKYLRLDGTTKTDQRGLLLKQFNEPDSPYFMFLLSTRAGGLGLNLQTADTVI 805

  Fly  1191 IFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQK 1255
            ||||||||..|.||:||||||||:.||||..|::|.||||.||..|:.|:.:|.||||||:|:..
plant   806 IFDSDWNPQMDQQAEDRAHRIGQKKEVRVFVLVSVGSVEEVILERAKQKMGIDAKVIQAGLFNTT 870

  Fly  1256 STGSERQQFLQTILHQDDNEEEEENEVPDDEMINMMIARSEEEIEIFKRMDAERKKEDEEIHPGR 1320
            ||..:|::.|:.|:.:  .......:||.:..||.:.||||:|..:|:|||.||::::..    |
plant   871 STAQDRREMLEEIMRK--GTSSLGTDVPSEREINRLAARSEDEFWMFERMDEERRRKENY----R 929

  Fly  1321 ERLIDESELPDWLTKDDDEVE-----RFHYQYDEDTILGRGSRQRKEVDYTDSLTEKEWLKAIDD 1380
            .||:.|.|:|:|......:.|     :||:    .::.|:  |:|||:.|:|:|:|.:||||::.
plant   930 ARLMQEQEVPEWAYTTQTQEEKLNNGKFHF----GSVTGK--RKRKEIVYSDTLSELQWLKAVES 988

  Fly  1381 G---------------------------------------AEFDEEEEEDDSKR----KRRKRKN 1402
            |                                       :|.||||:|::..:    |:|..|:
plant   989 GEDLSKLSMRYNRREENASNTKTSTSKKVIESIQTVSDGTSEEDEEEQEEERAKEMSGKQRVDKS 1053

  Fly  1403 RKEESD-----DDSLILKRRRRQNLDKRSK 1427
            .:||.:     |...|.|....:.  |||:
plant  1054 EEEEEEGEEENDGKAIFKWNTHKK--KRSR 1081

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	172..202	CDD:214931
		Drf_FH1	251..390	CDD:283903	14/76 (18%)
		HSA	501..573	CDD:214727	21/74 (28%)
		BRK	649..693	CDD:197800	6/43 (14%)
		PHA02934	687..>824	CDD:165245	54/136 (40%)
		SNF2_N	776..1071	CDD:278600	167/296 (56%)
		DEXDc	793..932	CDD:238005	76/139 (55%)
		Helicase_C	1097..1212	CDD:278689	77/114 (68%)
		SnAC	1304..1375	CDD:291293	24/75 (32%)
		Bromo_SNF2L2	1425..1530	CDD:99947	2/2 (100%)
ATCHR12	NP_187252.2	SNF2_N	406..695	CDD:278600	167/296 (56%)
		DEXDc	423..563	CDD:238005	76/139 (55%)
		Helicase_C	712..827	CDD:278689	77/114 (68%)
		SnAC	921..983	CDD:291293	21/71 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	321	1.000	Domainoid score	I277
eggNOG	1	0.900	-	-		E2759_KOG0386
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2308
Inparanoid	1	1.050	664	1.000	Inparanoid score	I154
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D685477at2759
OrthoFinder	1	1.000	-	-		FOG0001147
OrthoInspector	1	1.000	-	-		otm2826
orthoMCL	1	0.900	-	-		OOG6_101122
Panther	1	1.100	-	-	LDO	PTHR10799
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X702
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.830