DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brm and SYD

DIOPT Version :9

Sequence 1:	NP_001261906.1	Gene:	brm / 39744	FlyBaseID:	FBgn0000212	Length:	1658	Species:	Drosophila melanogaster
Sequence 2:	NP_001325348.1	Gene:	SYD / 817375	AraportID:	AT2G28290	Length:	3575	Species:	Arabidopsis thaliana

Alignment Length:	1789	Identity:	533/1789 - (29%)
Similarity:	790/1789 - (44%)	Gaps:	450/1789 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 NMSPYQT-----------HGMPPNAPTQPCIVSPGGPPGGPPPPERSSQENLHALQRAID-SMEE 150
            |..|||.           ||:...|....|:..|||     ...|.|...:|....:|:. |.|.
plant    48 NTMPYQVISRAMDTVVNQHGLDIEALKSSCLPHPGG-----TQTEDSGSAHLAGSSQAVGVSNEG 107

  Fly   151 KGL---QEDPRYSQLLAMR-------ATSKHQHLNGNQVNLLRTQITAYRLLARNKP-------- 197
            |..   .|..:|....:.|       |:......:|.|.|         |...|..|
plant   108 KATLVENEMTKYDAFTSGRQLGGSNSASQTFYQGSGTQSN---------RSFDRESPSNLDSTSG 163

  Fly   198 --------------------------ISMQMQQALQAAQ--------QQPPPGPPIGPPGAPGGP 228
                                      .|:...|.:..:|        .|......|..||..|
plant   164 ISQPHNRSETMNQRDVKSSGKRKRGESSLSWDQNMDNSQIFDSHKIDDQTGEVSKIEMPGNSG-- 226

  Fly   229 PPGSQHAGQPP---VPPQQQQQPPPSAGTPPQCSTPPASN-------PYGPPVPGQKMQ------ 277
            ...:.|.|...   ..||...|...:....|.....|.:|       |.|.|...|:::
plant   227 DIRNLHVGLSSDAFTTPQCGWQSSEATAIRPAIHKEPGNNVAGEGFLPSGSPFREQQLKQLRAQC 291

  Fly   278 ---------VAPPPPHMQ-------------QGQPLPPQ-----PPQVGGPPPI----QQQQPPQ 311
                     :.|...|::             :|:...|:     ...:||.|.:    .:...|.
plant   292 LVFLALRNGLVPKKLHVEIALRNTFREEDGFRGELFDPKGRTHTSSDLGGIPDVSALLSRTDNPT 356

  Fly   312 QQQQQSQPPPPEPHQHQLPNGGKPLSMGP-SGGQPL----IPSSPMQPQVRGT------LPGMPP 365
            .:..:......|..:.:|  |.|..:... |.||.|    ||||..|.||..:      .||:..
plant   357 GRLDEMDFSSKETERSRL--GEKSFANTVFSDGQKLLASRIPSSQAQTQVAVSHSQLTFSPGLTK 419

  Fly   366 GSQVPQPGGGPQRQVPPAGMPMPKPNRITTVAKPVGLDPI-----------------TLLQE--- 410
            .:        |...|...|  :.|.|.::|.|  |.||..                 |:.|:
plant   420 NT--------PSEMVGWTG--VIKTNDLSTSA--VQLDEFHSSADEEEGNLQPSPKYTMSQKWIM 472

  Fly   411 ---------------RENRIAARISLRMQELQRLPATMSEDL--RLQAAIELRALRVLNFQRQLR 458
                           ::.:....|..|..||:. ..::|:|:  :.::.|||:.|::||.||:||
plant   473 GRQNKRLLVDRSWSLKQQKADQAIGSRFNELKE-SVSLSDDISAKTKSVIELKKLQLLNLQRRLR 536

  Fly   459 MEFVQCTRRDTTLETALNIKLYKRTKRQGLREARATEKLEKQQKLEAERKRRQKHLEFLAAVLQH 523
            .|||....:....:.. ::|.||:.|..  |..:..||.|::.|.|.:|:.|::..||...:..|
plant   537 SEFVYNFFKPIATDVE-HLKSYKKHKHG--RRIKQLEKYEQKMKEERQRRIRERQKEFFGGLEVH 598

  Fly   524 GKDLREFHRNNKAQLARMNKAVMNHHANAEREQKKEQERIEKERMRRLMAEDEEGYRKLIDQKKD 588
            .:.|.:..:..:.:|...|:.....|...||..:::.::|::|::..|...|.|||.:::...|.
plant   599 KEKLEDLFKVRRERLKGFNRYAKEFHKRKERLHREKIDKIQREKINLLKINDVEGYLRMVQDAKS 663

  Fly   589 KRLAFLLSQTDEYISNLTQMVKQHKDDQMKKKEEEGKRLIQFKKELLMSGEYIGIDEGSIVADMR 653
            .|:..||.:|::|:..|...:|:.|                    ||.|
plant   664 DRVKQLLKETEKYLQKLGSKLKEAK--------------------LLTS---------------- 692

  Fly   654 VHVVEQCTGKKLTGDDAPMLKHLHRWLNMHPGWDWIDDEEDSCGSNDDHKPKVEEQPTATEDATD 718
                                    |:.|                         |...|.|.:|||
plant   693 ------------------------RFEN-------------------------EADETRTSNATD 708

  Fly   719 KAQATGNDEDAKDLITKAKVEDDEYRTEEQTYYSIAHTIHEKVVEQASIMVNGTLKEYQIKGLEW 783
            ......| ||..|   :||    .|....:.||.:||:|.|.:.||.|.:|.|.|:|||:.||.|
plant   709 DETLIEN-EDESD---QAK----HYLESNEKYYLMAHSIKENINEQPSSLVGGKLREYQMNGLRW 765

  Fly   784 LVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAV 848
            |||||||:||||||||||||||:|.|||:.|||:.|...||:|::||.|.||.|..|...|||::
plant   766 LVSLYNNHLNGILADEMGLGKTVQVISLICYLMETKNDRGPFLVVVPSSVLPGWQSEINFWAPSI 830

  Fly   849 GVVSYKGSPQGRR-LLQNQMRATKFNVLLTTYEYVIK--DKAVLAKIQWKYMIIDEGHRMKNHHC 910
            ..:.|.|:|..|| |.:.|:...|||||||||||::.  |:..|:||.|.|:|||||||:||..|
plant   831 HKIVYCGTPDERRKLFKEQIVHQKFNVLLTTYEYLMNKHDRPKLSKIHWHYIIIDEGHRIKNASC 895

  Fly   911 KLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTG----E 971
            ||...|. ||::.:|||||||||||.|.|||||||||||:||.|...|.||||.||.:.|    |
plant   896 KLNADLK-HYVSSHRLLLTGTPLQNNLEELWALLNFLLPNIFNSSEDFSQWFNKPFQSNGESSAE 959

  Fly   972 KVELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVL 1036
            :..|:|||.:|||.|||:|||||:|||||.:||::||:|:|.:|:|:.||.|::|.|.::
plant   960 EALLSEEENLLIINRLHQVLRPFVLRRLKHKVENELPEKIERLIRCEASAYQKLLMKRVE----- 1019

  Fly  1037 LTDGSEKGKHGKGGAKALMNTIVQLRKLCNHPFMFQHIEEKYCDHTGGHGVVSGPDLYRVSGKFE 1101
                ...|..|...::|:.|::::||.:||||::.|...|:..:....|.:   |.:.|:.||.|
plant  1020 ----DNLGSIGNAKSRAVHNSVMELRNICNHPYLSQLHSEEVNNIIPKHFL---PPIVRLCGKLE 1077

  Fly  1102 LLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSD 1166
            :|||:|||||||:||||.|..||:.:.::||||..:.:.||||||.|...|||.|:..||..||.
plant  1078 MLDRMLPKLKATDHRVLFFSTMTRLLDVMEDYLTLKGYKYLRLDGQTSGGDRGALIDGFNKSGSP 1142

  Fly  1167 VFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEER 1231
            .|:||||.||||:|:|||.||||::||:||||..|||||.|||||||:.:|.|||..|||||||:
plant  1143 FFIFLLSIRAGGVGVNLQAADTVILFDTDWNPQVDLQAQARAHRIGQKKDVLVLRFETVNSVEEQ 1207

  Fly  1232 ILAAARYKLNMDEKVIQAGMFDQKSTGSERQQFLQTILHQDDNEEEEENEVPDDEMINMMIARSE 1296
            :.|:|.:||.:..:.|.||.||..::..:|:::|:::|.  ::::||:..|.||:.:|.:|||.|
plant  1208 VRASAEHKLGVANQSITAGFFDNNTSAEDRKEYLESLLR--ESKKEEDAPVLDDDALNDLIARRE 1270

  Fly  1297 EEIEIFKRMDAERKKEDEE-----IH-PGRERLIDESELPDWLTKDDD-----EVERFH------ 1344
            .||:||:.:|.:||:.:.|     :| ||.:.......:|..|..:||     |..:.:
plant  1271 SEIDIFESIDKQRKENEMETWNTLVHGPGSDSFAHIPSIPSRLVTEDDLKLLYETMKLNDVPMVA 1335

  Fly  1345 -------------------YQYDEDTILGRGSRQRKEVDYTDSLTEKEWLKAIDDGAEFDEEEEE 1390
                               :||      |||.|.|:...|.:.|||:|:.|..        :.|.
plant  1336 KESTVGMKRKDGSMGGLDTHQY------GRGKRAREVRSYEEKLTEEEFEKLC--------QTES 1386

  Fly  1391 DDSKRKRRKRKNRKEESDDDSLILKRRRRQNLDKRSKKQMHKIMSAVIKHNQDGRTLSEPFMKL- 1454
            .||.:.:.:...|...:|..::                        .::::.|....:.|...:
plant  1387 PDSPQGKGEGSERSLANDTSNI------------------------PVENSSDTLLPTSPTQAIT 1427

  Fly  1455 --------PSRQRLPDYYEIIK----RPVDIKKILQRIEDCKYADLNELEKDFMQLCQNAQIYNE 1507
                    |....|.:..:.||    ||....|.|..:      .|:.:.:  .|...||
plant  1428 VQPMEPVRPQSHTLKEETQPIKRGRGRPKRTDKALTPV------SLSAVSR--TQATGNA----- 1479

  Fly  1508 EASLIYLDSIALQKVFVGARQRITAAA---DAAAVAAGDNTG----------------EAHGNGG 1553
                  :.|.|....||.:.:|:.||:   .:.|:.:.|.:|                ...|.|.
plant  1480 ------ISSAATGLDFVSSDKRLEAASHPTSSLALTSPDLSGPPGFQSLPASPAPTPIRGRGRGR 1538

  Fly  1554 SDNSDNDDDDGGDDGSDDEEIATTSAAAVKMKLKLNKSLAS-APAT----PTQSSSNVS-----S 1608
            |...      |...|...|.:...|.:::..:.:...|||| |.||    |..:|..||     :
plant  1539 SRGR------GAGRGRRVEGVLHGSNSSITQRTETATSLASDAEATKFALPRSASEIVSRVPKAN 1597

  Fly  1609 GAATTSKKQTRRKRSQKKYTISDD-DDDDMDXLP 1641
            ..:|::..|.....|......||. .|.|:|..|
plant  1598 EGSTSNPDQVSPVHSATTALRSDKAADKDLDAPP 1631

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	172..202	CDD:214931	7/63 (11%)
		Drf_FH1	251..390	CDD:283903	35/193 (18%)
		HSA	501..573	CDD:214727	16/71 (23%)
		BRK	649..693	CDD:197800	2/43 (5%)
		PHA02934	687..>824	CDD:165245	60/136 (44%)
		SNF2_N	776..1071	CDD:278600	164/301 (54%)
		DEXDc	793..932	CDD:238005	79/141 (56%)
		Helicase_C	1097..1212	CDD:278689	71/114 (62%)
		SnAC	1304..1375	CDD:291293	24/106 (23%)
		Bromo_SNF2L2	1425..1530	CDD:99947	18/117 (15%)
SYD	NP_001325348.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	77	1.000	Domainoid score	I3124
eggNOG	1	0.900	-	-		E2759_KOG0386
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D685477at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101122
Panther	1	1.100	-	-	O	PTHR10799
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.780