|
Fly 10 PMPPPQAP----------------------SPMAPPSQSPAPSPHSPYPHQ--------QPGPLQ 44
|:|.|.:| |||:...|:.:|:..||.|.| .|||..
Mouse 94 PLPNPTSPGFQFGAQQRRFEHGSPSYIQVTSPMSQQVQTQSPTQPSPGPGQTLQNVRAGAPGPGL 158
Fly 45 G----PPPPG-------------HPGAYGHPMQHGPPG--QGPPGHHMPPHHQGMIF-------- 82
| .|..| .|.:.||.:....|| |...|..:...|.|...
Mouse 159 GICSNSPTGGFVDASVLVRQISLSPSSGGHFVFQEAPGLTQMAQGAQVQLQHSGAPITVRERRLS 223
Fly 83 -----SKGP--HMGMQMPP----TG--PNMSP--YQTHGMPPNAPT------------------- 113
|.|. |:|.|.|. || |..|| ..|..:||...:
Mouse 224 QPHAQSGGTIHHLGPQSPAAAGGTGLQPLASPNHITTASLPPQISSIIQGQLIQQQQQVLQGQPM 288
Fly 114 --------QPCIVSP--GGPPG----GPPPPERSSQENLHALQRAI--DSMEEKGLQEDPR---- 158
.|.::.| |||.. .||||...|:..:.....:: .||...|:::.|:
Mouse 289 NRSLGFERTPGVLLPGVGGPSAFGMTSPPPPTSPSRTTMPPGLSSVPLTSMGSSGMKKVPKKLEE 353
Fly 159 -------------------YSQLLAMRATSKH--------QHLNGNQVNLLRTQITAYRLL---- 192
|.::.|::...|. |||.||.::.|..:...|..|
Mouse 354 IPPASQEMAQMRKQCLDYHYKEMEALKEVFKEYLIELFFLQHLQGNMMDFLAFKKKHYAPLQAYL 418
Fly 193 ------------------ARNKPIS----------------------MQMQQALQAAQQQPPPGP 217
.:::.|: .:.||.:...:|...|..
Mouse 419 RQNDLDIEEEEEEEEEEEGKSEVINDEHQSLTGSLVVGPGSATEADPFKRQQVMPPTEQSKRPRL 483
Fly 218 PIGPPGAPGGPPPGSQHAGQPPVPPQQQQQPPPSAGTPPQCSTPPASN-------------PYGP 269
.:|.||.. .||.|.....|.||..|....|.|| ||.|:. ..||
Mouse 484 EVGHPGVV------FQHPGVNAGVPLQQLMPTVQGGMPP---TPQATQLTGQKQSQQQYDPSTGP 539
Fly 270 PVPGQKMQVAPPPPHMQQGQPLPP-QPPQVGGPPPIQ------------QQQPPQQQQQQSQP-P 320
||........||| |....||| ..|....|..:| |.|.|.:.||.:.| |
Mouse 540 PVQNAASLHTPPP---QLPARLPPASVPATALPSTLQFSQQSQMVEASTQLQIPVKTQQLNAPIP 601
Fly 321 PPEPHQHQLPNG--GKPLSMGPSGGQPLIPSSPMQPQVRGTLPGMPP-----------------G 366
.|.|.|...|:. .:|....|..|:..:.:|.:..|.:......|| .
Mouse 602 APLPSQLPAPSSQPAQPALHVPMPGKAQMQTSQLSSQTQTVASTRPPLDSAQPCQRSLPTSSSSS 666
Fly 367 SQVPQPGGGPQRQVPPAGMPMPKPNRITTVAKPVGLDPITLLQERENRIAARISLRMQELQRLPA 431
|.||..|.||... |....|:.:|:..|..| |.||| .|...:|.....:.|...:..|
Mouse 667 SLVPVSGSGPGPS-PARSSPVNRPSSATNKA----LSPIT---SRSPGVAVSAPPKPQSPAQNAA 723
Fly 432 TMSEDLRLQAAIELRALRVLNFQRQLRMEFVQCTRRDTTLETALNIKLYKRTKRQGLREARATEK 496
:..:..:.:.|.:: |||..::.:: ...:::||...|...|
Mouse 724 SSQDGSQDKLAEQI------------------------TLENQIHQRI-ADLRKEGLWSLRRLPK 763
Fly 497 LEKQQKLEAERKRRQKHLEFLAAVLQ-HGKDLREFHRNNKAQLARMNKAVMNHHANAEREQKKEQ 560
|: |..|.:.|.::|...:| ...|..:..|...|...::.:.|..|| .|:|..:
Mouse 764 LQ-------EAPRPKSHWDYLLEEMQWMATDFAQERRWKLAAAKKLVRTVARHH----EEKKLRE 817
Fly 561 ERIEKE---RMRRL---MAEDEEGYRKLIDQKKDKRLAFLLSQTDEYISNLTQMVKQHKDDQMK- 618
||.:|| |:||: .|.:.|.:...|:|..:.:|...|.:..:...||.::.::.|:.::|
Mouse 818 ERGKKEEQSRLRRIAATTAREIEYFWSNIEQVVEIKLQVELEEKRKKALNLQKVSRRGKESRLKG 882
Fly 619 ---------------KKEEEGKRLIQFKKELLMSGEYIGIDEGSIVADMRVH--VVEQCTGKKLT 666
:|.:....|...:.| ||...:.:...| :|:..| :||
Mouse 883 FDTSPEHSLDLGISGRKRKASTSLTDDEVE----------DEEETIEEEEAHEGLVDHHT--ELT 935
Fly 667 G----DDAPMLKHLHRWLNMH-PGWDWID---DEEDSCGSNDDHKPKVEEQPTATEDATDKAQAT 723
. .:.|::..:..:.... |.:.|.. |.|:|.|..| ||:.|:..|...|..
Mouse 936 NLAKEAELPLIDLMKLYEGAFLPNFQWPQPEPDHEESSGEED-----VEDCPSDRESRRDSV--- 992
Fly 724 GNDEDAKDLITKAKVEDDEYRTEEQTYYSIAHT--------IHEKVVEQASIMVN---------- 770
||....:. |:::..|:.....::| :.|.::.:.|..|.
Mouse 993 --------LIDSLFIM-DQFKAAERMSIGKSNTKDITEVTAVAEAILPKGSARVTTAVKFSAPSL 1048
Fly 771 --GTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLST 833
|.|::||..||:||..||..|||||||||.|||||:|.|:...:|...:...||:|:::....
Mouse 1049 LYGALRDYQKIGLDWLAKLYRKNLNGILADEAGLGKTVQIIAFFAHLACNEGNWGPHLVVMRSCN 1113
Fly 834 LPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQNQMRATK---FNVLLTTYEYVIKDKAVLAKIQWK 895
:..|.||.::|.|.:..:||.|| .|.|...:...|: |::.:|:|:...:.....:::.||
Mouse 1114 ILKWELELKRWCPGLKTLSYVGS--HRELKAKRQEWTEPNNFHICITSYKQFFRGYTAFSRVHWK 1176
Fly 896 YMIIDEGHRMKNHHCKLTQVLNTHYIAPY------RLLLTGTPLQNKLPELWALLNFLLPSIFKS 954
.:::||..|:|. :...|:.|.: ||||...||.|...|||.:::||:|.|.:.
Mouse 1177 CLVVDEMQRVKG-------MTERHWEAIFKLQSQQRLLLIDVPLHNTFLELWTMVHFLIPGISRP 1234
Fly 955 CSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDM 1019
..:| |.....|: |::....::.|||:|.:||:|||.|::||.||..|.|:::||.:
Mouse 1235 YLSF------PLKAPNEE---NQDYYHKMVIRLHRVTQPFILRRTKRDVEKQLTRKYEHVLKCRL 1290
Fly 1020 SALQRVLYKHMQSKGVLLTDGSEKGKHGKGGAKALMNTIVQLRKLCNHPFMFQ------------ 1072
|:.|:.|| :.|:|...:::... .|...::::.:.:|:::||||.:.:
Mouse 1291 SSRQKALY-----EDVILQPRTQEALK-SGHFVSVLSVLTRLQRICNHPGLVEPRVPGSSFAAGS 1349
Fly 1073 -------------------------------------HIEEKYC--------------------- 1079
|..|..|
Mouse 1350 LQYKSASLILRVLEREFWKETDLSIFDLIGLENKITRHEAELLCKKKVTRKLMEEVFASPPPSAR 1414
Fly 1080 ---------------------------------------------------------------DH 1081
|.
Mouse 1415 PAAVKLKASRLFQPVQYGQKPEGRTVAFPSTHPPRMANTNTSTATPQGQVRGRPPIATFSANPDT 1479
Fly 1082 TGGHGV----------------------------------------------------------- 1087
.||..|
Mouse 1480 KGGEVVKIAQLASIAGPQSRVAQPETPVTLQFQGNKFTLSHSQLRQLTAGQPLQLQGSVLQIVSA 1544
Fly 1088 --------------------------------VSGP----------------------------- 1091
.|||
Mouse 1545 PGQPYLRAPGPVVMQTVSQAGAVHSTLGSKPPTSGPSPAPLTPQVGVPGRVAVSAMAVGEPGLAS 1609
Fly 1092 -----------------------------------------DLYRV------------------- 1096
||.|:
Mouse 1610 KPASPAAGPTQEEKSRLLKERLDQIHFINERRCSQAPVYGRDLLRICSLPGRRKRPLCWSLDSNF 1674
Fly 1097 ----------------------------------------------------------------- 1096
Mouse 1675 GKGPKGVNYDMSLSKSEGDLILTLSQESLQDVLGRVACVIPPVVATPPSLWVARPPSLYSSRLRA 1739
Fly 1097 ------------------------------------SGKFELLDRILPKLKATNHRVLLFCQMTQ 1125
|||.|.|..:|.|||:...|||:..||..
Mouse 1740 LRQCLREHTGPYHRQLQQLTALRSLQFPELRLVQFDSGKLEALAILLQKLKSEGRRVLILSQMVL 1804
Fly 1126 CMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVV 1190
.:.|:|.:|.:....|:|:|....:|.|.||:|.|| :...:|..||||.:...|:||..|||||
Mouse 1805 MLDILEMFLNFHYLTYVRIDENANSEQRQELMRSFN-RDRRIFCALLSTHSRATGINLVEADTVV 1868
Fly 1191 IFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQK 1255
.:|:|.||..|.:||:...|||:..::.:.||::.||:||::|......| :.|...|...:...
Mouse 1869 FYDNDLNPVMDAKAQEWCDRIGRCKDIHIYRLVSGNSIEEKLLKNGTKDL-IREVAAQGNDYSMA 1932
Fly 1256 -STGSERQQFLQTILHQDDN----EEEE----ENEVPDDEMINMMIARS-EEEIEIFKRMDAERK 1310
.|....|:..:.....||. :.|| ..|....|.|...|||. .|.::..:.::.:.:
Mouse 1933 FLTQRTIQELFEVYSPMDDTGFPVKAEEFVVLSQEPSVSETIAPKIARPFIEALKSIECLEEDAQ 1997
Fly 1311 KEDEEIHPGRERLIDESELPDWLTKDDDEVERFHYQYDEDTILGRGSRQRKEVDYTDSLTEKE-- 1373
:..||..||...:. ::.|.| ..:|||:. |:..:..|:.:.||..|
Mouse 1998 RSTEEAVPGSSSVA--------VSSDSD-----GSRYDEEP-----SQLEELADFMEQLTPIEKY 2044
Fly 1374 ---WLKAIDDGAEFDEEEEEDD------------SKRKRRKRKNR----KEES------------ 1407
:|:......|.::|...:| :.|..::|:.| :||:
Mouse 2045 ALNYLELFHTTTEQEKERISEDLVMASMKDWETRNARALQEREARLQLEQEEAELLTYTREDAYT 2109
Fly 1408 -------------------------DDDSL------------------------ILKRRRRQNLD 1423
||:.: :.|.|:|...|
Mouse 2110 MEYVYEDADGQTEVMPLWTPPTPPQDDNDIYIDSVMCLMYETTPIPEAKLPPVYVRKERKRHKTD 2174
Fly 1424 K----RSKKQMH------------KIMSAVIKHNQDGRTLSEPFM---KLPSRQRLPDYYEIIKR 1469
. |.|||.| :....::|..::|:...:..: :.|..:.||.|.:....
Mouse 2175 PSAAGRKKKQRHGEAVVPPRSLFDRATPGMLKIRREGKEQKKNLLLKQQTPFAKPLPTYVKSSGE 2239
Fly 1470 PVDIK---------KILQRIEDCKYADLN------------ELEKDFMQLC-------------- 1499
|.... .:||.::......|| :|..|.:..|
Mouse 2240 PAQDSPDWLIGEDWALLQAVKQLLELPLNLTIVSPAHTPNWDLVSDVVNSCSRIYRSSKQCRNRY 2304
Fly 1500 ------------------QNAQIY----NEEASLIYLDSIALQKVFVGAR 1527
:.:||| |...:.:|.....|.|:..|.|
Mouse 2305 ENVIIPREEGKSKNNRPLRTSQIYAQDENATHTQLYTSHFELMKMTAGKR 2354
| 
