DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brm and smarca2

DIOPT Version :9

Sequence 1:	NP_001261906.1	Gene:	brm / 39744	FlyBaseID:	FBgn0000212	Length:	1658	Species:	Drosophila melanogaster
Sequence 2:	XP_031746549.1	Gene:	smarca2 / 734002	XenbaseID:	XB-GENE-1013843	Length:	1606	Species:	Xenopus tropicalis

Alignment Length:	1743	Identity:	886/1743 - (50%)
Similarity:	1110/1743 - (63%)	Gaps:	265/1743 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MPPPQAPSPMAPPSQSPAPSPHSPYPHQQPGPLQGPPP-PG-HPGAYGHPMQHGPPGQGPPG--- 70
            |..|..|..|..|..||.|.|       .|||:.||.| || .||:. |.|.  .|..|||.
Frog     1 MATPTDPGAMPHPGPSPGPGP-------SPGPILGPSPGPGLSPGSV-HSMM--GPSPGPPSVTH 55

  Fly    71 ---------------HHMPPHHQGM--IFSKG-----------------PHMGMQMPPTGP---- 97
                           |.|  |.|.|  :..||                 ||.||. ||..|
Frog    56 QLSNMGSSDYAPESIHQM--HKQPMDNMHEKGISDDLHCGTLKSSSMRPPHTGMG-PPQSPMDQH 117

  Fly    98 ---NMSPYQTHGMPPNAPTQPCIVSPGGPPGGPPPPERSSQENLHALQRAIDSMEEKGLQEDP-- 157
               .|||   |..|..||..  :.||....|||.||:      :...|..:....|..:...|
Frog   118 SQGYMSP---HPSPLGAPEH--VSSPISSGGGPTPPQ------IPPAQPGLMIQGEPQVMSQPTR 171

  Fly   158 ---RYSQLLAMRATSKHQHLNGNQVNLLRTQITAYRLLARNKPISMQMQQALQ------AAQQQP 213
               .:||:               |::.||.||.||::|||.:|:|..:|.|:|      |.|||.
Frog   172 GPSAFSQV---------------QLHQLRAQILAYKMLARGQPLSENLQLAVQGKRTLPAVQQQQ 221

  Fly   214 PPGPPIGPPGAPGGPPPGSQHAGQPPVPPQQQQQPPPSAGTPPQCSTPPASNPYGPPVPGQKMQV 278
                              .|...|.....|||.|..|||    ..|.||:...:..||
Frog   222 ------------------QQQQQQQQQQQQQQSQQQPSA----TYSRPPSMAMHAMPV------- 257

  Fly   279 APPPPHMQQGQPLPPQPPQVGGPPP------IQQQQPPQQQQQQSQPPPPEPHQHQLPNGGKPLS 337
                            ||...||.|      ....|.|..:..||.       ...:||..:.|.
Frog   258 ----------------PPAGAGPAPGITGHVAGMMQKPWGEAGQSS-------DLNVPNAQQKLV 299

  Fly   338 MGPSGGQPLIPSSPMQPQVRGTLPGMPPGSQVPQPGGGPQRQVPPAGMPMP-----KPNRITTVA 397
            :.|..|:|    || .||.      .||...:|    ||....|..|.|.|     |.|||:.:.
Frog   300 VPPPSGRP----SP-APQT------APPSVSLP----GPSVPQPTPGQPAPIQLQQKQNRISPIQ 349

  Fly   398 KPVGLDPITLLQERENRIAARISLRMQELQRLPATMSEDLRLQAAIELRALRVLNFQRQLRMEFV 462
            ||.||||:.:|||||.|:.|||:.|:|||:.||.::..|||.:|.:||:|||:||||||||.|.|
Frog   350 KPQGLDPVEILQEREYRLQARIAHRIQELENLPGSLPPDLRTKATVELKALRLLNFQRQLRQEVV 414

  Fly   463 QCTRRDTTLETALNIKLYKRTKRQGLREARATEKLEKQQKLEAERKRRQKHLEFLAAVLQHGKDL 527
            .|.|||||||||||.|.|||:|||.|||||.|||||||||:|.||||||||.|:|.::|||.||.
Frog   415 ACMRRDTTLETALNSKAYKRSKRQTLREARMTEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDF 479

  Fly   528 REFHRNNKAQLARMNKAVMNHHANAEREQKKEQERIEKERMRRLMAEDEEGYRKLIDQKKDKRLA 592
            :|:||:...::.:::|||...|||.|||||||.||||||||||||||||||||||||||||:|||
Frog   480 KEYHRSVTGKIQKLSKAVATWHANTEREQKKETERIEKERMRRLMAEDEEGYRKLIDQKKDRRLA 544

  Fly   593 FLLSQTDEYISNLTQMVKQHKDDQMKKKEEEGKRLIQFKKELLMSGEYIG---------IDEGSI 648
            :||.|||||::|||.:|.:||..|..|::::.|:    ||:...:.|.:|         |||.|.
Frog   545 YLLQQTDEYVANLTSLVWEHKKAQAAKEKKKKKK----KKKAEENAEGVGSGLGMDGELIDESSQ 605

  Fly   649 VADMRVHVVEQCTGKKLTGDDAPMLKHLHRWLNMHPGWDWIDDEEDSCGSNDDHKPKVEEQPTAT 713
            ::|:.|.|:...|||.|...:||....|..||.|:||:: :....||.||:.:::.:.:|:.::.
Frog   606 MSDLPVKVIHTETGKVLLAPEAPKASQLETWLEMNPGYE-VAPRSDSEGSSSEYEEEEDEEESSR 669

  Fly   714 EDATDKAQATGNDE-----DAKDLITKAKVE-DDEYRTEE-----QTYYSIAHTIHEKVVEQASI 767
            .|..:|.:...|.|     |||.:|..||.: ||||..:|     |:||.:||.:.|:|.:|:|:
Frog   670 LDTEEKKRLGLNTEDNVKHDAKQIIETAKQDVDDEYSMQEDARQSQSYYGVAHAVTERVEKQSSL 734

  Fly   768 MVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLS 832
            ::||:||.|||:||||:|||:|||||||||||||||||||||:|:||||:.|::.||||||||||
Frog   735 LINGSLKHYQIQGLEWMVSLFNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLS 799

  Fly   833 TLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQNQMRATKFNVLLTTYEYVIKDKAVLAKIQWKYM 897
            ||.||:.||:||||:|..::|||:|..||.|..|:|..|||||||||||:||||.:||||:||||
Frog   800 TLSNWLYEFDKWAPSVVKIAYKGTPAMRRSLVPQLRTGKFNVLLTTYEYIIKDKHILAKIRWKYM 864

  Fly   898 IIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWF 962
            |:|||||||||||||||||||||:||.|:|||||||||||||||||||||||:||||||||||||
Frog   865 IVDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWF 929

  Fly   963 NAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLY 1027
            |||||.|||:|:||||||||||||||||||||||||||||||.|||:||||:|||||||||::||
Frog   930 NAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDMSALQKILY 994

  Fly  1028 KHMQSKGVLLTDGSEKGKHGKGGAKALMNTIVQLRKLCNHPFMFQHIEEKYCDHTG-GHGVVSGP 1091
            :|||:||:||||||||.|.||||||.|||||:||||:|||||:||||||.:.:|.| .:|:::||
Frog   995 RHMQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPFIFQHIEESFAEHLGYSNGIINGP 1059

  Fly  1092 DLYRVSGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGEL 1156
            ||||.||||||||||||||:|||||||||||||..|||:|||..:|.|.|||||||||:|||..|
Frog  1060 DLYRTSGKFELLDRILPKLRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTTKSEDRASL 1124

  Fly  1157 LRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLR 1221
            |::||.:||..|:|||||||||||||||.||||||||||||||||||||||||||||:|||||||
Frog  1125 LKRFNEEGSPFFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLR 1189

  Fly  1222 LMTVNSVEERILAAARYKLNMDEKVIQAGMFDQKSTGSERQQFLQTIL-HQDDNE---------- 1275
            |.|||||||:|||||:||||:|:||||||||||||:..||:.|||.|| |::.||
Frog  1190 LCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQNESQKKDDLSGD 1254

  Fly  1276 ------EEEENEVPDDEMINMMIARSEEEIEIFKRMDAERKKEDEEIHPGRE-RLIDESELPDWL 1333
                  .:||:||||||.:|.||||.|||.|:|.|||.:|::||.. :|.|: ||::|.:||.|:
Frog  1255 ISQEGASQEEDEVPDDETLNQMIARHEEEFELFMRMDLDRRREDAR-NPNRKPRLMEEDDLPSWI 1318

  Fly  1334 TKDDDEVERFHYQYDEDTILGRGSRQRKEVDYTDSLTEKEWLKAIDDGAEFDEEEEEDDSKRKRR 1398
            .|||.||||...:.:|:.|.|||||||::|||:|:||:|:||:||:||...:.|||....|||||
Frog  1319 IKDDAEVERLTCEEEEEKIFGRGSRQRRDVDYSDALTDKQWLRAIEDGNLEEMEEEVRLKKRKRR 1383

  Fly  1399 KRKNRKEESDDDSLILKRRRRQNLDKRS------KKQMHKIMSAVIKH-NQDGRTLSEPFMKLPS 1456
            :..::....:|.....|||.|...:|.|      .|||:.::..||.: :.:||.|||.|::|||
Frog  1384 RNVDKDVVKEDGEKTKKRRGRPPAEKLSPNPPKLTKQMNAVVDTVINYKDSNGRQLSEVFIQLPS 1448

  Fly  1457 RQRLPDYYEIIKRPVDIKKILQRIEDCKYADLNELEKDFMQLCQNAQIYNEEASLIYLDSIALQK 1521
            |:.||:|||:|::|||.|||.:||.:.||..:::||||.|.||.|||.:|.|.|.||.|||.||.
Frog  1449 RKELPEYYELIRKPVDFKKIKERIRNHKYRSISDLEKDIMLLCHNAQTFNLEGSQIYEDSIVLQS 1513

  Fly  1522 VFVGARQRITAAADAAAVAAGDNTGEAHGNGGSDNSDNDDDDGGDDGSDDEEIATTSAAAVKMKL 1586
            ||..|||:|..                     .|.|:.:.:|..||..|||  :.:.:.:||:|:
Frog  1514 VFRSARQKIVK---------------------EDESEEESNDEEDDDEDDE--SESESKSVKVKI 1555

  Fly  1587 KLNKSLASAPATPTQSSSNVSSGAATTSKKQTRRKRSQKKYTISD-DDDDDMD 1638
            ||:|.               ........|.:.|:.|.:.|..:|| |.::|.:
Frog  1556 KLSKK---------------DDKTREKGKGKKRQSRGKAKPVVSDYDSEEDQE 1593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	172..202	CDD:214931	12/29 (41%)
		Drf_FH1	251..390	CDD:283903	35/149 (23%)
		HSA	501..573	CDD:214727	45/71 (63%)
		BRK	649..693	CDD:197800	15/43 (35%)
		PHA02934	687..>824	CDD:165245	70/147 (48%)
		SNF2_N	776..1071	CDD:278600	241/294 (82%)
		DEXDc	793..932	CDD:238005	105/138 (76%)
		Helicase_C	1097..1212	CDD:278689	94/114 (82%)
		SnAC	1304..1375	CDD:291293	37/71 (52%)
		Bromo_SNF2L2	1425..1530	CDD:99947	57/111 (51%)
smarca2	XP_031746549.1	PHA03378	<83..399	CDD:223065	120/409 (29%)
		QLQ	175..209	CDD:400990	16/48 (33%)
		HSA	453..525	CDD:214727	45/71 (63%)
		BRK	606..648	CDD:400080	15/42 (36%)
		PLN03142	697..>1218	CDD:215601	402/520 (77%)
		DEXHc_SMARCA2	717..967	CDD:350821	195/249 (78%)
		SnAC	1294..1360	CDD:405324	34/66 (52%)
		Bromo_SNF2L2	1416..1522	CDD:99947	56/105 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	498	1.000	Domainoid score	I356
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2308
Inparanoid	1	1.050	1572	1.000	Inparanoid score	I88
OMA	1	1.010	-	-		QHG52479
OrthoDB	1	1.010	-	-		D41262at33208
OrthoFinder	1	1.000	-	-		FOG0001147
OrthoInspector	1	1.000	-	-		otm49003
Panther	1	1.100	-	-	O	PTHR10799
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X702
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	11.080