Protein Alignment brm and rad54l2

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: NP_001076824.1
• Gene: rad54l2 / 733747
• XenbaseID: XB-GENE-5829376
• Length: 1396
• Species: Xenopus tropicalis
• Alignment Length: 1001
• Identity: 231/1001 - (23%)
• Similarity: 390/1001 - (38%)
• Gaps: 296/1001 - (29%)

  Fly   553 EREQKKEQER------------IEKERMRRLMAED-----EEGYRKLI---------DQKKDKRL 591
            |.|:::|.|.            |.::.....:.||     |||:::..         |:.|.|||
 Frog    30 EEEEEEEDEEDNDGDDEDDKQDINEKSQNAALGEDSPEQGEEGWKRSTTSGQSGQESDEAKKKRL 94

  Fly   592 ---AFL------LSQTDEYISNLTQMVKQHKDDQMKKKEEEGKRL----------IQFKKELLMS 637
               |.|      |.:.|: :.::|:..:|.:.::.|:.|::.|..          :.|.:|.:
 Frog    95 QKPANLRRNIRKLLREDQ-LESVTKTAQQEELERRKRLEQQRKDYPLPLTLPPVSLDFLQEEI-- 156

  Fly   638 GEYIGIDEGSIVADMRVHVVEQCTGKKLTGDDAPMLKHLHRWLNMHPGWDWIDDEEDSCGSNDDH 702
             |....|...:|....:..::..:|:.                         |||    |....|
 Frog   157 -ELRAADVSQLVKSQEIICLDSSSGES-------------------------DDE----GKVKSH 191

  Fly   703 --KPKVEEQPTATED---ATDKAQATGNDEDAKDLITK---AKVEDDEYRTEE--QTYYSIAHTI 757
              |.::.|..:..||   .:|.|.:| |:.|. |:.|:   :.|.|...:.:.  :...:|.|..
 Frog   192 SIKDEIIELSSGEEDNLQISDNADST-NEVDG-DITTENSGSHVNDALNQADHLGRVLVNINHPP 254

  Fly   758 HEKVVEQASIMVNGTLKEYQIKGLEWLVSLYNNNLNG------------ILADEMGLGKTIQTIS 810
            :||.:..|..:.. .:|.:||.|:.:   ||:|.:..            |||..||||||:|.||
 Frog   255 NEKDIFLAPQLAR-AVKSHQIGGIRF---LYDNLVESLERFSGSSGFGCILAHSMGLGKTLQVIS 315

  Fly   811 LVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQNQMRATKFN-- 873
            .:..|....... ..|.|||::||.||:.||..|.|..     :..|:.......|.||.|.:
 Frog   316 FLDVLFQHTSAK-TVLAIVPVNTLQNWLAEFNMWLPPP-----ESLPKDHNQELVQPRAFKVHTM 374

  Fly   874 ----------------------VLLTTYEY------------------------VIKD------- 885
                                  |||..||.                        ||.|
 Frog   375 NDEHKTTAARAKVVNDWATDGGVLLMGYEMYRLLSLKKSFTAGRKKKSKKAAGPVIIDLDEEDRQ 439

  Fly   886 -------KAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWAL 943
                   :..|::.....:|.|||||:||.|...:|.|. :..:..|::|||.||||.|.|.|.:
 Frog   440 QEMLKGIEKALSRPGPDVVICDEGHRIKNCHASTSQALK-NIRSRRRVVLTGYPLQNNLIEYWCM 503

  Fly   944 LNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILIIRR---LHKVLRPFLLRRLKKEVEH 1005
            ::|:.|....:...|...|..|. ..|:.|:...::..|:..|   ||.:|..|:.||....::.
 Frog   504 VDFVRPDFLGTRQEFSNMFERPI-LNGQCVDSTPQDKRLMRYRSHVLHSLLEGFVQRRGHTVLKA 567

  Fly  1006 QLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEKGKHGKGGAKALMNTIVQLRKLCNHP-F 1069
            |||.|.|::|...:|.:||.||....::   ..|....|..|....||.....    |:.||| .
 Frog   568 QLPFKEEHVILVRLSKIQRDLYTEFMNR---FRDAGNSGWLGLNPLKAFCVCC----KIWNHPDV 625

  Fly  1070 MFQHIEEK-----------------YCDHTGG----------------------HGVVSGPDLYR 1095
            :::.::::                 .|:...|                      .|:|..|...:
 Frog   626 LYEALQKENLANEQDLDVEDLGTNNRCNAQSGKIKVEPNSLGALMGETAHTKQLQGIVLNPSHEK 690

  Fly  1096 V-----------------------SGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLG-- 1135
            .                       |.|..||..::.:......::|:|.|....::|:|::|.
 Frog   691 ANQVVTYEWAKEILSDYIPGQLQNSPKMVLLFHLIEESMRMGDKILVFSQSLSTLSIMEEFLAKR 755

  Fly  1136 ---------------W-RQFGYLRLDGTTKAEDRGELLRKFNAKGSD-VFVFLLSTRAGGLGLNL 1183
                           | |...|.||||:|.|.:|..|:.:||...:: |::||||||||.||:||
 Frog   756 KMPIPAGSDGQEGHTWIRNVNYYRLDGSTSASERERLINQFNDPSNEKVWLFLLSTRAGCLGVNL 820

  Fly  1184 QTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQ 1248
            ..|:.||:||:.|||..|.||..|.:|.|||....:.||::..::|::|......|..|.::|:.
 Frog   821 IGANRVVVFDASWNPCHDAQAVCRVYRYGQRKPCYIYRLVSDFTLEKKIYDRQITKQGMSDRVVD 885

  Fly  1249 AGMFDQKSTGSERQQFLQTILHQDDNEEEEENEVPDDEMI------------------------N 1289
                |.....:..::.::.:||..:.|.:...:..|....                        :
 Frog   886 ----DLNPEVNFTRREVENLLHFVEEEPDASRQHLDSSSFHEAVLQKACLQYPHLITKEPFQHES 946

  Fly  1290 MMIARSEEEIEIFKRMDAERKKEDEE 1315
            :::.|.|:::.:.::..|:|..|:|:
 Frog   947 LLLDRKEQKLTLAEKKAAKRGYEEEK 972

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580
		PTZ00121	<477..651	CDD:173412	29/142 (20%)
		HSA	501..573	CDD:214727	5/31 (16%)
		BRK	650..691	CDD:462196	1/40 (3%)
		PLN03142	739..>1368	CDD:215601	184/762 (24%)
		Bromo_SNF2L2	1425..1530	CDD:99947
rad54l2	NP_001076824.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..103		17/72 (24%)
		DEXHc_ARIP4	269..545	CDD:350827	76/286 (27%)
		HepA	<272..885	CDD:440319	166/630 (26%)
		DEAH box	461..464		2/2 (100%)
		LXXLL motif 1	549..553		2/3 (67%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1117..1168
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1194..1250
		LXXLL motif 2	1273..1277
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1340..1396