DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment brm and Smarca2

DIOPT Version :9

Sequence 1:	NP_001261906.1	Gene:	brm / 39744	FlyBaseID:	FBgn0000212	Length:	1658	Species:	Drosophila melanogaster
Sequence 2:	XP_006527344.1	Gene:	Smarca2 / 67155	MGIID:	99603	Length:	1601	Species:	Mus musculus

Alignment Length:	1744	Identity:	891/1744 - (51%)
Similarity:	1103/1744 - (63%)	Gaps:	276/1744 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ASPSPANSPMPPPQAPSPMAPPSQSPAPSPHSPYPHQQPGPLQGPPPPGHP----GAYGHPMQ-- 60
            |.|.|..||.|.| :|.|:..||..|.|||.|  .|...||..|||...||    |:...|.:
Mouse     9 AMPHPGPSPGPGP-SPGPILGPSPGPGPSPGS--VHSMMGPSPGPPSVSHPLSTMGSADFPQEGM 70

  Fly    61 ---HGP---------------------------PGQGPPGHHMPPHHQGMIFSKGPH---MG--- 89
               |.|                           ||.|||...|..|.||.:   .||   :|
Mouse    71 HQLHKPMDGIHDKGIVEDVHCGSMKGTSMRPPHPGMGPPQSPMDQHSQGYM---SPHPSPLGAPE 132

  Fly    90 -MQMPPTGPNMSPYQTHGMPPNAPTQPCIVSPGGPPG------GPPPPERSSQENLHALQRAIDS 147
             :..|.:|...:|.|   ||   |:||..:.||.|..      ||.|
Mouse   133 HVSSPISGGGPTPPQ---MP---PSQPGALIPGDPQAMNQPNRGPSP------------------ 173

  Fly   148 MEEKGLQEDPRYSQLLAMRATSKHQHLNGNQVNLLRTQITAYRLLARNKPISMQMQQALQAAQQQ 212
                       :|.:               |::.||.||.||::|||.:|:...:|.|:|..:..
Mouse   174 -----------FSPV---------------QLHQLRAQILAYKMLARGQPLPETLQLAVQGKRTL 212

  Fly   213 PPPGPPIGPPGAPGGPPPGSQHAGQPPVPPQQQQQPPPSAGTPPQCSTPPASNPYGPPVPGQKMQ 277
                             ||.|...|.....|||||                          |:.|
Mouse   213 -----------------PGMQQQQQQQQQQQQQQQ--------------------------QQQQ 234

  Fly   278 VAPPPPHMQQGQPLPPQPPQVGGPPPIQQQQPPQQQQQQSQPP------PPEPHQHQLPNG---- 332
                   .||.|..|.||.|..      |.||.||||||.||.      |..|.|..|.:|
Mouse   235 -------QQQQQQQPQQPQQQA------QAQPQQQQQQQQQPALVSYNRPSGPGQELLLSGQSAP 286

  Fly   333 GKPLSMGPSGGQPLIPSSPMQPQVRGTLPGMPPGSQVPQPGGGPQRQVPPAGMPMP------KPN 391
            .|..:..|||.....|.:.:||    |...:|          ||..|.|..|.|.|      |.:
Mouse   287 QKLSAPAPSGRPSPAPQAAVQP----TATAVP----------GPSVQQPAPGQPSPVLQLQQKQS 337

  Fly   392 RITTVAKPVGLDPITLLQERENRIAARISLRMQELQRLPATMSEDLRLQAAIELRALRVLNFQRQ 456
            ||:.:.||.||||:.:|||||.|:.|||:.|:|||:.||.::..|||.:|.:||:|||:||||||
Mouse   338 RISPIQKPQGLDPVEILQEREYRLQARIAHRIQELESLPGSLPPDLRTKATVELKALRLLNFQRQ 402

  Fly   457 LRMEFVQCTRRDTTLETALNIKLYKRTKRQGLREARATEKLEKQQKLEAERKRRQKHLEFLAAVL 521
            ||.|.|.|.|||||||||||.|.|||:|||.|||||.|||||||||:|.||||||||.|:|.::|
Mouse   403 LRQEVVACMRRDTTLETALNSKAYKRSKRQTLREARMTEKLEKQQKIEQERKRRQKHQEYLNSIL 467

  Fly   522 QHGKDLREFHRNNKAQLARMNKAVMNHHANAEREQKKEQERIEKERMRRLMAEDEEGYRKLIDQK 586
            ||.||.:|:||:...::.:::|||...|||.|||||||.||||||||||||||||||||||||||
Mouse   468 QHAKDFKEYHRSVAGKIQKLSKAVATWHANTEREQKKETERIEKERMRRLMAEDEEGYRKLIDQK 532

  Fly   587 KDKRLAFLLSQTDEYISNLTQMVKQHKDDQMKKKEEEGKRLIQFKKELLMSGE-YIG-----IDE 645
            ||:|||:||.|||||::|||.:|.:||..|..|::::.:|..:..:|....|| .:|     |||
Mouse   533 KDRRLAYLLQQTDEYVANLTNLVWEHKQAQAAKEKKKRRRRKKKAEENAEGGEPALGPDGEPIDE 597

  Fly   646 GSIVADMRVHVVEQCTGKKLTGDDAPMLKHLHRWLNMHPGWDWIDDEEDSCGSNDDHKPKVEEQP 710
            .|.::|:.|.|....|||.|.|.:||....|..||.|:||:: :....||..|..|::.:.||:.
Mouse   598 SSQMSDLPVKVTHTETGKVLFGPEAPKASQLDAWLEMNPGYE-VAPRSDSEESESDYEEEDEEEE 661

  Fly   711 TATEDATDKAQATGNDE-----DAKDLITKAKVE-DDEYRTE-----EQTYYSIAHTIHEKVVEQ 764
            ::.::..:|.....|.|     |||.:|..||.: ||||..:     .|:||::||.|.|:|.:|
Mouse   662 SSRQETEEKILLDPNSEEVSEKDAKQIIETAKQDVDDEYSMQYSARGSQSYYTVAHAISERVEKQ 726

  Fly   765 ASIMVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIV 829
            :::::|||||.||::||||:|||||||||||||||||||||||||:|:||||:.|::.|||||||
Mouse   727 SALLINGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIV 791

  Fly   830 PLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQNQMRATKFNVLLTTYEYVIKDKAVLAKIQW 894
            |||||.||..||:||||:|..:||||:|..||.|..|:|:.|||||||||||:||||.:||||:|
Mouse   792 PLSTLSNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHILAKIRW 856

  Fly   895 KYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFE 959
            ||||:|||||||||||||||||||||:||.|:|||||||||||||||||||||||:|||||||||
Mouse   857 KYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFE 921

  Fly   960 QWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQR 1024
            ||||||||.|||:|:||||||||||||||||||||||||||||||.|||:||||:|||||||||:
Mouse   922 QWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDMSALQK 986

  Fly  1025 VLYKHMQSKGVLLTDGSEKGKHGKGGAKALMNTIVQLRKLCNHPFMFQHIEEKYCDHTG-GHGVV 1088
            :||:|||:||:||||||||.|.||||||.|||||:||||:||||:|||||||.:.:|.| .:||:
Mouse   987 ILYRHMQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPYMFQHIEESFAEHLGYSNGVI 1051

  Fly  1089 SGPDLYRVSGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDR 1153
            :|.:|||.||||||||||||||:|||||||||||||..|||:|||..:|.|.|||||||||:|||
Mouse  1052 NGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTTKSEDR 1116

  Fly  1154 GELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVR 1218
            ..||:|||..||..|:|||||||||||||||.||||||||||||||||||||||||||||:||||
Mouse  1117 AALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVR 1181

  Fly  1219 VLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQKSTGSERQQFLQTIL-HQDDNEEEEENEV 1282
            ||||.|||||||:|||||:||||:|:||||||||||||:..||:.|||.|| |:::||||:  ||
Mouse  1182 VLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEENEEED--EV 1244

  Fly  1283 PDDEMINMMIARSEEEIEIFKRMDAERKKEDEEIHPGRERLIDESELPDWLTKDDDEVERFHYQY 1347
            ||||.:|.||||.|||.::|.|||.:|::||......:.||::|.|||.|:.|||.||||...:.
Mouse  1245 PDDETLNQMIARREEEFDLFMRMDMDRRREDARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEE 1309

  Fly  1348 DEDTILGRGSRQRKEVDYTDSLTEKEWLKAIDDGAEFDEEEEEDDSKRKRRKRKNRKEESDDDSL 1412
            :|:.|.|||||||::|||:|:||||:||:||:||...:.|||....|||||:..::....:|...
Mouse  1310 EEEKIFGRGSRQRRDVDYSDALTEKQWLRAIEDGNLEEMEEEVRLKKRKRRRNVDKDPVKEDVEK 1374

  Fly  1413 ILKRRRRQNLDKRS------KKQMHKIMSAVIKH-------------------NQDGRTLSEPFM 1452
            ..|||.|...:|.|      .|||:.|:..||.:                   |..||.|||.|:
Mouse  1375 AKKRRGRPPAEKLSPNPPKLTKQMNAIIDTVINYKDRCNVEKVPCNSQLEIEGNSSGRQLSEVFI 1439

  Fly  1453 KLPSRQRLPDYYEIIKRPVDIKKILQRIEDCKYADLNELEKDFMQLCQNAQIYNEEASLIYLDSI 1517
            :||||:.||:|||:|::|||.|||.:||.:.||..|.:||||.|.||.|||.:|.|.|.||.|||
Mouse  1440 QLPSRKDLPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSI 1504

  Fly  1518 ALQKVFVGARQRITAAADAAAVAAGDNTGEAHGNGGSDNSDNDDDDGGDDGSDDEEIATTSAAAV 1582
            .||.||..|||:|....:                  |:...|::::     .||||.:.:.|.:|
Mouse  1505 VLQSVFKSARQKIAKEEE------------------SEEESNEEEE-----EDDEEESESEAKSV 1546

  Fly  1583 KMKLKLNKSLASAPATPTQSSSNVSSGAATTSKKQTRRKRSQKKYTISDDDDDD 1636
            |:|:||||.               ......|.|.:.|..|.:.|..:||.|.|:
Mouse  1547 KVKIKLNKK---------------EEKGRDTGKGKKRPNRGKAKPVVSDFDSDE 1585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	172..202	CDD:214931	11/29 (38%)
		Drf_FH1	251..390	CDD:283903	41/154 (27%)
		HSA	501..573	CDD:214727	45/71 (63%)
		BRK	649..693	CDD:197800	16/43 (37%)
		PHA02934	687..>824	CDD:165245	70/147 (48%)
		SNF2_N	776..1071	CDD:278600	241/294 (82%)
		DEXDc	793..932	CDD:238005	106/138 (77%)
		Helicase_C	1097..1212	CDD:278689	95/114 (83%)
		SnAC	1304..1375	CDD:291293	37/70 (53%)
		Bromo_SNF2L2	1425..1530	CDD:99947	60/129 (47%)
Smarca2	XP_006527344.1	PHA03378	<74..393	CDD:223065	124/441 (28%)
		QLQ	173..207	CDD:370169	15/77 (19%)
		HSA	448..518	CDD:369406	43/69 (62%)
		BRK	600..641	CDD:369408	16/41 (39%)
		DEXHc_SMARCA2	712..962	CDD:350821	197/249 (79%)
		PLN03142	731..>1213	CDD:215601	388/481 (81%)
		SnAC	1272..1337	CDD:373166	33/64 (52%)
		Bromodomain	1344..>1430	CDD:383021	22/85 (26%)
		Bromo_SNF2L2	1393..1517	CDD:99947	59/123 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850302
Domainoid	1	1.000	503	1.000	Domainoid score	I340
eggNOG	1	0.900	-	-		E2759_KOG0386
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2308
Inparanoid	1	1.050	1579	1.000	Inparanoid score	I88
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52479
OrthoDB	1	1.010	-	-		D41262at33208
OrthoFinder	1	1.000	-	-		FOG0001147
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101122
Panther	1	1.100	-	-	O	PTHR10799
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1363
SonicParanoid	1	1.000	-	-		X702
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.800