Protein Alignment brm and Smarca2

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: NP_001392062.1
• Gene: Smarca2 / 67155
• MGIID: 99603
• Length: 1601
• Species: Mus musculus
• Alignment Length: 1744
• Identity: 891/1744 - (51%)
• Similarity: 1103/1744 - (63%)
• Gaps: 276/1744 - (15%)

  Fly     2 ASPSPANSPMPPPQAPSPMAPPSQSPAPSPHSPYPHQQPGPLQGPPPPGHP----GAYGHPMQ-- 60
            |.|.|..||.|.| :|.|:..||..|.|||.|  .|...||..|||...||    |:...|.:
Mouse     9 AMPHPGPSPGPGP-SPGPILGPSPGPGPSPGS--VHSMMGPSPGPPSVSHPLSTMGSADFPQEGM 70

  Fly    61 ---HGP---------------------------PGQGPPGHHMPPHHQGMIFSKGPH---MG--- 89
               |.|                           ||.|||...|..|.||.:   .||   :|
Mouse    71 HQLHKPMDGIHDKGIVEDVHCGSMKGTSMRPPHPGMGPPQSPMDQHSQGYM---SPHPSPLGAPE 132

  Fly    90 -MQMPPTGPNMSPYQTHGMPPNAPTQPCIVSPGGPPG------GPPPPERSSQENLHALQRAIDS 147
             :..|.:|...:|.|   ||   |:||..:.||.|..      ||.|
Mouse   133 HVSSPISGGGPTPPQ---MP---PSQPGALIPGDPQAMNQPNRGPSP------------------ 173

  Fly   148 MEEKGLQEDPRYSQLLAMRATSKHQHLNGNQVNLLRTQITAYRLLARNKPISMQMQQALQAAQQQ 212
                       :|.:               |::.||.||.||::|||.:|:...:|.|:|..:..
Mouse   174 -----------FSPV---------------QLHQLRAQILAYKMLARGQPLPETLQLAVQGKRTL 212

  Fly   213 PPPGPPIGPPGAPGGPPPGSQHAGQPPVPPQQQQQPPPSAGTPPQCSTPPASNPYGPPVPGQKMQ 277
                             ||.|...|.....|||||                          |:.|
Mouse   213 -----------------PGMQQQQQQQQQQQQQQQ--------------------------QQQQ 234

  Fly   278 VAPPPPHMQQGQPLPPQPPQVGGPPPIQQQQPPQQQQQQSQPP------PPEPHQHQLPNG---- 332
                   .||.|..|.||.|..      |.||.||||||.||.      |..|.|..|.:|
Mouse   235 -------QQQQQQQPQQPQQQA------QAQPQQQQQQQQQPALVSYNRPSGPGQELLLSGQSAP 286

  Fly   333 GKPLSMGPSGGQPLIPSSPMQPQVRGTLPGMPPGSQVPQPGGGPQRQVPPAGMPMP------KPN 391
            .|..:..|||.....|.:.:||    |...:|          ||..|.|..|.|.|      |.:
Mouse   287 QKLSAPAPSGRPSPAPQAAVQP----TATAVP----------GPSVQQPAPGQPSPVLQLQQKQS 337

  Fly   392 RITTVAKPVGLDPITLLQERENRIAARISLRMQELQRLPATMSEDLRLQAAIELRALRVLNFQRQ 456
            ||:.:.||.||||:.:|||||.|:.|||:.|:|||:.||.::..|||.:|.:||:|||:||||||
Mouse   338 RISPIQKPQGLDPVEILQEREYRLQARIAHRIQELESLPGSLPPDLRTKATVELKALRLLNFQRQ 402

  Fly   457 LRMEFVQCTRRDTTLETALNIKLYKRTKRQGLREARATEKLEKQQKLEAERKRRQKHLEFLAAVL 521
            ||.|.|.|.|||||||||||.|.|||:|||.|||||.|||||||||:|.||||||||.|:|.::|
Mouse   403 LRQEVVACMRRDTTLETALNSKAYKRSKRQTLREARMTEKLEKQQKIEQERKRRQKHQEYLNSIL 467

  Fly   522 QHGKDLREFHRNNKAQLARMNKAVMNHHANAEREQKKEQERIEKERMRRLMAEDEEGYRKLIDQK 586
            ||.||.:|:||:...::.:::|||...|||.|||||||.||||||||||||||||||||||||||
Mouse   468 QHAKDFKEYHRSVAGKIQKLSKAVATWHANTEREQKKETERIEKERMRRLMAEDEEGYRKLIDQK 532

  Fly   587 KDKRLAFLLSQTDEYISNLTQMVKQHKDDQMKKKEEEGKRLIQFKKELLMSGE-YIG-----IDE 645
            ||:|||:||.|||||::|||.:|.:||..|..|::::.:|..:..:|....|| .:|     |||
Mouse   533 KDRRLAYLLQQTDEYVANLTNLVWEHKQAQAAKEKKKRRRRKKKAEENAEGGEPALGPDGEPIDE 597

  Fly   646 GSIVADMRVHVVEQCTGKKLTGDDAPMLKHLHRWLNMHPGWDWIDDEEDSCGSNDDHKPKVEEQP 710
            .|.::|:.|.|....|||.|.|.:||....|..||.|:||:: :....||..|..|::.:.||:.
Mouse   598 SSQMSDLPVKVTHTETGKVLFGPEAPKASQLDAWLEMNPGYE-VAPRSDSEESESDYEEEDEEEE 661

  Fly   711 TATEDATDKAQATGNDE-----DAKDLITKAKVE-DDEYRTE-----EQTYYSIAHTIHEKVVEQ 764
            ::.::..:|.....|.|     |||.:|..||.: ||||..:     .|:||::||.|.|:|.:|
Mouse   662 SSRQETEEKILLDPNSEEVSEKDAKQIIETAKQDVDDEYSMQYSARGSQSYYTVAHAISERVEKQ 726

  Fly   765 ASIMVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIV 829
            :::::|||||.||::||||:|||||||||||||||||||||||||:|:||||:.|::.|||||||
Mouse   727 SALLINGTLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIV 791

  Fly   830 PLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQNQMRATKFNVLLTTYEYVIKDKAVLAKIQW 894
            |||||.||..||:||||:|..:||||:|..||.|..|:|:.|||||||||||:||||.:||||:|
Mouse   792 PLSTLSNWTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHILAKIRW 856

  Fly   895 KYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFE 959
            ||||:|||||||||||||||||||||:||.|:|||||||||||||||||||||||:|||||||||
Mouse   857 KYMIVDEGHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFE 921

  Fly   960 QWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQR 1024
            ||||||||.|||:|:||||||||||||||||||||||||||||||.|||:||||:|||||||||:
Mouse   922 QWFNAPFAMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDMSALQK 986

  Fly  1025 VLYKHMQSKGVLLTDGSEKGKHGKGGAKALMNTIVQLRKLCNHPFMFQHIEEKYCDHTG-GHGVV 1088
            :||:|||:||:||||||||.|.||||||.|||||:||||:||||:|||||||.:.:|.| .:||:
Mouse   987 ILYRHMQAKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPYMFQHIEESFAEHLGYSNGVI 1051

  Fly  1089 SGPDLYRVSGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDR 1153
            :|.:|||.||||||||||||||:|||||||||||||..|||:|||..:|.|.|||||||||:|||
Mouse  1052 NGAELYRASGKFELLDRILPKLRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTTKSEDR 1116

  Fly  1154 GELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVR 1218
            ..||:|||..||..|:|||||||||||||||.||||||||||||||||||||||||||||:||||
Mouse  1117 AALLKKFNEPGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVR 1181

  Fly  1219 VLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQKSTGSERQQFLQTIL-HQDDNEEEEENEV 1282
            ||||.|||||||:|||||:||||:|:||||||||||||:..||:.|||.|| |:::||||:  ||
Mouse  1182 VLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEENEEED--EV 1244

  Fly  1283 PDDEMINMMIARSEEEIEIFKRMDAERKKEDEEIHPGRERLIDESELPDWLTKDDDEVERFHYQY 1347
            ||||.:|.||||.|||.::|.|||.:|::||......:.||::|.|||.|:.|||.||||...:.
Mouse  1245 PDDETLNQMIARREEEFDLFMRMDMDRRREDARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEE 1309

  Fly  1348 DEDTILGRGSRQRKEVDYTDSLTEKEWLKAIDDGAEFDEEEEEDDSKRKRRKRKNRKEESDDDSL 1412
            :|:.|.|||||||::|||:|:||||:||:||:||...:.|||....|||||:..::....:|...
Mouse  1310 EEEKIFGRGSRQRRDVDYSDALTEKQWLRAIEDGNLEEMEEEVRLKKRKRRRNVDKDPVKEDVEK 1374

  Fly  1413 ILKRRRRQNLDKRS------KKQMHKIMSAVIKH-------------------NQDGRTLSEPFM 1452
            ..|||.|...:|.|      .|||:.|:..||.:                   |..||.|||.|:
Mouse  1375 AKKRRGRPPAEKLSPNPPKLTKQMNAIIDTVINYKDRCNVEKVPCNSQLEIEGNSSGRQLSEVFI 1439

  Fly  1453 KLPSRQRLPDYYEIIKRPVDIKKILQRIEDCKYADLNELEKDFMQLCQNAQIYNEEASLIYLDSI 1517
            :||||:.||:|||:|::|||.|||.:||.:.||..|.:||||.|.||.|||.:|.|.|.||.|||
Mouse  1440 QLPSRKDLPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSI 1504

  Fly  1518 ALQKVFVGARQRITAAADAAAVAAGDNTGEAHGNGGSDNSDNDDDDGGDDGSDDEEIATTSAAAV 1582
            .||.||..|||:|....:                  |:...|::::     .||||.:.:.|.:|
Mouse  1505 VLQSVFKSARQKIAKEEE------------------SEEESNEEEE-----EDDEEESESEAKSV 1546

  Fly  1583 KMKLKLNKSLASAPATPTQSSSNVSSGAATTSKKQTRRKRSQKKYTISDDDDDD 1636
            |:|:||||.               ......|.|.:.|..|.:.|..:||.|.|:
Mouse  1547 KVKIKLNKK---------------EEKGRDTGKGKKRPNRGKAKPVVSDFDSDE 1585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622	11/28 (39%)
		Pro-rich	<247..401	CDD:464580	47/169 (28%)
		PTZ00121	<477..651	CDD:173412	108/179 (60%)
		HSA	501..573	CDD:214727	45/71 (63%)
		BRK	650..691	CDD:462196	16/40 (40%)
		PLN03142	739..>1368	CDD:215601	468/636 (74%)
		Bromo_SNF2L2	1425..1530	CDD:99947	60/129 (47%)
Smarca2	NP_001392062.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..77		27/70 (39%)
		PHA03378	<74..393	CDD:223065	124/441 (28%)
		QLQ	173..207	CDD:462622	15/77 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	211..346		54/204 (26%)
		HSA	447..519	CDD:214727	45/71 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	562..603		11/40 (28%)
		BRK	600..643	CDD:462196	16/43 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	638..683		9/45 (20%)
		DEXHc_SMARCA2	712..962	CDD:350821	197/249 (79%)
		PLN03142	731..>1213	CDD:215601	388/481 (81%)
		DEGH box	862..865		2/2 (100%)
		SnAC	1270..1337	CDD:464219	34/66 (52%)
		Bromodomain	1344..>1430	CDD:445827	22/85 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1357..1394		11/36 (31%)
		Bromo_SNF2L2	1393..1517	CDD:99947	59/123 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1517..1601		24/107 (22%)