DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment brm and SMARCA2

DIOPT Version :9

Sequence 1:NP_001261906.1 Gene:brm / 39744 FlyBaseID:FBgn0000212 Length:1658 Species:Drosophila melanogaster
Sequence 2:NP_001276325.1 Gene:SMARCA2 / 6595 HGNCID:11098 Length:1590 Species:Homo sapiens


Alignment Length:1740 Identity:886/1740 - (50%)
Similarity:1104/1740 - (63%) Gaps:274/1740 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 ASPSPANSPMPPPQAPSPMAPPSQSPAPSPHSPYPHQQPGPLQGPPPPGHP----GAYGHPMQ-- 60
            |.|.|..||.|.| :|.|:..||..|.|||.|  .|...||..|||...||    |:...|.:  
Human     9 AMPHPGPSPGPGP-SPGPILGPSPGPGPSPGS--VHSMMGPSPGPPSVSHPMPTMGSTDFPQEGM 70

  Fly    61 ---HGP---------------------------PGQGPPGHHMPPHHQGMIFSKGPH---MG--- 89
               |.|                           ||.|||...|..|.||.:   .||   :|   
Human    71 HQMHKPIDGIHDKGIVEDIHCGSMKGTGMRPPHPGMGPPQSPMDQHSQGYM---SPHPSPLGAPE 132

  Fly    90 -MQMPPTGPNMSPYQTHGMPPNAPTQPCIVSPGGPPGGPPPPERSSQENLHALQRAIDSMEEKGL 153
             :..|.:|...:|.|   ||   |:||..:.||       .|:..||.|                
Human   133 HVSSPMSGGGPTPPQ---MP---PSQPGALIPG-------DPQAMSQPN---------------- 168

  Fly   154 QEDPRYSQLLAMRATSKHQHLNGNQVNLLRTQITAYRLLARNKPISMQMQQALQAAQQQPPPGPP 218
                        |..|....:   |::.||.||.||::|||.:|:...:|.|:|           
Human   169 ------------RGPSPFSPV---QLHQLRAQILAYKMLARGQPLPETLQLAVQ----------- 207

  Fly   219 IGPPGAPGGPPPGSQHAGQPPVPPQQQQQPPPSAGTPPQCSTPPASNPYGPPVPGQKMQVAPPPP 283
                             |:..:|..||||                          |:.|      
Human   208 -----------------GKRTLPGLQQQQ--------------------------QQQQ------ 223

  Fly   284 HMQQGQPLPPQPPQVGGPPPIQQQQPPQQQQQQSQPPPPEPHQHQ--------LPNGGKPLSMGP 340
             .||.|               ||||..||||.|.|||.|:..|.|        .|:|..|...||
Human   224 -QQQQQ---------------QQQQQQQQQQPQQQPPQPQTQQQQQPALVNYNRPSGPGPELSGP 272

  Fly   341 SGGQPL-IPSSPMQPQVRGTLPGMPPGSQVPQPGGGPQRQVPPAGMPMP------KPNRITTVAK 398
            |..|.| :|:...:|.........||.:.||    ||....|..|.|.|      |.:||:.:.|
Human   273 STPQKLPVPAPGGRPSPAPPAAAQPPAAAVP----GPSVPQPAPGQPSPVLQLQQKQSRISPIQK 333

  Fly   399 PVGLDPITLLQERENRIAARISLRMQELQRLPATMSEDLRLQAAIELRALRVLNFQRQLRMEFVQ 463
            |.||||:.:|||||.|:.|||:.|:|||:.||.::..|||.:|.:||:|||:||||||||.|.|.
Human   334 PQGLDPVEILQEREYRLQARIAHRIQELENLPGSLPPDLRTKATVELKALRLLNFQRQLRQEVVA 398

  Fly   464 CTRRDTTLETALNIKLYKRTKRQGLREARATEKLEKQQKLEAERKRRQKHLEFLAAVLQHGKDLR 528
            |.|||||||||||.|.|||:|||.|||||.|||||||||:|.||||||||.|:|.::|||.||.:
Human   399 CMRRDTTLETALNSKAYKRSKRQTLREARMTEKLEKQQKIEQERKRRQKHQEYLNSILQHAKDFK 463

  Fly   529 EFHRNNKAQLARMNKAVMNHHANAEREQKKEQERIEKERMRRLMAEDEEGYRKLIDQKKDKRLAF 593
            |:||:...::.:::|||...|||.|||||||.||||||||||||||||||||||||||||:|||:
Human   464 EYHRSVAGKIQKLSKAVATWHANTEREQKKETERIEKERMRRLMAEDEEGYRKLIDQKKDRRLAY 528

  Fly   594 LLSQTDEYISNLTQMVKQHKDDQMKKKEEEGKRLIQFKKELLMSGE-YIG-----IDEGSIVADM 652
            ||.|||||::|||.:|.:||..|..|::::.:|..:..:|....|| .:|     |||.|.::|:
Human   529 LLQQTDEYVANLTNLVWEHKQAQAAKEKKKRRRRKKKAEENAEGGESALGPDGEPIDESSQMSDL 593

  Fly   653 RVHVVEQCTGKKLTGDDAPMLKHLHRWLNMHPGWDWIDDEEDSCGSNDDHKPKVEEQPTATEDAT 717
            .|.|....|||.|.|.:||....|..||.|:||:: :....||..|:.|::.:.||:.::.::..
Human   594 PVKVTHTETGKVLFGPEAPKASQLDAWLEMNPGYE-VAPRSDSEESDSDYEEEDEEEESSRQETE 657

  Fly   718 DKAQATGNDE-----DAKDLITKAKVE-DDEYRTE-----EQTYYSIAHTIHEKVVEQASIMVNG 771
            :|.....|.|     |||.:|..||.: ||||..:     .|:||::||.|.|:|.:|:::::||
Human   658 EKILLDPNSEEVSEKDAKQIIETAKQDVDDEYSMQYSARGSQSYYTVAHAISERVEKQSALLING 722

  Fly   772 TLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPN 836
            |||.||::||||:|||||||||||||||||||||||||:|:||||:.|::.||||||||||||.|
Human   723 TLKHYQLQGLEWMVSLYNNNLNGILADEMGLGKTIQTIALITYLMEHKRLNGPYLIIVPLSTLSN 787

  Fly   837 WVLEFEKWAPAVGVVSYKGSPQGRRLLQNQMRATKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDE 901
            |..||:||||:|..:||||:|..||.|..|:|:.|||||||||||:||||.:||||:|||||:||
Human   788 WTYEFDKWAPSVVKISYKGTPAMRRSLVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDE 852

  Fly   902 GHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPF 966
            |||||||||||||||||||:||.|:|||||||||||||||||||||||:||||||||||||||||
Human   853 GHRMKNHHCKLTQVLNTHYVAPRRILLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPF 917

  Fly   967 ATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQ 1031
            |.|||:|:||||||||||||||||||||||||||||||.|||:||||:|||||||||::||:|||
Human   918 AMTGERVDLNEEETILIIRRLHKVLRPFLLRRLKKEVESQLPEKVEYVIKCDMSALQKILYRHMQ 982

  Fly  1032 SKGVLLTDGSEKGKHGKGGAKALMNTIVQLRKLCNHPFMFQHIEEKYCDHTG-GHGVVSGPDLYR 1095
            :||:||||||||.|.||||||.|||||:||||:||||:|||||||.:.:|.| .:||::|.:|||
Human   983 AKGILLTDGSEKDKKGKGGAKTLMNTIMQLRKICNHPYMFQHIEESFAEHLGYSNGVINGAELYR 1047

  Fly  1096 VSGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKF 1160
            .||||||||||||||:|||||||||||||..|||:|||..:|.|.|||||||||:|||..||:||
Human  1048 ASGKFELLDRILPKLRATNHRVLLFCQMTSLMTIMEDYFAFRNFLYLRLDGTTKSEDRAALLKKF 1112

  Fly  1161 NAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTV 1225
            |..||..|:|||||||||||||||.||||||||||||||||||||||||||||:||||||||.||
Human  1113 NEPGSQYFIFLLSTRAGGLGLNLQAADTVVIFDSDWNPHQDLQAQDRAHRIGQQNEVRVLRLCTV 1177

  Fly  1226 NSVEERILAAARYKLNMDEKVIQAGMFDQKSTGSERQQFLQTIL-HQDDNEEEEENEVPDDEMIN 1289
            |||||:|||||:||||:|:||||||||||||:..||:.|||.|| |:::||||:  ||||||.:|
Human  1178 NSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEENEEED--EVPDDETLN 1240

  Fly  1290 MMIARSEEEIEIFKRMDAERKKEDEEIHPGRERLIDESELPDWLTKDDDEVERFHYQYDEDTILG 1354
            .||||.|||.::|.|||.:|::||......:.||::|.|||.|:.|||.||||...:.:|:.|.|
Human  1241 QMIARREEEFDLFMRMDMDRRREDARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKIFG 1305

  Fly  1355 RGSRQRKEVDYTDSLTEKEWLKAIDDGAEFDEEEEEDDSKRKRRKRKNRKEESDDDSLILKRRRR 1419
            ||||||::|||:|:||||:||:||:||...:.|||....|||||:..::....:|.....|||.|
Human  1306 RGSRQRRDVDYSDALTEKQWLRAIEDGNLEEMEEEVRLKKRKRRRNVDKDPAKEDVEKAKKRRGR 1370

  Fly  1420 QNLDKRS------KKQMHKIMSAVIKH-------------------NQDGRTLSEPFMKLPSRQR 1459
            ...:|.|      .|||:.|:..||.:                   |..||.|||.|::||||:.
Human  1371 PPAEKLSPNPPKLTKQMNAIIDTVINYKDRCNVEKVPSNSQLEIEGNSSGRQLSEVFIQLPSRKE 1435

  Fly  1460 LPDYYEIIKRPVDIKKILQRIEDCKYADLNELEKDFMQLCQNAQIYNEEASLIYLDSIALQKVFV 1524
            ||:|||:|::|||.|||.:||.:.||..|.:||||.|.||.|||.:|.|.|.||.|||.||.||.
Human  1436 LPEYYELIRKPVDFKKIKERIRNHKYRSLGDLEKDVMLLCHNAQTFNLEGSQIYEDSIVLQSVFK 1500

  Fly  1525 GARQRITAAADAAAVAAGDNTGEAHGNGGSDNSDNDDDDGGDDGSDDEEIATTSAAAVKMKLKLN 1589
            .|||:|                       :...:::|:...::..:|||.:.:.|.:||:|:|||
Human  1501 SARQKI-----------------------AKEEESEDESNEEEEEEDEEESESEAKSVKVKIKLN 1542

  Fly  1590 KSLASAPATPTQSSSNVSSGAATTSKKQTRRKRSQKKYTISD-DDDDDMD 1638
            |.               ........|.:.|..|.:.|..:|| |.|::.|
Human  1543 KK---------------DDKGRDKGKGKKRPNRGKAKPVVSDFDSDEEQD 1577

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
brmNP_001261906.1 QLQ 172..202 CDD:214931 11/29 (38%)
Drf_FH1 251..390 CDD:283903 40/153 (26%)
HSA 501..573 CDD:214727 45/71 (63%)
BRK 649..693 CDD:197800 16/43 (37%)
PHA02934 687..>824 CDD:165245 70/147 (48%)
SNF2_N 776..1071 CDD:278600 241/294 (82%)
DEXDc 793..932 CDD:238005 106/138 (77%)
Helicase_C 1097..1212 CDD:278689 95/114 (83%)
SnAC 1304..1375 CDD:291293 37/70 (53%)
Bromo_SNF2L2 1425..1530 CDD:99947 60/129 (47%)
SMARCA2NP_001276325.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..71 26/64 (41%)
Forkhead_N 40..174 CDD:254796 41/177 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 95..176 29/124 (23%)
QLQ 173..207 CDD:286024 13/36 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 212..334 48/173 (28%)
HSA 436..508 CDD:214727 45/71 (63%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 551..592 11/40 (28%)
BRK 590..632 CDD:197800 16/42 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 627..672 9/45 (20%)
SNF2_N 727..1022 CDD:278600 241/294 (82%)
DEXDc 744..883 CDD:238005 106/138 (77%)
DEGH box 851..854 2/2 (100%)
Helicase_C 1049..1164 CDD:278689 95/114 (83%)
SnAC 1259..1326 CDD:291293 34/66 (52%)
Bromodomain 1333..>1419 CDD:295360 22/85 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1344..1383 12/38 (32%)
Bromo_SNF2L2 1382..1506 CDD:99947 59/123 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1506..1590 22/110 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165159932
Domainoid 1 1.000 503 1.000 Domainoid score I336
eggNOG 1 0.900 - - E2759_KOG0386
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H2308
Inparanoid 1 1.050 1559 1.000 Inparanoid score I90
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG52479
OrthoDB 1 1.010 - - D41262at33208
OrthoFinder 1 1.000 - - FOG0001147
OrthoInspector 1 1.000 - - otm41782
orthoMCL 1 0.900 - - OOG6_101122
Panther 1 1.100 - - O PTHR10799
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1363
SonicParanoid 1 1.000 - - X702
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.800

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