|
Fly 5 SPANSPMPPPQAPSPMAPPSQSPAPSPHSPYPHQ---QPGPLQGPPPPGHPGAYGHPMQHGPPGQ 66
|.|:..:|||:..:|.....:|.||:|.|...|. ||...:.|..| .:|...|..
Human 61 SSASELVPPPEETAPTELSKESTAPAPESITLHDYTTQPASQEQPAQP--------VLQTSTPTS 117
Fly 67 GPPGHHMPPHHQGMIFSKG-PHMGMQMPPTGPNMSPYQTHGMPPNAPTQPCIVSPGGPPGGPPPP 130
| .:.......|.|:| |.||: :...:|.....|.||. :.|.||....||.
Human 118 G----LLQVSKSQEILSQGNPFMGV----SATAVSSSSAGGQPPQ--SAPKIVILKAPPS----- 167
Fly 131 ERSSQENLHALQRAIDSMEEKGLQEDPRYSQLLAMRATSKHQHL-----NGNQVNLLR------- 183
||....|. :|:.|...||..|.| ||.:|...:
Human 168 --SSVTGAHV-------------------AQIQAQGITSTAQPLVAGTANGGKVTFTKVLTGTPL 211
Fly 184 -------------------TQITAYRLLARNKPISMQMQQALQAAQQQPPPGPPIGPPGAPGGPP 229
.|....|::..::|:...:.|.::.: .|.|.|||.|
Human 212 RPGVSIVSGNTVLAAKVPGNQAAVQRIVQPSRPVKQLVLQPVKGS-------APAGNPGATG--- 266
Fly 230 PGSQHAGQPPVPPQQQQQPPPSAGTPPQCS----TPPASNPYG------PPVPG----QKMQVAP 280
||:.|.......|:.|...:.: .|.:..|.| ..:|| |..|:|.
Human 267 --------PPLKPAVTLTSTPTQGESKRITLVLQQPQSGGPQGHRHVVLGSLPGKIVLQGNQLAA 323
Fly 281 -PPPHMQQGQPLPPQPPQVGGPPPIQQQQPPQQQQQQSQPPPPEPHQHQLPNGGKPLSMGPSGGQ 344
......||||......| :|.|||.|:.|...|||..:|...| |...|
Human 324 LTQAKNAQGQPAKVVTIQ------LQVQQPQQKIQIVPQPPSSQPQPQQ-----------PPSTQ 371
Fly 345 PLIPSSPMQPQVRGTLPGMPPGSQ--VP-----QPGGGPQRQVPPAGMPMPK---PNRITTVAKP 399
|:..||..|.|:.| ||..||.: || ||..| ..|...:|:.:.| .:.:..::.|
Human 372 PVTLSSVQQAQIMG--PGQSPGQRLSVPVKVVLQPQAG-SSQGASSGLSVVKVLSASEVAALSSP 433
Fly 400 ----------VGLDPITLL-----QERENRIAARISLRMQEL--QRLPATMSEDLRLQAAIELRA 447
.|::....| ||:.|||.|....|.:.. |.:|..::|| ||.:
Human 434 ASSAPHSGGKTGMEENRRLEHQKKQEKANRIVAEAIARARARGEQNIPRVLNED-------ELPS 491
Fly 448 LRVLNFQRQLRMEFVQCTRRDTTLETALNIKLYKRTKRQGLREARATEKLEKQQKLEAERKRRQK 512
:| ..|..:..||..:....|..:..|::|..|..:.:...||.....:..::::|..
Human 492 VR--------PEEEGEKKRRKKSAGERLKEEKPKKSKTSGASKTKGKSKLNTITPVVGKKRKRNT 548
Fly 513 HLEFLAAVLQHGKDLREFHRNNKAQLARMNKAVMNHHANAEREQKKEQERIEKE----------- 566
..:.....:...:..|| ...:..|..|.|:.|.......:.:.|...:..|:|
Human 549 SSDNSDVEVMPAQSPRE-DEESSIQKRRSNRQVKRKKYTEDLDIKITDDEEEEEVDVTGPIKPEP 612
Fly 567 ---------------RMRRLMAEDEEGYRKLIDQKKDKRL------AFLLSQTDEYISNLTQMVK 610
.|:..:....|....::|:....|: :...::.:|:.........
Human 613 ILPEPVQEPDGETLPSMQFFVENPSEEDAAIVDKVLSMRIVKKELPSGQYTEAEEFFVKYKNYSY 677
Fly 611 QHKD----DQMKKKEEEGKRLIQFKKELLMSGEYIGIDEGSIVADM----RV----HVVEQCTGK 663
.|.: .|::|.:...::|.:||.::.....:...||.....|. |: |.:::..|:
Human 678 LHCEWATISQLEKDKRIHQKLKRFKTKMAQMRHFFHEDEEPFNPDYVEVDRILDESHSIDKDNGE 742
Fly 664 KLTGDDAPMLKHLHRWLNM---HPGWDWIDDEEDSCGSNDDHKPKVEEQPTATEDATDKAQATGN 725
|::.:|.:|.:: ...|:..:|.:: |...:.|......|........:|.|.
Human 743 -------PVIYYLVKWCSLPYEDSTWELKEDVDE--GKIREFKRIQSRHPELKRVNRPQASAW-- 796
Fly 726 DEDAKDLITKAKVE-DDEYRTEEQTYYSIAHTIHEKVVEQASIMVNGTLKEYQIKGLEWLVSLYN 789
.|:| ..||:...| |:|||::|:.||:..:.
Human 797 ----------KKLELSHEYKNRNQ------------------------LREYQLEGVNWLLFNWY 827
Fly 790 NNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYK 854
|..|.|||||||||||||:|:.:..:.: ..:.||:|:|.||||:.||..||..|. .:..:.|.
Human 828 NRQNCILADEMGLGKTIQSIAFLQEVYN-VGIHGPFLVIAPLSTITNWEREFNTWT-EMNTIVYH 890
Fly 855 GSPQGRRLLQNQMR------------ATKFNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKN 907
||...|:::|.... |.||:.|:||:|.::.|...|.:|:|:.:||||.||:||
Human 891 GSLASRQMIQQYEMYCKDSRGRLIPGAYKFDALITTFEMILSDCPELREIEWRCVIIDEAHRLKN 955
Fly 908 HHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEK 972
.:|||...|. |....:::|||||||||.:.||::||:||.||.|.|.|.|.:.|.
Human 956 RNCKLLDSLK-HMDLEHKVLLTGTPLQNTVEELFSLLHFLEPSQFPSESEFLKDFG--------- 1010
Fly 973 VELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGV-L 1036
:|..||. :::|..:|:|.:|||||::||..|..|.|.||:.:::.:|:..|:.:..|.. .
Human 1011 -DLKTEEQ---VQKLQAILKPMMLRRLKEDVEKNLAPKQETIIEVELTNIQKKYYRAILEKNFSF 1071
Fly 1037 LTDGSEKGKHGKGGAKALMNTIVQLRKLCNHPFMFQHIEEKY-------CDHTGGHGVVSGPDLY 1094
|:.|: |......|:||:::|||.||||::....|||. | |...| |.:
Human 1072 LSKGA-----GHTNMPNLLNTMMELRKCCNHPYLINGAEEKILTEFREAC-HIIPH------DFH 1124
Fly 1095 -----RVSGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRG 1154
|.:||..|:|::||||||..|:||:|.||.:|:.|:||||..|::.|.|:||..:...|.
Human 1125 LQAMVRSAGKLVLIDKLLPKLKAGGHKVLIFSQMVRCLDILEDYLIQRRYLYERIDGRVRGNLRQ 1189
Fly 1155 ELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRV 1219
..:.:|:...||.|||||.|||||||:||..|||.:||||||||..|||||.|.|||||...|:|
Human 1190 AAIDRFSKPDSDRFVFLLCTRAGGLGINLTAADTCIIFDSDWNPQNDLQAQARCHRIGQSKAVKV 1254
Fly 1220 LRLMTVNSVEERILAAARYKLNMDEKVIQ--AGMFDQKSTGSERQQF----LQTILHQDD----N 1274
.||:|.||.|..:...|..||.:|:.|:| :|. |...||. ||| ::.:|.:.. .
Human 1255 YRLITRNSYEREMFDKASLKLGLDKAVLQSMSGR-DGNITGI--QQFSKKEIEDLLRKGAYAAIM 1316
Fly 1275 EEEEENEVPDDEMINMMIAR--------SEEEIEIFKRMDAERKKEDEEIHPGRERLIDESELPD 1331
||::|.....:|.|:.::.| ||.:...|.:......:...:| .|.|.:....
Human 1317 EEDDEGSKFCEEDIDQILLRRTTTITIESEGKGSTFAKASFVASENRTDI-----SLDDPNFWQK 1376
Fly 1332 WLTKDDDEVERFHYQYDEDTILGRGSRQRKEVDYTDSLTEKEWLKAIDDGAEFDEEEEEDDSKRK 1396
|..|.|.:::..: .::.::....|.||:..:..:|.: ||..||.:.|.|||.:.:
Human 1377 WAKKADLDMDLLN---SKNNLVIDTPRVRKQTRHFSTLKD-------DDLVEFSDLESEDDERPR 1431
Fly 1397 RRKR-----------------------------------KNRKEESDDDSL--------ILKRRR 1418
.|:. |.|..|.|.::: :|..|.
Human 1432 SRRHDRHHAYGRTDCFRVEKHLLVYGWGRWRDILSHGRFKRRMTERDVETICRAILVYCLLHYRG 1496
Fly 1419 RQNL-------------DKRSKKQMHKIMSAVIKHNQDGRTL-SEPFMKLPS----RQRLPD--- 1462
.:|: .|..:.|.|..:|..:...:.|:.: |:....:.. |:..||
Human 1497 DENIKGFIWDLISPAENGKTKELQNHSGLSIPVPRGRKGKKVKSQSTFDIHKADWIRKYNPDTLF 1561
Fly 1463 ----YYEIIKRPVDIKKILQRIEDCKYADLNELEKDFMQLCQNAQIYNE-----------EASLI 1512
|.:.:|. ...|:|.|:....|. ..|:..|..:......|.:| |....
Human 1562 QDESYKKHLKH--QCNKVLLRVRMLYYL-RQEVIGDQAEKVLGGAIASEIDIWFPVVDQLEVPTT 1623
Fly 1513 YLDSIALQKVFVGA-----RQRITAAADAA-------------AVAAG----DNTGEAHGNGGSD 1555
:.||.|.:.:.:|. .:..|..||.| |:||. ||..:.......|
Human 1624 WWDSEADKSLLIGVFKHGYEKYNTMRADPALCFLEKAGRPDDKAIAAEHRVLDNFSDIVEGVDFD 1688
Fly 1556 NSDNDDD---------DGGDDGSD----DEEIATTSAAAVKMKLKLNKSLASAPATPTQSSSNV- 1606
....|.: |..|:|.. ||||:. :....|..||...::
Human 1689 KDCEDPEYKPLQGPPKDQDDEGDPLMMMDEEISV---------------IDGDEAQVTQQPGHLF 1738
Fly 1607 -SSGAATTSK-------KQTRRKRSQKKYTISDDDD 1634
..|:|.|:: .|...||.|.|...::..|
Human 1739 WPPGSALTARLRRLVTAYQRSYKREQMKIEAAERGD 1774
| 
