Protein Alignment brm and chd2

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: XP_021323365.1
• Gene: chd2 / 569795
• ZFINID: ZDB-GENE-050419-256
• Length: 1817
• Species: Danio rerio
• Alignment Length: 1359
• Identity: 388/1359 - (28%)
• Similarity: 599/1359 - (44%)
• Gaps: 293/1359 - (21%)

  Fly   482 RTKRQGLREARATEKLEKQQKL----------EAERKRRQKHLEFLAAVLQHGKDLREFHRNNKA 536
            :||....::::...|..||:..          |.:..:||.... .|..:.:.:|..:|..::.
Zfish   194 QTKSSASKQSQKGRKQRKQESSDEDDDDDDDDEEDTPKRQTRRR-AATKVSYKEDQNDFETDSD- 256

  Fly   537 QLARMNKAVMNHHANAEREQKKEQERIEKERMRR------------LMAEDEEGYRKLID----- 584
            .|..|.:       .||.:|..:.|.|||....|            |.|.:|.|     |
Zfish   257 DLIEMAE-------GAEEQQDDDSETIEKVVDTRTGKKGATGASTTLYAIEENG-----DPGADF 309

  Fly   585 --QKKDKRLAFLLS--------QTDEYISNLTQM-VK-QHKDDQMKKKEEEGKRLIQFKKELLMS 637
              :|::....||:.        .|.|.:.:|||. || ..|.:..|||.||....:  ||.....
Zfish   310 DPEKEEGETQFLIKWKGWSYIHNTWESVDSLTQQKVKGMKKLENFKKKNEELNAWL--KKASPED 372

  Fly   638 GEYIGIDEGSIVADM--RVHVVEQC----TGKKLTGDDAPMLK-------HLHRWLNM-HPGWDW 688
            .||....: .:..|:  :..::|:.    |||.....|.|..|       :|.:|:.: :....|
Zfish   373 LEYYNCQQ-ELTNDLSKQFQIIERVIATRTGKSQATSDTPSHKSSSGEPEYLCKWMGLPYAECTW 436

  Fly   689 IDDEEDSCGSNDDHKPKVEEQPTATEDA--TDKAQATGNDEDAKDLITKAKV----EDDEYRTEE 747
                |||.        .::::..|..|:  ...:..|...:|.|.|..:.:.    :...|..:|
Zfish   437 ----EDSA--------LIKKKFQACIDSFHNRNSSKTVPSKDCKVLKQRPRFVPLKKQPSYIGDE 489

  Fly   748 QTYYSIAHTIHEKVVEQASIMVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLV 812
                                  |..|::||:.|:.||...:....:.||||||||||||||||.:
Zfish   490 ----------------------NLELRDYQLDGVNWLAHSWCRCNSVILADEMGLGKTIQTISFL 532

  Fly   813 TYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQN------QMRATK 871
            :||..:.::.||::::||||||.:|..||:.|||.:.||.|.|....|:.:::      |.:..|
Zfish   533 SYLFHQHQLYGPFIVVVPLSTLTSWQREFDTWAPDMNVVVYLGDVTSRKTIRDYEWINPQTKRIK 597

  Fly   872 FNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNK 936
            ||.||||||.::|||.||..|.|.::.:||.||:||....|.:.| ..:.:.:|||:|||||||.
Zfish   598 FNALLTTYEILLKDKGVLGNINWAFLGVDEAHRLKNDDSLLYKTL-IDFRSNHRLLITGTPLQNS 661

  Fly   937 LPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKK 1001
            |.|||:||:||:...|:|...||....        |...|..::      |||||.||||||:||
Zfish   662 LKELWSLLHFLMSDKFESWEDFEDEHG--------KGRDNGYQS------LHKVLEPFLLRRVKK 712

  Fly  1002 EVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEKGKHGKGGAKALMNTIVQLRKLCN 1066
            :||..||.|||.|::.||||.|:..|     |.:|..:.....|..:|.:...:|.:::|:|.||
Zfish   713 DVEKSLPAKVEQILRVDMSAQQKQFY-----KWILTRNFKALSKGTRGSSSGFLNIVMELKKCCN 772

  Fly  1067 HPFMFQHIEEKYCDHTGGHGVVSGPDLYRVSGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIE 1131
            |.|:.:..|:...|....|    ...|.|..||..|||::|.:||...:|||:|.||.:.:.|:.
Zfish   773 HAFLIKQPEDGENDAPQEH----LQSLVRGGGKLVLLDKLLTRLKDRGNRVLIFSQMVRMLDILA 833

  Fly  1132 DYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDW 1196
            |||..:::.:.||||:.|.|.|.:.|..|||:||:.|.|||||||||||:||.:|||||||||||
Zfish   834 DYLSMKRYQFQRLDGSIKGELRKQALDHFNAEGSEDFCFLLSTRAGGLGINLASADTVVIFDSDW 898

  Fly  1197 NPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQ------AGMFDQK 1255
            ||..|||||.|||||||:.:|.:.||:|..:|||.|:..|:.|:.:|..|||      ..:.|..
Zfish   899 NPQNDLQAQARAHRIGQKKQVNIYRLVTKGTVEEDIIERAKKKMVLDHLVIQRMDTTGRTVLDNS 963

  Fly  1256 STGSERQQF----LQTIL--------HQDDNEEEEENEVPDDEMINMMIAR--------SEEEIE 1300
            |..|....|    |..||        .:.:.||.|..|:..||::.:...|        ::|.:.
Zfish   964 SANSNSNPFNKEELSAILKFGAEDLFKEAEGEESEPQEMDIDEILRLAETRESDQGSSATDELLS 1028

  Fly  1301 IFK----RMDAERKKEDEEIHPGR--ERLIDESELPDWLTKDDDEVERFHYQYDEDTILGRGSRQ 1359
            .||    .||......||:  |||  :.:|.|.:      :...|.|:...:.::..:|.|....
Zfish  1029 QFKVANFTMDESTPDLDEK--PGRDWDEIIPEEQ------RRKVEEEQKQKEMEDIYMLPRSRSS 1085

  Fly  1360 RKEVDYTDSLTE-KEWLKAIDDGAEFDEEEEEDDSKRKR----RKRKNRKEESDDDSL--ILKRR 1417
            .|:....||.:: ...||....|::.:.::.|||.:.||    |.|||..|...|..:  .:|..
Zfish  1086 NKKAQANDSDSDVGSKLKHRSSGSDSETDDSEDDKRPKRRGRPRARKNNVEGFTDAEIRRFIKAY 1150

  Fly  1418 RR-----QNLD----------------KRSKKQMHKIMSAVIKHNQDGRTLSEPFMKLPSRQRLP 1461
            ::     :.|:                ||..:.:|......::.:::....:....|.|.::|..
Zfish  1151 KKFGAPLERLEAIARDSELVEKSIADLKRLGELVHNSCVTAVQEHEEHLKENPVEAKGPGKRRGI 1215

  Fly  1462 DYYEIIKRPVDIKKILQRIEDC----KYADLNELEKDFMQL-CQ--------------------- 1500
            : .:|....|:.|.|:|..|:.    |....|..|::..|| |:
Zfish  1216 N-IKISGVQVNAKSIIQHEEEFEPLHKAVPSNPAERNKFQLTCRVKTPHFDVDWDIHDDTQLLLG 1279

  Fly  1501 -------NAQIYNEEASLIYLDSIAL---QKVFVGARQRITA----------AADAAAVAAGDN- 1544
                   |..:...:..|...:.|.|   :|...|.:.::..          .....|:.|||.
Zfish  1280 IYEHGYGNWDLIKTDPDLKLSEKILLDDPEKKPQGKQLQMRTDYLLKMLKKDLESQDAIKAGDEP 1344

  Fly  1545 --------------TGEAHGNGGSDN-SDNDDDDG--GDDGSDDEEIATTSAAAVKMKLKLNKSL 1592
                          :.|......|.. |||..::|  .|||::       .....|.:.|.||..
Zfish  1345 KIKKRKPRMKKKAPSNELVNEIASPRLSDNPSEEGEVKDDGAE-------KTPTKKKQKKDNKEN 1402

  Fly  1593 ASAPATPTQSSSNVSSGAATTSKKQTRR-----KRSQKKYTISD--------DDDDDMD 1638
            .....||.:..........:..||:..:     |::|....|:.        ::||::|
Zfish  1403 KEKTGTPKKEKEGDKDKKRSKPKKEKAKPAGKGKKAQGPVHITQGSEPIPIGEEDDELD 1461

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580
		PTZ00121	<477..651	CDD:173412	46/207 (22%)
		HSA	501..573	CDD:214727	17/93 (18%)
		BRK	650..691	CDD:462196	11/54 (20%)
		PLN03142	739..>1368	CDD:215601	253/666 (38%)
		Bromo_SNF2L2	1425..1530	CDD:99947	23/140 (16%)
chd2	XP_021323365.1	CD1_tandem_CHD1-2_like	272..356	CDD:349313	21/88 (24%)
		CD2_tandem_CHD1-2_like	389..456	CDD:349308	15/78 (19%)
		DEAD-like_helicase_N	473..709	CDD:475120	104/272 (38%)
		PLN03142	479..>1054	CDD:215601	246/622 (40%)
		CDH1_2_SANT_HL1	1137..1225	CDD:477096	10/88 (11%)
		DUF4208	1455..1549	CDD:464035	3/7 (43%)
		PTZ00449	<1503..>1796	CDD:185628