Protein Alignment brm and chd7

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: XP_697956.4
• Gene: chd7 / 569471
• ZFINID: ZDB-GENE-070912-179
• Length: 3140
• Species: Danio rerio
• Alignment Length: 1966
• Identity: 526/1966 - (26%)
• Similarity: 771/1966 - (39%)
• Gaps: 583/1966 - (29%)

  Fly    13 PPQAPSPMAPPSQSPAPSPHSPYPHQQPGPLQGPPPPGHPGAYGHPMQHGP-PGQGP---PGHHM 73
            |.|.|....||.|...|...|   ||.          |..|..||..|.|| .|:|.   .||:.
Zfish   148 PMQVPEQTRPPFQQQPPQASS---HQH----------GPAGPQGHAHQMGPFIGRGDYAIQGHNQ 199

  Fly    74 ---PPH-----------------HQGMIFSKGPHMGMQMPPTGPNMSPYQTHGMPPNAPTQPCIV 118
               ||.                 |.||  ::.|  ||..||......|.|.|    ..|.|..:.
Zfish   200 TQTPPRMNHFPQGLPQEANHFLGHVGM--TQNP--GMSGPPIRHLAQPSQQH----QQPNQQFLH 256

  Fly   119 SPG-GP----------PGGPPPPERSSQE---------------NLHALQRAIDSMEEKGLQEDP 157
            .|| ||          |..|..|.|..|:               |:|..|...:::...|  :.|
Zfish   257 RPGQGPVHPDSVASHNPQFPQSPSRQQQQQQQVMGGRPHQNMGFNMHNQQVPSNTVNSSG--QYP 319

  Fly   158 RYS------QLLAMRATSKHQHLNGNQVNLLRTQITAYRLLARNKPISMQMQQALQAAQQQPPPG 216
            .||      |.||        :.:|...||   .:|.......|.|::       |..:...|.|
Zfish   320 PYSSYGNLNQGLA--------NTSGMSPNL---SLTTSSNSNPNAPVT-------QVQRYPAPAG 366

  Fly   217 PPIGP-PGAPGGP-----------------PPGSQHAGQP------PVPPQQQQQPPPS------ 251
            |...| ||...||                 |..:|...||      |.|||.....|||
Zfish   367 PQRYPTPGGQQGPLHQQPIHVNQINTQPMHPAQNQATAQPKLQQHLPPPPQGSYSSPPSMSPMRN 431

  Fly   252 ----AGTPPQCSTPPASNPYGPPV---PGQKMQVAPPPPHMQQG-------QPLP---------- 292
                |||||.....|.|......|   ||...|...|..|.|:|       ||||
Zfish   432 LATPAGTPPPQQVRPPSAGLATDVGGYPGVPHQSQGPMAHAQRGAGPMNAAQPLPHQQLPSHSTH 496

  Fly   293 PQPPQV-----------------------GG----PPPIQQQQ--PPQQQQQQSQPPPPEPHQHQ 328
            |.||..                       ||    ||..|.|:  ..|.|.||.|.||....|.|
Zfish   497 PHPPTTQMYAALSPNHRATAAQGRSSTTPGGNHTEPPGPQDQRLHAQQAQCQQLQKPPLPFQQQQ 561

  Fly   329 LPNGGKPLSMGPSGGQPLIPSSPMQPQVRGTLPGMPPGSQVPQPGGGPQRQVPPAGMPM------ 387
            |.....|         |.||  |.|..:.......||..|    ...|..|.||   ||
Zfish   562 LQQVHTP---------PSIP--PSQTHLAAHHQSSPPSQQ----AWAPTHQSPP---PMQKVPHM 608

  Fly   388 ----PKPN-RITTVAKPVGLDPITL-----LQERENRIAARISLRMQELQRLPATMSE-----DL 437
                |.|: .|.|.:|...:.|...     ||::|:      .|:.::.::..|.:||     ::
Zfish   609 LHSPPDPSLEIITSSKTPAMGPNLQPANCDLQQKES------ELKPKKKKKKKAKVSEGQECNNI 667

  Fly   438 RLQAAIELRALRVLNFQRQLRMEFVQCTRRDTTLETALNIKLYKRTKRQGLREAR--ATEKLEKQ 500
            ..:|..|:.||  :|....|          .|.:|.....|..|:.|.:..:|.:  .|.|..|.
Zfish   668 SSEAGGEVTAL--MNEGDSL----------ITPVEKPAEKKSKKKPKEKEPKEPKEPKTPKTPKT 720

  Fly   501 QKLEAERKR-RQKHLEFLAAVLQHGKDLREFHRNNKAQLARMNKAVMNHHANAEREQKKE---QE 561
            .|...|.|. ::|.:          |......:::|...|:.:.:...:....|.::|:|   ..
Zfish   721 PKTPKEPKEPKEKKV----------KTATPKPKSSKKPSAKKSDSESGNSTKKEAKRKREPSVTS 775

  Fly   562 RIEKERMRRLMAEDEEGYRKLIDQKKDKR------LAFLLSQTDEYISNLTQMVKQHKDD----- 615
            .:||...:....||::|.:|....::.||      |.|.:|..|:            .||
Zfish   776 DVEKTPPQSPEEEDDDGVQKRRSSRQVKRKRYTEDLEFRISDDDD------------GDDSAGPK 828

  Fly   616 ------QMKKKEEEGKRL-----IQFKKELLMSGEYIGIDEGSIVADMRVHVVEQCTGKKLTGDD 669
                  |.:..:.||..:     ::..|:.|.|||.|.::|..:               |..|
Zfish   829 SPTTSEQQELPDAEGPVVEKIMGMRMGKKELASGEEIEVEEFYV---------------KFKG-- 876

  Fly   670 APMLKHLHRWLNMHPGWDWIDDEEDSCGSNDDHKPK--------------VEEQP-----TATED 715
               ..:||        ..|.|.||.........|.|              ::::|     ...:.
Zfish   877 ---FSYLH--------CRWADIEELEKDKRIQQKIKRFRAKQALSTFVTEMDDEPFNPDYVEVDR 930

  Fly   716 ATDKAQATGNDEDAKDLITKAKVEDDEYRTEEQTYYSIAHTIHEKVVEQASIMVN---------- 770
            ..|.:::|  ||:. :|:|...|:......|:.|:...|.....|:.|...:|..
Zfish   931 VLDVSEST--DENG-ELVTLYLVKWCSLPYEDSTWELKADIDQVKIEEFERVMAREPQLKRVERP 992

  Fly   771 -----------------GTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDR 818
                             ..|:|||::|:.||:..:.|..|.|||||||||||||:|:.: |.:..
Zfish   993 PTSDWQKSESSREYKNANALREYQLEGVNWLLFNWYNTRNCILADEMGLGKTIQSITFL-YEIYL 1056

  Fly   819 KKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQ--------NQMR----ATK 871
            |.:.||:|:|.||||:|||..||..|. .:.||.|.||...|:.:|        .|.|    |.|
Zfish  1057 KGIHGPFLVIAPLSTIPNWEREFRTWT-ELNVVVYHGSQASRKTIQAYEMYYRDTQGRIIKGAYK 1120

  Fly   872 FNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNK 936
            |:.::||:|.::.|...|..:.|:.:||||.||:||.:|||.:.|....: .:::|||||||||.
Zfish  1121 FHAVITTFEMILTDCPELRNVPWRCVIIDEAHRLKNRNCKLLEGLKMMDM-EHKVLLTGTPLQNT 1184

  Fly   937 LPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKK 1001
            :.||::|||||.|..|.|.|||.|.|.          :|..||.   :::|..:|:|.:|||||:
Zfish  1185 VEELFSLLNFLEPDRFPSESTFMQEFG----------DLKTEEQ---VQKLQGILKPMMLRRLKE 1236

  Fly  1002 EVEHQLPDKVEYIIKCDMSALQRVLYKHMQSK--GVLLTDGSEKGKHGKGGAKA--LMNTIVQLR 1062
            :||..|..|.|.||:.:::.:|:..|:.:..|  ..|...|:..|..|.||:..  |:||:::||
Zfish  1237 DVEKNLAPKEETIIEVELTNVQKKYYRAILEKNFAFLSKSGAGGGSGGGGGSNVPNLLNTMMELR 1301

  Fly  1063 KLCNHPFMFQHIEEKYCDHTGGHGVVSGPDLY-----RVSGKFELLDRILPKLKATNHRVLLFCQ 1122
            |.||||::....|||..:.......:..|:.:     :.:||..|:|::||||||..||||:|.|
Zfish  1302 KCCNHPYLINGAEEKIMEEFRETHPLDQPEFHLQAMIQAAGKLVLIDKLLPKLKAGGHRVLIFSQ 1366

  Fly  1123 MTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTAD 1187
            |.:|:.|:||||..|::.|.|:||..:...|...:.:|:...||.|||||.|||||||:||..||
Zfish  1367 MVRCLDILEDYLIQRRYPYERIDGRVRGNLRQAAIDRFSRPDSDRFVFLLCTRAGGLGINLTAAD 1431

  Fly  1188 TVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMF 1252
            |.:||||||||..|||||.|.|||||...|::.||:|.||.|..:...|..||.:|:.|:|: |.
Zfish  1432 TCIIFDSDWNPQNDLQAQARCHRIGQSKSVKIYRLITRNSYEREMFDKASLKLGLDKAVLQS-MS 1495

  Fly  1253 DQKSTGSERQQF----LQTILHQDD----NEEEEENEVPDDEMINMMIARSEEEIEIFKRMDAER 1309
            .:::..:..||.    ::.:|.:..    .|||:|.....:|.|:.::.|..:.|.|........
Zfish  1496 GRENAANGVQQLSKKEIEDLLRKGAYGALMEEEDEGSKFCEEDIDQILQRRTQTITIESEGKGST 1560

  Fly  1310 KKEDEEIHPGRERLIDESELPDWLTKDDDEVERFHYQYDEDTILGRGS------RQRKEVDYTDS 1368
            ..:...:..|....| ..|.||:..|...:.|     .|.|.|.||.:      |.||:..:..|
Zfish  1561 FAKASFVSAGNRTDI-SLEDPDFWQKWAKKAE-----LDLDAINGRNNLVIDTPRVRKQTRHYSS 1619

  Fly  1369 LTEKEWLKAIDDGAEFDEEEEEDDSK--RKRRKRKNRKE---ESD----DDSLIL---------- 1414
            :.|       ||..|:.|.|.:.:.|  :|.|:.::|.:   .|:    :.:|::
Zfish  1620 MKE-------DDLMEYSELESDSEDKPIQKPRRPQDRTQGYPRSECFRVEKNLLVYGWGRWGDIL 1677

  Fly  1415 -----KRRRRQN--------------LDKRSKKQMHKIMSAVIKHNQDGRT--------LSEPFM 1452
                 ||..|:.              |..|..:.:...:..:|...:||::        ||.|..
Zfish  1678 SHGRFKRPLRERDVETICRALLAYCLLHYRGDENIKGFIWDLITPTEDGQSRTLTNHSGLSAPVP 1742

  Fly  1453 --------KLPSRQ-RLP----------------DYYEIIKRPV--DIKKILQRIEDCKY----- 1485
                    |||..| |:|                |.|   ||.:  ...|:|.|:....|
Zfish  1743 RGRKGKKGKLPVAQTRMPQADWLADCNPDLLLQEDSY---KRHLKHHCNKVLLRVRMLYYLRQEV 1804

  Fly  1486 -----------ADLNELE------------KDFMQLCQNAQI-----------YNE---EASLIY 1513
                       .|.:||:            .|:..|..:..:           ||.   :.:|.:
Zfish  1805 IGDQADRILEGTDSSELDIWIPQPFHADVPTDWWDLDADKSLLIGVFKHGYEKYNSMRADPTLCF 1869

  Fly  1514 LDSIALQKVFVGARQRITAAADAAAVAAGDNTGE--AHGNGGSD--------------------N 1556
            |:.:.:              .||.|:||.....:  |.|..|.:                    |
Zfish  1870 LERVGM--------------PDAKAIAAEQRGADMMADGVEGEEEDPEYKPLRMSFKDDLDDFTN 1920

  Fly  1557 SDNDDDDGGDDGSDDE 1572
            |..||::.|.||...|
Zfish  1921 SPLDDNNDGMDGETGE 1936

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622	6/28 (21%)
		Pro-rich	<247..401	CDD:464580	61/223 (27%)
		PTZ00121	<477..651	CDD:173412	41/201 (20%)
		HSA	501..573	CDD:214727	12/75 (16%)
		BRK	650..691	CDD:462196	5/40 (13%)
		PLN03142	739..>1368	CDD:215601	249/690 (36%)
		Bromo_SNF2L2	1425..1530	CDD:99947	30/181 (17%)
chd7	XP_697956.4	Med15	<30..>317	CDD:312941	49/191 (26%)
		PAT1	<258..>399	CDD:401645	35/160 (22%)
		Atrophin-1	362..>608	CDD:460830	72/263 (27%)
		CD1_tandem_CHD5-9_like	840..905	CDD:349315	19/92 (21%)
		CD2_tandem_CHD5-9_like	923..980	CDD:349310	12/59 (20%)
		PLN03142	1012..>1618	CDD:215601	243/628 (39%)
		BRK	2741..2784	CDD:462196