Protein Alignment brm and SMARCAD1

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: NP_001121901.1
• Gene: SMARCAD1 / 56916
• HGNCID: 18398
• Length: 1028
• Species: Homo sapiens
• Alignment Length: 1112
• Identity: 298/1112 - (26%)
• Similarity: 485/1112 - (43%)
• Gaps: 256/1112 - (23%)

  Fly   307 QQPPQQQQQQSQPPPPEPHQHQLPNGGKPLSMGPSGGQPLIPSSPMQPQVRGTLPGMPPGSQVPQ 371
            ::.|:...|.|||.|..|                      |..|..:....|.:      |:...
Human    18 EEAPEATPQPSQPGPSSP----------------------ISLSAEEENAEGEV------SRANT 54

  Fly   372 PGGGPQRQVPPAGMPMPKPNR----ITTVAKPVGLDPITLLQERENRIAARISLRMQ-------- 424
            |......:...:.:|....|.    |:......|:..|.|..:.|:.::...|..:|
Human    55 PDSDITEKTEDSSVPETPDNERKASISYFKNQRGIQYIDLSSDSEDVVSPNCSNTVQEKTFNKDT 119

  Fly   425 -----------ELQRLP--ATMSEDL-RLQAAIELRALRVLNFQRQLRMEFVQCTRRD------- 468
                       |.|.||  |..::|: .|:...||..|:....| .|:..|.|.:..|
Human   120 VIIVSEPSEDEESQGLPTMARRNDDISELEDLSELEDLKDAKLQ-TLKELFPQRSDNDLLKLIES 183

  Fly   469 -TTLETALNIKLY---------KRTKRQGLREARATEKLEKQQKLEAERKRRQKHLEFLAAVLQH 523
             :|::.|:...|.         ::.|.....|....::....|.::..|             |.|
Human   184 TSTMDGAIAAALLMFGDAGGGPRKRKLSSSSEPYEEDEFNDDQSIKKTR-------------LDH 235

  Fly   524 GKDLREFHRNN------KAQLARMNKAVMNHHANAEREQKKEQERIEKERMR--RLMAEDEEGYR 580
            |::..|...::      ::.:.::.|...|......||..||.|.:..|.:.  ::.|||::  .
Human   236 GEESNESAESSSNWEKQESIVLKLQKEFPNFDKQELREVLKEHEWMYTEALESLKVFAEDQD--M 298

  Fly   581 KLIDQKKDKRLAFLLSQTDEYISNLTQMVKQHKDDQMKKKEEEG-----KRLIQFKKELLMSGEY 640
            :.:.|.:......:.|::..|..|.|:...:.|   ...|.:.|     |:.:...|.::...||
Human   299 QYVSQSEVPNGKEVSSRSQNYPKNATKTKLKQK---FSMKAQNGFNKKRKKNVFNPKRVVEDSEY 360

  Fly   641 -IGIDEGSIVADMRVHVVEQCTGKKLTGDDAPMLKHLHRWLNMHPGWDWIDDEE-------DSCG 697
             .|.|.||.:.:      :..:|:::. :|....|.||          ::.|..       ..|.
Human   361 DSGSDVGSSLDE------DYSSGEEVM-EDGYKGKILH----------FLQDASIGELTLIPQCS 408

  Fly   698 SNDDHKPKVEEQPTATEDA--TDKAQATGNDED----------AKDLITKA--KVEDDEYRTEEQ 748
            .....| ..|.:|..:.:|  |..::..|..||          .:|::.:.  |.||
Human   409 QKKAQK-ITELRPFNSWEALFTKMSKTNGLSEDLIWHCKTLIQERDVVIRLMNKCED-------- 464

  Fly   749 TYYSIAHTIHEKV-----------VEQASIMVNG-TLKEYQIKGLEWLVSLYNNNLNGILADEMG 801
                |::.:.::|           :||.||:... :||.||..||.||..::.:.||||||||||
Human   465 ----ISNKLTKQVTMLTGNGGGWNIEQPSILNQSLSLKPYQKVGLNWLALVHKHGLNGILADEMG 525

  Fly   802 LGKTIQTISLVTYLMDRKKVMGPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQNQ 866
            ||||||.|:.:.||..... .||:||:||.||:.||:.|...|.|.:.|:.|.||.:.|:.::..
Human   526 LGKTIQAIAFLAYLYQEGN-NGPHLIVVPASTIDNWLREVNLWCPTLKVLCYYGSQEERKQIRFN 589

  Fly   867 M--RATKFNVLLTTYEYVIK---DKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYI---AP 923
            :  |...:||::|||...|.   |:::..:::..|.|.||||.:||    :..:...|.:   |.
Human   590 IHSRYEDYNVIVTTYNCAISSSDDRSLFRRLKLNYAIFDEGHMLKN----MGSIRYQHLMTINAN 650

  Fly   924 YRLLLTGTPLQNKLPELWALLNFLLPSIF-KSCSTFEQWFNAPFATTGEKVELNEEETILIIRRL 987
            .||||||||:||.|.||.:||||::|.:| .|.|...:.|::...:..|: .:.|:|.   |...
Human   651 NRLLLTGTPVQNNLLELMSLLNFVMPHMFSSSTSEIRRMFSSKTKSADEQ-SIYEKER---IAHA 711

  Fly   988 HKVLRPFLLRRLKKEVEHQLPDKVEYIIKCDMSALQRVLY-----KHMQSKGVLLTDGSEKGKHG 1047
            .::::||:|||:|:||..|||.|.:.|..|.||..|..||     :..:|...|:|:.:.:
Human   712 KQIIKPFILRRVKEEVLKQLPPKKDRIELCAMSEKQEQLYLGLFNRLKKSINNLVTEKNTE---- 772

  Fly  1048 KGGAKALMNTIVQLRKLCNHPFMFQHI---------------EEKYCDHTGGHGVVSGPDL---- 1093
                  :.|.::||||:.|||.:.:..               |..:|:        :.|||
Human   773 ------MCNVMMQLRKMANHPLLHRQYYTAEKLKEMSQLMLKEPTHCE--------ANPDLIFED 823

  Fly  1094 ---------------YR-------------VSGKFELLDRILPKLKATNHRVLLFCQMTQCMTII 1130
                           ||             .||||.:|..||.:||....||:||.|.|..:.|:
Human   824 MEVMTDFELHVLCKQYRHINNFQLDMDLILDSGKFRVLGCILSELKQKGDRVVLFSQFTMMLDIL 888

  Fly  1131 EDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSD 1195
            |..|...|..||||||.|:..:|..|:.:||. ..|:|||||||:|||||:||.:|:.|::.|.|
Human   889 EVLLKHHQHRYLRLDGKTQISERIHLIDEFNT-DMDIFVFLLSTKAGGLGINLTSANVVILHDID 952

  Fly  1196 WNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQKSTGSE 1260
            .||:.|.||:||.||:||..||.|::|::..::||.:|...:.||.:::.:......|:.|..::
Human   953 CNPYNDKQAEDRCHRVGQTKEVLVIKLISQGTIEESMLKINQQKLKLEQDMTTVDEGDEGSMPAD 1017

  Fly  1261 RQQFLQT 1267
            ....|:|
Human  1018 IATLLKT 1024

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580	15/97 (15%)
		PTZ00121	<477..651	CDD:173412	36/196 (18%)
		HSA	501..573	CDD:214727	14/79 (18%)
		BRK	650..691	CDD:462196	5/40 (13%)
		PLN03142	739..>1368	CDD:215601	207/602 (34%)
		Bromo_SNF2L2	1425..1530	CDD:99947
SMARCAD1	NP_001121901.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..82		15/91 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	203..251		8/60 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	302..328		5/25 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	354..373		6/24 (25%)
		HepA	<496..999	CDD:440319	195/530 (37%)
		DEGH box	628..631		2/2 (100%)
		Nuclear localization signal. /evidence=ECO:0000255	721..738		9/16 (56%)
		DEGD box	1007..1010		0/2 (0%)