Protein Alignment brm and chd4a

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: XP_021323760.1
• Gene: chd4a / 558344
• ZFINID: ZDB-GENE-041111-187
• Length: 1931
• Species: Danio rerio
• Alignment Length: 1876
• Identity: 454/1876 - (24%)
• Similarity: 710/1876 - (37%)
• Gaps: 548/1876 - (29%)

  Fly    83 SKGPHMGMQMPPTGPNMSPYQTHGMPPNAPTQPCIVSPGGPPGGPPPPERSSQENLHALQR--AI 145
            |:...:|:..|.  |...|....|....:.::....:||..........:..:.|..|.:|  |.
Zfish    56 SRREEIGISSPE--PGEGPDLDDGEEDRSESEGSDYTPGRKKKKRASTAKDKKRNSSAAERNSAA 118

  Fly   146 DSMEEKGLQED-------PR-YSQLLAMRATSKHQHLNGNQ-----------VNLLRTQITA--- 188
            ....|...:||       |: .||||.........|:...:           ...:|..|.|
Zfish   119 SKRREPEEEEDEDDDDSEPKSSSQLLDTWGMEDIDHIFTEEDYRTLTNYKAFSQFVRPLIAAKNP 183

  Fly   189 --------------YRLLARNKPISMQMQQALQAAQQQPPPGPP-------IGPPGAPGGP---- 228
                          :|..:.|.|:.......:.||..:.||..|       |.|...|..|
Zfish   184 KIAVSKMMMVLGAKWREFSTNNPLRGSATSLVAAASVETPPETPTSASAAQISPESTPAAPVRKA 248

  Fly   229 ------PPGSQHAGQPPVPPQQQ----QQPPP--------------------------------- 250
                  .|.::...:|...||::    ::..|
Zfish   249 KTKEGKGPNARKKSKPAPKPQEKKVKTKKVAPLKIKLGGFNSKRKRSSSEEDDVDVDSDFDDGSI 313

  Fly   251 -----SAGTPPQCSTPPASNPYGPPVPGQKMQVA------------------------------P 280
                 |.|:..:.|...|...     |.:|.:.|                              |
Zfish   314 NSVSVSNGSNSRSSRSSAKKK-----PKKKTKKADEDGDGYETDHQDYCEVCQQGGEIILCDTCP 373

  Fly   281 PPPHMQQGQPLPPQPPQVGGPPPIQQQQPPQQQQQQSQPPPPEPHQHQLPNGGKP---------L 336
            ...||....|...:.|:.....|..::...|.:.::......|.::    .||:.         .
Zfish   374 RAYHMVCLDPDMEKAPEGTWSCPHCEKMGIQWEAREDASEGEEDNE----AGGEAEEDDHHMEFC 434

  Fly   337 SMGPSGGQPL----IPSSPMQPQVRGTLPGMPPGSQV------PQPGGGPQRQV------PPAGM 385
            .:...||:.|    .|||.....:...||.:|.|..:      |...|..|:.:      ||...
Zfish   435 RVCKDGGELLCCDSCPSSYHIHCLNPPLPEIPNGEWICPRCTCPSMKGKVQKILTWRWTEPPPPT 499

  Fly   386 PMPKPNRITTVAKPVGLDPITLL--QERENRIAARISLRMQELQRLPATMSEDLRLQAAIELRAL 448
            |:|:|:.:.|.|.    ||..|.  .|||      ..::.|.:.....:...:|:|:...:   :
Zfish   500 PVPRPSDLPTDAP----DPTPLAGRPERE------FFVKWQNMSYWHCSWVTELQLEIHCQ---V 551

  Fly   449 RVLNFQRQLRMEFVQCTRRDTTLETALNIKLYKRTKRQGLREARATEKLEKQQKLEAERKRRQKH 513
            ...|:||:..|:      ....::..            |..|...::|.:|:....|  :..:|:
Zfish   552 MFRNYQRKNDMD------EPPPIDFG------------GEGEEEKSDKRKKKDPTYA--RMEEKY 596

  Fly   514 LEF--------LAAVLQHGKDLREFHRNNKAQLARMNKAVMNHHANAEREQKKEQERIEKERMRR 570
            ..|        :..:|.|..|    .:||            .|:....|:...:|...|.|.|.
Zfish   597 YRFGIKMEWMVIHRILNHSVD----KKNN------------CHYLIKWRDLTYDQATWELEDMD- 644

  Fly   571 LMAEDEEGYRKLIDQKKDKRLAFLLSQTDEYISNLTQMVKQHKDDQMKKKEEEGKRLIQF--KKE 633
                                    |...|.|                         .:|:  .:|
Zfish   645 ------------------------LPDYDTY-------------------------KLQYWNHRE 660

  Fly   634 LLMSGEYIGIDEGSIVADMRVHVVEQCTGKKLTGDDAPMLKHLHRWLNMHPGWDWIDDEEDSCGS 698
            |:|.      |||.             .|||:      .:|...|.|:..|....:|
Zfish   661 LMMG------DEGK-------------PGKKI------KIKGKMRKLDRPPENPVVD-------- 692

  Fly   699 NDDHKP--KVEEQPTATEDATDKAQATGNDEDAKDLITKAKVEDDEYRTEEQTYYSIAHTIHEKV 761
                 |  |.|.||       |....||
Zfish   693 -----PTIKFERQP-------DYLDTTG------------------------------------- 708

  Fly   762 VEQASIMVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVMGPYL 826
                     |||..||::||.||...:....:.|||||||||||:||...:..|.......||:|
Zfish   709 ---------GTLHPYQLEGLNWLRFSWAQGTDTILADEMGLGKTVQTAVFLYSLYKEGHSKGPFL 764

  Fly   827 IIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRLLQ--------NQMR------------ATK 871
            :..||||:.||..|||.|||.:.||:|.|....|.:::        |.:|            :.|
Zfish   765 VSAPLSTIINWEREFEMWAPDMYVVTYVGDKDSRAVIRENEFSFENNAIRGGKKPSKMKKEASVK 829

  Fly   872 FNVLLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNK 936
            |:||||:||.:..|.|||..|.|..:::||.||:||:..|..::|| :|...::||||||||||.
Zfish   830 FHVLLTSYELITIDTAVLGSIDWACLVVDEAHRLKNNQSKFFRILN-NYPLQHKLLLTGTPLQNN 893

  Fly   937 LPELWALLNFLLPSIFKSCSTFEQWFNAPFATTGEKVELNEEETILIIRRLHKVLRPFLLRRLKK 1001
            |.||:.|||||.|..|.:...|.:.|          .::.:|:.   |::||.:|.|.:|||||.
Zfish   894 LEELFHLLNFLTPERFSNLEGFLEEF----------ADIAKEDQ---IKKLHDMLGPHMLRRLKA 945

  Fly  1002 EVEHQLPDKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEK-GKHGKGGAKALMNTIVQLRKLC 1065
            :|...:|.|.|.|::.::|.:|:..||      .:||...|. ...|.|...:|:|.::.|:|.|
Zfish   946 DVFKHMPSKTELIVRVELSPMQKKYYK------FILTRNFEALNTRGGGNQVSLLNVVMDLKKCC 1004

  Fly  1066 NHPFMFQHIEEKYCDHTGGHGVVSGPDLYRVSGKFELLDRILPKLKATNHRVLLFCQMTQCMTII 1130
            |||::|.....:.....  :|:..|..|.:.|||..||.::|.|||...||||:|.|||:.:.::
Zfish  1005 NHPYLFPAAAMEAAKMP--NGMYEGGGLTKSSGKLLLLQKMLRKLKEGGHRVLIFSQMTKMLDLL 1067

  Fly  1131 EDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSD 1195
            ||:|....:.|.|:||......|.|.:.:|||.|:..|||||||||||||:||.|||||||:|||
Zfish  1068 EDFLENEGYKYERIDGGITGGMRQEAIDRFNAPGAPQFVFLLSTRAGGLGINLATADTVVIYDSD 1132

  Fly  1196 WNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQKSTGSE 1260
            ||||.|:||..|||||||..:|.:.|.:|..||||||...|:.|:.:...|::.|:  ...|||.
Zfish  1133 WNPHNDIQAFSRAHRIGQNKKVMIYRFVTKASVEERITQVAKKKMMLTHLVVRPGL--GSKTGSM 1195

  Fly  1261 RQQFLQTILH-----------QDDNEEEEENEVP---DDEMINMMIARSE------------EEI 1299
            .:|.|..||.           :.:|:|.:|:...   ||:.|:.::.|::            |.:
Zfish  1196 SKQELDDILKFGTEELFKDEGEGENKEGQEDSSVIHYDDKAIDRLLDRNQDATDDTELQSMNEYL 1260

  Fly  1300 EIFKRMDAERKKEDEEIHPGRERLI--DESELPDWLTKDDDEVERFHYQYDEDTI---LGRGSRQ 1359
            ..||......|.|:|.....:..:|  :||..||:..|    :.|.||:..::.:   ||:|.|.
Zfish  1261 SSFKVAQYVVKDEEEAEEEVQREIIKQEESVDPDYWEK----LLRHHYEQQQEDLARNLGKGKRI 1321

  Fly  1360 RKEVDYTD-SLTEKEWLKAIDDG------------AEFDEEEEEDDSKRKRRKRKNRKEE----- 1406
            ||:|:|.| |..:::|.....||            .:|||..|.:..:..|:..:|.|::
Zfish  1322 RKQVNYNDGSQEDRDWQDDQSDGQSDYSVASEEGDEDFDERSEANSRRPNRKGLRNDKDKPLPPL 1386

  Fly  1407 -----SDDDSLILKRRRR------------------------QNLDKRSKKQMHKIMSAVIKH-- 1440
                 .:.:.|....|:|                        ::|..:|:::....:|..::|
Zfish  1387 LARVSGNIEVLGFNARQRKAFLNAVMRYGMPPQDAFTTQWLVRDLRGKSEREFKAYVSLFMRHLC 1451

  Fly  1441 --NQDGRTLSEPFMKLPSRQRLPDYYEIIKRPVDIKKILQRIEDCKYADLNELEKDFMQLCQNAQ 1503
              ..||   :|.|.....|:.|...: ::.|...:..|.:::::.::.:........|:|.:|.
Zfish  1452 EPGADG---AESFADGVPREGLSRQH-VLTRIGVMSLIRKKVQEFEHVNGQWSMPWMMELSENK- 1511

  Fly  1504 IYNEEASLIYLDSIALQKVFVGA---RQRITAAADA---AAVAAGDNTGEAHGNGGSDNSDNDDD 1562
              ....:..:.||.: :....|.   .|..|.|.|.   |..|..|...|...||..:...|::.
Zfish  1512 --TTSTAGSHPDSPS-KTPTTGTPSDTQPNTPAPDGVPKAEDAGKDADKEKVKNGDGEKEANENK 1573

  Fly  1563 DGGDDGSDDEEIATTSAAAVKMKLKLNKSLASAPATPTQSS--------------SNVSSG---- 1609
            :.......||:....||:..|.|.|..|.     .||..||              .|..||
Zfish  1574 NSEVIAVPDEDGRAASASEEKEKGKEEKE-----KTPESSSEAEKADGKQEEKEEENAKSGDSEE 1633

  Fly  1610 --------AATTSKKQTRRKRSQKKYTISDDDDDDMDXLPLGVIFKRGSSDVEGMG 1657
                    ..:.:.|:|...:.:||    ||:.:.||..|: ...|:|..|.:..|
Zfish  1634 KTDDTDKPKGSEADKETSDAKGEKK----DDEPEKMDTTPV-TDEKKGQKDEKDSG 1684

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622	7/56 (13%)
		Pro-rich	<247..401	CDD:464580	38/246 (15%)
		PTZ00121	<477..651	CDD:173412	28/183 (15%)
		HSA	501..573	CDD:214727	14/79 (18%)
		BRK	650..691	CDD:462196	7/40 (18%)
		PLN03142	739..>1368	CDD:215601	248/681 (36%)
		Bromo_SNF2L2	1425..1530	CDD:99947	18/111 (16%)
chd4a	XP_021323760.1	CHDNT	153..206	CDD:462357	6/52 (12%)
		kgd	196..>280	CDD:476867	16/83 (19%)
		PHD1_CHD_II	356..398	CDD:277006	6/41 (15%)
		PHD2_CHD_II	433..475	CDD:277007	10/41 (24%)
		CD1_tandem_CHD3-4_like	480..558	CDD:349314	19/90 (21%)
		CD2_tandem_CHD3-4_like	604..657	CDD:349309	15/118 (13%)
		PLN03142	709..>1250	CDD:215601	224/564 (40%)
		DEXHc_CHD4	711..942	CDD:350814	96/244 (39%)
		DUF1087	1280..1327	CDD:461922	16/50 (32%)
		CHDII_SANT-like	1368..1502	CDD:461920	18/137 (13%)
		PTZ00121	<1547..>1713	CDD:173412	35/148 (24%)
		CHDCT2	1747..1892	CDD:462358