DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment brm and hells

DIOPT Version :10

Sequence 1:NP_001261906.1 Gene:brm / 39744 FlyBaseID:FBgn0000212 Length:1658 Species:Drosophila melanogaster
Sequence 2:NP_001032178.1 Gene:hells / 553328 ZFINID:ZDB-GENE-030131-9923 Length:853 Species:Danio rerio


Alignment Length:920 Identity:298/920 - (32%)
Similarity:461/920 - (50%) Gaps:186/920 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly   503 LEAERKRRQKHLEFLAAVLQHGKDLREFHRNNKAQLARMNKAVMNHHANAEREQKKEQERIEKER 567
            :|.....:.||.|.:..     |::.|..:|.:                 |..:|||:|.:|:.|
Zfish    30 IEETTMEKSKHEEMVIT-----KEMEEEEKNLE-----------------EEGEKKEREMMEEAR 72

  Fly   568 MRRLMAEDEEGYRKLIDQKKDKRLAFLLSQTDEYIS-NLTQMVKQHKDDQMKKKEEEGKRLIQFK 631
            ..|  ..|.:       :.:.|||..||.:::.|.. .||:|.:|.:::::||:..|.|..:..:
Zfish    73 QSR--GNDSQ-------EMRFKRLQHLLEKSNIYSKFLLTKMEQQQQEEKLKKERLEKKAAVLKQ 128

  Fly   632 KELLMSGEYIGIDEGSIVADMRVHVVEQCTGKKLTGDDAPMLKHLHRWLNMHPGWDWIDDEEDSC 696
            |             ||   |.:...||:   ||...:|..:.             |.:..||...
Zfish   129 K-------------GS---DKKTVKVER---KKRGREDYKIA-------------DVMTKEEIMS 161

  Fly   697 GSNDDHKPKVEEQPTATE--DATDKAQATGNDEDAKDLITKAKVEDDEYRTEEQTYYSIAHTIHE 759
            .:.   |||:||:..|:.  :|.|..:.:..:.|.|..:::...|:.:...:.:      .|::.
Zfish   162 KAK---KPKMEEEAQASVKLEAEDIEKLSDTNSDIKGRLSETLRENSKQMLDPE------RTVNG 217

  Fly   760 KVV--EQASIMVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLMDRKKVM 822
            :.|  :|..:...|.::.||::|:|||..|:.|.:|||||||||||||||.|:.:. :|..|||:
Zfish   218 QPVPAQQPQLFTGGVMRWYQVEGIEWLRMLWENGINGILADEMGLGKTIQCIAHIA-MMVEKKVL 281

  Fly   823 GPYLIIVPLSTLPNWVLEFEKWAPAVGVVSYKGSPQGRRL------LQNQMRATKFNVLLTTYEY 881
            ||:|::.||||||||:.||:::.|.|.|:.|.| ||..||      .|:|.......|::|::|.
Zfish   282 GPFLVVAPLSTLPNWISEFKRFTPEVSVLLYHG-PQKERLDLVKKIRQHQGSLRMCPVVVTSFEI 345

  Fly   882 VIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAP--YRLLLTGTPLQNKLPELWALL 944
            .::|:..|.:..|.|:|:|||||:||.:|:|.|.|.   :.|  .:||||||||||.|.|||:||
Zfish   346 AMRDRKFLQRFHWNYLIVDEGHRIKNLNCRLVQELK---MLPTDNKLLLTGTPLQNNLSELWSLL 407

  Fly   945 NFLLPSIFKSCSTFEQWFNAPFATT-GEKVELNEEETILIIRRLHKVLRPFLLRRLKKEVEHQLP 1008
            |||||.:|....:||.||:....|: .|.:..||.|. .|:..||.:|.||||||||.:|..::|
Zfish   408 NFLLPDVFDDLKSFESWFDISTITSDAENIVANEREQ-NILHMLHLILTPFLLRRLKSDVTLEVP 471

  Fly  1009 DKVEYIIKCDMSALQRVLYKHMQSKGVLLTDGSEK-----------GKHGKGGAKA--------- 1053
            .|.|.::...::..|...|..:.:|.:....|.||           |:..:...|.         
Zfish   472 PKKEIVVYAPLTNKQEAFYMAIVNKTIAKLLGQEKDESAPAPLTPSGRPKRRSRKVVNYTEPNTD 536

  Fly  1054 ---------------------------------------LMNTIVQLRKLCNHPFMFQHIEEKYC 1079
                                                   |.|.::.|::.|||.::.::    ..
Zfish   537 SMKDLEKYLEKVQQELDSQASSTPVVNVFMPVDAQVNLKLQNILMLLKRCCNHAYLIEY----PL 597

  Fly  1080 DHTGGHGVVSGPDLYRVSGKFELLDRILPKLKATNHRVLLFCQMTQCMTIIEDYLGWRQFGYLRL 1144
            |.|.|...:. ..|...||||.:|||:||:||...|:||:|.|||..:.|:.||...|.:.|.||
Zfish   598 DPTTGDFKID-EQLVEASGKFLILDRMLPELKKRGHKVLIFSQMTSILDILMDYCYLRGYEYSRL 661

  Fly  1145 DGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGGLGLNLQTADTVVIFDSDWNPHQDLQAQDRAH 1209
            ||:....||.|.::||:: ..:||:|||||||||||:||.:||||:||||||||..|||||||.|
Zfish   662 DGSMSYADRDENMKKFSS-DPEVFLFLLSTRAGGLGINLTSADTVIIFDSDWNPQADLQAQDRCH 725

  Fly  1210 RIGQRNEVRVLRLMTVNSVEERILAAARYKLNMDEKVIQAGMFDQKSTGSERQQF--------LQ 1266
            ||||...|.|.||:|.|:::|:||..|..|..:::.||....|  |.:.:|.:|.        |.
Zfish   726 RIGQTKPVVVHRLITANTIDEKILERASAKRKLEKMVIHKNKF--KGSKAELKQSKSCLDVDELV 788

  Fly  1267 TILHQDDNE---EEEENEVPDDEMINMMIARSEEEIEIFKRMDAERKKEDEEIHPGRERLIDESE 1328
            .:|...|.:   :..:.:|..|:.:.:::.||:       .||..:|:..:| ..|..::|:   
Zfish   789 ELLKSRDYDGAVKGTKGKVISDKDLQILLDRSD-------LMDQAKKRVKQE-KDGVFKVIE--- 842

  Fly  1329 LPDWLTKDDD 1338
                 .|||:
Zfish   843 -----AKDDN 847

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
brmNP_001261906.1 QLQ 173..202 CDD:462622
Pro-rich <247..401 CDD:464580
PTZ00121 <477..651 CDD:173412 33/148 (22%)
HSA 501..573 CDD:214727 15/69 (22%)
BRK 650..691 CDD:462196 7/40 (18%)
PLN03142 739..>1368 CDD:215601 246/681 (36%)
Bromo_SNF2L2 1425..1530 CDD:99947
hellsNP_001032178.1 nuclear localization signal 140..145 2/7 (29%)
PLN03142 224..>813 CDD:215601 232/602 (39%)
DEXHc_HELLS_SMARCA6 230..463 CDD:350767 114/238 (48%)
conserved domain I 241..265 16/23 (70%)
conserved domain Ia 285..294 5/8 (63%)
conserved domain II 353..371 9/17 (53%)
leucine zipper motif 389..410 17/20 (85%)
conserved domain III 390..397 6/6 (100%)
conserved domain IV 456..466 8/9 (89%)
Shugoshin_C 518..>534 CDD:462207 2/15 (13%)
conserved domain IVa 580..592 4/11 (36%)
conserved domain IVb 631..642 6/10 (60%)
conserved domain V 688..701 11/12 (92%)
conserved domain VI 719..729 8/9 (89%)
Blue background indicates that the domain is not in the aligned region.

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