Protein Alignment brm and ercc6

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: NP_001361595.1
• Gene: ercc6 / 548810
• XenbaseID: XB-GENE-1007918
• Length: 1371
• Species: Xenopus tropicalis
• Alignment Length: 1403
• Identity: 340/1403 - (24%)
• Similarity: 577/1403 - (41%)
• Gaps: 373/1403 - (26%)

  Fly   407 LLQERENRI--AARISLRM----QELQRLPATMSEDLRLQAAIELR----ALRVLN-FQRQLRME 460
            :||:.:|.|  |:|:| |:    ||||:|            |.|||    :||.:| ...||..:
 Frog    87 VLQQVDNAINEASRVS-RLAEAEQELQQL------------ADELRSCVTSLRQINKIIEQLTPQ 138

  Fly   461 FVQCTRRDTTLETALNIKLYKRTKRQGLREARATEKLEKQQKLEAERKRRQKHLEFLAAVLQHGK 525
            ...|......|:   ::|..|..|.|.|::.:|     ||::|:|.....|:..:.       .:
 Frog   139 AATCKEIGRKLD---SVKRQKHNKEQQLKKIKA-----KQKRLKAVLGGSQEEPDI-------EE 188

  Fly   526 DLREFHRNNKAQLARMNKAVMNHHANAEREQKKEQERI----------------EKERMRRLMAE 574
            ||:.:|..:....: :...:|       ..|.:|.|.:                |:.|.|:||..
 Frog   189 DLQGYHEEDVLPNS-LGSMLM-------PSQDREWEDLIRTGQMTPFGTKIPPKEERRPRKLMLN 245

  Fly   575 DEEGYRKLIDQKKDKRLAFLLSQTDEYISNLTQMVKQHKDDQMKKKEEEGKRLIQFKKELLMSGE 639
            :...:.|                   |:::..||..|.|..|..||.:        ||.||....
 Frog   246 ESSDFEK-------------------YLADQAQMAVQRKRPQTPKKVK--------KKTLLTKSP 283

  Fly   640 YIGIDEGSIVADMRVHVVEQCTGKKL----------------------------------TGDD- 669
                   |:|..:: .....||.|||                                  .||:
 Frog   284 -------SLVPSVK-KTDTSCTEKKLQKKMRKLQTKALQIQYRVGVPHAKPNLVPKNKIENGDES 340

  Fly   670 -----APMLKHLHRWLNMHPGWDWIDDEEDSCGSNDDHKPKVE----EQP----------TATED 715
                 :|..|......|..   :|:.:.:|   :..:.||.::    ::|          .::|:
 Frog   341 EGSVYSPEKKEESMEENEE---EWVPESQD---TEYELKPLIQRTNGKRPRENGMDPGFLPSSEE 399

  Fly   716 ATDKAQATG------------------------NDEDAKDLITKAKVEDDEYRTEEQTYYSIAHT 756
            ..|....:|                        .:::.::.|...:.||.:...:|.  :||..:
 Frog   400 KEDHLSRSGKGQRCRDDGNAQLYKQRLRQWHKQREKEKEERIATEESEDSDVEFDEG--FSIPCS 462

  Fly   757 IHEKVVEQASIMVNGTLKEYQIKGLEWLVSLYNNNLNGILADEMGLGKTIQTISLVTYLM----- 816
            |.:|            |.:||..|:.||..|:.....|||.||||||||||.|:.:..|.
 Frog   463 IWKK------------LYKYQQTGVRWLWELHCQQAGGILGDEMGLGKTIQIIAFLAGLSYSRIR 515

  Fly   817 -----DRKKVMGPYLIIVPLSTLPNWVLEFEKWAP--AVGVVSYKGSPQGRRLLQNQMRATKFNV 874
                 .|.:.:||.:|:.|.:.:..||.||..|.|  .|.::...||..|:::...........:
 Frog   516 TRGSDYRYEGLGPSIIVCPATVMHQWVKEFHTWWPQFRVVILHETGSYAGKKVKLIGELGNGCGI 580

  Fly   875 LLTTYEYVIKDKAVLAKIQWKYMIIDEGHRMKNHHCKLTQVLNTHYIAPYRLLLTGTPLQNKLPE 939
            |:|:|.||...:..|.|..|.|:|:||||:::|.:..:|.... .:..|:|::|:|:|:||.|.|
 Frog   581 LITSYSYVRLMQEELQKYHWHYIILDEGHKIRNPNAGVTLACK-QFRTPHRIILSGSPMQNNLRE 644

  Fly   940 LWALLNFLLPSIFKSCSTFEQWFNAPFATTG----EKVELNEEETILIIRRLHKVLRPFLLRRLK 1000
            ||:|.:|:.|....:...|.:.|:.|....|    ..|::........:  |...:.|:||||:|
 Frog   645 LWSLFDFVFPGKLGTLPVFMEQFSVPITMGGYSNASPVQVKTAYKCACV--LRDTINPYLLRRMK 707

  Fly  1001 KEVEHQ--LPDKVEYIIKCDMSALQRVLYK-HMQSK---GVLLTDGSEKGKHGKGGAKALMNTIV 1059
            .:|:..  ||||.|.::.|.::..||.:|: .:.||   |:|            .|...:...::
 Frog   708 ADVKMSLALPDKNEQVLFCRLTDEQRQVYQTFIDSKEVYGIL------------NGEMQVFPGLI 760

  Fly  1060 QLRKLCNHPFMFQHIEEKYCDHTGGHGVVSG---PDL--------YRVSGKFELLDRILPKLKAT 1113
            .|||:||||.:|          :||..::.|   .||        ::.|||..:::.:|......
 Frog   761 ALRKICNHPDLF----------SGGPKILKGTRDEDLEEEEQFGFWKRSGKLIVVEALLKIWHRQ 815

  Fly  1114 NHRVLLFCQMTQCMTIIEDYLGWRQFGYLRLDGTTKAEDRGELLRKFNAKGSDVFVFLLSTRAGG 1178
            .||||||.|..|.:.|:|.::..|.:.||::||||....|..|:.|:|...| :|||||:||.||
 Frog   816 GHRVLLFTQSRQMLQILEVFVRSRCYSYLKMDGTTTIASRQPLIAKYNEDPS-LFVFLLTTRVGG 879

  Fly  1179 LGLNLQTADTVVIFDSDWNPHQDLQAQDRAHRIGQRNEVRVLRLMTVNSVEERILAAARYKLNMD 1243
            ||:||..|:.|:|:|.||||..|.||::||.||||:.:|.|.||:|..::||:|.....:|..:.
 Frog   880 LGVNLTGANRVIIYDPDWNPSTDTQARERAWRIGQKKQVTVYRLLTAGTIEEKIYHRQIFKQFLT 944

  Fly  1244 EKVIQAGMFDQKSTGSERQQFLQTILHQ-------DDNEEEEENEVPDDEMINMMIARSEEEIEI 1301
            .:|::    |.|    :|:.|....|::       |.:...|.:.:         .|.:..::::
 Frog   945 NRVLK----DPK----QRRFFKSNDLYELFTFSSPDTSHGTETSAI---------FAGTGSDVQV 992

  Fly  1302 FKRMDAERKKEDEEIHPGRERL------------IDESELPDWLTKDDDEVERFHYQYDEDTILG 1354
            .||             ||.:.:            :..|..|...:|..:.|  ..:..:...::|
 Frog   993 VKR-------------PGNQNVAHTQTTFHKEPPVSISNTPSLPSKPLNSV--LQHAQENPMLVG 1042

  Fly  1355 RGSRQRKEVDYTDSLTEKEWLKAIDDGAEFDEEEEEDDSKRKRRKRKNR-KEESDDDSLILKRRR 1418
            ..:|...||..:.|:       .::.|.:..:....:..:...||.|.: |.:|...|  :|||
 Frog  1043 FEARSNSEVTPSTSI-------KLESGKDCKQGSLTEAPENCHRKHKAKTKHQSKGKS--VKRR- 1097

  Fly  1419 RQNLDKRSKKQMHKIMSAVIKHNQDGRTLSEPFMKLPSRQRLPDYYEIIKRPVD--IKKILQR-- 1479
                 |.:|.:..:| |.::|.|             |.|:...|.:|..::..|  ::|:.::
 Frog  1098 -----KDAKYEGERI-SHLVKQN-------------PFRREEGDQHEDRRKSDDYVLEKLFKKSG 1143

  Fly  1480 IEDCKYAD--LNELEKDFMQLCQNAQIYNEEASLIYLDSIALQKVFVGARQRITAAADAAAVAAG 1542
            :......|  ::....||:       :..||||.:..:::   :|...:|||..||:.......|
 Frog  1144 VHSAMKHDVIMDAANPDFV-------LVEEEASRVAHEAL---RVLKASRQRCYAASSGVPTWTG 1198

  Fly  1543 DN----TGEAHGNGGSDNS--DNDDDDG--GDDGSDDEEIATTSAAAVKMKLKLNKSLASAPATP 1599
            .|    :|..|..|...|.  ...|..|  ..|...|            :.:...|..:||.|..
 Frog  1199 MNGVTPSGTKHRFGQKRNPLLQTPDVPGRLPQDKCKD------------LNITKQKDQSSADAPS 1251

  Fly  1600 TQSSSNVSSG-AATTSKKQTRRKRSQKKYTISDDDDDD 1636
            ..|..|.|:. ||.:|.....|.|::....:...|:::
 Frog  1252 HFSGENQSTATAALSSSSLLSRMRARNNMLLPPRDENE 1289

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622
		Pro-rich	<247..401	CDD:464580
		PTZ00121	<477..651	CDD:173412	38/189 (20%)
		HSA	501..573	CDD:214727	14/87 (16%)
		BRK	650..691	CDD:462196	11/80 (14%)
		PLN03142	739..>1368	CDD:215601	200/680 (29%)
		Bromo_SNF2L2	1425..1530	CDD:99947	21/110 (19%)
ercc6	NP_001361595.1	COG4913	<24..>206	CDD:443941	38/147 (26%)
		cc_ERCC-6_N	61..137	CDD:411064	22/62 (35%)
		HepA	<458..948	CDD:440319	176/527 (33%)
		CSB_WHD	1300..1371	CDD:439329