Protein Alignment brm and ERCC6L

DIOPT Version :10

• Sequence 1: NP_001261906.1
• Gene: brm / 39744
• FlyBaseID: FBgn0000212
• Length: 1658
• Species: Drosophila melanogaster
• Sequence 2: NP_060139.2
• Gene: ERCC6L / 54821
• HGNCID: 20794
• Length: 1250
• Species: Homo sapiens
• Alignment Length: 223
• Identity: 47/223 - (21%)
• Similarity: 78/223 - (34%)
• Gaps: 83/223 - (37%)

  Fly    16 SSSEDVDEEISSGEDEKEHISNSSSSEEENELKDLSTQTLNSPSTEAPTLDSGSETNSDSDKPIV 80
            :.|:.:..|...||.||                 :..:.|.:|:..|..:.:    |.|..:.|:
Human   248 AQSQKIPREPRPGEFEK-----------------IIKRLLETPNARAVIMFA----NEDDIRRIL 291

  Fly    81 LTSQKKKE-------GTDSSGTKRA--------SEGTSSKDIKRAKKVSGDDDNKKFQSLWTKED 130
            ..::|..:       |:||.|:|.|        :||..:...|||   |.|..::.|:|
Human   292 EAAKKLNQSGHFLWIGSDSWGSKIAPVYQQEEIAEGAVTILPKRA---SIDGFDRYFRS------ 347

  Fly   131 EISLLQGMIDFKAETGTSAHDDMNGFFDIAKRYISFDVSKIQFGDKIRGLKKKYFGVRKKKGLDL 195
                           .|.|::..|.:|             .:|.::..|.|....|.|.
Human   348 ---------------RTLANNRRNVWF-------------AEFWEENFGCKLGSHGKRN------ 378

  Fly   196 DHDKKCLGLAK----SIWGLDGKEVVVL 219
            .|.|||.||.:    |.:..:||...|:
Human   379 SHIKKCTGLERIARDSSYEQEGKVQFVI 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brm	NP_001261906.1	QLQ	173..202	CDD:462622	8/28 (29%)
		Pro-rich	<247..401	CDD:464580
		PTZ00121	<477..651	CDD:173412
		HSA	501..573	CDD:214727
		BRK	650..691	CDD:462196
		PLN03142	739..>1368	CDD:215601
		Bromo_SNF2L2	1425..1530	CDD:99947
ERCC6L	NP_060139.2	TPR 1	21..54
		HepA	<90..610	CDD:440319	47/223 (21%)
		DEXHc_ERCC6L	96..328	CDD:350759	20/100 (20%)
		DEAH box	228..231
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	735..768
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	926..946
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1061..1092
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1110..1199
		TPR 2	1200..1233